基本信息
王明 男 中国科学院动物研究所
电子邮件： wangming@ioz.ac.cn
通信地址： 北京市朝阳区北辰西路1号院5号中国科学院动物研究所D座 D513室
邮政编码：100101
研究领域
媒介昆虫传播的植物病毒病害对我国农业生产构成了严重威胁。深入解析植物的防御机制、昆虫的病原传递途径及病毒的致病机理，是当前植物保护研究的关键科学问题。在此研究基础上创制抗病种质是攻克农作物病虫灾害的有效策略。本研究组主要研究表观遗传信号在植物、昆虫和病毒的种内、种间的传递与调控机制，结合表观遗传学、基因组学、分子生物学和合成生物学等方法，挖掘植物与表观遗传相关的抗病基因并解析分子机理，最终将其用于农作物抗病种质的培育。
1. 表观遗传信号调控植物、昆虫与病毒三元互作
通过高通量测序技术，解析植物的转录组、翻译组、和表观基因组，包括DNA甲基化、组蛋白修饰（如乙酰化、甲基化）、染色质开放程度等，在植物与病虫害互作前后所发生的变化，挖掘植物潜在的抗病基因，并使用分子生物学与遗传学等方法进行验证。
2. 开发表观基因组编辑工具调控植物基因表达，创制抗病种质
以CRISPR/dCas为基因靶标系统结合不同的表观遗传相关效应蛋白，开发出高效且精准的表观基因组编辑工具，通过改造目标位点的表观遗传修饰、调控基因表达。并将该工具运用于植物抗病基因的调控，创制抗病种质。
招生信息
招生专业
0710Z1-基因组学
071001-植物学
071010-生物化学与分子生物学
071001-植物学
071010-生物化学与分子生物学
招生方向
表观遗传学
植物保护学
植物保护学
教育背景
2010-09--2015-08 美国加州大学河滨分校 博士
2006-09--2010-06 中国农业大学 学士
2006-09--2010-06 中国农业大学 学士
工作经历
工作简历
2021-10~2023-06,美国加州大学洛杉矶分校, 副项目科学家
2017-09~2021-10,美国加州大学洛杉矶分校, 博士后
2015-10~2017-09,美国加州大学河滨分校, 博士后
2017-09~2021-10,美国加州大学洛杉矶分校, 博士后
2015-10~2017-09,美国加州大学河滨分校, 博士后
出版信息
发表论文
[1] Current Opinion in Plant Biology. 2024, 通讯作者
[2] Wang, Ming, Zhong, Zhenhui, GallegoBartolome, Javier, Li, Zheng, Feng, Suhua, Kuo, Hsuan Yu, Kan, Ryan L, Lam, Hoiyan, Richey, John Curtis, Tang, Linli, Zhou, Jessica, Liu, Mukun, JamiAlahmadi, Yasaman, Wohlschlegel, James, Jacobsen, Steven E. A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis. NATURE PLANTS[J]. 2023, 第 1 作者9(3): 460-+, http://dx.doi.org/10.1038/s41477-023-01362-8.
[3] Zhenhui Zhong, Yan Xue, C Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman JamiAlahmadi, Suhua Feng, James A Wohlschlegel, Steven E Jacobsen. MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions. GENOME BIOLOGY. 2023, 第 4 作者24: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131428/.
[4] Li, Zheng, Wang, Ming, Zhong, Zhenhui, GallegoBartolome, Javier, Feng, Suhua, JamiAlahmadi, Yasaman, Wang, Xinyi, Wohlschlegel, James, Bischof, Sylvain, Long, Jeff A, Jacobsen, Steven E. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation. NATURE COMMUNICATIONS[J]. 2023, 第 2 作者14(1): http://dx.doi.org/10.1038/s41467-023-39751-4.
[5] Wang, Ming, Zhong, Zhenhui, GallegoBartolome, Javier, Feng, Suhua, Shih, YuanHsin, Liu, Mukun, Zhou, Jessica, Richey, John Curtis, Ng, Charmaine, JamiAlahmadi, Yasaman, Wohlschlegel, James, Wu, Keqiang, Jacobsen, Steven E. Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14. NATURE COMMUNICATIONS[J]. 2023, 第 1 作者14(1): http://dx.doi.org/10.1038/s41467-023-37263-9.
