基本信息

王怀雨  男  博士生导师  中国科学院深圳先进技术研究院
电子邮件: hy.wang1@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055

研究领域

骨科植入材料

纳米生物材料

表面功能化修饰


招生信息

招收生物材料及相关领域研究生

招生专业
0703Z1-化学生物学
071010-生物化学与分子生物学
080503-材料加工工程
招生方向
生物材料
表面改性
生物学评价

教育背景

2004-09--2009-07   中国科学院理化技术研究所   博士学位
2000-09--2004-07   北京大学医学部   学士学位

发表论文

1.       Xu Chen, Xinrui Li, Wenbo He, Miao Wang, Ang Gao, *Liping Tong, Shun Guo, *Huaiyu Wang(Corresponding author), *Guoqing Pan. Rational Multivalency Construction Enables Bactericidal Effect Amplification and Dynamic Biomaterial Design. The Innovation, In press.

2.       Yaoyao Xu, Yanyue Li, *Ang Gao, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Gasotransmitter Delivery for Bone Diseases and Regeneration. The Innovation Life, 1, 100015, 2023.

3.       #Weifang Zhang, #Lvhua Liu, Huang Zhou, Chanjuan He, Xueli Yang, Jingjing Fu, *Huaiyu Wang(Corresponding author), *Ying Liu, *Yanyan Zheng. Surface Bisphosphonation of Polyetheretherketone to Manipulate Immune Response for Advanced Osseointegration. Materials & Design, 232, 112151, 2023.

4.       Zhen Zhang, Yi Liu, Xuelian Tao, Ping Du, Myagmartsend Enkhbat, Khoon S. Lim, *Huaiyu Wang(Corresponding author), *Pengyuan Wang. Engineering Cell Microenvironment Using Nanopattern-Derived Multicellular Spheroids and Photo-Crosslinked Gelatin/Hyaluronan Hydrogels. Polymers, 15, 1925, 2023.

5.       Zhen Zhang, Yuanliang Lv, Javad Harati, Jianan Song, Ping Du, Peiyan Ou, Jiaqi Liang, *Huaiyu Wang(Corresponding author), *Pengyuan Wang. Submicron-Grooved Films Modulate the Directional Alignment and Biological Function of Schwann Cells. Journal of Functional Biomaterials, 14, 238, 2023.

6.       Wanling Chen, Wanlin Wang, Hongyun Xing, Wan Li, Haiwei He, Wei Li, Chu, Paul K. Chu, *Guofen Song, *Huaiyu Wang(Corresponding author), *Penghui Li. Interfacial Self-Assembled Dual-Functional Nanocomposite Films for SERS Monitoring of Visible-Light Photocatalytic Degradation of Organic Dye Pollutants. Surfaces and Interfaces, 38, 102808, 2023.

7.       Manshan Xie, *Yunhua Chen, Qian Yang, Qingtao Li, Runlin Zhang, Wenzhi Bi, Yong-Guang Jia, Paul K. Chu, *Huaiyu Wang(Corresponding author), *Xuetao Shi. Nano-Enabled DNA Supramolecular Sealant for Soft Tissue Surgical Applications. Nano Today, 50, 101825, 2023.

8.       #Kai Zheng, #Jiaxiang Bai, #Wanling Chen, Yaozeng Xu, Huilin Yang, Wei Li, Penghui Li, *Liping Tong, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Dechun Geng. Multifunctional BPs/MT@PLGA-ALE Nanospheres for Treatment of Osteoporotic Fracture with Near-Infrared Irradiation. Advanced Functional Materials, 2214126, 2023.

9.       #Yuzheng Wu, #Dezhi Xiao, Pei Liu, Qing Liao, Qingdong Ruan, Chao Huang, Liangliang Liu, Dan Li, Xiaolin Zhang, Wei Li, Kaiwei Tang, *Zhengwei Wu, *Guomin Wang, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Nanostructured Conductive Polypyrrole for Antibacterial Components in Flexible Wearable Devices. Research, 6, 0044, 2023.

10.   #Shi Mo, #Kaiwei Tang, Qing Liao, Lingxia Xie, Yuzheng Wu, Guomin Wang, Qingdong Ruan, Ang Gao, Yuanliang Lv, Kaiyong Cai, *Liping Tong, *Zhengwei Wu, Paul K Chu, *Huaiyu Wang(Corresponding author). Tuning the Arrangement of Lamellar Nanostructures: Achieving Dual Functions of Physical Killing Bacteria and Promoting Osteogenesis. Materials Horizons, 10, 881-888, 2023.

11.   #Xiaoxue Ren, #Xiaoting Gao, *Yicheng Cheng, Lingxia Xie, Liping Tong, *Wei Li, Paul K. Chu, *Huaiyu Wang(Corresponding author). Maintenance of Multipotency of Bone Marrow Mesenchymal Stem Cells on Poly(ε-caprolactone) Nanoneedle Arrays through the Enhancement of Cell-Cell Interaction. Frontiers in Bioengineering and Biotechnology, 10, 1076345, 2023.

12.   Kai Zheng, *Jiaxiang Bai, Huilin Yang, Yaozeng Xu, Guoqing Pan, *Huaiyu Wang(Corresponding author), *Dechun Geng. Nanomaterial-assisted Theranosis of Bone Diseases. Bioactive Materials, 24, 263-312, 2023.

