专注于超声、光学等多模态医学影像和多源医疗数据的智能解析和可视化技术研究。通过医学影像和人工智能的交叉融合与方法创新，不断提高对肿瘤等重大疾病的可视化观测能力和定量认知能力，推进疾病诊疗的个体化和动态化决策。

他以第一或通讯作者（含并列）在Nature Reviews Bioengineering、Nature Communications、Journal of Hepatology、Gut、IEEE Transactions on Medical Imaging、Medical Image Analysis等SCI检索期刊发表论文90余篇，发表论文在“谷歌学术”总引用10000余次（h指数55）。他的多项医学AI技术研究被编入美国高校医学影像人工智能的教科书（IPEM-IOP Textbook）；他的AI技术临床转化研究被编入Springer学术手册（Handbook）；他的AI技术临床应用研究被写入世界医学和生物学超声联合会（WFUMB）的国际临床指南。

081203-计算机应用技术

医学影像与人工智能
医学影像设备与装备
多模态分子影像

2008-01--2011-12   英国纽卡斯尔大学医学院   医学影像博士
2006-09--2007-12   比利时鲁汶大学医学院   医学影像硕士
2005-09--2006-07   比利时鲁汶大学工程学院   电子电气工程硕士
2003-09--2005-07   比利时鲁汶大学工程学院   电子电气工程学士
2002-09--2006-07   北京交通大学电子信息技术学院   通讯工程学士

   

2021-01~现在, 中国科学院自动化研究所, 研究员
2014-10~2021-01,中国科学院自动化研究所, 副研究员
2012-11~2014-10,中国科学院自动化研究所, 助理研究员

2023-06-01-今,中国医学装备协会人工智能和医用机器人工作委员会委员, 委员
2019-12-31-今,中国抗癌协会肿瘤人工智能专业委员会委员, 委员
2019-12-31-今,中国研究型医院学会超声医学专业委员会委员, 委员
2018-01-01-今,中国医师协会放射医师分会第四届专业委员会委员,
2016-01-01-今,中国科学院青年创新促进会会员,
2014-12-31-2015-12-30,世界分子影像学会程序委员会委员,
2014-01-01-今,IEEE医学和生物工程学会北京分会秘书,
2013-12-30-2017-12-31,中国生物物理学会分子影像专业委员会副秘书长,

   

