Shi’an Wang received his B.S. in Biological Sciences from Shaanxi Normal University in

2003 and his Ph.D. in Microbiology from the Institute of Microbiology, Chinese

Academy of Sciences (CAS), in 2008. He subsequently joined the Qingdao

Institute of Bioenergy and Bioprocess Technology (QIBEBT), CAS, where he

currently serves as a Professor and leads the Yeast Biotechnology research

team. He is also a Fellow of the Youth Innovation Promotion Association, CAS. From

August 2013 to August 2014, he was a Visiting Scholar at the Massachusetts

Institute of Technology, working with Prof. Gregory Stephanopoulos.

His research focuses on yeast biotechnology and metabolic regulation, with

particular emphasis on the biosynthesis of lipids and proteins in yeast. He

adopts microbe-specific and product-specific strategies (MPSS) to optimize

metabolic pathways and cellular performance. He has established research

platforms based on oleaginous yeasts(Yarrowia lipolytica, Xanthophyllomyces

dendrorhous, and Cutaneotrichosporon oleaginosus), Pichia

pastoris, and Saccharomyces cerevisiae, enabling systematic studies

and biotechnological applications across diverse yeast systems. He has

published over 30 peer-reviewed articles in leading journals, including PNAS

and Science Advances. He has filed more than 20 patents, of which 4 have been

granted in the United States, Europe, and Japan, and 8 have been granted in

China. In addition, several of his technologies—such as yeast-based production

of nervonic acid and astaxanthin—have been transferred to industry.

1.      Ruilin Huang, Jiurong Wang, Ruirui Ding, Yu Liu, Juanjuan Su, Zhihang Chen, Yong Fan, Fuli Li, Linqi Wang, Xiao Liu and Shi’an Wang*. A conserved E3 ubiquitin

ligase rewires carotenoid, sterol, and lipid metabolism in Xanthophyllomyces dendrorhous. PNAS, 2026, 123(17):e2530496123. (2026.4.24 online)

2.      Qian Ling^# , Bozhao Li^# , Yuhua Feng, Jing Yang*, Shi’an Wang*, Suping Li*, Cheng Zhang*. Conformation Programmed DNA Computing. Science

Advances, 2026, 12(8):eaec8383. (2026.2.18 online)

3.     Zhihang Chen^#, Jiajun Deng^#, Peijie Han^#, Jiabao Li, Dong Li*, and Shi’an Wang*. Mass production of microbial protein using low-value materials. The

Innovation Life, 2026, 4:100200. (2026.1.7 online)

4.     Runze Miao, Yu Liu, Hui Wang, Guangwei Yu, Shi’an Wang, Juanjuan Su*, Feng Han*. A combined TLC–GC approach for the regiospecific analysis of triacylglycerols in Yarrowia lipolytica. Journal of Chromatography B, 2026, 1273:124945.

5.      Yuanping Fang, Pingzhong Feng, Li Wang, Lei Qin, Zhongming Wang, Shunni Zhu*, Wen Wang, Wei Qi, Shi’an Wang, Yong Fan. Evaluation of culture conditions of Trichosporon oleaginosus DSM11815 for enhancement of growth and lipid production in sugarcane bagasse hydrolysate as a substrate. Process Biochemistry,

2025, 155:23-36.

6.      Juanjuan Su, Shiyou Xing, Wei Qi, Shi’an Wang*. Scaling sustainable aviation fuel from microbial oils: challenges and opportunities. 10 Breakthrough Ideas in Energy for The Next Ten Years (6th Anniversary edition), 2025, 25-33.

7.      Shi’an Wang*, Juanjuan Su. Organisms for biofuel production. 10 Breakthrough Ideas in Energy for The Next Ten Years (5th Anniversary edition), 2024, 18-26.