[6] Gardiner, Jason, Ghoshal, Basudev, Wang, Ming, Jacobsen, Steven E. CRISPR-Cas-mediated transcriptional control and epi-mutagenesis. PLANT PHYSIOLOGY[J]. 2022, 第 3 作者188(4): 1811-1824, http://dx.doi.org/10.1093/plphys/kiac033.
[7] Zhong, Zhenhui, Wang, Yafei, Wang, Ming, Yang, Fan, Thomas, Quentin Angelo, Xue, Yan, Zhang, Yaxin, Liu, Wanlu, JamiAlahmadi, Yasaman, Xu, Linhao, Feng, Suhua, Marquardt, Sebastian, Wohlschlegel, James A, Ausin, Israel, Jacobsen, Steven E. Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis. NATURE COMMUNICATIONS[J]. 2022, 第 3 作者13(1): http://dx.doi.org/10.1038/s41467-022-34648-0.
[8] Jihui Sha, James Wohlschlegel, Yasaman JamiAlahmadi, Shan Hua, Jason Gardiner, Yan Xue, Ivy Kwok, Colette Picard, Xueshi Cao, Zhenhui Zhong, Ming Wang, C Jake Harris, Suhua Feng, Steven E Jacobsen, Javier GallegoBartolom. Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. NATURE COMMUNICATIONS. 202, 第 11 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202108121440559ZK.
[9] Zhenhui Zhong, Ming Wang, Suhua Feng, Steven E Jacobsen. Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing. EPIGENETICS & CHROMATIN. 202, 第 2 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202104267056077ZK.
[10] Cai, Qiang, Qiao, Lulu, Wang, Ming, He, Baoye, Lin, FengMao, Palmquist, Jared, Huang, SiennaDa, Jin, Hailing. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. SCIENCE[J]. 2018, 第 3 作者360(6393): 1126-1129, https://www.webofscience.com/wos/woscc/full-record/WOS:000434635500048.
[11] Wang, Ming, Thomas, Nicholas, Jin, Hailing. Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection. CURRENT OPINION IN PLANT BIOLOGY. 2017, 第 1 作者38: 133-141, http://dx.doi.org/10.1016/j.pbi.2017.05.003.
[12] Wang, Ming, Jin, Hailing. Spray-Induced Gene Silencing: a Powerful Innovative Strategy for Crop Protection. TRENDS IN MICROBIOLOGY. 2017, 第 1 作者25(1): 4-6, http://dx.doi.org/10.1016/j.tim.2016.11.011.
[13] Wang, Ming, Weiberg, Arne, Dellota, Exequiel, Jr, Yamane, Daniel, Jin, Hailing. Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi. RNA BIOLOGY. 2017, 第 1 作者14(4): 421-428, https://www.webofscience.com/wos/woscc/full-record/WOS:000399929600005.
[14] Trends in microbiology. 2017, 第 1 作者
[15] Wang, Ming, Weiberg, Arne, Lin, FengMao, Thomma, Bart P H J, Huang, HsienDa, Jin, Hailing. Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection. NATUREPLANTS[J]. 2016, 第 1 作者2(10): 16151-16151, https://www.webofscience.com/wos/woscc/full-record/WOS:000413438600008.
[16] Dong, Oliver X, Meteignier, LouisValentin, Plourde, Melodie B, Ahmed, Bulbul, Wang, Ming, Jensen, Cassandra, Jin, Hailing, Moffett, Peter, Li, Xin, Germain, Hugo. Arabidopsis TAF15b Localizes to RNA Processing Bodies and Contributes to snc1-Mediated Autoimmunity. MOLECULAR PLANT-MICROBE INTERACTIONS[J]. 2016, 第 5 作者29(4): 247-257, https://www.webofscience.com/wos/woscc/full-record/WOS:000373422600002.
[17] Wang, Ming, Weiberg, Arne, Jin, Hailing. Pathogen small RNAs: a new class of effectors for pathogen attacks. MOLECULAR PLANT PATHOLOGY[J]. 2015, 第 1 作者16(3): 219-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000352152200001.
[18] Weiberg, Arne, Wang, Ming, Bellinger, Marschal, Jin, Hailing, VanAlfen, NK. Small RNAs: A New Paradigm in Plant-Microbe Interactions. ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 52. 2014, 第 2 作者52: 495-516, http://dx.doi.org/10.1146/annurev-phyto-102313-045933.
[19] Weiberg, Arne, Wang, Ming, Lin, FengMao, Zhao, Hongwei, Zhang, Zhihong, Kaloshian, Isgouhi, Huang, HsienDa, Jin, Hailing. Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways. SCIENCE[J]. 2013, 第 2 作者342(6154): 118-123, http://dx.doi.org/10.1126/science.1239705.
