基本信息
王盛典  男  博导  中国科学院生物物理研究所
电子邮件: sdwang@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号
邮政编码:

研究领域

研究方向主要是抗肿瘤T细胞免疫和免疫治疗,研究工作重点聚焦于T细胞活化调控、肿瘤微环境对T细胞的免疫抑制、记忆性CD8+T细胞的分化机制。


招生信息

   
招生专业
071009-细胞生物学
100102-免疫学
招生方向
肿瘤免疫
T细胞免疫的调控

教育背景

2004-03--2005-02   美国Johns Hopkins University School of Medicine   助理研究员
1998-10--2004-02   美国Mayo Clinic Medical School   博士后/助理研究员
1995-09--1998-06   中国医学科学院协和医科大学   博士
学历
博士

学位
博士

工作经历

   
工作简历
2005-03~现在, 中国科学院生物物理研究所, 研究员
社会兼职
2022-08-15-今,中国抗癌协会合成生物医药专业委员会副主任委员,
2022-05-24-今,中国抗癌协会生物治疗专业委员会副主任委员,
2018-05-01-今,国家药品监督管理局医疗器械技术审评咨询委员会专家委员,
2018-01-01-今,中国免疫学会肿瘤免疫与生物治疗专业委员会会副主任委员,
2017-11-01-今,国家知识产权局中国专利审查技术专家,

专利与奖励

   
专利成果
[1] 王盛典, 李颖, 丛艳妮. 一种靶向抗原特异性T细胞诱导其向记忆干性细胞分化的融合蛋白. CN: CN110894241B, 2022-01-18.

[2] 王盛典, 傅阳心, 徐萌. 用于肿瘤治疗的白细胞介素21(IL-21)药物. CN: CN102775501A, 2012-11-14.

