电子邮件： wangliming@ihep.ac.cn
通信地址： 石景山区玉泉路19号乙高能所多学科中心
邮政编码： 100049
研究领域
纳米生物学与纳米医学、分析化学、同步辐射应用
招生信息
生物无机化学
招生专业
招生方向
纳米生物分析
同步辐射应用
教育背景
工作经历
2025.1-至今，中国科学院高能物理研究所，研究员
2013.12-2024.12，中国科学院高能物理研究所，副研究员
2011.7-2013.11，中国科学院高能物理研究所，助理研究员
社会兼职
2021-09-01-今,中国毒理学会呼吸毒理分会, 青年委员
2018-05-28-今,中华预防医学会卫生毒理分会, 青年委员
2017-03-01-今,中国毒理学会纳米毒理学分会, 青年委员
专利与奖励
奖励信息
（2） 中国科学院杰出科技成就奖, , 院级, 2019
（3） 中国毒理学会联合利华毒理学替代法创新奖, , 其他, 2017
（4） 中国毒理学会-皇家化学会最佳论文奖, , 其他, 2015
（5） 2012年西班牙国际纳米药剂学大会Travel Grant奖, , 其他, 2012
专利成果
[2] 王黎明, 王静, 白满诺夫·迪达尔, 陈春英, 赵宇亮, 周云龙, 丛亚林. 一种纳米颗粒表面多层蛋白冠成分的原位鉴定与定量方法. CN: CN115453124A, 2022-12-09.
[3] 李洋, 王黎明, 张国芳. 二维纳米材料在抑制冠状病毒的应用. CN: CN114642682A, 2022-06-21.
发表论文
1) Jiacheng Yang, Jing Wang, Heng Zhang, Shijiao Li, Xiaofeng Wang, Didar Baimanov, Zehao Zhang, Yang Li, Peng Yu,* Xinfeng Zhang,* Liming Wang.* Rapid detection of spike protein receptor binding region of SARS-CoV‑2 and its variants using a nanosheet probe. Analytical Chemistry 2025, doi.org/10.1021/acs.analchem.4c06613
2) Yalin Cong, Rongrong Qiao, Xiaofeng Wang, Yinglu Ji, Jiacheng Yang, Didar Baimanov, Shengtao Yu, Rui Cai, Yuliang Zhao, Xiaochun Wu,* Chunying Chen,* Liming Wang.* Protein corona-mediated inhibition of nanozyme activity: Impact of protein shape. J. Am. Soc. Chem. 2024, 146 (15), 10478-10488.
3) Junguang Wu, Xuan Bai, Liang Yan, Didar Baimanov, Yalin Cong, Peiyu Quan, Rui Cai, Yong Guan, Wei Bu, Binhua Lin, Jing Wang, Shengtao Yu, Shijiao Li, Yu Chong, Yang Li, Guoqing Hu, Yuliang Zhao, Chunying Chen*, Liming Wang.* Selective regulation of macrophage lipid metabolism via nanomaterials' surface chemistry. Nature Communications 2024, 15, 8349.
4) Yuting Liu, Damin Xu, Xiaoyi Xing, Anqi Shen, Xinpeng Jin, Shijiao Li, Zhonghua Liu,* Liming Wang,* Yongwei Huang.* Lung-targeting perylenediimide nanocomposites for efficient therapy of idiopathic pulmonary fibrosis. Nano Letters 2024, 24 (40), 12701−12708.
5) Didar Baimanov, Zhuda Song, Zehao Zhang, Longxing Sun, Qingxi Yuan, Wanxia Huang, Yuxi Gao, Liming Wang,* and Zhiyong Zhang.* Preferred lung accumulation of polystyrene nanoplastics with negative charges. Nano Letters 24 (41), 12857−12865.
6) Rui Cai, Didar Baimanov, Hao Yuan, Hongxin Xie, Shengtao Yu, Zehao Zhang, Jiacheng Yang, Feng Zhao, Yue You, Yong Guan, Pingping Zheng, Ming Xu, Mengying Qi, Zhiyong Zhang, Shengliang Zhong*, Yu-Feng Li,* Liming Wang.* Protein corona-directed cellular recognition and uptake of polyethylene nanoplastics by macrophages. Environ. Sci. Technol. 2024, 58 (32), 14158-14168.