[20] Zhenhui Zhong, Ming Wang, Peggy Hsuanyu Kuo, Jason Gardiner, Somsakul Pop Wongpalee, Suhua Feng, Steven E Jacobsen, Javier GallegoBartolom, Wanlu Liu, Yuxing Zhou. Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase. SPRINGER. 第 2 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202107070951724ZK.
[2] Wang, Ming, Zhong, Zhenhui, GallegoBartolome, Javier, Li, Zheng, Feng, Suhua, Kuo, Hsuan Yu, Kan, Ryan L, Lam, Hoiyan, Richey, John Curtis, Tang, Linli, Zhou, Jessica, Liu, Mukun, JamiAlahmadi, Yasaman, Wohlschlegel, James, Jacobsen, Steven E. A gene silencing screen uncovers diverse tools for targeted gene repression in Arabidopsis. NATURE PLANTS[J]. 2023, 第 1 作者9(3): 460-+, http://dx.doi.org/10.1038/s41477-023-01362-8.
[3] Zhenhui Zhong, Yan Xue, C Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman JamiAlahmadi, Suhua Feng, James A Wohlschlegel, Steven E Jacobsen. MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions. GENOME BIOLOGY. 2023, 第 4 作者24: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10131428/.
[4] Li, Zheng, Wang, Ming, Zhong, Zhenhui, GallegoBartolome, Javier, Feng, Suhua, JamiAlahmadi, Yasaman, Wang, Xinyi, Wohlschlegel, James, Bischof, Sylvain, Long, Jeff A, Jacobsen, Steven E. The MOM1 complex recruits the RdDM machinery via MORC6 to establish de novo DNA methylation. NATURE COMMUNICATIONS[J]. 2023, 第 2 作者14(1): http://dx.doi.org/10.1038/s41467-023-39751-4.
[5] Wang, Ming, Zhong, Zhenhui, GallegoBartolome, Javier, Feng, Suhua, Shih, YuanHsin, Liu, Mukun, Zhou, Jessica, Richey, John Curtis, Ng, Charmaine, JamiAlahmadi, Yasaman, Wohlschlegel, James, Wu, Keqiang, Jacobsen, Steven E. Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14. NATURE COMMUNICATIONS[J]. 2023, 第 1 作者14(1): http://dx.doi.org/10.1038/s41467-023-37263-9.
[6] Gardiner, Jason, Ghoshal, Basudev, Wang, Ming, Jacobsen, Steven E. CRISPR-Cas-mediated transcriptional control and epi-mutagenesis. PLANT PHYSIOLOGY[J]. 2022, 第 3 作者188(4): 1811-1824, http://dx.doi.org/10.1093/plphys/kiac033.
[7] Zhong, Zhenhui, Wang, Yafei, Wang, Ming, Yang, Fan, Thomas, Quentin Angelo, Xue, Yan, Zhang, Yaxin, Liu, Wanlu, JamiAlahmadi, Yasaman, Xu, Linhao, Feng, Suhua, Marquardt, Sebastian, Wohlschlegel, James A, Ausin, Israel, Jacobsen, Steven E. Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis. NATURE COMMUNICATIONS[J]. 2022, 第 3 作者13(1): http://dx.doi.org/10.1038/s41467-022-34648-0.
[8] Jihui Sha, James Wohlschlegel, Yasaman JamiAlahmadi, Shan Hua, Jason Gardiner, Yan Xue, Ivy Kwok, Colette Picard, Xueshi Cao, Zhenhui Zhong, Ming Wang, C Jake Harris, Suhua Feng, Steven E Jacobsen, Javier GallegoBartolom. Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation. NATURE COMMUNICATIONS. 202, 第 11 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202108121440559ZK.
[9] Zhenhui Zhong, Ming Wang, Suhua Feng, Steven E Jacobsen. Efficient and accurate determination of genome-wide DNA methylation patterns in Arabidopsis thaliana with enzymatic methyl sequencing. EPIGENETICS & CHROMATIN. 202, 第 2 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202104267056077ZK.
[10] Cai, Qiang, Qiao, Lulu, Wang, Ming, He, Baoye, Lin, FengMao, Palmquist, Jared, Huang, SiennaDa, Jin, Hailing. Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. SCIENCE[J]. 2018, 第 3 作者360(6393): 1126-1129, https://www.webofscience.com/wos/woscc/full-record/WOS:000434635500048.