13.   Guofen Song, Haiwei He, Wanling Chen, Yuanliang Lv, Paul K. Chu, *Huaiyu Wang(Corresponding author), *Penghui Li. Reversibly Migratable Fluorescent Probe for Precise and Dynamic Evaluation of Cell Mitochondrial Membrane Potentials. Biosensors, 12, 798, 2022.

14.   Guofen Song, Lei Yan, Qing Liao, Wanling Chen, Liping Tong, Yi Zeng, Paul K. Chu, *Penghui Li, *Huaiyu Wang(Corresponding author). Mitochondria/RNA Cascade-targeted and Fluorescence-switchable Photosensitizer for Photodynamic Therapy Augmentation and Real-time Efficacy Self-monitoring. Sensors and Actuators B: Chemical, 369, 132260, 2022.

15.   #Lei Yu, #Wenming Li, #Peng Yang, Wei Zhang, Huaqiang Tao, Gaoran Ge, Huilin Yang, *Jiaxiang Bai, *Huaiyu Wang(Corresponding author), *Dechun Geng. Osteoblastic MicroRNAs in Skeletal Disease: Biological Functions and Therapeutic Implications. Engineered Regeneration, 3, 241-257, 2022.

16.   #Yanyan Zheng, #Ang Gao, #Jiaxiang Bai, Qing Liao, Yuzheng Wu, Wei Zhang, Min Guan, *Liping Tong, *Dechun Geng, Xin Zhao, Paul K. Chu, *Huaiyu Wang(Corresponding author). A Programmed Surface on Polyetheretherketone for Sequentially Dictating Osteoimmunomodulation and Bone Regeneration to Achieve Ameliorative Osseointegration under Osteoporotic Conditions. Bioactive Materials, 14, 364-376, 2022.

17.   Junfeng Chen, Lingxia Xie, Qingdong Ruan, Ang Gao, Qing Liao, Shi Mo, Yuanliang Lv, *Liping Tong, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xiaoming Li. Diamond-like Carbon Coating and Surface Grafting of Osteoprotegerin and Alendronate on Polyetheretherketone to Ameliorate the Mechanical Performance and Osseointegration Simultaneously. Composites Part B: Engineering, 236, 109815, 2022.

18.   #Yuzheng Wu, #Qingdong Ruan, Chao Huang, Qing Liao , Liangliang Liu, Pei Liu, Shi Mo, *Guomin Wang, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Balancing the Biocompatibility and Bacterial Resistance of Polypyrrole by Optimized Silver Incorporation. Biomaterials Advances, 134, 112701, 2022.

19.   #Meng Li, #Jiaxiang Bai, #Huaqiang Tao, Li Hao, Weiling Yin, Xiaoxue Ren, Ang Gao, Ning Li, Miao Wang, Shiyuan Fang, Yaozeng Xu, Liang Chen, Huilin Yang, *Huaiyu Wang(Corresponding author), *Guoqing Pan, *Dechun Geng. Rational Integration of Defense and Repair Synergy on PEEK Osteoimplants via Biomimetic Peptide Clicking Strategy. Bioactive Materials, 8, pp 309-324, 2022.

20.   #Yuzheng Wu, #Qing Liao, #Lie Wu, Yongxiang Luo, Wei Zhang, Min Guan, Haobo Pan, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter. ACS Nano, 15, 17854-17869, 2021.

21.   #Lingxia Xie, #Guomin Wang, Yuzheng Wu, Qing Liao, Shi Mo, Xiaoxue Ren, Liping Tong, Wei Zhang, Min Guan, Haobo Pan, Paul K. Chu, *Huaiyu Wang(Corresponding author). Programmed Surface on Poly(Aryl-Ether-Ether-Ketone) Initiating Immune Mediation and Fulfilling Bone Regeneration Sequentially. The Innovation, 2, 100148, 2021.

22.   #Shi Mo, #Feilong Zhao, #Ang Gao, Yuzheng Wu, Qing Liao, Lingxia Xie, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Simultaneous Application of Diamond-like Carbon Coating and Surface Amination on Polyether Ether Ketone: Towards Superior Mechanical Performance and Osseointegration. Smart Materials in Medicine, 2, pp 219-228, 2021.

23.   Nan Hu, Lingxia Xie, Qing Liao, Ang Gao, Yanyan Zheng, Haobo Pan, *Liping Tong, *Dazhi Yang, Nong Gao, Marco J. Starink, Paul K. Chu, *Huaiyu Wang(Corresponding author). A More Defective Substrate Leads to a Less Defective Passive Layer: Enhancing the Mechanical Strength, Corrosion Resistance and Anti-inflammatory Response of the Low-Modulus Ti-45Nb Alloy by Grain Refinement. Acta Biomaterialia, 126, pp 524-536, 2021.

24.   Saud Khalid, Ang Gao, *Guomin Wang, Paul K. Chu, *Huaiyu Wang(Corresponding author). Tuning Surface Topographies on Biomaterials to Control Bacterial Infection.  Biomaterials Science, 8, pp 6840-6857, 2020.