7) Didar Baimanov, Su Li, Xuejiao J. Gao, Rui Cai, Ke Liu, Junjie Li, Yuchen Liu, Yalin Cong, Xiaoyu Wang, Fen Liu, Qi Li, Guofang Zhang, Hui Wei, Jian Wang, Chunying Chen, Xingfa Gao,* Yang Li,* Liming Wang.* A phosphatase-like nanomaterial promotes autophagy and reprograms macrophages for cancer immunotherapy. Chemical Science 2024, 15, 10838-10850.
8) Xiaoqing Han, Panpan Song, Rui Cai, Heng Zhu, Jiao Yan, Xingbo Wang, Yanjing Wang, Yaqing Kang, Yuting Ma,* Liming Wang,* Haiyuan Zhang.* Construction of janus mesenchymal stem cell-hitchhiked melanin nanoparticles to modulate the Th17/Treg balance for rheumatoid arthritis therapy. Nano Today 2024, 57, 102322.
9) You Zhang, Xiaofeng Wang, Shu Liu,* Jing Wang, Pingping Zheng, Damin Xu. Qian Liu, Liming Wang,* Wenhong Fan, Fengchang Wu.* Hydrogen nanobubbles enhancing antioxidant activity of glutathione peroxidase: Superiority at the nanoscale over molecular scale. Nano Today 2024, 59, 102510.
10) Quan Liu, Yaping Ren, Huimin Jia, Hao Yuan, Yuping Tong, Sumasri Kotha, Xiaobo Mao, Yongwei Huang,* Chunying Chen, Zhi Zheng, Liming Wang,* Weiwei He.* Vanadium carbide nanosheets with broad-spectrum antioxidant activity for pulmonary fibrosis therapy. ACS Nano 2023,17(22), 22527-22538.
11) Hongqi Geng, Xiumin Li, Xuejiao J. Gao, Yalin Cong, Quan Liu, Jianjiang Li, Yong Guan, Liming Wang,* Weiwei He.* Highly adhesive and catalytic VOxC nanosheets with strong antibacterial activity. Nano Today 2023, 52, 101989.
12) Pingping Zheng, Shengtao Yu, Liming Wang*. Progress in analytical methods for the interaction between nanomaterials and biomolecules based on large-scale scientific facilities. CCS Chem. 2023, 11, 2157-2174.
13) Rongrong Qiao, Yalin Cong, Muhammad Ovais, Rui Cai, Chunying Chen*, Liming Wang*. Performance modulation and analysis for catalytic biomedical nanomaterials in biological systems. Cell Reports Physical Science 2023, 4 (6), 101453.
14) Guofang Zhang, Yalin Cong, Feng-Liang Liu, J Sun, J Zhang, Guoli Cao, Lingqiang Zhou, Wenjie Yang, Qingle Song, Fangjun Wang, Ke Liu, Jing Qu, Jing Wang, Min He, Shun Feng, Didar Baimanov, Wei Xu, Rong-Hua Luo, Xin-Yan Long, Shumin Liao, Yunping Fan, Yu-Feng Li, Bai Li, Ximing Shao, Guocheng Wang, Lijing Fang, Huaiyu Wang, Xue-Feng Yu, Yan-Zhong Chang, Yuliang Zhao, Liang Li, Peng Yu, Yong-Tang Zheng,* Diana Boraschi, Hongchang Li,* Chunying Chen,* Liming Wang* and Yang Li.* A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nature Nanotechnology 2022, 17: 993-1003.
15) Didar Baimanov, Jing Wang, Ke Liu, Yalin Cong, Yunlong Zhou,* Liming Wang,* Chunying Chen.* In situ analysis of nanoparticle soft corona and dynamic evolution. Nature Communications 2022, 13, 5389.
16) Yalin Cong, Didar Baimanov, Yunlong Zhou, Chunying Chen, Liming Wang.* Penetration and translocation of functional inorganic nanomaterials into biological barriers. Advanced Drug Delivery Reviews 2022, 191, 114615.
17) Haiyun Li, Jiao Yan, Dejing Meng, Rui Cai, Xingshuang Gao, Yinglu Ji, Liming Wang,* Chunying Chen,* Xiaochun Wu.* Gold nanorod-based nanoplatform catalyzes constant no generation and protects from cardiovascular injury. ACS Nano 2020, 14 (10), 12854−12865.
18) Didar Baimanov, Junguang Wu, Runxuan Chu, Rong Cai, Bing Wang, Mingjing Cao, Ye Tao, Jiaming Liu, Mengyu Guo, Jing Wang, Xia Yuan, Chengdong Ji, Yuliang Zhao, Weiyue Feng,* Liming Wang,* Chunying Chen.* Immunological responses induced by blood protein coronas on two-dimensional MoS2 Nanosheets. ACS Nano 2020, 14 (5), 5529-5542.