出版信息

   
发表论文
[1] Liu, Pei, Gao, Youshui, Luo, Pengbo, Yu, Hongping, Guo, Shang, Liu, Fuyun, Gao, Junjie, Xu, Jianzhong, Wang, Shengdian, Zhang, Changqing. Glucocorticoid-induced expansion of classical monocytes contributes to bone loss. EXPERIMENTAL AND MOLECULAR MEDICINE[J]. 2022, 第 9 作者  通讯作者  54(6): 765-776, http://dx.doi.org/10.1038/s12276-022-00764-6.
[2] Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, Jinke Cheng. Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. NATURE COMMUNICATIONS[J]. 2021, 第 11 作者12(1): http://dx.doi.org/10.1038/s41467-021-24619-2.
[3] Liu, Lei, Zheng, Yaqiong, Cai, Liping, Wu, Wanlei, Tang, Shi, Ding, Yinjuan, Liu, Wanbing, Kou, Guomei, Xiong, Zhou, Wang, Shengdian, Zheng, Shangen. Neutrophil-to-lymphocyte ratio, a critical predictor for assessment of disease severity in patients with COVID-19. INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY[J]. 2021, 第 10 作者  通讯作者  43(2): 329-335, http://dx.doi.org/10.1111/ijlh.13374.
[4] Li, Tiepeng, Zhao, Lingdi, Yang, Yonghao, Wang, Yao, Zhang, Yong, Guo, Jindong, Chen, Guangyu, Qin, Peng, Xu, Benling, Ma, Baozhen, Zhang, Fang, Shang, Yiman, Li, Qingjun, Zhang, Kai, Yuan, Dongfeng, Feng, Chaojie, Ma, Yan, Liu, Zhiyong, Tian, Zhichao, Li, Hongle, Wang, Shengdian, Gao, Quanli. T Cells Expanded from PD-1(+) Peripheral Blood Lymphocytes Share More Clones with Paired Tumor-Infiltrating Lymphocytes. CANCER RESEARCH[J]. 2021, 第 21 作者81(8): 2184-2194, http://dx.doi.org/10.1158/0008-5472.CAN-20-2300.
[5] Ying Li, Yanni Cong, Mingming Jia, Qianqian He, Haiqing Zhong, Yun Zhao, Hang Li, Meining Yan, Jia You, Jia Liu, Lieping Chen, Haiying Hang, Shengdian Wang. Targeting IL-21 to tumor-reactive T cells enhances memory T cell responses and anti-PD-1 antibody therapy. NATURE COMMUNICATIONS[J]. 2021, 第 13 作者  通讯作者  12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878483/.
[6] Wang, Xiang, Qiu, Zhiqiang, Ji, Xiangwen, Ning, Weihai, An, Yihua, Wang, Shengdian, Zhang, Hongwei. A novel workflow for cancer blood biomarker identification. ANNALS OF TRANSLATIONAL MEDICINE[J]. 2020, 第 6 作者8(21): http://dx.doi.org/10.21037/atm-20-2047.
[7] Ning, Weihai, Qiu, Zhiqiang, Ji, Xiangwen, Wang, Xiang, An, Yihua, Wang, Shengdian, Zhang, Hongwei. The Prognostic Value of EMT in Glioma and its Role in the Glioma Immune Microenvironment. JOURNAL OF MOLECULAR NEUROSCIENCE[J]. 2020, 第 6 作者70(10): 1501-1511, http://dx.doi.org/10.1007/s12031-020-01583-y.
[8] Lu, Shuangshuang, Zhang, Zhe, Du, Pan, Chard, Louisa S, Yan, Wenli, El Khouri, Margueritte, Wang, Zhizhong, Zhang, Zhongxian, Chu, Yongchao, Gao, Dongling, Zhang, Qinxian, Zhang, Lirong, Nagano, Ai, Wang, Jun, Chelala, Claude, Liu, Jing, Chen, Jiekai, Liu, Pentao, Dong, Yunshu, Wang, Shengdian, Li, Xiaozhu, Dong, Jianzeng, Lemoine, Nick R, Pei, Duanqing, Wang, Yaohe. A Virus-Infected, Reprogrammed Somatic Cell-Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer. CLINICAL CANCER RESEARCH[J]. 2020, 第 20 作者26(2): 465-476, http://dx.doi.org/10.1158/1078-0432.CCR-19-1395.
[9] Liu, Lei, Liu, Wanbing, Zheng, Yaqiong, Jiang, Xiaojing, Kou, Guomei, Ding, Jinya, Wang, Qiongshu, Huang, Qianchuan, Ding, Yinjuan, Ni, Wenxu, Wu, Wanlei, Tang, Shi, Tan, Li, Hu, Zhenhong, Xu, Weitian, Zhang, Yong, Zhang, Bo, Tang, Zhongzhi, Zhang, Xinhua, Li, Honghua, Rao, Zhiguo, Jiang, Hui, Ren, Xingfeng, Wang, Shengdian, Zheng, Shangen. A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients. MICROBES AND INFECTION[J]. 2020, 第 24 作者  通讯作者  22(4-5): 206-211, http://dx.doi.org/10.1016/j.micinf.2020.05.008.
[10] Fan, Ying, Li, Shu, Ding, Xiaoyan, Yue, Jian, Jiang, Jun, Zhao, Hong, Hao, Rui, Qiu, Weiliang, Liu, Kezhen, Li, Ying, Wang, Shengdian, Zheng, Limin, Ye, Bin, Meng, Kun, Xu, Binghe. First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers. BMC CANCER[J]. 2019, 第 11 作者19(1): https://doaj.org/article/e5def464c08b4bc7a24691f63732eb8e.