（1） Artificial intelligence-enabled ultrasound diagnosis and stratification of follicular thyroid neoplasms: a multi-center study, NPJ Digital Medicine, 2026, 第 28 作者  通讯作者
（2） Artificial intelligence-assisted diagnosis of early allograft dysfunction based on ultrasound image and data, Visual Computing for Industry, Biomedicine, and Art, 2025, 第 9 作者  通讯作者
（3） ViT-based quantification of intratumoral heterogeneity for predicting the early recurrence in HCC following multiple ablation, Liver International, 2025, 第 12 作者  通讯作者
（4） Preoperative Prediction of Axillary Lymph Node Metastasis in Patients With Breast Cancer Through Multimodal Deep Learning Based on Ultrasound and Magnetic Resonance Imaging Images, Academic Radiology, 2025, 第 10 作者  通讯作者
（5） Contrast-enhanced ultrasound-based AI model for multi-classification of focal liver lesions, Journal of Hepatology, 2025, 第 9 作者  通讯作者
（6） Deep learning model based on contrast-enhanced ultrasound for predicting vessels encapsulating tumor clusters in hepatocellular carcinoma, European Radiology, 2025, 第 8 作者  通讯作者
（7） Vision transformer-based model can optimize curative-intent treatment for patients with recurrent hepatocellular carcinoma, Nature Communications, 2025, 第 20 作者  通讯作者
（8） Cervical lymph node metastasis prediction from papillary thyroid carcinoma US videos: a prospective multicenter study, BMC Medicine, 2024, 第 9 作者  通讯作者
（9） NIR-II light in clinical oncology: opportunities and challenges, NATURE REVIEWS CLINICAL ONCOLOGY, 2024, 第 4 作者
（10） Deep learning-based automatic scoring models for the disease activity of rheumatoid arthritis based on multimodal ultrasound images, Rheumatology, 2024, 第 16 作者  通讯作者
（11） Deep learning models of ultrasonography significantly improved the differential diagnosis performance for superficial soft-tissue masses: a retrospective multicenter study, BMC medicine, 2023, 第 11 作者  通讯作者
（12） Application and prospects of AI-based radiomics in ultrasound diagnosis, Visual Computing for Industry, Biomedicine, and Art, 2023, 第 5 作者  通讯作者
（13） Deep learning radiomics of ultrasonography for comprehensively predicting tumor and axillary lymph node status after neoadjuvant chemotherapy in breast cancer patients: A multicenter study, Cancer, 2023, 第 10 作者  通讯作者
（14） Dual-Input Transformer: An End-to-End Model for Preoperative Assessment of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Ultrasonography, IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS, 2023, 第 7 作者  通讯作者
（15） Intraoperative Fluorescence Visualization in Thoracoscopic Surgery, ANNALS OF THORACIC SURGERY, 2023, 第 2 作者
（16） Fluorescence image-guided tumour surgery, Nature Reviews Bioengineering, 2023, 第 1 作者
（17） MSMFN: An ultrasound based multi-step modality fusion network for identifying the histologic subtypes of metastatic cervical lymphadenopathy, IEEE TRANSACTIONS ON MEDICAL IMAGING, 2023, 第 6 作者  通讯作者
（18） A c-MET-targeted topical fluorescent probe cMBP-ICG improves oral squamous cell carcinoma detection in humans, Annals of Surgical Oncology, 2023, 第 3 作者
（19） Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment, Nano Today, 2023, 第 6 作者  通讯作者
（20） Deep learning radiomics of multimodal ultrasound for classifying metastatic cervical lymphadenopathy into primary cancer sites: a feasibility study, Ultraschall in der Medizin, 2023, 第 6 作者  通讯作者
（21） Specular highlight removal for endoscopic images using partial attention network, Physics in Medicine & Biology, 2023, 第 3 作者  通讯作者
（22） Efficacy of Near-Infrared Fluorescence Video-Assisted Thoracoscopic Surgery for Small Pulmonary Nodule Resection with Indocyanine Green Inhalation: A Randomized Clinical Trial, Annals of Surgical Oncology, 2023, 第 1 作者
（23） Deep learning radiomics of dual-energy computed tomography for predicting lymph node metastases of pancreatic ductal adenocarcinoma, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 第 12 作者  通讯作者
（24） Deep learning radiomics based on contrast-enhanced ultrasound images for assisted diagnosis of pancreatic ductal adenocarcinoma and chronic pancreatitis, BMC MEDICINE, 2022, 第 11 作者  通讯作者
（25） Carbonic anhydrase IX stratifies patient prognosis and identifies nodal status in animal models of nasopharyngeal carcinoma using a targeted imaging strategy, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 第 2 作者
（26） Deep learning radiomics of dual-modality ultrasound images for hierarchical diagnosis of unexplained cervical lymphadenopathy, BMC MEDICINE, 2022, 第 10 作者  通讯作者
（27） Adaptive brightness fusion method for intraoperative near-infrared fluorescence and visible images, BIOMEDICAL OPTICS EXPRESS, 2022, 第 2 作者
（28） Deep learning radiomics of ultrasonography can predict response to neoadjuvant chemotherapy in breast cancer at an early stage of treatment: a prospective study, EUROPEAN RADIOLOGY, 2022, 第 8 作者  通讯作者