25.   #Zhibin Li, #Guanghong Luo, #Weiping Hu, Jianlan Hua, Shengyong Geng, Paul K. Chu, *Jing Zhang, *Huaiyu Wang(Corresponding author), *Xuefeng Yu. Mediated Drug Release from Nano-Vehicles by Black Phosphorus Quantum Dots for Efficient Therapy of Chronic Obstructive Pulmonary Disease. Angewandte Chemie International Edition, 59, pp 20568-20576, 2020.

26.   #Jiaxiang Bai, #Huaiyu Wang (Co-first author), #Hao Chen, Gaoran Ge, Miao Wang, Ang Gao, Liping Tong, Yaozeng Xu, Huiling Yang, *Guoqing Pan, *Paul K. Chu, *Dechun Geng. Biomimetic Osteogenic Peptide with Mussel Adhesion and Osteoimmunomodulatory Functions to Ameliorate Interfacial Osseointegration under Chronic Inflammation. Biomaterials, 255, 120197, 2020.

27.   #Nan Hu, #Yuzheng Wu, Lingxia Xie, Shahir Mohd Yusuf, Nong Gao, Marco J. Starink, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Enhanced Interfacial Adhesion and Osseointegration of Anodic TiO2 Nanotube Arrays on Ultra-Fine-Grained Titanium and Underlying Mechanisms. Acta Biomaterialia, 106, pp360-375, 2020.

28.   Ang Gao, Qing Liao, Lingxia Xie, Guomin Wang, Wei Zhang, Yuzheng Wu, Penghui Li, Min Guan, Haobo Pan, *Liping Tong, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Tuning the Surface Immunomodulatory Functions of Polyetheretherketone for Enhanced Osseointegration. Biomaterials, 230, 119642, 2020.

29.   Guomin Wang, Wenjuan Jiang, Shi Mo, Lingxia Xie, Qing Liao, Liangsheng Hu, Qingdong Ruan, Kaiwei Tang, Babak Mehrjou, Mengting Liu, Liping Tong, *Huaiyu Wang(Corresponding author), *Jie Zhuang, *Guosong Wu, *Paul K. Chu. Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium. Advanced Science, 7, 1902089, 2020.

30.   Penghui Li, Jin Chen, *Paul K. Chu, *Huaiyu Wang(Corresponding author). Fundamentals and Applications of Surface-enhanced Raman Spectroscopy (SERS) Based Biosensor. Current Opinion in Biomedical Engineering, 13, pp 51-59, 2020.

31.   *Wei Zhang, Jun Liu, Kun Yang, Wei Qu, Ke Liu, Na Liu, Bin Gu, Nan Hu, Junhui Ji, Paul K. Chu, *Huaiyu Wang(Corresponding author). Unique Role of Arginine in Positively-Charged Surface for Promotion of Antibacterial and Osteogenetic Capabilities. Advanced Materials Interfaces, 6, 1901414, 2019.

32.   Nan Hu, Tao Hu, Ang Gao, Nong Gao, Marco J. Starink, Ying Chen, Wanting Sun, Qing Liao, *Liping Tong, *Xiaochang Xu, Paul K. Chu, *Huaiyu Wang(Corresponding author). Homogeneous Anodic TiO2 Nanotube Layers on Ti-6Al-4V Alloy with Improved Adhesion Strength and Corrosion Resistance. Advanced Materials Interfaces, 6, 1801964, 2019.

33.    #Zhibin Li, #Lie Wu, *Huaiyu Wang(Corresponding author), Wenhua Zhou, Hanxia Liu, Haodong Cui, Penghui Li, *Paul K. Chu, *Xuefeng Yu. Synergistic Antibacterial Activity of Black Phosphorus Nanosheets Modified with Titanium Aminobenzenesulfanato Complexes. ACS Applied Nano Materials, 2, pp 1202-1209, 2019.

34.   Liping Tong, Qing Liao, Yuetao Zhao, Hao Huang, Ang Gao, Wei Zhang, Xiaoyong Gao, Wei Wei, Min Guan, Paul K. Chu, *Huaiyu Wang(Corresponding author). Near-Infrared Light Control of Bone Regeneration with Biodegradable Photothermal Osteoimplant. Biomaterials, 193, pp 1-11, 2019.

35.   #Guomin Wang, #Hongqing Feng, Liangsheng Hu, Weihong Jin, Qi Hao, Ang Gao, Xiang Peng, Wan Li, Kwok-Yin Wong, *Huaiyu Wang(Corresponding author), *Zhou Li, *Paul K. Chu. An Antibacterial Platform Based on Capacitive Carbon-Doped TiO2 Nanotubes after Direct or Alternating Current Charging. Nature Communications, 9, 2055, 2018.

36.    #Yuchang Weng, #Hanxia Liu, Shunping Ji, Qian Huang, Hao Wu, Zhibin Li, *Zhongzhen Wu, *Huaiyu Wang(Corresponding author), Liping Tong, Ricky K.Y. Fu, *Paul K. Chu, Feng Pan. A Promising Orthopedic Implant Material with Enhanced Osteogenic and Antibacterial Activity: Al2O3-Coated Aluminum Alloy. Applied Surface Science, 457, pp 1025-1034, 2018.

37.    Jundong Shao, Changshun Ruan, Hanhan Xie, Zhibin Li, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xuefeng Yu. Black-Phosphorus-Incorporated Hydrogel as a Sprayable and Biodegradable Photothermal Platform for Postsurgical Treatment of Cancer. Advanced Science, 5, 1700848, 2018.