[11] Xu, Benling, Yuan, Long, Chen, Guangyu, Li, Tiepeng, Zhou, Jinxue, Zhang, Chengjuan, Qin, Peng, Muthana, Musleh M, Wang, Shengdian, Du, Xuexiang, Gao, Quanli. S-15 in combination of Akt inhibitor promotes the expansion of CD45RA(-)CCR7(+) tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1(+)Tim-3(+) cells as well as regulatory T cells. CANCER CELL INTERNATIONAL[J]. 2019, 第 9 作者  通讯作者  19(1): http://dx.doi.org/10.1186/s12935-019-1043-3.
[12] Chao Zhang, Xiaomei Wang, Shuran Li, Trix Twelkmeyer, Weihong Wang, Shengyuan Zhang, Shufeng Wang, Jizheng Chen, Xia Jin, Yuzhang Wu, Xinwen Chen, Shengdian Wang, Junqi Niu, Hairong Chen, Hong Tang. NKG2A is a NK cell exhaustion checkpoint for HCV persistence. NATURE COMMUNICATIONS[J]. 2019, 第 12 作者10(1): 1-11, http://www.corc.org.cn/handle/1471x/2373162.
[13] Wang, Pengju, Li, Xiaozhu, Wang, Jiwei, Gao, Dongling, Li, Yuenan, Li, Haoze, Chu, Yongchao, Zhang, Zhongxian, Liu, Hongtao, Jiang, Guozhong, Cheng, Zhenguo, Wang, Shengdian, Dong, Jianzeng, Feng, Baisui, Chard, Louisa S, Lemoine, Nicholas R, Wang, Yaohe. Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent (vol 8, 2017). NATURE COMMUNICATIONS. 2018, 第 12 作者9: https://www.webofscience.com/wos/woscc/full-record/WOS:000419677600001.
[14] Wang, Conghui, Cheng, Yuqiang, Zhang, Xiuping, Li, Nan, Zhang, Lin, Wang, Shengdian, Tong, Xuemei, Xu, Ying, Chen, Guoqiang, Cheng, Shuqun, Fan, Xuemei, Liu, Junling. Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis. HEPATOLOGY[J]. 2018, 第 6 作者68(6): 2239-2253, https://www.webofscience.com/wos/woscc/full-record/WOS:000451622600058.
[15] Li, Dongling, Hu, Minling, Liu, Ying, Ye, Peiying, Du, Peishuang, Li, ChiShan, Cheng, Liang, Liu, Ping, Jiang, Jing, Su, Lishan, Wang, Shengdian, Zheng, Pan, Liu, Yang. CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages. CELL DISCOVERY[J]. 2018, 第 11 作者4(1): https://doaj.org/article/87186af3194a41d18b0cef851952576f.
[16] 王盛典. CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellylar carcinogenesis by sustaining intrahepatic macrophages. Cell Discov. 2018, 第 1 作者
[17] Zhang, Jinhua, Song, Kun, Wang, Jun, Li, Yanan, Liu, Shuangqing, Dai, Chengliang, Chen, Lieping, Wang, Shengdian, Qin, Zhihai. S100A4 blockage alleviates agonistic anti-CD137 antibody-induced liver pathology without disruption of antitumor immunity. ONCOIMMUNOLOGY[J]. 2018, 第 8 作者7(4): https://doaj.org/article/868c19de8a3844e29ad6c0ca3f084355.
[18] Wang, LiXin, Chen, Xiaoping, Jia, Mingming, Wang, Shengdian, Shen, Jianliang. Arthritis of large joints shown as a rare clinical feature of cytokine release syndrome after chimeric antigen receptor T cell therapy A case report. MEDICINE[J]. 2018, 第 4 作者97(16): https://www.webofscience.com/wos/woscc/full-record/WOS:000431517200040.
[19] Nie, Xinxin, Chen, Wenni, Zhu, Ying, Huang, Baozhu, Yu, Weiwei, Wu, Zhanshuai, Guo, Sizheng, Zhu, Yiping, Luo, Liqun, Wang, Shengdian, Chen, Lieping. B7-DC (PD-L2) costimulation of CD4(+) T-helper 1 response via RGMb. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2018, 第 10 作者15(10): 888-897, https://www.webofscience.com/wos/woscc/full-record/WOS:000448672300004.
[20] Li, Xiaozhu, Wang, Pengju, Li, Hang, Du, Xuexiang, Liu, Mingyue, Huang, Qibin, Wang, Yaohe, Wang, Shengdian. The Efficacy of Oncolytic Adenovirus Is Mediated by T-cell Responses against Virus and Tumor in Syrian Hamster Model. CLINICAL CANCER RESEARCH[J]. 2017, 第 8 作者  通讯作者  23(1): 239-249, https://www.webofscience.com/wos/woscc/full-record/WOS:000393876300027.
[21] Pengju Wang, Xiaozhu Li, Jiwei Wang, Dongling Gao, Yuenan Li, Haoze Li, Yongchao Chu, Zhongxian Zhang, Hongtao Liu, Guozhong Jiang, Zhenguo Cheng, Shengdian Wang, Jianzeng Dong, Baisui Feng, Louisa S Chard, Nicholas R Lemoine, Yaohe Wang. Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent. NATURE COMMUNICATIONS[J]. 2017, 第 12 作者8(1): https://doaj.org/article/d991a41699f34b37801c9116d53e2378.
[22] 王盛典. Re-designing interluekin-12 to enhancs its safety and potential as an anti-tumor immunothreapeutic agent. Nat Commun. 2017, 第 1 作者
