生物组医学工程

材料表面改性

招收生物医学工程、材料科学、生物与医药等专业方向硕士及博士生

071010-生物化学与分子生物学
083100-生物医学工程

生物化学与分子生物学
生物医学工程

2009-01--2011-01   香港城市大学   客座学生
2006-09--2011-06   中国科学院合肥物质科学研究院   博士

生物物理学博士

   

2022-01~现在, 中国科学院深圳先进技术研究院, 研究员
2016-12~2021-12,中国科学院深圳先进技术研究院, 副研究员
2014-03~2016-10,中国科学院深圳先进技术研究院, 博士后/助理研究员
2011-07~2014-03,中国科学院合肥物质科学研究院, 助理研究员

2022-01-01-2025-12-31,Journal of Orthopaedic Translation编委, 编委会成员
2020-10-01-2024-09-30,中国生物材料学会康复器械与生物材料分会, 委员

生物材料综合实验

   

[1] 王怀雨, 梁嘉琪, 童丽萍, 高昂. 具有双重抗菌功效的可降解伤口敷料及其制备方法和应用. CN202310049722.5, 2023-02-01.
[2] 莫师, 王怀雨, 童丽萍, 高昂, 朱剑豪. 兼具抗菌与促成骨的高分子植入材料及其制备方法. CN202211078013.1, 2022-09-05.
[3] 王怀雨, 伍煜政, 童丽萍. 一种具有逐步抗菌和促进骨再生功能的骨组织工程支架及其制备方法和应用. CN: CN113425894A, 2021-09-24.
[4] 胡楠, 童丽萍, 王怀雨. 一种具有二氧化钛纳米管阵列的结构件及其制备方法和应用. CN: CN112795967A, 2021-05-14.
[5] 胡楠, 童丽萍, 王怀雨. 一种阳极氧化二氧化钛纳米管阵列及其制备方法. CN: CN110923780A, 2020-03-27.
[6] 王怀雨, 刘涵霞, 童丽萍. 聚醚醚酮材料及基于等离子体浸没注入的改性方法与应用. CN: CN106702341A, 2017-05-24.
[7] 童丽萍, 喻学锋, 王怀雨. 一种骨植入材料及其制备方法和应用. CN: CN108066815A, 2018-05-25.

   

