基本信息
王奇慧  女    中国科学院微生物研究所
电子邮件: wangqihui@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究领域

主要研究病原感染与宿主免疫,在SCI刊物上发表论文30余篇(包括以第一/共第一/通讯/共通讯作者,在Cell, Nature, Nature Microbiology, Science Translational Medicine, Cell Host & Microbe, Journal of Virology等杂志发表研究论文),申请专利9项,揭示MERS-CoVSARS-CoV-2等冠状病毒受体识别机制及跨种传播机制(Cell, Nature, Cell Host & Microbe, Journal of Virology),研究寨卡病毒及裂谷热病毒等引起新发突发疫情的病原微生物的人体B细胞应答规律及抗体干预(Science Translational Medicine Nature Microbiology),为寨卡病毒等黄病毒、裂谷热病毒的疫苗设计提供重要理论基础,为其引发疾病的治疗提供重要的候选药物。


招生信息

   
招生专业
100102-免疫学
招生方向
新发、突发传染病,尤其冠状病毒相关疾病的致病机制和干预手段
肿瘤病毒的治疗和干预手段

教育背景

2006-09--2012-01   中国科学院生物物理研究所   博士学位
2002-09--2006-07   哈尔滨工业大学   学士学位

工作经历

   
工作简历
2019-11~现在, 中国科学院微生物研究所, 研究员
2015-10~2019-11,中国科学院微生物研究所, 副研究员
2014-07~2015-09,中国科学院微生物研究所, 助理研究员
2012-02~2014-06,中国科学院微生物研究所, 博士后
社会兼职
2020-05-01-今,中国生物工程学会抗体工程专业委员会(筹), 秘书长
2016-12-01-今,中国研究型医院学会空间微生物学与感染专业委员会, 青年委员
2016-06-01-今,中国生物工程学会, 青年工作委员会委员
2016-05-31-今,中国科学技术协会, 第九届全国委员会委员

专利与奖励

   
奖励信息
(1) 入选2018年“中国科学院青年创新促进会”, , 其他, 2018
(2) 中源协和生命医学创新突破奖, 其他, 2017
(3) 2016年中国科学院病原微生物与免疫学重点实验室科研成就奖, 研究所(学校), 2016
(4) 2016年中科院微生物生理与代谢工程重点实验室优秀报告, 研究所(学校), 2016
专利成果
[1] 高福, 戴连攀, 严景华, 徐坤, 韩雨旋, 王奇慧, 黄庆瑞, 李金和. 一种寨卡/登革疫苗及其应用. CN: CN112194712A, 2021-01-08.

[2] 严景华, 王奇慧, 马桐, 杨化冰, 高福, 马素芳. 一种裂谷热病毒人源单克隆抗体及其应用. CN: CN111978400A, 2020-11-24.

[3] 严景华, 王奇慧, 马桐, 杨化冰, 高福, 马素芳. 一种裂谷热病毒人源单克隆抗体及其应用. CN: CN109734800B, 2020-11-06.

[4] 高福, 严景华, 王奇慧, 仝舟. 一种高中和活性的寨卡病毒人源单克隆抗体及其应用. CN: CN110172095B, 2020-09-04.

[5] 高福, 严景华, 王奇慧, 仝舟. 一种寨卡病毒特异性中和抗体及其应用. CN: CN110066333B, 2020-09-04.

[6] 王奇慧, 严景华, 高福. 一种黄病毒人源单克隆抗体及应用. CN: CN106589116B, 2020-01-03.

[7] 高福, 严景华, 王奇慧, 仝舟. 一种寨卡病毒人源单克隆抗体及其应用. CN: CN106279409B, 2019-11-26.