19) Jie Ding, Yong Guan, Yalin Cong, Liang Chen, Yu-Feng Li, Lijuan Zhang, Lili Zhang, Jian Wang, Ru Bai, Yuliang Zhao, Chunying Chen, and Liming Wang.* Single-particle analysis for structure and iron chemistry of atmospheric particulate matter. Anal. Chem. 2020, 92(1): 975-982.
20) Liming Wang, Peiyu Quan, Serena H. Chen, Wei Bu, Yufeng Li, Xiaochun Wu, Junguang Wu, Leili Zhang, Yuliang Zhao, Xiaoming Jiang, Binhua Lin,* Ruhong Zhou,* Chunying Chen.* Stability of ligands on nanoparticles regulating the integrity of biological membranes at the nano–lipid Interface. ACS Nano 2019,13, 8680-8693.
21) Liming Wang, Liang Yan, Jing Liu, Chunying Chen, Yuliang Zhao. Quantification of nanomaterial/nanomedicine trafficking in vivo. Anal. Chem. 2018, 90 (1), 589-614.
22) Jing Liu, Pengyang Wang, Xiao Zhang, Liming Wang,* Dongliang Wang, Zhanjun Gu, Jinglong Tang, Mengyu Guo, Mingjing Cao, Huige Zhou, Ying Liu,* Chunying Chen.* Rapid degradation and high renal clearance of Cu3BiS3 nanodots for efficient cancer diagnosis and photothermal therapy in vivo. ACS Nano 2016, 10, (4), 4587-4598.
23) Liming Wang, Tianlu Zhang, Panyun Li, Wanxia Huang, Jinglong Tang, Pengyang Wang, Jing Liu, Qingxi Yuan, Ru Bai, Kai Zhang, Yuliang Zhao, Chunying Chen. Use of synchrotron radiation-analytical techniques to reveal chemical origin of silver-nanoparticle cytotoxicity. ACS Nano 2015, 9, 6532-6547.
24) Liming Wang, Qiang Sun, Xin Wang, Tao Wen, Junjie Yin, Pengyang Wang, Ru Bai, Xiang-Qian Zhang, Lu-Hua Zhang, An-Hui Lu, Chunying Chen. Using hollow carbon nanospheres as a light-induced free radical generator to overcome chemotherapy resistance. J. Am. Chem. Soc. 2015, 137: 1947-1955.
25) Liming Wang, Xiaoying Lin, Jing Wang, Zhijian Hu, Yinglu Ji, Shuai Hou, Yuliang Zhao, Xiaochun Wu, Chunying Chen. Novel insights into combating cancer chemotherapy resistance using a plasmonic nanocarrier: enhancing drug sensitiveness and accumulation simultaneously with localized mild photothermal stimulus of femtosecond pulsed laser. Adv. Funct. Mater. 2014, 24: 4229-4239.
26) Liming Wang, Jingyuan Li, Jun Pan, Xiumei Jiang, Yinglu Ji, Yufeng Li, Ying Qu, Yuliang Zhao, Xiaochun Wu, Chunying Chen. Revealing the binding structure of the protein corona on gold nanorods using synchrotron radiation-based techniques: Understanding the reduced damage in cell membranes. J. Am. Chem. Soc. 2013, 135: 17359-17368.
27) Liming Wang, Xiumei Jiang, Yinglu Ji, Ru Bai, Yuliang Zhao, Xiaochun Wu, Chunying Chen. Surface chemistry of gold nanorods: origin of cell membrane damage and cytotoxicity. Nanoscale 2013, 5, 8384-8391.
28) Zhenjiang Zhang, Liming Wang, Jing Wang#, Xiumei Jiang, Xiaohui Li, Zhijian Hu, Yinglu Ji, Xiaochun Wu, Chunying Chen. Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment. Adv. Mater. 2012, 24, 1418-1423.
29) Liming Wang, Ying Liu, Wei Li, Xiumei Jiang, Yinglu Ji, Xiaochun Wu, Ligeng Xu, Yang Qiu, Kai Zhao, Taotao Wei, Yufeng Li, Yuliang Zhao, Chunying Chen. Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy. Nano Lett. 2011, 11 (2), 772-780.
30) Liming Wang, Yufeng Li, Ying Liu, Li Meng, Ke Zhang, Xiaochun Wu, Lili Zhang, Bai Li, Chunying Chen. Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms. Anal. Bioanal. Chem. 2010, 396 (3), 1105-1114.