（29） A novel co-targeting strategy of EGFR/SEC61G for multi-modality fluorescence/MR/photoacoustic imaging of glioblastoma, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2022, 第 2 作者
（30） The potential indicators for pulmonary fibrosis in survivors of severe COVID-19, JOURNAL OF INFECTION, 2021, 第 5 作者
（31） Dynamic Contrast-Enhanced Ultrasound Radiomics for Hepatocellular Carcinoma Recurrence Prediction After Thermal Ablation, MOLECULAR IMAGING AND BIOLOGY, 2021, 第 9 作者  通讯作者
（32） Comparing radiomics models with different inputs for accurate diagnosis of significant fibrosis in chronic liver disease, EUROPEAN RADIOLOGY, 2021, 第 3 作者
（33） Application of deep learning to predict underestimation in ductal carcinoma in situ of the breast with ultrasound, ANNALS OF TRANSLATIONAL MEDICINE, 2021, 第 4 作者
（34） The Role of Imaging in the Detection and Management of COVID-19: A Review, IEEE REVIEWS IN BIOMEDICAL ENGINEERING, 2021, 第 12 作者
（35） Adaptive Grouping Block Sparse Bayesian Learning Method for Accurate and Robust Reconstruction in Bioluminescence Tomography, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2021, 第 2 作者  通讯作者
（36） A review of the application of machine learning in molecular imaging, ANNALS OF TRANSLATIONAL MEDICINE, 2021, 第 3 作者
（37） Deep pyramid local attention neural network for cardiac structure segmentation in two-dimensional echocardiography, MEDICAL IMAGE ANALYSIS, 2021, 第 2 作者
（38） Domain Transform Network for Photoacoustic Tomography from Limited-view and Sparsely Sampled Data, PHOTOACOUSTICS, 2020, 第 3 作者  通讯作者
（39） Accurate prediction of responses to transarterial chemoembolization for patients with hepatocellular carcinoma by using artificial intelligence in contrast-enhanced ultrasound, EUROPEAN RADIOLOGY, 2020, 第 11 作者
（40） Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2020, 第 2 作者
（41） A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 2020, 第 5 作者
（42） K-nearest Neighbor Based Locally Connected Network for Fast Morphological Reconstruction in Fluorescence Molecular Tomography, IEEETRANSACTIONSONMEDICALIMAGING, 2020, 第 4 作者  通讯作者
（43） Fluorescence Molecular Tomography Based on Group Sparsity Priori for Morphological Reconstruction of Glioma, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2020, 第 6 作者  通讯作者
（44） Application of machine learning method in optical molecular imaging: a review, Application of machine learning method in optical molecular imaging: a review, SCIENCE CHINA-INFORMATION SCIENCES, 2020, 第 6 作者
（45） Online Transfer Learning for Differential Diagnosis of Benign and Malignant Thyroid Nodules With Ultrasound Images, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2020, 第 2 作者
（46） In vivo three-dimensional evaluation of tumor hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT, European Journal of Nuclear Medicine and Molecular Imaging, 2020, 第 1 作者
（47） The first visualization of chemotherapy-induced tumor apoptosis via magnetic particle imaging in a mouse model, PHYSICS IN MEDICINE AND BIOLOGY, 2020, 第 2 作者
（48） Improved Block Sparse Bayesian Learning Method Using K-Nearest Neighbor Strategy for Accurate Tumor Morphology Reconstruction in Bioluminescence Tomography, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2020, 第 2 作者
（49） Deep Learning Radiomics Based on Contrast-Enhanced Ultrasound Might Optimize Curative Treatments for Very-Early or Early-Stage Hepatocellular Carcinoma Patients, LIVER CANCER, 2020, 第 3 作者
（50） Cascaded one-shot deformable convolutional neural networks: Developing a deep learning model for respiratory motion estimation in ultrasound sequences, MEDICAL IMAGE ANALYSIS, 2020, 第 6 作者  通讯作者
（51） In vivo three-dimensional evaluation of tumour hypoxia in nasopharyngeal carcinomas using FMT-CT and MSOT, EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 第 2 作者
（52） Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography, APPLIED OPTICS, 2020, 第 5 作者
（53） Differential Diagnosis of Benign and Malignant Thyroid Nodules Using Deep Learning Radiomics of Thyroid Ultrasound Images, EUROPEAN JOURNAL OF RADIOLOGY, 2020, 第 6 作者  通讯作者
（54） Construction of a novel bispecific fusion protein to enhance targeting for pancreatic cancer imaging, BIOMATERIALS, 2020, 第 7 作者  通讯作者
（55） Reconstruction of fluorescence molecular tomography via a fused lasso method based on group sparsity prior, IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2019, 第 7 作者  通讯作者
（56） Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition, NATURE COMMUNICATIONS, 2019, 第 5 作者
（57） Adaptive Gaussian Weighted Laplace Prior Regularization Enables Accurate Morphological Reconstruction in Fluorescence Molecular Tomography, IEEE TRANSACTIONS ON MEDICAL IMAGING, 2019, 第 2 作者  通讯作者