[23] Yang, Zuyu, Jia, Mingming, Liu, Guojing, Hao, Huaining, Chen, Li, Li, Guanghao, Liu, Sixue, Li, Yawei, Wu, ChungI, Lu, Xuemei, Wang, Shengdian. Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model. PLOS ONE[J]. 2017, 第 11 作者  通讯作者  12(11): https://doaj.org/article/3feae3bf3f434306a27008679c2ae64e.
[24] Liu, Zengjin, Han, Huamin, He, Xin, Li, Shouwei, Wu, Chenxing, Yu, Chunjiang, Wang, Shengdian. Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. ONCOLOGY LETTERS[J]. 2016, 第 7 作者  通讯作者  11(3): 1829-1834, https://www.webofscience.com/wos/woscc/full-record/WOS:000371634000034.
[25] Yan, Zhongyi, Wu, Yahong, Du, Jiangfeng, Li, Guodong, Wang, Shengdian, Cao, Wenpeng, Zhou, Xiuman, Wu, Chunjing, Zhang, Dan, Jing, Xueli, Li, Yifan, Wang, Hongfei, Gao, Yanfeng, Qi, Yuanming. A novel peptide targeting Clec9a on dendritic cell for cancer immunotherapy. ONCOTARGET[J]. 2016, 第 5 作者7(26): 40437-40450, https://www.webofscience.com/wos/woscc/full-record/WOS:000378614700112.
[26] Wang, Shengdian, Jia, Mingming, Zhang, S. Antibody Therapies in Cancer. PROGRESS IN CANCER IMMUNOTHERAPY[J]. 2016, 第 1 作者909: 1-67, https://www.webofscience.com/wos/woscc/full-record/WOS:000387463200002.
[27] 王盛典. Expression of the galectin-9-Tim-3 pathway in glima tissues is associated with the clinical manifextations of glima. Oncology Letters. 2016, 第 1 作者  通讯作者  
[28] Xu, Meng, Liu, Mingyue, Du, Xuexiang, Li, Sirui, Li, Hang, Li, Xiaozhu, Li, Ying, Wang, Yang, Qin, Zhihai, Fu, YangXin, Wang, Shengdian. Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 11 作者  通讯作者  194(10): 4997-5006, https://www.webofscience.com/wos/woscc/full-record/WOS:000353728800041.
[29] Wang, Fei, Yang, Li, Gao, Qun, Huang, Lan, Wang, Liping, Wang, Jing, Wang, Shengdian, Zhang, Bin, Zhang, Yi. CD163+CD14+macrophages, a potential immune biomarker for malignant pleural effusion. CANCER IMMUNOLOGY IMMUNOTHERAPY[J]. 2015, 第 7 作者64(8): 965-976, https://www.webofscience.com/wos/woscc/full-record/WOS:000358087400004.
[30] Wang, Huiru, Sun, Qing, Wu, Yanhong, Wang, Lin, Zhou, Chunxia, Ma, Wenbo, Zhang, Youhui, Wang, Shengdian, Zhang, Shuren. Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation. ONCOTARGET[J]. 2015, 第 8 作者6(8): 5818-5831, https://www.webofscience.com/wos/woscc/full-record/WOS:000352793000025.
[31] Chard, Louisa S, Maniati, Eleni, Wang, Pengju, Zhang, Zhongxian, Gao, Dongling, Wang, Jiwei, Cao, Fengyu, Ahmed, Jahangir, El Khouri, Margueritte, Hughes, Jonathan, Wang, Shengdian, Li, Xiaozhu, Denes, Bela, Fodor, Istvan, Hagemann, Thorsten, Lemoine, Nicholas R, Wang, Yaohe. A Vaccinia Virus Armed with Interleukin-10 Is a Promising Therapeutic Agent for Treatment of Murine Pancreatic Cancer. CLINICAL CANCER RESEARCH[J]. 2015, 第 11 作者21(2): 405-416, http://dx.doi.org/10.1158/1078-0432.CCR-14-0464.
[32] Chen, Lin, Li, Jie, Zhang, Jinhua, Dai, Chengliang, Liu, Xiaoman, Wang, Jun, Gao, Zhitao, Guo, Hongyan, Wang, Rui, Lu, Shichun, Wang, Fusheng, Zhang, Henghui, Chen, Hongsong, Fan, Xiaolong, Wang, Shengdian, Qin, Zhihai. S100A4 promotes liver fibrosis via activation of hepatic stellate cells. JOURNAL OF HEPATOLOGY[J]. 2015, 第 15 作者62(1): 156-164, http://dx.doi.org/10.1016/j.jhep.2014.07.035.
[33] 王盛典. Immunotherapy of metastatic and autochthonous liver cancer with IL-15/IL-15Ra fusion protein. OncoImmunology. 2014, 第 1 作者  通讯作者  
[34] Cheng, Liang, Du, Xuexiang, Su, Lishan, Wang, Shengdian. Immunotherapy of metastatic and autochthonous liver cancer with IL-15/IL-15R alpha fusion protein. ONCOIMMUNOLOGY. 2014, 第 4 作者3(11): http://dx.doi.org/10.4161/21624011.2014.963409.
[35] Ju JianQi, Jia MingMing, Cong YanNi, Wang ShengDian. Tumor Repression Mediated by IL-15 Expanded CD8 T Cell Correlated With Sustained Tumor-specific CD8 T Cells in Spleen. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 第 4 作者  通讯作者  41(12): 1245-1254, https://www.webofscience.com/wos/woscc/full-record/WOS:000346818200007.