[1] Ihsan Ullah, Peiyan Ou, Lingxia Xie, Qing Liao, Feilong Zhao, Ang Gao, Xiaoxue Ren, Yiting Li, Guomin Wang, Zhengwei Wu, Paul K Chu, Huaiyu Wang, Liping Tong. Diffusion-driven fabrication of calcium and phosphorous-doped zinc oxide heterostructures on titanium to achieve dual functions of osteogenesis and preventing bacterial infections. ACTA BIOMATERIALIA. 2024, 第 13 作者  通讯作者  175: 382-394, http://dx.doi.org/10.1016/j.actbio.2023.12.046.
[2] 周建良, 王怀雨, 童丽萍. 天然黑色素的提取、改性和应用. 科学通报[J]. 2023, 第 3 作者68(11): 1406-1420, http://lib.cqvip.com/Qikan/Article/Detail?id=7109562652.
[3] Kai Zheng, Jiaxiang Bai, Wanling Chen, Yaozeng Xu, huilin yang, Wei Li, Penghui Li, 童丽萍, Huaiyu Wang, Paul K. Chu, 耿德春. Multifunctional BPs/MT@PLGA-ALE Nanospheres for Treatment of Osteoporotic Fracture with Near-Infrared Irradiation. ADVANCED FUNCTIONAL MATERIALS[J]. 2023, 第 8 作者  通讯作者  33: 2214126, 
[4] Mo, Shi, Tang, Kaiwei, Liao, Qing, Xie, Lingxia, Wu, Yuzheng, Wang, Guomin, Ruan, Qingdong, Gao, Ang, Lv, Yuanliang, Cai, Kaiyong, Tong, Liping, Wu, Zhengwei, Chu, Paul K, Wang, Huaiyu. Tuning the arrangement of lamellar nanostructures: achieving the dual function of physically killing bacteria and promoting osteogenesis. Materials Horizons[J]. 2023, 第 11 作者  通讯作者  10(3): 881-888, http://dx.doi.org/10.1039/d2mh01147f.
[5] Xingyun Huang, Zhiyong Wang, Huaiyu Wang, Di Chen, Liping Tong. Novel strategies for the treatment of osteoarthritis based on biomaterials and critical molecular signaling. 材料科学技术:英文版[J]. 2023, 第 5 作者  通讯作者  42-55, http://lib.cqvip.com/Qikan/Article/Detail?id=7110257644.
[6] Xu Chen, Xinrui Li, Wenbo He, Miao Wang, Ang Gao, Liping Tong, Shun Guo, Huaiyu Wang, Guoqing Pan. Rational multivalency construction enables bactericidal effect amplification and dynamic biomaterial design. THE INNOVATION. 2023, 第 6 作者4(5): http://dx.doi.org/10.1016/j.xinn.2023.100483.
[7] 童丽萍, CHEN, DI. Senescence of Bone marrow fat cells: a new clue for glucocorticoids-induced bone deterioration. Cell Metablism[J]. 2023, 第 1 作者  通讯作者  35(4): 551-553, 
[8] Lu, Ke, Wang, Qingyun, Hao, Liuzhi, Wei, Guizheng, Wang, Tingyu, Lu, William W, Xiao, Guozhi, Tong, Liping, Zhao, Xiaoli, Chen, Di. miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction. BIOACTIVE MATERIALS[J]. 2023, 第 8 作者26: 425-436, http://dx.doi.org/10.1016/j.bioactmat.2023.03.010.
[9] Guizheng Wei, Ke Lu, Muhammad Umar, Zhenglin Zhu, William W. Lu, John R. Speakman, Yan Chen, Liping Tong, Di Chen. Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms. BONE RESEARCH[J]. 2023, 第 8 作者11(1): 1-16, http://dx.doi.org/10.1038/s41413-023-00301-9.
[10] Ihsan Ullah, Peiyan Ou, Lingxia Xie, Qing Liao, Feilong Zhao, Ang Gao, Xiaoxue Ren, Yiting Li, Guomin Wang, Zhengwei Wu, Paul K Chu, Huaiyu Wang, Liping Tong. Diffusion-driven fabrication of calcium and phosphorous-doped zinc oxide heterostructures on titanium to achieve dual functions of osteogenesis and preventing bacterial infections. ACTA BIOMATERIALIA[J]. 2023, 第 13 作者  通讯作者  http://dx.doi.org/10.1016/j.actbio.2023.12.046.
[11] Zhenglin Zhu, Yanran Huang, Jun Li, Dan Yi, Junyi Liao, Jun Xiao, Guozhi Xiao, Liping Tong, Wei Huang, Chen Di. AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes. JOURNAL OF ORTHOPAEDIC TRANSLATION. 2022, 第 8 作者38: 158-166, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668625/.
[12] Chen, Junfeng, Xie, Lingxia, Ruan, Qingdong, Gao, Ang, Liao, Qing, Mo, Shi, Lv, Yuanliang, Tong, Liping, Wang, Huaiyu, Chu, Paul K, Li, Xiaoming. Diamond-like carbon coating and surface grafting of osteoprotegerin and alendronate on polyetheretherketone to ameliorate the mechanical performance and osseointegration simultaneously. COMPOSITES PART B-ENGINEERING[J]. 2022, 第 8 作者  通讯作者  236: http://dx.doi.org/10.1016/j.compositesb.2022.109815.
[13] Mo, Shi, Tang, Kaiwei, Liao, Qing, Xie, Lingxia, Wu, Yuzheng, Wang, Guomin, Ruan, Qingdong, Gao, Ang, Lv, Yuanliang, Cai, Kaiyong, Tong, Liping, Wu, Zhengwei, Chu, Paul K, Wang, Huaiyu. Tuning the arrangement of lamellar nanostructures: achieving the dual function of physically killing bacteria and promoting osteogenesis. MATERIALS HORIZONS. 2022, 第 11 作者  通讯作者  
