1. 天然产物全合成

2. 基于天然产物的新化学实体分子库构建

3. 天然产物靶标发现与验证

   

100701-药物化学
070303-有机化学

药物化学
天然产物合成
有机合成方法学

2009-09--2014-06   中国科学院上海有机化学研究所   博士
2004-09--2009-06   南京大学   学士

   

2019-01~2019-10,Scripps研究所（Calibr）, 博士后
2015-05~2018-12,Scripps研究所（化学）, 博士后
2014-07~2015-04,中国科学院上海有机化学研究所, 研究助理

高等有机化学

   

（ 1 ） Cu- and Ni-catalyzed decarboxylative borylation reactions, 发明, 2017, 第 3 作者, 专利号: WO2018/175173A1
（ 2 ） 合成埃坡霉素碳1—6片段的中间体,合成方法和用途, 发明, 2014, 第 3 作者, 专利号: CN102268031B
（ 3 ） 一种合成埃坡霉素碳7-19片段的中间体、合成方法和用途, 发明, 2015, 第 3 作者, 专利号: CN102675357B
（ 4 ） Monocyclic agonists of stimulator of interferon genes sting, 发明, 2019, 第 3 作者, 专利号: WO/2021/035257A1
（ 5 ） Bicyclic agonists of stimulator of interferon genes sting, 发明, 2019, 第 3 作者, 专利号: WO2021035258A1

   

[1] Tian, Guang, Zhang, YiChi, Qin, Chuanguang, Wang, Jie. A modular and divergent approach for the total synthesis of Elaeocarpus alkaloids. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 10(1): 68-73, http://dx.doi.org/10.1039/d2qo01460b.
[2] Flood, Dillon T, Asai, Shota, Zhang, Xuejing, Wang, Jie, Yoon, Leonard, Adams, Zoe C, Dillingham, Blythe C, Sanchez, Brittany B, Vantourout, Julien C, Flanagan, Mark E, Piotrowsld, David W, Richardson, Paul, Green, Samantha A, Shenvi, Ryan A, Chen, Jason S, Baran, Phil S, Dawson, Philip E. Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(25): 9998-10006, https://www.webofscience.com/wos/woscc/full-record/WOS:000473251500036.
[3] Wang, Jie, Lundberg, Helena, Asai, Shota, MartinAcosta, Pedro, Chen, Jason S, Brown, Stephen, Farrell, William, Dushin, Russell G, ODonnell, Christopher J, Ratnayake, Anokha S, Richardson, Paul, Liu, Zhiqing, Qin, Tian, Blackmond, Donna G, Baran, Phil S. Kinetically guided radical-based synthesis of C(sp(3))-C(sp(3)) linkages on DNA. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(28): E6404-E6410, http://dx.doi.org/10.1073/pnas.1806900115.
[4] Wang, Jie, Shang, Ming, Lundberg, Helena, Feu, Karla S, Hecker, Scott J, Qin, Tian, Blackmond, Donna G, Baran, Phil S. Cu-Catalyzed Decarboxylative Borylation. ACS CATALYSIS[J]. 2018, 8(10): 9537-9542, http://dx.doi.org/10.1021/acscatal.8b02928.
[5] Lopchuk, Justin M, Fjelbye, Kasper, Kawamata, Yu, Malins, Lara R, Pan, ChungMao, Gianatassio, Ryan, Wang, Jie, Prieto, Liher, Bradow, James, Brandt, Thomas A, Collins, Michael R, Elleraas, Jeff, Ewanicki, Jason, Farrell, William, Fadeyi, Olugbeminiyi O, Gallego, Gary M, Mousseau, James J, Oliver, Robert, Sach, Neal W, Smith, Jason K, Spangler, Jillian E, Zhu, Huichin, Zhu, Jinjiang, Baran, Phil S. Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(8): 3209-3226, https://www.webofscience.com/wos/woscc/full-record/WOS:000395493400056.
[6] Knochel Paul, Lutter Ferdinand H. Decarboxylative Borylation. SYNFACTS: HIGHLIGHTS IN CHEMICAL SYNTHESIS[J]. 2017, [7] Wang, Jie, Qin, Tian, Chen, TieGen, Wimmer, Laurin, Edwards, Jacob T, Cornella, Josep, Vokits, Benjamin, Shaw, Scott A, Baran, Phil S. Nickel-Catalyzed Cross-Coupling of Redox-Active Esters with Boronic Acids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(33): 9676-9679, https://search.proquest.com/docview/1967855414.
[8] Gianatassio, Ryan, Lopchuk, Justin M, Wang, Jie, Pan, ChungMao, Malins, Lara R, Prieto, Liher, Brandt, Thomas A, Collins, Michael R, Gallego, Gary M, Sach, Neal W, Spangler, Jillian E, Zhu, Huichin, Zhu, Jinjiang, Baran, Phil S. Strain-release amination. SCIENCE[J]. 2016, 351(6270): 241-246, [9] Cornella Josep Edwards Jacob T Qin Tian Kawamura Shuhei Wang Jie Pan ChungMao Gianatassio Ryan Schmidt Michael Eastgate Martin D Baran Phil S. Practical Ni-Catalyzed Aryl-Alkyl Cross-Coupling of Secondary Redox-Active Esters. 2016, 138(7): 2174-2177, [10] Wang, Jie, Sun, WangBin, Li, YingZi, Wang, Xuan, Sun, BingFeng, Lin, GuoQiang, Zou, JianPing. A concise formal synthesis of platencin. ORGANIC CHEMISTRY FRONTIERS[J]. 2015, 2(6): 674-676, https://www.webofscience.com/wos/woscc/full-record/WOS:000364445900009.
[11] Li, YingZi, Wang, Jie, Sun, WangBin, Shan, YiFan, Sun, BingFeng, Lin, GuoQiang, Zou, JianPing. Enantioselective synthesis of bicyclo2.2.2octane-1-carboxylates under metal free conditions. ORGANIC CHEMISTRY FRONTIERS[J]. 2015, 2(3): 274-278, https://www.webofscience.com/wos/woscc/full-record/WOS:000364444000014.
[12] 王现磊, 卢云宇, 王杰, 王璇, 姚和权, 林国强, 孙炳峰. A novel synthetic approach to the bicyclo5.3.1-undecan-11-one framework of vinigrol. ORG. BIOMOL. CHEM.[J]. 2014, 12(22): 3562-3566, http://ir.sioc.ac.cn/handle/331003/38982.
[13] Jie Wang, ShuGuang Chen, Prof. Dr. BingFeng Sun, Prof. GuoQiang Lin, Prof. YongJia Shang. Collective Total Synthesis of Englerin A and B, Orientalol E and F, and Oxyphyllol: Application of the Organocatalytic 4+3 Cycloaddition Reaction. CHEMISTRY – A EUROPEAN JOURNAL. 2013, https://www.webofscience.com/wos/woscc/full-record/WOS:000314662700039.
[14] Wang, Jie, Sun, BingFeng, Cui, Kai, Lin, GuoQiang. An Efficient Total Synthesis of (-)-Epothilone B. ORGANIC LETTERS[J]. 2012, 14(24): 6354-6357, http://www.irgrid.ac.cn/handle/1471x/681744.

   

（ 1 ） 三尖杉二萜天然产物的集体全合成, 主持, 国家级, 2022-01--2024-12

（1）Forging C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds in DEL format.   2018-10-20

现指导学生

周进锌  硕士研究生  078001-药物化学