[36] Cheng, Yushan, Liu, Chongdong, Zhang, Nawei, Wang, Shengdian, Zhang, Zhenyu. Proteomics Analysis for Finding Serum Markers of Ovarian Cancer. BIOMED RESEARCH INTERNATIONAL[J]. 2014, 第 4 作者2014: https://doaj.org/article/02bfd0fb97bf40cbae8b47eb4bee0484.
[37] Wu, X, Zhang, H, Xing, Q, Cui, J, Li, J, Li, Y, Tan, Y, Wang, S. PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients. BRITISH JOURNAL OF CANCER[J]. 2014, 111(7): 1391-1399, https://www.webofscience.com/wos/woscc/full-record/WOS:000343323100017.
[38] Tan, Yi, Han, Xue, Wu, Xiaoran, Xing, Qiao, Chen, Lieping, Wang, Shengdian. Anti-TOSO antibody treatment promotes T cell activation-induced cell death (AICD) in vitro and in vivo. CHINESE SCIENCE BULLETIN[J]. 2014, 第 6 作者  通讯作者  59(13): 1374-1385, https://www.webofscience.com/wos/woscc/full-record/WOS:000333613100005.
[39] Zhu, Lei, Chen, Yuxuan, Liu, Chongdong, Deng, Haiteng, Zhang, Nawei, Wang, Shengdian, Zhang, Zhenyu. Transthyretin as a novel candidate biomarker for preeclampsia. EXPERIMENTAL AND THERAPEUTIC MEDICINE[J]. 2014, 第 6 作者7(5): 1332-1336, https://www.webofscience.com/wos/woscc/full-record/WOS:000337557700048.
[40] Cheng, Liang, Du, Xuexiang, Wang, Zheng, Ju, Jianqi, Jia, Mingming, Huang, Qibin, Xing, Qiao, Xu, Meng, Tan, Yi, Liu, Mingyue, Du, Peishuang, Su, Lishan, Wang, Shengdian. Hyper-IL-15 suppresses metastatic and autochthonous liver cancer by promoting tumour-specific CD8(+) T cell responses. JOURNAL OF HEPATOLOGY[J]. 2014, 第 13 作者61(6): 1297-1303, http://dx.doi.org/10.1016/j.jhep.2014.07.004.
[41] Ju JianQi, Jia MingMing, Cong YanNi, Wang ShengDian. Tumor Repression Mediated by IL-15 Expanded CD8 T Cell Correlated With Sustained Tumor-specific CD8 T Cells in Spleen. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 第 4 作者  通讯作者  41(12): 1245-1254, https://www.webofscience.com/wos/woscc/full-record/WOS:000346818200007.
[42] 黄启彬, 刘明月, 符少月, 邢巧, 刘潇淇, 王盛典, 易发平. mIL-21-hIgGFc融合蛋白在293 E细胞中的表达纯化及其对CD8^+T细胞表型的影响. 中国免疫学杂志[J]. 2014, 第 6 作者30(7): 884-887,892, http://lib.cqvip.com/Qikan/Article/Detail?id=661813473.
[43] Wu, Xiaoran, Tan, Yi, Xing, Qiao, Wang, Shengdian. IL-21 accelerates xenogeneic graft-versus-host disease correlated with increased B-cell proliferation. PROTEIN & CELL[J]. 2013, 第 4 作者4(11): 863-871, https://www.webofscience.com/wos/woscc/full-record/WOS:000326939900008.
[44] Li, Xinghui, Liu, Zhen, Yan, Xiaoli, Zhang, Xiaojun, Li, Yang, Zhao, Bao, Wang, Shengdian, Zhou, Xuyu, Gao, George F, Meng, Songdong. Induction of Regulatory T Cells by High-Dose gp96 Suppresses Murine Liver Immune Hyperactivation. PLOS ONE[J]. 2013, 第 7 作者8(7): https://doaj.org/article/17ebb4e46790479abee023d23227ea27.
[45] Mortenson, Eric D, Park, SaeGwang, Jiang, Zhujun, Wang, Shengdian, Fu, YangXin. Effective Anti-Neu-Initiated Antitumor Responses Require the Complex Role of CD4(+) T Cells. CLINICAL CANCER RESEARCH[J]. 2013, 第 4 作者19(6): 1476-1486, http://dx.doi.org/10.1158/1078-0432.CCR-12-2522.
[46] YANG YaJun, LI XiaoZhu, WANG YaoHe, WANG ShengDian. CD8^+ T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. 中国科学通报:英文版[J]. 2012, 第 4 作者57(1): 48-53, http://lib.cqvip.com/Qikan/Article/Detail?id=40772511.
[47] Tysome, James R, Li, Xiaozhu, Wang, Shengdian, Wang, Pengju, Gao, Dongling, Du, Pan, Chen, Dong, Gangeswaran, Rathi, Chard, Louisa S, Yuan, Ming, Alusi, Ghassan, Lemoine, Nicholas R, Wang, Yaohe. A Novel Therapeutic Regimen to Eradicate Established Solid Tumors with an Effective Induction of Tumor-Specific Immunity. CLINICAL CANCER RESEARCH[J]. 2012, 第 3 作者18(24): 6679-6689, http://www.irgrid.ac.cn/handle/1471x/756706.
[48] 王盛典, 贾明明. 肿瘤免疫微环境在肿瘤常规治疗效应中的作用. 中国肿瘤生物治疗杂志[J]. 2012, 第 1 作者19(3): 229-238, http://lib.cqvip.com/Qikan/Article/Detail?id=42366859.
[49] Xu, Meng, Du, Xuexiang, Liu, Mingyue, Li, Sirui, Li, Xiaozhu, Fu, YangXin, Wang, Shengdian. The tumor immunosuppressive microenvironment impairs the therapy of anti-HER2/neu antibody. PROTEIN & CELL[J]. 2012, 第 7 作者3(6): 441-449, http://www.irgrid.ac.cn/handle/1471x/756971.