（58） Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma, NANOMEDICINE, 2019, 第 2 作者
（59） Improved generative adversarial networks using the total gradient loss for the resolution enhancement of fluorescence images, BIOMEDICAL OPTICS EXPRESS, 2019, 第 2 作者
（60） An Innovation for Treating Orthotopic Pancreatic Cancer by Preoperative Screening and Imaging-Guided Surgery, MOLECULAR IMAGING AND BIOLOGY, 2019, 第 9 作者  通讯作者
（61） Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning, EUROPEAN RESPIRATORY JOURNAL, 2019, 第 9 作者
（62） Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study, GUT, 2019, 第 1 作者
（63） Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 
（64） A novel plectin/integrin-targeted bispecific molecular probe for magnetic resonance/near-infrared imaging of pancreatic cancer, BIOMATERIALS, 2018, 第 9 作者
（65） Recent methodology advances in fluorescence molecular tomography, VISUAL COMPUTING FOR INDUSTRY, BIOMEDICINE, AND ART, 2018, 第 2 作者
（66） "All-in-One" Nanoparticles for Trimodality Imaging-Guided Intracellular Photo-magnetic Hyperthermia Therapy under Intravenous Administration, ADVANCED FUNCTIONAL MATERIALS, 2018, 第 10 作者
（67） Ferritin Nanocarrier Traverses the Blood Brain Barrier and Kills Glioma, ACS NANO, 2018, 第 4 作者
（68） Sorafenib-loaded polymeric micelles as passive targeting therapeutic agents for hepatocellular carcinoma therapy, NANOMEDICINE, 2018, 第 2 作者
（69） A New Approach to Predict Progression-free Survival in Stage IV EGFR-mutant NSCLC Patients with EGFR-TKI Therapy, CLINICAL CANCER RESEARCH, 2018, 第 6 作者
（70） In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 第 10 作者
（71） Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer, THERANOSTICS, 2018, 第 5 作者
（72） Near-infrared Intraoperative Molecular Imaging of Thoracic Sympathetic Nerves:From Preclinical Study to Clinical Trial, Theranostics (SCI IF: 8.712), 2018, 第 1 作者  通讯作者
（73） Sparse Reconstruction of Fluorescence Molecular Tomography Using Variable Splitting and Alternating Direction Scheme, MOLECULAR IMAGING AND BIOLOGY, 2018, 第 9 作者  通讯作者
（74） Non model-based bioluminescence tomography using a machine-learning reconstruction strategy, OPTICA, 2018, 第 2 作者  通讯作者
（75） From Detection to Resection: Photoacoustic Tomography and Surgery Guidance with Indocyanine Green Loaded Gold Nanorod@liposome Core-Shell Nanoparticles in Liver Cancer, BIOCONJUGATE CHEMISTRY, 2017, 第 7 作者  通讯作者
（76） Development and application of the near-infrared and white-light thoracoscope system for minimally invasive lung cancer surgery, JOURNAL OF BIOMEDICAL OPTICS, 2017, 第 2 作者
（77） Bioluminescence Tomography Based on Gaussian Weighted Laplace Prior Regularization for In Vivo Morphological Imaging of Glioma, IEEE TRANSACTIONS ON MEDICAL IMAGING, 2017, 第 2 作者  通讯作者
（78） Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma, ADVANCEDMATERIALS, 2017, 第 7 作者  通讯作者
（79） Reconstruction Method for In Vivo Bioluminescence Tomography Based on the Split Bregman Iterative and Surrogate Functions, MOLECULAR IMAGING AND BIOLOGY, 2017, 第 2 作者  通讯作者
（80） Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer, NANOSCALE, 2016, 第 8 作者
（81） Dye-conjugated single-walled carbon nanotubes induce photothermal therapy under the guidance of near-infrared imaging, CANCER LETTERS, 2016, 第 5 作者
（82） Lung Lesion Extraction Using a Toboggan Based Growing Automatic Segmentation Approach., IEEE TRANSACTIONS ON MEDICAL IMAGING, 2016, 第 4 作者
（83） Intraoperative Identification of Liver Cancer Microfoci Using a Targeted Near-Infrared Fluorescent Probe for Imaging-Guided Surgery, SCIENTIFIC REPORTS, 2016, 第 3 作者
（84） Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles, NANOSCALE, 2016, 第 8 作者  通讯作者
（85） Curve-Driven-Based Acoustic Inversion for Photoacoustic Tomography, IEEE TRANSACTIONS ON MEDICAL IMAGING, 2016, 第 2 作者  通讯作者
（86） Targeted Aucore-Agshell nanorods as a dual-functional contrast agent for photoacoustic imaging and photothermal therapy, BIOMEDICAL OPTICS EXPRESS, 2016, 第 3 作者
（87） Lp Regularization for Bioluminescence Tomography Based on the Split Bregman Method, MOLECULAR IMAGING AND BIOLOGY, 2016, 第 6 作者  通讯作者
（88） In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging, NATURE COMMUNICATIONS, 2015, 第 3 作者
（89） Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method, JOURNAL OF BIOMEDICAL OPTICS, 2015, 第 7 作者
（90） Optical Molecular Imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity, Optical Molecular Imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity, Engineering, 2015, 第 1 作者
（91） Bioluminescence Tomography by an Iterative Reweighted l2 Norm Optimization Using Structure Priors, IEEE Transactions on Biomedical Engineering (SCI IF: 3.577), 2014, 第 3 作者
（92） Probability method for Cerenkov luminescence tomography based on conformance error minimization, BIOMEDICAL OPTICS EXPRESS, 2014, 第 2 作者