38.   Huaiyu Wang, *Xuefeng Yu. Few-Layered Black Phosphorus: From Fabrication and Customization to Biomedical Applications. Small, 14, 1702830, 2018.

39.   #Jundong Shao, #Hanhan Xie, *Huaiyu Wang(Corresponding author), Wenhua Zhou, Qian Luo, *Xuefeng Yu, *Paul K. Chu. 2D Material-Based Nanofibrous Membrane for Photothermal Cancer Therapy. ACS Applied Materials & Interfaces, 10, pp 1155-1163, 2018.

40.   Ang Gao, Ruiqiang Hang, Wan Li, Wei Zhang, Penghui Li, Guomin Wang, Long Bai, Xuefeng Yu, *Huaiyu Wang(Corresponding author), *Liping Tong, *Paul K. Chu. Linker-free Covalent Immobilization of Heparin, SDF-1α, and CD47 on PTFE Surface for Antithrombogenicity, Endothelialization and Anti-Inflammation. Biomaterials, 140, pp 201-211, 2017.

41.   Zhibin Li, Jundong Shao, Qian Luo, *Xuefeng Yu, Hanhan Xie, Haidi Fu, Siying Tang, *Huaiyu Wang(Corresponding author), Guangli Han, *Paul K. Chu. Cell-Borne 2D Nanomaterials for Efficient Cancer Targeting and Photothermal Therapy. Biomaterials, 133, pp 37-48, 2017.

42.   Zhengbo Sun, Yuetao Zhao, Zhibin Li, Haodong Cui, Yayan Zhou, Weihao Li, Wei Tao, *Han Zhang, *Huaiyu Wang(Corresponding author), Paul K. Chu, *Xuefeng Yu. TiL4-Coordinated Black Phosphorus Quantum Dots as an Efficient Contrast Agent for In Vivo Photoacoustic Imaging of Cancer. Small, 13, 1602896, 2017.

43.   Yuetao Zhao, *Huaiyu Wang(Corresponding author), Hao Huang, Quanlan Xiao, Yanhua Xu, Zhinan Guo, Hanhan Xie, Jundong Shao, Zhengbo Sun, Weijia Han, *Xuefeng Yu, Penghui Li, *Paul K. Chu. Surface Coordination of Black Phosphorus for Robust Air and Water Stability. Angewandte Chemie International Edition, 55, pp 5003-5007, 2016.

44.   Yuetao Zhao, Liping Tong, Yong Li, Haobo Pan, Wei Zhang, Min Guan, Weihao Li, Yixin Chen, Qing Li, Zhongjun Li, *Huaiyu Wang(Corresponding author), *Xuefeng Yu, *Paul K. Chu. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS Applied Materials & Interfaces, 8, pp 5813-5820, 2016.

45.    #Zhibin Li, #Siying Tang, #Beike Wang, Yong Li, Hao Huang, *Huaiyu Wang(Corresponding author), Penghui Li, *Chengzhang Li, *Paul K. Chu, Xuefeng Yu. Metabolizable Small Gold Nanorods: Size-Dependent Cytotoxicity, Cell Uptake and In Vivo Biodistribution. ACS Biomaterials Science & Engineering, 2, pp 789-797, 2016.

46.   #Liping Tong, #Wenhua Zhou, Yuetao Zhao, Xuefeng Yu, *Huaiyu Wang(Corresponding author), *Paul K. Chu. Enhanced Cytocompatibility and Reduced Genotoxicity of Polydimethylsiloxane Modified by Plasma Immersion Ion Implantation. Colloids and Surfaces B: Biointerfaces, 148, pp 139-146, 2016.