出版信息

   
发表论文
[1] Niu, Sheng, Wang, Jia, Bai, Bin, Wu, Lili, Zheng, Anqi, Chen, Qian, Du, Pei, Han, Pengcheng, Zhang, Yanfang, Jia, Yunfei, Qiao, Chengpeng, Qi, Jianxun, Tian, Wenxia, Wang, HongWei, Wang, Qihui, Gao, George Fu. Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin. EMBO JOURNAL[J]. 2021, 40(16): http://dx.doi.org/10.15252/embj.2021107786.
[2] Liu, Kefang, Tan, Shuguang, Niu, Sheng, Wang, Jia, Wu, Lili, Sun, Huan, Zhang, Yanfang, Pan, Xiaoqian, Qu, Xiao, Du, Pei, Meng, Yumin, Jia, Yunfei, Chen, Qian, Deng, Chuxia, Yan, Jinghua, Wang, HongWei, Wang, Qihui, Qi, Jianxun, Gao, George Fu. Cross-species recognition of SARS-CoV-2 to bat ACE2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(1): http://dx.doi.org/10.1073/pnas.2020216118.
[3] 仵丽丽, 苏佳岐, 牛胜, 陈茜, 张艳芳, 严景华, 施一, 齐建勋, 高福, 王奇慧. 新型冠状病毒结合穿山甲ACE2受体的分子机制. 科学通报[J]. 2021, 66(1): 73-84, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKMypi3qVj28LEUDxQXHYyS3fbyEOrIfBzBmBRFaMT6jP23wYg5Jq-cLBjBjjGwOxsumlyLgjCtUb&uniplatform=NZKPT.
[4] Liu, Kefang, Pan, Xiaoqian, Li, Linjie, Yu, Feng, Zheng, Anqi, Du, Pei, Han, Pengcheng, Meng, Yumin, Zhang, Yanfang, Wu, Lili, Chen, Qian, Song, Chunli, Jia, Yunfei, Niu, Sheng, Lu, Dan, Qiao, Chengpeng, Chen, Zhihai, Ma, Dongli, Ma, Xiaopeng, Tan, Shuguang, Zhao, Xin, Qi, Jianxun, Gao, George F, Wang, Qihui. Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species. CELL[J]. 2021, 184(13): 3438-+, http://dx.doi.org/10.1016/j.cell.2021.05.031.
[5] Wang, Qihui, Song, Hao, Cheng, Hao, Qi, Jianxun, Nam, Gol, Tan, Shuguang, Wang, Junzhi, Fang, Min, Shi, Yi, Tian, Zhigang, Cao, Xuetao, An, Zhiqiang, Yan, Jinghua, Gao, George F. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2020, 17(9): 966-975, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609294/.
[6] Qihui Wang. Molecular basis of binding between MERS-CoV and CD26s from seven bat species. Journal of Virology. 2020, [7] Bai, Chongzhi, Cai, Jianpiao, Han, Pengcheng, Qi, Jianxun, Yuen, KwokYung, Wang, Qihui. The crystal structure of the emerging human-infecting hepatitis E virus E2s protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 532(1): 25-31, http://dx.doi.org/10.1016/j.bbrc.2020.07.074.
[8] Wu, Lili, Chen, Qian, Liu, Kefang, Wang, Jia, Han, Pengcheng, Zhang, Yanfang, Hu, Yu, Meng, Yumin, Pan, Xiaoqian, Qiao, Chengpeng, Tian, Siyu, Du, Pei, Song, Hao, Shi, Weifeng, Qi, Jianxun, Wang, HongWei, Yan, Jinghua, Gao, George Fu, Wang, Qihui. Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2. CELL DISCOVERY[J]. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00210-9.
[9] Sun, Huan, Li, Yan, Liu, Peipei, Qiao, Chengpeng, Wang, Xiaomin, Wu, Lianao, Liu, Kefang, Hu, Yu, Su, Chao, Tan, Shuguang, Zou, Shumei, Wu, Guizhen, Yan, Jinghua, Gao, George Fu, Qi, Jianxun, Wang, Qihui. Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry. EMERGING MICROBES & INFECTIONSnull. 2020, 9(1): 1238-1241, https://www.webofscience.com/wos/woscc/full-record/WOS:000546855900001.
[10] Yuan, Yuan, Qi, Jianxun, Peng, Ruchao, Li, Chunrui, Lu, Guangwen, Yan, Jinghua, Wang, Qihui, Gao, George Fu. Molecular Basis of Binding between Middle East Respiratory Syndrome Coronavirus and CD26 from Seven Bat Species. JOURNAL OF VIROLOGY[J]. 2020, 94(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000514575000006.
[11] Gary Kobinger, Trina Racine, Qihui Wang, Jinghua Yan. Isolation of Monoclonal Antibodies from Zika Virus-Infected Patient Samples. Zika Virus. 2020, 2142: 261-288, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197385/.