[50] Luan, Y, Ju, J, Luo, L, Zhang, Z, Wang, J, Zhu, D M, Cheng, L, Zhang, S Y, Chen, L, Wang, F S, Wang, S. Potential role of soluble B7-H3 in liver immunopathogenesis during chronic HBV infection. JOURNAL OF VIRAL HEPATITIS[J]. 2012, 19(1): 23-31, http://dx.doi.org/10.1111/j.1365-2893.2010.01421.x.
[51] 王盛典. A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models.. Journal of Immunology. 2012, 第 1 作者
[52] Yang YaJun, Li XiaoZhu, Wang YaoHe, Wang ShengDian. CD8(+) T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. CHINESE SCIENCE BULLETIN[J]. 2012, 第 4 作者  通讯作者  57(1): 48-53, http://lib.cqvip.com/Qikan/Article/Detail?id=40772511.
[53] Yang, Yajun, Li, Xiaozhu, Wang, Yaohe, Wang, Shengdian. CD8+T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model. CANCER RESEARCH. 2012, 第 4 作者72: https://www.webofscience.com/wos/woscc/full-record/WOS:000209701500239.
[54] Flies, Dallas B, Wang, Shengdian, Xu, Haiying, Chen, Lieping. Cutting Edge: A Monoclonal Antibody Specific for the Programmed Death-1 Homolog Prevents Graft-versus-Host Disease in Mouse Models. JOURNAL OF IMMUNOLOGY[J]. 2011, 第 2 作者187(4): 1537-1541, http://www.irgrid.ac.cn/handle/1471x/757459.
[55] Liu, Yang, Wang, Shengdian, Wang, Fusheng, Li, Dongling, Zheng, Linghua, Zheng, Pan. Clusters of Differentiation 24 Polymorphism and Hepatocellular Carcinoma Reply. HEPATOLOGY. 2011, 第 2 作者54(6): 2273-2274, http://www.irgrid.ac.cn/handle/1471x/757558.
[56] Han, Xue, Ye, Peiying, Luo, Liqun, Zheng, Linghua, Liu, Yang, Chen, Lieping, Wang, Shengdian. The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2011, 第 7 作者  通讯作者  8(4): 333-340, http://www.irgrid.ac.cn/handle/1471x/757405.
[57] 王盛典. B7-H2 is a costimulatory ligand for CD28 in human. Immunity. IMMUNITY. 2011, 第 1 作者  通讯作者  
[58] Cheng, Liang, Wang, Jun, Li, Xiaozhu, Xing, Qiao, Du, Peishuang, Su, Lishan, Wang, Shengdian. Interleukin-6 Induces Gr-1+CD11b+Myeloid Cells to Suppress CD8+T Cell-Mediated Liver Injury in Mice. PLOS ONE[J]. 2011, 第 7 作者6(3): http://dx.doi.org/10.1371/journal.pone.0017631.
[59] Wang, Shengdian, Chen, Lieping, Dranoff, G. Immunobiology of Cancer Therapies Targeting CD137 and B7-H1/PD-1 Cosignal Pathways. CANCER IMMUNOLOGY AND IMMUNOTHERAPY[J]. 2011, 第 1 作者344: 245-267, http://www.irgrid.ac.cn/handle/1471x/757561.
[60] 王盛典. Interleukin-6 induces Gr-1+CD11b+ myeloid cells to suppress CD8+ T cells-mediated liver injury in mice. PLoS One. 2011, 第 1 作者  通讯作者  
[61] 王盛典. Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal athways. Current Topics in Microbiology and Immunology. 2011, 第 1 作者
[62] Xue Han, Peiying Ye, Liqun Luo, Linghua Zheng, Yang Liu, Lieping Chen, Shengdian Wang. The development and functions of CD~4+ T cells expressing a transgenic TCR specific for an MHC-l-restricted tumor antigenic epitope. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2011, 第 7 作者8(4): 333-340, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4274409&detailType=1.
[63] Yao, Sheng, Zhu, Yuwen, Zhu, Gefeng, Augustine, Mathew, Zheng, Linghua, Goode, Diana J, Broadwater, Megan, Ruff, William, Flies, Sarah, Xu, Haiying, Flies, Dallas, Luo, Liqun, Wang, Shengdian, Chen, Lieping. B7-H2 Is a Costimulatory Ligand for CD28 in Human. IMMUNITY[J]. 2011, 第 13 作者34(5): 729-740, http://dx.doi.org/10.1016/j.immuni.2011.03.014.
[64] Liang Cheng, Yunsheng Yang, Suping Ma, Dongling Li, Suyun Li, Mingzhou Guo, Wenxia Zhao, Yi Tan, Jun Wang, Xiaozhu Li, Shengdian Wang, Lieping Chen. CD137-Mediated Pathogenesis from Chronic Hepatitis to Hepatocellular Carcinoma in Hepatitis B Virus-Transgenic Mice. AMERICAN ASSOCIATION OF IMMUNOLOGISTS. 2010, 第 11 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902021923517ZK.
[65] 程亮, 王盛典. 从动物模型看乙型病毒性肝炎致病机制的研究进展. 生命科学[J]. 2010, 第 2 作者338-344, http://lib.cqvip.com/Qikan/Article/Detail?id=33859756.
[66] 王盛典. 从动物模型看乙型肝炎致病机制的研究进展.. 生命科学. 2010, 第 1 作者  通讯作者  