发表论文
[1] Composites Part B: Engineering. 2024,   通讯作者  
[2] bioRxiv. 2024,   通讯作者  
[3] Advanced Healthcare Materials. 2024,   通讯作者  
[4] Advanced Functional Materials. 2024,   通讯作者  
[5] Yaoyao Xu, Yanyue Li, Ang Gao, Paul K Chu, Huaiyu Wang. Gasotransmitter delivery for bone diseases and regeneration. The Innovation Life[J]. 2023, 第 5 作者  通讯作者  1: 100015, 
[6] Xu Chen, Xinrui Li, Wenbo He, Miao Wang, Ang Gao, Liping Tong, Shun Guo, Huaiyu Wang, Guoqing Pan. Rational multivalency construction enables bactericidal effect amplification and dynamic biomaterial design. THE INNOVATION. 2023, 第 8 作者4(5): http://dx.doi.org/10.1016/j.xinn.2023.100483.
[7] Zhang, Zhen, Lv, Yuanliang, Harati, Javad, Song, Jianan, Du, Ping, Ou, Peiyan, Liang, Jiaqi, Wang, Huaiyu, Wang, PengYuan. Submicron-Grooved Films Modulate the Directional Alignment and Biological Function of Schwann Cells. JOURNAL OF FUNCTIONAL BIOMATERIALS[J]. 2023, 第 8 作者  通讯作者  14(5): https://doaj.org/article/fb32e804bc864913975613c100f2cfbe.
[8] 周建良, 王怀雨, 童丽萍. 天然黑色素的提取、改性和应用. 科学通报[J]. 2023, 第 2 作者68(11): 1406-1420, http://lib.cqvip.com/Qikan/Article/Detail?id=7109562652.
[9] Kai Zheng, Jiaxiang Bai, Wanling Chen, Yaozeng Xu, huilin yang, Wei Li, Penghui Li, 童丽萍, Huaiyu Wang, Paul K. Chu, 耿德春. Multifunctional BPs/MT@PLGA-ALE Nanospheres for Treatment of Osteoporotic Fracture with Near-Infrared Irradiation. ADVANCED FUNCTIONAL MATERIALS[J]. 2023, 第 9 作者  通讯作者  33: 2214126, 
[10] Zhen Zhang, Yi Liu, Xuelian Tao, Ping Du, Myagmartsend Enkhbat, Khoon S Lim, Huaiyu Wang, PengYuan Wang. Engineering Cell Microenvironment Using Nanopattern-Derived Multicellular Spheroids and Photo-Crosslinked Gelatin/Hyaluronan Hydrogels. POLYMERS[J]. 2023, 第 7 作者  通讯作者  15: https://doaj.org/article/da86798b83044c438f016bc73265da03.
[11] Xiaoxue Ren, Xiaoting Gao, Yicheng Cheng, Lingxia Xie, Liping Tong, Wei Li, Paul K Chu, Huaiyu Wang. Maintenance of multipotency of bone marrow mesenchymal stem cells on poly(ε-caprolactone) nanoneedle arrays through the enhancement of cell-cell interaction. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2023, 第 8 作者  通讯作者  10: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9870049/.
[12] Wanling Chen, Wanlin Wang, Hongyun Xing, Wan Li, Haiwei He, Wei Li, Paul K Chu, Guofen Song, Huaiyu Wang, Penghui Li. Interfacial self-assembled dual-functional nanocomposite films for SERS monitoring of visible-light photocatalytic degradation of organic dye pollutants. SURFACES AND INTERFACES[J]. 2023, 第 9 作者  通讯作者  38: 102808, http://dx.doi.org/10.1016/j.surfin.2023.102808.
[13] Kai Zheng, Jiaxiang Bai, Huilin Yang, Yaozeng Xu, Guoqing Pan, Huaiyu Wang, Dechun Geng. Nanomaterial-assisted theranosis of bone diseases. BIOACTIVE MATERIALS[J]. 2023, 第 6 作者  通讯作者  24: 263-312, http://dx.doi.org/10.1016/j.bioactmat.2022.12.014.
[14] Manshan Xie, Yunhua Chen, Qian Yang, Qingtao Li, Runlin Zhang, Wenzhi Bi, YongGuang Jia, Paul K Chu, Huaiyu Wang, Xuetao Shi. Nano-enabled DNA supramolecular sealant for soft tissue surgical applications. NANO TODAY[J]. 2023, 第 9 作者  通讯作者  50: http://dx.doi.org/10.1016/j.nantod.2023.101825.
[15] Ihsan Ullah, Peiyan Ou, Lingxia Xie, Qing Liao, Feilong Zhao, Ang Gao, Xiaoxue Ren, Yiting Li, Guomin Wang, Zhengwei Wu, Paul K Chu, Huaiyu Wang, Liping Tong. Diffusion-driven fabrication of calcium and phosphorous-doped zinc oxide heterostructures on titanium to achieve dual functions of osteogenesis and preventing bacterial infections. ACTA BIOMATERIALIA[J]. 2023, 第 12 作者  通讯作者  http://dx.doi.org/10.1016/j.actbio.2023.12.046.
[16] Xingyun Huang, Zhiyong Wang, Huaiyu Wang, Di Chen, Liping Tong. Novel strategies for the treatment of osteoarthritis based on biomaterials and critical molecular signaling. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY[J]. 2023, 第 3 作者http://dx.doi.org/10.1016/j.jmst.2022.11.027.
[17] Xiaoting Gao, Lei Yan, Wei Zhang, Yuanliang Lv, Peiyan Ou, Ruiqiang Hang, Ang Gao, Liping Tong, Paul K Chu, Huaiyu Wang. Dual-switched carbon monoxide nano gas tank for auto-diagnosis and precision therapy of osteoarthritis. Nano Today[J]. 2023, 第 10 作者  通讯作者  53: http://dx.doi.org/10.1016/j.nantod.2023.102047.
