Chunhe (Clay) Wang, Ph.D

Professor, Mentor for Ph.D students

Email: wangc@simm.ac.cn
Mobile: 13391144656
Address: Room 342, Lane 720, Cai Lun Road, Pudong New District, Shanghai
Postcode: 201203

Research Areas

Antibody therapeutics for cancers and metabolic diseases  

Novel linker engineering for antibody and drug conjugates (ADCs) 


Education

1994.09 - 1999.07  Ph.D. in Pharmacology, Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai, China

1990.09 - 1994.06  B.S. in Microbiology (with honors), Shandong University, Jinan, China.

 

Experience

   
Work Experience

2015.05-Present   Professor, Biotherapeutics Discovery Research, Shanghai Institute of Material Medica, Chinese Academy of Sciences, Shanghai, China

2009.03 – 2015.04  Senior Research Scientist, Biotechnology Discovery Research, Eli Lilly and Company, Indianapolis, Indiana

2005.04 - 2009.02  Assistant Professor, Department of Neurology, Oregon Health & Science University, Portland, Oregon

1999.09 - 2005.07  Postdoctoral Research Fellow in Neuroimmunology, Oregon Health & Science University, Portland, Oregon  

 

Honors & Distinctions

2009.06  John Whitaker MS Research Track Young Investigator Award

2006.06  John Whitaker MS Research Track Young Investigator Award

1999.06  President’s Scholarship, Chinese Academy of Sciences 

1999.05  Wei Hua Technologies Scholarship


Publications

   
Papers

1. Li H, Chen Y, Deng X, Li H, Tan J, Liu G, Zheng Y, Pei M, Peng K, Yue L, Chen X, Liu Y, Zhao Y, Wang C. 2023. Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities. Acta Pharmacol Sin. 44:2322-2330.

2.      Zhang, Y.N., Zhang, H.Q., Wang, G.F., Zhang, Z.R., Li, J.Q., Chen, X.L., Hu, Y.Y., Yue X.Y., Zeng, Shi, Y.J., Wang, J., Li, Y.H., Li, X.D., Wang, C., Zhu, B., Zhang, B. 2023. Intranasal delivery of replicating mRNA encoding hACE2-targeting antibody against SARS-CoV-2 Omicron infection in the hamster. Antiviral Research 209: 105507.

3.      Ma T., Cao B., Huang L., Yang Y., Geng Y. Xie P., Zhao Y., Lin H., Wang K., Wang C., Sun R,, Li J. 2022. First-in-human study to assess the safety, tolerability, pharmacokinetics and immunogenicity of DS002, an anti-nerve growth factor monoclonal antibody. Frontiers in Pharmacology. 13, 1075309.    

4.      Liu X., Chen Y., Liu G., Deng X, Cui Y., Tan J., Dong X., Li H., Chen G., Ou Z., Wang C. Development of a variant of dinutuximab with enhanced antitumor efficacy and reduced induction of neuropathic pain. 2022. FEBS Open Bio. 12:1644-1656.

5.      Dong, X, Li H, Pei M, Tan J, Chen G, Li S, Xie Z, Wang Q, Wang G, Chen Y, Wang C. 2022. Analgesic effects of nerve growth factor-directed monoclonal antibody on diabetic neuralgia in an animal model. FEBS Open Bio. 12:1325-1335.

6.      Liu X, Zhou T, Wang Y, Pei M, Chen YL, Wang G, Chu W, Wang Q, Wang C. 2022. TROP2 as patient-tailoring but not prognostic biomarker for breast cancer. OncoTargets and Therapy. 15: 509–520.

7.      Liang Z, Tan J, Xie Z, Chen G, Liu G, Lin Yuan, Wang K, Ding H, Qiu H, Wang C. 2022. Chemotherapy-Induced Peripheral Neuropathy Is Alleviated by NGF Monoclonal Antibody. Acta Pharmacologica Sinica 0:1-7.

8.      Chu W, Xu H, Wang Y, Xie Y, Chen YL, Tan X, Huang C, Wang G, Wang Q, Luo W, Xia N, Geng M, Xie Z, Wang C. 2022. HER2/PD-1 Bispecific Antibody in IgG4 Subclass with Superior Antitumor Activities. Clinical and Translational Medicine 12e791.

9.      Mu S, Liang Z, Wang1 Y, Chu1 W, Chen Y, Wang Q, Wang G, Wang C. 2022. PD-L1/TIGIT bispecific antibody showed survival advantage in animal model. Clinical and Translational Medicine. 12:e754.