[67] Wang, Jun, Zhao, Wenxia, Cheng, Liang, Guo, Mingzhou, Li, Dongling, Li, Xiaozhu, Tan, Yi, Ma, Suping, Li, Suyun, Yang, Yunsheng, Chen, Lieping, Wang, Shengdian. CD137-Mediated Pathogenesis from Chronic Hepatitis to Hepatocellular Carcinoma in Hepatitis B Virus-Transgenic Mice. JOURNAL OF IMMUNOLOGY[J]. 2010, 第 12 作者  通讯作者  185(12): 7654-7662, http://dx.doi.org/10.4049/jimmunol.1000927.
[68] Wang ShengDian, Chen LiePing. Structural immunology of costimualtory and coinhibitory molecules. SCIENCE CHINA-LIFE SCIENCES[J]. 2010, 第 1 作者  通讯作者  53(2): 183-189, http://www.irgrid.ac.cn/handle/1471x/757276.
[69] Park, SaeGwang, Jiang, Zhujun, Mortenson, Eric D, Deng, Liufu, RadkevichBrown, Olga, Yang, Xuanming, Sattar, Husain, Wang, Yang, Brown, Nicholas K, Greene, Mark, Liu, Yang, Tang, Jie, Wang, Shengdian, Fu, YangXin. The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity. CANCER CELL[J]. 2010, 第 13 作者  通讯作者  18(2): 160-170, http://dx.doi.org/10.1016/j.ccr.2010.06.014.
[70] Li, Xiangqun, Han, Xue, Wang, Shengdian, Duan, Ziyuan. Development and Characterization of Monoclonal Antibodies Against Mouse TSLP. HYBRIDOMA[J]. 2010, 第 3 作者29(5): 425-430, http://www.irgrid.ac.cn/handle/1471x/757216.
[71] Deng, Liufu, Zhang, Haizeng, Luan, Yan, Zhang, Jianfeng, Xing, Qiao, Dong, Shuxiao, Wu, Xiaoran, Liu, Mingyue, Wang, Shengdian. Accumulation of Foxp3(+) T Regulatory Cells in Draining Lymph Nodes Correlates with Disease Progression and Immune Suppression in Colorectal Cancer Patients. CLINICAL CANCER RESEARCH[J]. 2010, 第 9 作者  通讯作者  16(16): 4105-4112, http://dx.doi.org/10.1158/1078-0432.CCR-10-1073.
[72] 王盛典. he Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity.. Cancer Cell. 2010, 第 1 作者  通讯作者  
[73] Zheng, Linghua, Li, Dongling, Wang, Fusheng, Wu, Hao, Li, Xiaozhu, Fu, Junliang, Chen, Xinyue, Wang, Lizhong, Liu, Yang, Wang, Shengdian. Association Between Hepatitis B Viral Burden in Chronic Infection and a Functional Single Nucleotide Polymorphism of the PDCD1 Gene. JOURNAL OF CLINICAL IMMUNOLOGY[J]. 2010, 第 10 作者  通讯作者  30(6): 855-860, http://www.corc.org.cn/handle/1471x/2414542.
[74] Yao, Sheng, Wang, Shengdian, Zhu, Yuwen, Luo, Liqun, Zhu, Gefeng, Flies, Sarah, Xu, Haiying, Ruff, William, Broadwater, Megan, Choi, InHak, Tamada, Koji, Chen, Lieping. PD-1 on dendritic cells impedes innate immunity against bacterial infection. BLOOD[J]. 2009, 第 2 作者113(23): 5811-5818, http://www.irgrid.ac.cn/handle/1471x/757838.
[75] Li, Dongling, Zheng, Linghua, Jin, Lei, Zhou, Yuesu, Li, Haiying, Fu, Junliang, Shi, Ming, Du, Peishuang, Wang, Lizhong, Wu, Hao, Chen, GuoYun, Zheng, Pan, Liu, Yang, Wang, FuSheng, Wang, Shengdian. CD24 Polymorphisms Affect Risk and Progression of Chronic Hepatitis B Virus Infection. HEPATOLOGY[J]. 2009, 第 15 作者50(3): 735-742, http://www.irgrid.ac.cn/handle/1471x/757834.
[76] Wang, Shengdian, Wang, Shengdian. Contribution of CD137 signaling to Hepatic Fibrosis via T cell and Macrophage Mediated Chronic Liver Inflammation. JOURNAL OF IMMUNOLOGY. 2009, 第 1 作者182: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000209763600344.
[77] 刘书漫, 孟青, 张钦宪, 王盛典, 刘占举, 张谢夫. B7-H1及其受体PD-1在胃癌组织中的表达与意义. 中华肿瘤杂志[J]. 2008, 第 4 作者30(3): 192-195, http://lib.cqvip.com/Qikan/Article/Detail?id=26821190.
[78] Wang, Shengdian, Chen, Lieping. T Lymphocyte Co-Signaling Pathways of the B7-CD28 Family. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2004, 第 1 作者1(1): 37-42, http://lib.cqvip.com/Qikan/Article/Detail?id=9686612.
[79] Han Xue, Ye Peiying, Luo Liqun, Zheng Linghua, Liu Yang, Chen Lieping, Wang Shengdian. The development and functions of CD4 + T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope. CELLULAR AND MOLECULAR IMMUNOLOGY. 第 7 作者8(4): 333-340, http://www.irgrid.ac.cn/handle/1471x/757405.
发表著作
(1) 抗病毒天然免疫与适应性免疫的关系. 《抗病毒天然免疫》, Innate Immunity against virus, 科学出版社, 2009-04, 第 2 作者
(2) Antibody therapies in cancer, Springer, 2016-09, 第 1 作者