[18] Wei Wang, Qing Wang, Lei Yu, Gaoran Ge, Xin Liu, Ang Gao, Guomin Wang, Zhengwei Wu, Jiaxiang Bai, Huaiyu Wang, Paul K Chu, Dechun Geng. Bio-orthogonal engineered peptide: A multi-functional strategy for the gene therapy of osteoporotic bone loss. BIOMATERIALS. 2023, 第 10 作者302: http://dx.doi.org/10.1016/j.biomaterials.2023.122352.
[19] Yuzheng Wu, Dezhi Xiao, Pei Liu, Qing Liao, Qingdong Ruan, Chao Huang, Liangliang Liu, Dan Li, Xiaolin Zhang, Wei Li, Kaiwei Tang, Zhengwei Wu, Guomin Wang, Huaiyu Wang, Paul K Chu. Nanostructured Conductive Polypyrrole for Antibacterial Components in Flexible Wearable Devices. RESEARCH[J]. 2023, 第 14 作者6: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10013960/.
[20] Mo, Shi, Tang, Kaiwei, Liao, Qing, Xie, Lingxia, Wu, Yuzheng, Wang, Guomin, Ruan, Qingdong, Gao, Ang, Lv, Yuanliang, Cai, Kaiyong, Tong, Liping, Wu, Zhengwei, Chu, Paul K, Wang, Huaiyu. Tuning the arrangement of lamellar nanostructures: achieving the dual function of physically killing bacteria and promoting osteogenesis. Materials Horizons[J]. 2023, 第 14 作者  通讯作者  10(3): 881-888, http://dx.doi.org/10.1039/d2mh01147f.
[21] Han, Jian, Wu, Jinzhe, Xiang, Xinjian, Xie, Lingxia, Chen, Ruiguo, Li, Ling, Ma, Kun, Sun, Qing, Yang, Runhuai, Huang, Tongling, Tong, Liping, Zhu, Lei, Wang, Huaiyu, Wen, Cuie, Zhao, Yu, Wang, Junfeng. Biodegradable BBG/PCL composite scaffolds fabricated by selective laser sintering for directed regeneration of critical-sized bone defects. MATERIALS & DESIGN[J]. 2023, 第 13 作者225: http://dx.doi.org/10.1016/j.matdes.2022.111543.
[22] The Innovation Life. 2023,   通讯作者  
[23] Weifang Zhang, Lvhua Liu, Huang Zhou, Chanjuan He, Xueli Yang, Jingjing Fu, Huaiyu Wang, Ying Liu, Yanyan Zheng. Surface bisphosphonation of polyetheretherketone to manipulate immune response for advanced osseointegration. MATERIALS & DESIGN[J]. 2023, 第 7 作者  通讯作者  232: 112151, http://dx.doi.org/10.1016/j.matdes.2023.112151.
[24] Wang, Guomin, Tang, Kaiwei, Jiang, Wenjuan, Liao, Qing, Li, Yong, Liu, Pei, Wu, Yuzheng, Liu, Mengting, Wang, Huaiyu, Li, Bin, Du, Jianzhong, Chu, Paul K. Quantifiable Relationship Between Antibacterial Efficacy and Electro-Mechanical Intervention on Nanowire Arrays. ADVANCED MATERIALS[J]. 2023, 第 9 作者35(19): http://dx.doi.org/10.1002/adma.202212315.
[25] Tong, Liping, Yu, Huan, Huang, Xingyun, Shen, Jie, Xiao, Guozhi, Chen, Lin, Wang, Huaiyu, Xing, Lianping, Chen, Di. Current understanding of osteoarthritis pathogenesis and relevant new approaches. BONE RESEARCH. 2022, 第 7 作者10(1): 627-643, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7361067&detailType=1.
[26] Chen, Jiaxin, Zhu, Haifeng, Zhu, Yutao, Zhao, Chenchen, Wang, Shengyu, Zheng, Yixin, Xie, Ziang, Jin, Yang, Song, Honghai, Yang, Linjun, Zhang, Jin, Dai, Jiayong, Hu, Zhijun, Wang, Huaiyu. Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration. BIOACTIVE MATERIALS[J]. 2022, 第 14 作者9: 29-43, 
[27] Zhao, Yuyu, Bai, Long, Zhang, Yi, Yao, Runhua, Sun, Yonghua, Hang, Ruiyue, Chen, Xiangyang, Wang, Huaiyu, Yao, Xiaohong, Xiao, Yin, Hang, Ruiqiang. Type I collagen decorated nanoporous network on titanium implant surface promotes osseointegration through mediating immunomodulation, angiogenesis, and osteogenesis. BIOMATERIALS[J]. 2022, 第 8 作者288: http://dx.doi.org/10.1016/j.biomaterials.2022.121684.
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[85] Wang, BeiKe, Yu, XueFeng, Wang, JiaHong, Li, ZhiBin, Li, PengHui, Wang, Huaiyu, Song, Li, Chu, Paul K, Li, Chengzhang. Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing. BIOMATERIALS[J]. 2016, 第 6 作者78: 27-39, http://dx.doi.org/10.1016/j.biomaterials.2015.11.025.
[86] Zhao, Yuetao, Wang, Huaiyu, Huang, Hao, Xiao, Quanlan, Xu, Yanhua, Guo, Zhinan, Xie, Hanhan, Shao, Jundong, Sun, Zhengbo, Han, Weijia, Yu, XueFeng, Li, Penghui, Chu, Paul K. Surface Coordination of Black Phosphorus for Robust Air and Water Stability. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 第 2 作者  通讯作者  55(16): 5003-5007, https://www.webofscience.com/wos/woscc/full-record/WOS:000374496100023.