10.  Ou J, Zhang Y, Wang Y, Zhang Z, Wei H, Yu J, Wang Q, Wang G, Zhang B, Wang C. 2022. ACE2-Targeting Antibody Suppresses SARS-CoV-2 Omicron and Delta Variants. Signal Transduction and Targeted Therapy.7:43.

11.  Dai X, Wang Y, Li X, Pei M, Dong X, Gold BG, Zhong Y,Vandenbark, AA, Neve KA, Offner H, Wang G, Wang C. 2022. Tyrphostin A9 Protects Axons in Experimental Autoimmune Encephalomyelitis through Activation of ERKs. Life Science. 94:120383.

12.  Chen YL, Cui Y, Liu X, Liu G, Dong X, Tang L, Hung Y, Wang C, Feng MQ. 2022. Bispecific Antibody Targeting HER2 and PD-L1 Inhibits Tumor Growth with Superior Efficacy. J Biol Chem. 297101420.

13.  Pei M., Liu T, Ouyang L, Sun J, Deng X, Sun X, Wu W, Huang P, Chen Y, Tan X, Liu X, Zhu P, Liu Y, Wang D, Wu J, Wang Q, Wang G, Gong L, Qin Q, Wang C. 2022. Enzyme-linked Immunosorbent Assays for Quantification of MMAE-Conjugated ADCs and Total antibodies in Cynomolgus Monkey Sera. J Pharm Anal. 12: 645-652.

14.  Chen, Y., Zhang, YN., Yan, R. Wang, G., Zhang Y., Zhang Z.R., Li Y, Ou J., Chu, W., Liang Z., Wang Y., Chen Y.L., Chen G., Wang Q., Zhou Q., Zhang B., Wang C. 2021. ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Signal Transduction and Targeted Therapy. 6: 315 .

15.  Shao, T., Chen T., Chen, Y., Liu, X., Chen, Y.L., Wang, Q., Wang C. 2020. Construction of Paclitaxel-Based Antibody Drug Conjugate with PEGylated Linker to Achieve Superior Therapeutic Index. Signal Transduction and Targeted Therapy. 15:132.

16.  Bodhankar, S., Wang, C., Vandenbark, A.A., and Offner, H. 2011. Estrogen-induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells. Eur. J. Immunol. 41:1165

17.  Wang, C., Li, Y., Proctor, T. M., Vandenbark, A. A. and Offner, H. 2010. Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis. J. Neurosci. Res. 88:7.

18.  Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Vandenbark, A. A., and Offner, H., 2009. Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1. Immunology 126:329.

19.  Wang, C., Dehghani, B., Li, Y., Kaler, L. J., Proctor, T., Vandenbark, A. A. and Offner, H. 2009. Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J. Immunol. 182:3294.

20.  Offner, H., Sinha, S., Wang, C., Burrows, G. G., and Vandenbark. A. A., 2008. Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis. Rev. Neurosci. 19:327.

21.  Wang, C., Dehghani, B., Magrisso, I. J., Rick, E. A., Bonhomme, E., Cody, D. B., Elenich, L. A., Subramanian, S., Murphy, S. J., Kelly, M. J., Rosenbaum, J. S., Vandenbark, A. A. and Offner, H. 2008. GPR30 contributes to estrogen-induced thymic atrophy. Mol. Endocrinol. 22:636.

22.  Wang, C., Gold, B.G., Kaler, L.J., Yu, X., Afentoulis, M.E., Burrows G.G., Vandenbark, A.A., Bourdette, D.N., Offner, H. 2006. Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE. J. Neurochem. 98: 1816.

23.  Wang, C., Chou, Y. C., Rich, C. M., Link, J.M., Afentoulisa, M. E., van Noort, J. M., Wawrousekd, E. F., Offner, H., Vandenbarka, A. A. 2006. αB-crystallin-reactive T cells from knockout mice are not encephalitogenic. J. Neruoimmunol. 176: 51.

24.  Offner, H., Subramanian, S., Parker, S.M., Wang, C., Afentoulis, M. E., Lewis, A., Vandenbark, A. A. and Hurn, P. D. 2006. Splenic atrophy in experimental stroke is accompanied by increased Treg cells and circulating macrophages. J. Immunol. 176: 6523.

25.  Offner, H., Subramanian, S., Wang, C., Afentoulis, M. E., Vandenbark, A. A., Huan, J., and Burrows, G. G. 2005. Treatment of passive EAE in SJL mice with a recombinant TCR ligand induces high levels of IL-13. J.Immunol. 175: 4103.