科研活动

   
科研项目
( 1 ) 慢性肝炎恶性转化的分子机制研究, 负责人, 国家任务, 2011-01--2013-12
( 2 ) 防治乙型肝炎新技术、新方法的研究, 参与, 国家任务, 2012-01--2015-12
( 3 ) 慢性乙型病毒肝炎临床转归预警预测的研究, 参与, 国家任务, 2012-01--2015-12
( 4 ) 肿瘤细胞与免疫细胞膜蛋白分子间的相互作用, 负责人, 国家任务, 2012-01--2016-12
( 5 ) 细胞逐步适应新环境的多基因作用机制, 负责人, 国家任务, 2013-01--2016-12
( 6 ) 结直肠癌肠道免疫微环境对抗肿瘤T细胞PD-1/Tim-3信号通路的调控作用及其机制, 负责人, 国家任务, 2017-01--2019-12
( 7 ) 新型CAR-T细胞治疗关键技术开发与应用, 参与, 国家任务, 2016-09--2020-12
( 8 ) 表达高亲和力PD-1分子的CD19-CAR-T细胞治疗技术研发, 负责人, 企业委托, 2017-04--2019-12
( 9 ) 编导高亲和力PD-1分子的BCMACAR-T和NY-ESOCAR-T细胞治疗技术研发, 负责人, 企业委托, 2018-04--2021-04
( 10 ) 抗T细胞受体beta链(TRBC1和TRBC2)单克隆抗体制备, 负责人, 企业委托, 2018-04--2019-12
( 11 ) 表达高亲和力突变型PD-1融合蛋白的CAR-T细胞用于治疗血液肿瘤的临床前研究, 负责人, 国家任务, 2019-01--2023-12
( 12 ) 新型溶瘤病毒恶性肿瘤治疗及增效策略的研发, 负责人, 国家任务, 2019-08--2022-12
参与会议
(1)The roles of co-signaling pathways in pathogenesis of chronic hepatitis B    第8届海峡两岸细胞生物学学术研讨会   王盛典   2011-05-13
(2)Immunological mechanisms of tumor clinical therapy   2010年北京免疫学会年会   王盛典   2011-01-09
(3)机体免疫反应在抗her2抗体治疗中的作用   中国免疫学会第七届学术大会   王盛典   2010-10-22

指导学生

已指导学生

杨亚军  博士研究生  071010-生物化学与分子生物学  

栾彦  博士研究生  071010-生物化学与分子生物学  

邓刘福  博士研究生  071009-细胞生物学  

王俊  博士研究生  071010-生物化学与分子生物学  

谭毅  博士研究生  071009-细胞生物学  

程亮  博士研究生  071009-细胞生物学  

韩雪  博士研究生  071010-生物化学与分子生物学  

姜竺君  博士研究生  071010-生物化学与分子生物学  

吴晓冉  博士研究生  071009-细胞生物学  

鞠见齐  博士研究生  071009-细胞生物学  

林伟  硕士研究生  071010-生物化学与分子生物学  

杜雪相  博士研究生  071009-细胞生物学  

刘明月  博士研究生  071009-细胞生物学  

李思睿  硕士研究生  085238-生物工程  

李思睿  博士研究生  071009-细胞生物学  

丛艳妮  博士研究生  071009-细胞生物学  

黎小珠  博士研究生  071009-细胞生物学  

陈立  博士研究生  071009-细胞生物学  

张宇  硕士研究生  071009-细胞生物学  

郑晓晓  硕士研究生  085238-生物工程  

贺倩倩  博士研究生  071009-细胞生物学  

钟海晴  博士研究生  071009-细胞生物学  

现指导学生

田然  博士研究生  071009-细胞生物学  

安悦仪  博士研究生  071009-细胞生物学  

肖锐  硕士研究生  071009-细胞生物学  

王小文  博士研究生  071009-细胞生物学  

郑晓晓  博士研究生  071009-细胞生物学  

谢禹  硕士研究生  071009-细胞生物学  

党逸群  博士研究生  071009-细胞生物学  

陈妍  博士研究生  071009-细胞生物学  

张展颜  硕士研究生  071010-生物化学与分子生物学  

王瑶佳  硕士研究生  071009-细胞生物学  

田永琴  硕士研究生  071009-细胞生物学  

赵记涛  博士研究生  071009-细胞生物学