[11] Wang, Ming, Thomas, Nicholas, Jin, Hailing. Cross-kingdom RNA trafficking and environmental RNAi for powerful innovative pre- and post-harvest plant protection. CURRENT OPINION IN PLANT BIOLOGY. 2017, 第 1 作者38: 133-141, http://dx.doi.org/10.1016/j.pbi.2017.05.003.
[12] Wang, Ming, Jin, Hailing. Spray-Induced Gene Silencing: a Powerful Innovative Strategy for Crop Protection. TRENDS IN MICROBIOLOGY. 2017, 第 1 作者25(1): 4-6, http://dx.doi.org/10.1016/j.tim.2016.11.011.
[13] Wang, Ming, Weiberg, Arne, Dellota, Exequiel, Jr, Yamane, Daniel, Jin, Hailing. Botrytis small RNA Bc-siR37 suppresses plant defense genes by cross-kingdom RNAi. RNA BIOLOGY. 2017, 第 1 作者14(4): 421-428, https://www.webofscience.com/wos/woscc/full-record/WOS:000399929600005.
[14] Trends in microbiology. 2017, 第 1 作者
[15] Wang, Ming, Weiberg, Arne, Lin, FengMao, Thomma, Bart P H J, Huang, HsienDa, Jin, Hailing. Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection. NATUREPLANTS[J]. 2016, 第 1 作者2(10): 16151-16151, https://www.webofscience.com/wos/woscc/full-record/WOS:000413438600008.
[16] Dong, Oliver X, Meteignier, LouisValentin, Plourde, Melodie B, Ahmed, Bulbul, Wang, Ming, Jensen, Cassandra, Jin, Hailing, Moffett, Peter, Li, Xin, Germain, Hugo. Arabidopsis TAF15b Localizes to RNA Processing Bodies and Contributes to snc1-Mediated Autoimmunity. MOLECULAR PLANT-MICROBE INTERACTIONS[J]. 2016, 第 5 作者29(4): 247-257, https://www.webofscience.com/wos/woscc/full-record/WOS:000373422600002.
[17] Wang, Ming, Weiberg, Arne, Jin, Hailing. Pathogen small RNAs: a new class of effectors for pathogen attacks. MOLECULAR PLANT PATHOLOGY[J]. 2015, 第 1 作者16(3): 219-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000352152200001.
[18] Weiberg, Arne, Wang, Ming, Bellinger, Marschal, Jin, Hailing, VanAlfen, NK. Small RNAs: A New Paradigm in Plant-Microbe Interactions. ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 52. 2014, 第 2 作者52: 495-516, http://dx.doi.org/10.1146/annurev-phyto-102313-045933.
[19] Weiberg, Arne, Wang, Ming, Lin, FengMao, Zhao, Hongwei, Zhang, Zhihong, Kaloshian, Isgouhi, Huang, HsienDa, Jin, Hailing. Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways. SCIENCE[J]. 2013, 第 2 作者342(6154): 118-123, http://dx.doi.org/10.1126/science.1239705.
[20] Zhenhui Zhong, Ming Wang, Peggy Hsuanyu Kuo, Jason Gardiner, Somsakul Pop Wongpalee, Suhua Feng, Steven E Jacobsen, Javier GallegoBartolom, Wanlu Liu, Yuxing Zhou. Ectopic targeting of CG DNA methylation in Arabidopsis with the bacterial SssI methyltransferase. SPRINGER. 第 2 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202107070951724ZK.
科研活动
科研项目
（ 1 ） IPM自主课题（人才启动费）-王明, 负责人, 研究所自主部署, 2023-07--2029-06
（ 2 ） 农业生物育种重大项目“基因编辑新技术与应用”, 参与, 国家任务, 2023-12--2025-12
（ 3 ） 国家引才青年项目院拨经费, 负责人, 中国科学院计划, 2024-01--2026-12
（ 4 ） 人才计划研究所启, 负责人, 研究所自主部署, 2023-12--2026-12
（ 2 ） 农业生物育种重大项目“基因编辑新技术与应用”, 参与, 国家任务, 2023-12--2025-12
（ 3 ） 国家引才青年项目院拨经费, 负责人, 中国科学院计划, 2024-01--2026-12
（ 4 ） 人才计划研究所启, 负责人, 研究所自主部署, 2023-12--2026-12