26.  Wang, C., Buck, D. C., Yang, R, Macey, T. A., and Neve, K. A. 2005. Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases. J.Neurochem. 93: 899.

27.  Chou, Y. K., Burrows, G. G., LaTocha, D., Wang, C., Subramanian, S., Bourdette, D. N., and Vandenbark, A. A. 2004. CD4 T-cell epitopes of human alpha B-crystallin. J.Neurosci.Res. 75: 516.

28.  Wang, C., Mooney, J. L., Meza-Romero, R., Chou, Y. K., Huan, J., Vandenbark, A. A., Offner, H., and Burrows, G. G. 2003. Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation. J.Immunol. 171: 1934.

29.  Vandenbark, A. A., Rich, C., Mooney, J., Zamora, A., Wang, C., Huan, J., Fugger, L., Offner, H., Jones, R., and Burrows, G. G. 2003. Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. J.Immunol. 171: 127.

30.  Burrows G. G., Chou Y. K., Wang C, Chang J. W., Finn T. P., Culbertson N. E., Kim J, Bourdette D. N., Lewinsohn D. A., Lewinsohn D. M., Ikeda M, Yoshioka T, Allen C. N., Offner H, Vandenbark A. A. 2001. Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells. J Immunol 167: 4386.

31.  Wang C, Zhou D. H., Chen J, Chi Z. Q. 1999. Leucine-2-alanine enkephalin induced delta opioid receptors internalization expressed stably in CHO cells. Acta Pharmacol Sin. 20: 491.

32.  Wang C, Zhou D. H., Chen Z. J., Wei Q, Chen J, Li G. F., Pei G, Chi Z. Q. 1998. The C-truncated delta-opioid receptor underwent agonist-dependent activation and desensitization. Biochem Biophys Res Commun 249: 321.

33.  Wang C, Zhou D. H., Chen J, Li G. F., Pei G., Chi Z. Q. 1997. Binding properties of C-truncated delta opioid receptors. Acta Pharmacol Sin 18: 337.

34.  Wei Q, Zhou D. H., Shen Q. X., Wang C, Pei G, Chi Z. Q. 1998. Human mu-opioid receptor overexpressed in baculovirus system and its pharmacological characterizations. Acta Pharmacol Sin 19: 218.

35. Zhu X. L., Wang C, Chen Z. J., Wu Y. L., Zhou D. H., Pei G. 1997. The carboxyl terminus mouse delta-opioid receptor is not required for agonist-dependent activation. Biochem Biophys Res Commun 232: 513.

 


Patents

1. Wang Chunhe, Geng Meiyu, Xie Zuoquan, Wang Yanfei, Xu Hui, Chen Yili, Huang Chenghao, Luo Wenxin, Xia Ningshao, Ding Jian. A Bispecific Antibody Targeting HER2 and PD-1 and Its Application . CN : CN111995685B , 2022-03-08.

2. Wang Chunhe, Chen Yili, Liu Xinyuan, Yan Shuai, Luo Weidong, Liu Guojian, Li Huanhuan, Lin Yijun, Wang Mina, Wang Qi . B7-H3 nanobody, preparation method and use thereof . CN : CN110642948B , 2021-06-29.

3. Chen Yili, Wang Chunhe, Yan Shuai, Lin Yijun, Wang Mina. A GD2 nanobody and its application . CN : CN110551218B , 2021-03-30.

4. Wang Chunhe, Tan Xiaorong, Chen Yili, Wang Guifeng, Wang Qi . An anti-MMAE monoclonal antibody, its coding sequence and application . CN : CN112457406A , 2021-03-09.

5. Wang Chunhe, Chen Yuning, Chen Yili, Chen Ganjun, Wang Guifeng, Wang Qi . Monoclonal antibodies against a variety of coronaviruses and their applications . CN : CN112409488A , 2021-02-26.

6. Wang Chunhe, Li Huanhuan, Liu Guojian, Chen Ganjun, Li Santai, Wen Jiaming, Chen Yili, Wang Qi, Lin Yijun, Wang Mina. A Monoclonal Antibody Targeting Nerve Growth Factor and Its Application . CN : CN110684106B , 2021-02-02.

7. Wang Chunhe . Antibodies targeting TACSTD2 and drug conjugate (ADC) molecules. CN : CN108066772A , 2018-05-25.


Students