[12] Shi, Rui, Shan, Chao, Duan, Xiaomin, Chen, Zhihai, Liu, Peipei, Song, Jinwen, Song, Tao, Bi, Xiaoshan, Han, Chao, Wu, Lianao, Gao, Ge, Hu, Xue, Zhang, Yanan, Tong, Zhou, Huang, Weijin, Liu, William Jun, Wu, Guizhen, Zhang, Bo, Wang, Lan, Qi, Jianxun, Feng, Hui, Wang, FuSheng, Wang, Qihui, Gao, George Fu, Yuan, Zhiming, Yan, Jinghua. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. NATURE[J]. 2020, 584(7819): 120-+, http://dx.doi.org/10.1038/s41586-020-2381-y.
[13] Wang, Qihui, Zhang, Yanfang, Wu, Lili, Niu, Sheng, Song, Chunli, Zhang, Zengyuan, Lu, Guangwen, Qiao, Chengpeng, Hu, Yu, Yuen, KwokYung, Wang, Qisheng, Zhou, Huan, Yan, Jinghua, Qi, Jianxun. Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2. CELL[J]. 2020, 181(4): 894-+, http://dx.doi.org/10.1016/j.cell.2020.03.045.
[14] Wang, Qihui, Ma, Tong, Wu, Yan, Chen, Zhihai, Zeng, Hui, Tong, Zhou, Gao, Feng, Qi, Jianxun, Zhao, Zhennan, Chai, Yan, Yang, Huabing, Wong, Gary, Bi, Yuhai, Wu, Lili, Shi, Rui, Yang, Mi, Song, Jian, Jiang, Haihai, An, Zhiqiang, Wang, Junzhi, Yilma, Tilahun D, Shi, Yi, Liu, William J, Liang, Mifang, Qin, Chuan, Gao, George F, Yan, Jinghua. Neutralization mechanism of human monoclonal antibodies against Rift Valley fever virus. NATURE MICROBIOLOGY[J]. 2019, 4(7): 1231-1241, http://www.corc.org.cn/handle/1471x/2205968.
[15] Wang, Qihui, Yan, Jinghua, Gao, George Fu. Monoclonal Antibodies against Zika Virus: Therapeutics and Their Implications for Vaccine Design. JOURNAL OF VIROLOGY[J]. 2017, 91(20): http://dx.doi.org/10.1128/JVI.01049-17.
[16] Wang, Qihui, Wong, Gary, Lu, Guangwen, Yan, Jinghua, Gao, George F. MERS-CoV spike protein: Targets for vaccines and therapeutics. ANTIVIRAL RESEARCHnull. 2016, 133: 165-177, http://www.corc.org.cn/handle/1471x/2375014.
[17] Wang, Qihui, Yang, Huabing, Liu, Xiaoqing, Dai, Lianpan, Ma, Tong, Qi, Jianxun, Wong, Gary, Peng, Ruchao, Liu, Sheng, Li, Junfu, Li, Shihua, Song, Jian, Liu, Jianying, He, Jianhua, Yuan, Hui, Xiong, Ying, Liao, Yong, Li, Jianhua, Yang, Jianping, Tong, Zhou, Griffin, Bryan D, Bi, Yuhai, Liang, Mifang, Xu, Xiaoning, Qin, Chuan, Cheng, Gong, Zhang, Xinzheng, Wang, Peiyi, Qiu, Xiangguo, Kobinger, Gary, Shi, Yi, Yan, Jinghua, Gao, George F. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus. SCIENCE TRANSLATIONAL MEDICINE[J]. 2016, 8(369): http://ir.sinap.ac.cn/handle/331007/26577.
[18] Wang, Qihui, Qi, Jianxun, Yuan, Yuan, Xuan, Yifang, Han, Pengcheng, Wan, Yuhua, Ji, Wei, Li, Yan, Wu, Ying, Wang, Jianwei, Iwamoto, Aikichi, Woo, Patrick C Y, Yuen, KwokYung, Yan, Jinghua, Lu, Guangwen, Gao, George F. Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26. CELL HOST & MICROBE[J]. 2014, 16(3): 328-337, http://www.corc.org.cn/handle/1471x/2157676.
[19] 高福. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature[J]. 2013, 500(7461): 227-+, http://124.16.173.210/handle/834782/1294.
[20] Wang, Qihui, Mou, Xiaoning, Cao, Henghua, Meng, Qingzhang, Ma, Yanni, Han, Pengcheng, Jiang, Junjie, Zhang, Hao, Ma, Yue. A novel xeno-free and feeder-cell-free system for human pluripotent stem cell culture. PROTEIN & CELL[J]. 2012, 3(1): 51-59, http://www.irgrid.ac.cn/handle/1471x/756707.

科研活动

   
科研项目
( 1 ) 病原生物与宿主的相互作用, 主持, 国家级, 2020-01--2022-12
( 2 ) 应用抗原特异记忆B细胞筛选与单细胞测序技术获得狂犬病毒治疗性抗体, 主持, 国家级, 2020-01--2023-12
( 3 ) “个性化药物—— 疾病分子分型的普惠新药研发”专项,“肿瘤个性化药物研究”课题, 主持, 部委级, 2018-01--2019-12
( 4 ) 重点研发计划(公共安全风险防控与应急技术装备)重点专项“新冠病毒分子溯源研究”, 参与, 国家级, 2020-04--2021-02
( 5 ) 重点研发计划(公共安全风险防控与应急技术装备),2019-nCoV溯源与传播途径研究, 参与, 国家级, 2020-01--2020-12
参与会议
(1)Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus   第二届全国病毒学青年学者学术研讨会   2017-11-07
(2)Protective antibodies against Zika and their molecular determinants   2017-03-22
(3)Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus   2017-02-25
(4)Human neutralizing antibodies isolated from a Zika patient and their molecular determinants   中国第11届免疫学大会   2016-11-04