[87] Zhang, Wei, Liu, Jun, Shi, Haigang, Yang, Kun, Wang, Pingli, Wang, Gexia, Liu, Na, Wang, Huaiyu, Ji, Junhui, Chu, Paul K. Communication between nitric oxide synthase and positively-charged surface and bone formation promotion. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2016, 第 8 作者148: 354-362, http://dx.doi.org/10.1016/j.colsurfb.2016.08.049.
[88] Tong, Liping, Zhou, Wenhua, Zhao, Yuetao, Yu, Xuefeng, Wang, Huaiyu, Chu, Paul K. Enhanced cytocompatibility and reduced genotoxicity of polydimethylsiloxane modified by plasma immersion ion implantation. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2016, 第 5 作者  通讯作者  148: 139-146, http://dx.doi.org/10.1016/j.colsurfb.2016.08.057.
[89] Zhao, Yuetao, Tong, Liping, Li, Yong, Pan, Haobo, Zhang, Wei, Guan, Min, Li, Weihao, Chen, Yixin, Li, Qing, Li, Zhongjun, Wang, Huaiyu, Yu, XueFeng, Chu, Paul K. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 11 作者  通讯作者  8(9): 5813-5820, https://www.webofscience.com/wos/woscc/full-record/WOS:000371945700011.
[90] Li, Zhibin, Tang, Siying, Wang, Beike, Li, Yong, Huang, Hao, Wang, Huaiyu, Li, Penghui, Li, Chengzhang, Chu, Paul K, Yu, XueFeng. Metabolizable Small Gold Nanorods: Size-dependent Cytotoxicity, Cell Uptake and In Vivo Biodistribution. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2016, 第 6 作者  通讯作者  2(5): 789-797, https://www.webofscience.com/wos/woscc/full-record/WOS:000375893600010.
[91] Zhang, Wei, Liu, Na, Shi, Haigang, Liu, Jun, Shi, Lianxin, Zhang, Bo, Wang, Huaiyu, Ji, Junhui, Chu, Paul K. Upregulation of BMSCs Osteogenesis by Positively-Charged Tertiary Amines on Polymeric Implants via Charge/iNOS Signaling Pathway. SCIENTIFIC REPORTS[J]. 2015, 第 7 作者5: https://www.webofscience.com/wos/woscc/full-record/WOS:000351355700001.
[92] Zhang, Wei, Liu, Jun, Shi, Haigang, Liu, Na, Yang, Kun, Shi, Lianxin, Gu, Bin, Wang, Huaiyu, Ji, Junhui, Chu, Paul K. Effects of plasma-generated nitrogen functionalities on the upregulation of osteogenesis of bone marrow-derived mesenchymal stem cells. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2015, 第 8 作者3(9): 1856-1863, https://www.webofscience.com/wos/woscc/full-record/WOS:000350343700012.
[93] Zhang, Wei, Liu, Jun, Wang, Huaiyu, Xu, Ying, Wang, Pingli, Ji, Junhui, Chu, Paul K. Enhanced cytocompatibility of silver-containing biointerface by constructing nitrogen functionalities. APPLIED SURFACE SCIENCE[J]. 2015, 第 3 作者349: 327-332, http://dx.doi.org/10.1016/j.apsusc.2015.05.012.
[94] Sun, Zhengbo, Xie, Hanhan, Tang, Siying, Yu, XueFeng, Guo, Zhinan, Shao, Jundong, Zhang, Han, Huang, Hao, Wang, Huaiyu, Chu, Paul K. Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 第 9 作者54(39): 11526-11530, http://dx.doi.org/10.1002/anie.201506154.
[95] Guo, Zhinan, Zhang, Han, Lu, Shunbin, Wang, Zhiteng, Tang, Siying, Shao, Jundong, Sun, Zhengbo, Xie, Hanhan, Wang, Huaiyu, Yu, XueFeng, Chu, Paul K. From Black Phosphorus to Phosphorene: Basic Solvent Exfoliation, Evolution of Raman Scattering, and Applications to Ultrafast Photonics. ADVANCED FUNCTIONAL MATERIALS[J]. 2015, 第 9 作者25(45): 6996-7002, https://www.webofscience.com/wos/woscc/full-record/WOS:000366502900004.
[96] Lin, Manping, Wang, Huaiyu, Ruan, Changshun, Xing, Juan, Wang, Jinfeng, Wang, Yuanliang, Luo, Yanfeng. Adsorption Force of Fibronectin on Various Surface Chemistries and Its Vital Role in Osteoblast Adhesion. BIOMACROMOLECULES[J]. 2015, 第 2 作者16(3): 973-984, https://www.webofscience.com/wos/woscc/full-record/WOS:000350841100032.
[97] Huang, Hao, Wang, JiaHong, Jin, Weihong, Li, Penghui, Chen, Ming, Xie, HanHan, Yu, XueFeng, Wang, Huaiyu, Dai, Zhigao, Xiao, Xiangheng, Chu, Paul K. Competitive Reaction Pathway for Site-Selective Conjugation of Raman Dyes to Hotspots on Gold Nanorods for Greatly Enhanced SERS Performance. SMALL[J]. 2014, 第 8 作者10(19): 4012-4019, https://www.webofscience.com/wos/woscc/full-record/WOS:000344451900027.