8.      Ruirui Ding, Ruilin Huang, Hang Su, Jiawen Li, Fuli Li, Shi’an Wang*. Screening of astaxanthin-overproducing Xanthophyllomyces dendrorhous strains

via iterative ARTP mutagenesis and cell sorting by flow cytometry. J Appl Microbiol, 2024, 135(2):lxae020. 2024 Feb 1

9.      Hang Su^#, Penghui Shi^#, Zhaoshuang Shen^#, Huimin Meng, Ziyue Meng, Xingfeng Han, Yanna Chen, Weiming Fan, Yun Fa, Chunyu Yang,

Fuli Li^*, Shi’an Wang^*. High-level production of nervonic acid in the oleaginous yeast Yarrowia lipolytica by systematic metabolic engineering. Communications Biology, 2023, 6:1125. Published: 07 November 2023

10.   Nghi Van Phung^#, Fei Rong^#, Wan Yue Xia, Yong Fan^*, Xian Yu Li, Shi’an Wang, Fu Li Li^*. Nervonic acid and its sphingolipids: Biological functions and potential food applications. Critical Reviews in Food Science and Nutrition, 2023, 28:1-20.

11.  Qingqing Xu^#, Qingyun Tang^#, Yang Xu, Junjun Wu, Xiangzhao Mao, Fuli Li, Shi’an Wang, Yonghua Wang. Biotechnology in Future Food Lipids: Opportunities and Challenges. Annual Review of Food Science and Technology, 2023, 14:225-246.

12.  Ruilin Huang^#, Ruirui Ding^#, Yu Liu, Fuli Li, Zhaohui Zhang^*, Shi’an Wang^*. GATA transcription factor WC2 regulates the biosynthesis of astaxanthin in yeast Xanthophyllomyces dendrorhous. Microbial Biotechnology, 2022, 15(10):2578-2593. First published: 13 July 2022

13.  Jixuan Hong^#, Ziyue Meng^#, Zixi Zhang^#, Hang Su, Yuxuan Fan, Ruilin Huang, Ruirui Ding, Ning Zhang, Fuli Li*, Shi’an Wang*. Comprehensive analysis of CRISPR-Cas9 editing outcomes in yeast Xanthophyllomyces dendrorhous. The CRISPR Journal, 2022, 5(4):558-570. DOI:10.1089/crispr.2021.0116. PMID: 35506993. 2022 May 3

14.  Jiao X, Lyu L, Zhang Y, Huang Q, Zhou R, Wang S, Wang S, Zhang S, Zhao ZK. Reduction of lipid-accumulation of oleaginous yeast Rhodosporidium toruloides through CRISPR/Cas9-mediated inactivation of lipid droplet structural proteins. FEMS Microbiol Lett, 2021, 368(16):fnab111.

15.  Jiaxin Li, Jing Xu, Jianchang Ruan, Huimin Meng, Hangsu, Xingfeng Han, Ming Lu, Fuli Li, Shi’an Wang*. Disrupting a phospholipase A2 gene increasing lipid

accumulation in the oleaginous yeast Yarrowia lipolytica. J Appl Microbiol, 2020, 130(1):100-108.

16.  Ning Zhang, Jiaxin Li, Fuli Li, Shi’an Wang*. Selectable marker recycling in the nonconventional yeast Xanthophyllomyces dendrorhous by transient expression of Cre on a genetically unstable vector. Appl Microbiol Biotech, 2019, 103:963-971.

17.  Ning Zhang, Yuxuan Fan, Chen Li, Qiming Wang, Noppol Leksawasdi, Fuli Li, Shi’an Wang*. Cell permeability and nuclear DNA staining by propidium iodide in basidiomycetous yeasts. Appl Microbiol Biotech, 2018, 102:4183-4191.

18.  Da Wang, Fuli Li*, Shi’an Wang*. Engineering a natural Saccharomyces cerevisiae strain for ethanol production from inulin by consolidated bioprocessing. Biotechnology for Biofuels, 2016, 9:96.

19.  Da Wang, Fuli Li*, Shi’an Wang*. A one-step bioprocess for production of high-content fructo-oligosaccharides from inulin by yeast. Carbohydrate Polymers, 2016, 151:1220–1226.

20.  Alimadadi N, Soudi MR, Wang SA, Wang QM, Talebpour Z, Bai FY. Starmerella orientalis f.a., sp. nov., an ascomycetous yeast species isolated from flowers. Int J Syst Evol Microbiol, 2016, 66(3):1476-1481.

已指导学生

范雨萱  硕士研究生  085238-生物工程  

孟子越  硕士研究生  071005-微生物学  

现指导学生

苏航  博士研究生  071005-微生物学 

等