发表著作
（2） Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics, Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics, Springer, 2016-01, 第 1 作者
（3） Analyses Methods for Nanoparticle Interaction with Biomacromolecules, Analyses Methods for Nanoparticle Interaction with Biomacromolecules, Wiley-VCH Verlag GmbH & Co, 2016-06, 第 1 作者
（4） 第5章，医用纳米材料新型检测方法及药代动力学研究技术, 科学出版社, 2022-10, 第 1 作者
科研活动
科研项目
（ 2 ） 纳米材料体内转运与效应的多维度测量分析方法, 负责人, 国家任务, 2021-12--2026-11
（ 3 ） 纳米材料的蛋白冠主动调控, 负责人, 国家任务, 2020-12--2025-11
（ 4 ） 中科院国际人才计划博士后项目PIFI, 负责人, 中国科学院计划, 2020-12--2022-11
（ 5 ） 典型纳米材料与低密度脂蛋白的作用及其生物学效应的研究, 负责人, 国家任务, 2020-01--2023-12
（ 6 ） 大科学装置高端用户培育基金：软X射线高分辨成像研究纳米颗粒与细胞的作用, 负责人, 中国科学院计划, 2018-10--2020-09
（ 7 ） 纳米界面上污染物分子识别及相互作用机理研究, 负责人, 国家任务, 2016-07--2021-06
（ 8 ） 雾霾中细/超细颗粒物的健康效应研究, 参与, 国家任务, 2015-01--2019-12
参与会议
（2）纳米生物界面作用及其关联的生物效应 第17届全国生物无机化学会议 2024-08-19
（3）纳米材料-生物界面作用及其调控的生物效应 2024年合肥光源用户年会 2024-08-07
（4）纳米-生物/纳米-化学界面分析 及其在纳米环境健康效应研究的应用 第九届全国生态毒理学大会 2024-04-28
（5）纳米生物界面作用及驱动的生物效应 第十二届全国环境化学大会 2023-11-18
（6）Analysis for Nanomaterial-Biological Interaction and Its Application in Nanomedicine 2023-11-08
（7）纳米材料与生物体多层级相互作用与分析 大科学装置在化学测量学中发展应用战略研讨会 2023-09-16
（8）Advanced Analysis for Nanomaterial-Biological Interaction and Its Biomedical Applications 第九届中国国际纳米科学技术会议(ChinaNano2023) 2023-08-26
（9）纳米生物界面作用驱动的抗病原纳米技术 2023-08-14
（10）纳米生物界面作用驱动的抗病原纳米技术 上海光源第十一届用户学术年会 2023-08-14
（11）纳米药物与生物体多层级作用分析 2023-08-02
（12）纳米材料与生物体多层级相互作用分析 第16届全国生物无机化学会议 2023-07-28
（13）纳米药物-生物作用界面的分析及应用 第十二届全国化学生物学学术会议 2023-04-14
（14）基于同步辐射的纳米生物界面分析 2022年合肥光源用户年会 2022-08-01
（15）Quantitative analysis for nanomaterial and biological system interaction by synchrotron radiation technology 2021-12-20
（16）纳米材料-生物界面作用定量分析 第七届全国生态毒理大会 2021-09-27
（17）纳米生物效应多层级定量分析 2021年合肥光源用户年会 2021-08-02
（18）基于同步辐射大科学装置的 纳米生物效应分析 粤港澳湾区创新论坛 2021-03-31
（19）Characterization of Nanomaterials During Nano-Biological System Interaction Spectro Nanoscopy 2019 Workshop 2019-11-14
（20）纳米-生物界面分析及其在纳米生物学的应用 中国毒理学会第九次学术年会 2019-09-19
（21）Quantitative Analysis at Nano-Cell Interface ChinaNano2019 2019-08-17
（22）Characterization of Nanomaterial-Biological System Interaction 2019-04-12
（23）Study in Uptake and Transformation of Nanomaterials by Synchrotron Radiation Techniques 2018-08-10
（24）纳米生物效应相关的纳米分析 中国化学会31届学术年会 2018-05-06
（25）Application of Synchrotron Radiation in the Study of Nano-Biology 上海光源软X射线谱学显微和光刻技术讲习班 2017-11-10
（26）Use of Synchrotron Radiation Techniques in Studying Biomedical Effects of Nanomaterials ChinaNano2017 王黎明 2017-08-29
合作情况
1-国内：国家纳米科学中心、北京同步辐射装置、上海光源、合肥同步
2-国外：加拿大光源、KEK、APS等