[98] Ruan, Changshun, Hu, Yang, Jiang, Lixin, Cai, Qingqing, Pan, Haobo, Wang, Huaiyu. Tunable Degradation of Piperazine-Based Polyurethane Ureas. JOURNAL OF APPLIED POLYMER SCIENCE[J]. 2014, 第 6 作者  通讯作者  131(19): 40527-1-40527-6, https://www.webofscience.com/wos/woscc/full-record/WOS:000340238300001.
[99] Mei, Shenglin, Wang, Huaiyu, Wang, Wei, Tong, Liping, Pan, Haobo, Ruan, Changshun, Ma, Qianli, Liu, Mengyuan, Yang, Huiling, Zhang, Liang, Cheng, Yicheng, Zhang, Yumei, Zhao, Lingzhou, Chu, Paul K. Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes. BIOMATERIALS[J]. 2014, 第 2 作者35(14): 4255-4265, http://dx.doi.org/10.1016/j.biomaterials.2014.02.005.
[100] Wang Huaiyu. Study on the tunable degradation of piperazine-based polyurethane ureas. Journal of Applied Polymer Science. 2014, 第 1 作者  通讯作者  
[101] Wang, Huaiyu, Kwok, Dixon T K, Xu, Ming, Shi, Haigang, Wu, Zhengwei, Zhang, Wei, Chu, Paul K. Tailoring of Mesenchymal Stem Cells Behavior on Plasma-Modified Polytetrafluoroethylene. ADVANCEDMATERIALS[J]. 2012, 第 1 作者24(25): 3315-3324, https://www.webofscience.com/wos/woscc/full-record/WOS:000305553700003.
[102] Wang, Huaiyu, Xu, Ming, Wu, Zhengwei, Zhang, Wei, Ji, Junhui, Chu, Paul K. Biodegradable Poly(Butylene Succinate) Modified by Gas Plasmas and Their In vitro Functions as Bone Implants. ACS APPLIED MATERIALS & INTERFACES[J]. 2012, 第 1 作者4(8): 4380-4386, https://www.webofscience.com/wos/woscc/full-record/WOS:000307698600082.
[103] Zhang, Wei, Wang, Huaiyu, Oyane, Ayako, Tsurushima, Hideo, Chu, Paul K. Osteoblast differentiation and disinfection induced by nitrogen plasma-treated surfaces. BIO-MEDICAL MATERIALS AND ENGINEERING[J]. 2011, 第 2 作者21(2): 75-82, https://www.webofscience.com/wos/woscc/full-record/WOS:000294512600002.
[104] Wang, Huaiyu, Xu, Ming, Zhang, Wei, Kwok, Dixon T K, Jiang, Jiang, Wu, Zhengwei, Chu, Paul K. Mechanical and biological characteristics of diamond-like carbon coated poly aryl-ether-ether-ketone. BIOMATERIALS[J]. 2010, 第 1 作者31(32): 8181-8187, http://dx.doi.org/10.1016/j.biomaterials.2010.07.054.
[105] Wang, Huaiyu, Kwok, Dixon T K, Wang, Wei, Wu, Zhengwei, Tong, Liping, Zhang, Yumei, Chu, Paul K. Osteoblast behavior on polytetrafluoroethylene modified by long pulse, high frequency oxygen plasma immersion ion implantation. BIOMATERIALS[J]. 2010, 第 1 作者31(3): 413-419, http://dx.doi.org/10.1016/j.biomaterials.2009.09.066.
[106] Wang, Huaiyu, Ji, Junhui, Zhang, Wei, Wang, Wei, Zhang, Yihe, Wu, Zhengwei, Zhang, Yumei, Chu, Paul K. Rat calvaria osteoblast behavior and antibacterial properties of O-2 and N-2 plasma-implanted biodegradable poly(butylene succinate). ACTA BIOMATERIALIA[J]. 2010, 第 1 作者6(1): 154-159, http://dx.doi.org/10.1016/j.actbio.2009.07.026.
[107] Kwok, Dixon T K, Wang, Huaiyu, Zhang, Yumei, Yeung, Kelvin W K, Chu, Paul K. Effects of long pulse width and high pulsing frequency on surface superhydrophobicity of polytetrafluoroethylene in quasi-direct-current plasma immersion ion implantation. JOURNAL OF APPLIED PHYSICS[J]. 2009, 第 2 作者105(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000264156300013.
[108] Wang, Huaiyu, Ji, Junhui, Zhang, Wei, Zhang, Yihe, Jiang, Jiang, Wu, Zhengwei, Pu, Shihao, Chu, Paul K. Biocompatibility and bioactivity of plasma-treated biodegradable poly(butylene succinate). ACTA BIOMATERIALIA[J]. 2009, 第 1 作者5(1): 279-287, http://dx.doi.org/10.1016/j.actbio.2008.07.017.
[109] 王怀雨, 季君晖, 王晓艳, 李焕新. 聚丁二酸丁二醇酯的表面改性及相关研究. 塑料[J]. 2009, 第 1 作者61-63, http://lib.cqvip.com/Qikan/Article/Detail?id=32517256.
书籍章节

Characterization of biomaterials, Chapter 4: Surface characterization of biomaterials, Elsevier, 2013-07

获批项目

  1. 国家自然科学基金委面上项目,82272157PEEK植入材料表/界面时序功能设计与构建及其调节骨组织再生机理研202301~202612月,52万,在研,主持;
  2. 中国科学院青年创新促进会优秀会员,Y2021099202201~202412月,150万,在研,主持;
  3. 国家重点研发计划,2021YFB3800800,精准生物适配型骨再生修复材料及关键技术,202112-202511月,2100(270)在研,课题负责人
  4. 广东省科学技术厅联合基金重点项目,2020B1515120078,植介入器械表界面仿生功能涂层及其摩擦学研究,202010~202309100(50),在研,参与

荣誉奖励

广东省科技创新青年拔尖人才;

深圳市海外高层次“孔雀计划”B类人才;

中国科学院青年促进会会员;

中国科学院青年促进会优秀会员;

深圳市自然科学一等奖(2/5)