   

（ 1 ） 淋巴瘤动态演进的多模超声智能分型与疗效预测研究, 参与, 国家任务, 2026-01--2029-12
（ 2 ） 国家自然科学基金专项项目（重大疾病智慧诊疗），“早期肝癌多维异构临床数据的智能解析与诊疗应用”, 负责人, 国家任务, 2025-01--2027-12
（ 3 ） 国家重点研发计划“生物与信息融合（BT 与IT 融合）”重点专项, 负责人, 国家任务, 2023-11--2026-10
（ 4 ） 肺癌新辅助免疫治疗中肿瘤演进机制及关键分子功能的可视化研究, 负责人, 国家任务, 2023-01--2026-12
（ 5 ） 北京市杰出青年科学基金项目, 负责人, 地方任务, 2022-10--2025-12
（ 6 ） 肝癌演进监测与治疗决策的分子功能多模态超声可视化研究, 负责人, 国家任务, 2022-01--2025-12
（ 7 ） 中国科学院青年创新促进会优秀会员项目, 负责人, 中国科学院计划, 2021-01--2023-12
（ 8 ） 动物活体多通道多功能近红外术中成像设备, 负责人, 中国科学院计划, 2019-01--2020-12
（ 9 ） 乳腺癌术中多通道近红外成像系统研发及示范应用, 负责人, 中国科学院计划, 2019-01--2023-06
（ 10 ） 基于近红外纳米探针的肝癌分子影像及其手术导航技术研发, 参与, 国家任务, 2017-07--2022-06
（ 11 ） 外源性与内源性光学三维断层成像融合新方法研究, 负责人, 国家任务, 2017-01--2020-12
（ 12 ） 基于多光谱混合组织特异性模型的契伦科夫荧光高精度三维成像研究, 负责人, 国家任务, 2015-01--2017-12
（ 13 ） 脑胶质瘤精准诊疗技术的关键科学问题研究, 参与, 国家任务, 2015-01--2019-12
（ 14 ） 小动物光学和光声断层多模融合分子影像设备, 参与, 中国科学院计划, 2014-01--2015-12
（ 15 ） 小动物光学多模融合分子影像成像设备, 参与, 国家任务, 2013-01--2017-12