[14] Tong, Liping, Yu, Huan, Huang, Xingyun, Shen, Jie, Xiao, Guozhi, Chen, Lin, Wang, Huaiyu, Xing, Lianping, Chen, Di. Current understanding of osteoarthritis pathogenesis and relevant new approaches. BONE RESEARCH. 2022, 第 1 作者10(1): 627-643, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7361067&detailType=1.
[15] Yu, Huan, Huang, Tianwen, Lu, William Weijia, Tong, Liping, Chen, Di. Osteoarthritis Pain. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022, 第 4 作者  通讯作者  23(9): http://dx.doi.org/10.3390/ijms23094642.
[16] Yanyan Zheng, Ang Gao, Jiaxiang Bai, Qing Liao, Yuzheng Wu, Wei Zhang, Min Guan, Liping Tong, Dechun Geng, Xin Zhao, Paul K Chu, Huaiyu Wang. A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions. Bioactive Materials[J]. 2022, 第 8 作者  通讯作者  14: 364-376, 
[17] Rong Xie, Dan Yi, Daofu Zeng, Qiang Jie, Qinglin Kang, Zeng Zhang, Zhenlin Zhang, Guozhi Xiao, Lin Chen, Liping Tong, Di Chen. Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice. ELIFE[J]. 2022, 第 10 作者11: https://doaj.org/article/f1882fe9f96941eb8be0accd3a87bb45.
[18] Mo Shi, zhao feilong, 高昂, wu yuzheng, liao qing, xie lingxia, pan haobo, tong liping, Paul K. chu, wang huaiyu. Simultaneous application of diamond-like carbon coating and surface amination on polyether ether ketone: Towards superior mechanical performance and osseointegration. Smart Materials in Medicine[J]. 2021, 第 8 作者  通讯作者  
[19] yuzheng wu, qing liao, wu lie, Yongxiang Luo, Wei Zhang, min guan, haobo pan, liping tong, paul k chu, Huaiyu Wang. ZnL 2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter. ACS Nano.[J]. 2021, 第 8 作者
[20] Hu, Nan, Xie, Lingxia, Liao, Qing, Gao, Ang, Zheng, Yanyan, Pan, Haobo, Tong, Liping, Yang, Dazhi, Gao, Nong, Starink, Marco J, Chu, Paul K, Wang, Huaiyu. A more defective substrate leads to a less defective passive layer: Enhancing the mechanical strength, corrosion resistance and anti-inflammatory response of the low-modulus Ti-45Nb alloy by grain refinement. Acta Biomaterialia[J]. 2021, 第 7 作者  通讯作者  126: 524-536, http://dx.doi.org/10.1016/j.actbio.2021.02.045.
[21] Guomin Wang, Wenjuan Jiang, Shi Mo, Lingxia Xie, Qing Liao, Liangsheng Hu, Qingdong Ruan, Kaiwei Tang, Babak Mehrjou, Mengting Liu, Liping Tong, Huaiyu Wang, Jie Zhuang, Guosong Wu, Paul K Chu. Nonleaching Antibacterial Concept Demonstrated by In Situ Construction of 2D Nanoflakes on Magnesium. ADVANCED SCIENCE[J]. 2020, 第 11 作者7(1): n/a-n/a, https://doaj.org/article/7bcf68770d834d96ba27b738d0e2c2ae.
[22] Hu, Nan, Wu, Yuzheng, Xie, Lingxia, Yusuf, Shahir Mohd, Gao, Nong, Starink, Marco J, Tong, Liping, Chu, Paul K, Wang, Huaiyu. Enhanced interfacial adhesion and osseointegration of anodic TiO2 nanotube arrays on ultra-fine-grained titanium and underlying mechanisms. Acta Biomaterialia[J]. 2020, 第 7 作者  通讯作者  106: 360-375, http://dx.doi.org/10.1016/j.actbio.2020.02.009.
[23] Bai, Jiaxiang, Wang, Huaiyu, Chen, Hao, Ge, Gaoran, Wang, Miao, Gao, Ang, Tong, Liping, Xu, Yaozeng, Yang, Huiling, Pan, Guoqing, Chu, Paul K, Geng, Dechun. Biomimetic osteogenic peptide with mussel adhesion and osteoimmunomodulatory functions to ameliorate interfacial osseointegration under chronic inflammation. BIOMATERIALS[J]. 2020, 第 7 作者255: http://dx.doi.org/10.1016/j.biomaterials.2020.120197.
[24] Gao, Ang, Liao, Qing, Xie, Lingxia, Wang, Guomin, Zhang, Wei, Wu, Yuzheng, Li, Penghui, Guan, Min, Pan, Haobo, Tong, Liping, Chu, Paul K, Wang, Huaiyu. Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration. Biomaterials[J]. 2020, 第 10 作者  通讯作者  230: http://dx.doi.org/10.1016/j.biomaterials.2019.119642.
[25] Tong, Liping, Liao, Qing, Zhao, Yuetao, Huang, Hao, Gao, Ang, Zhang, Wei, Gao, Xiaoyong, Wei, Wei, Guan, Min, Chu, Paul K, Wang, Huaiyu. Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant. Biomaterials[J]. 2019, 第 1 作者193: 1-11, http://ir.ipe.ac.cn/handle/122111/27870.
[26] Hu, Nan, Hu, Tao, Gao, Ang, Gao, Nong, Starink, Marco J, Chen, Ying, Sun, Wanting, Liao, Qing, Tong, Liping, Xu, Xiaochang, Chu, Paul K, Wang, Huaiyu. Homogeneous Anodic TiO2 Nanotube Layers on Ti-6Al-4V Alloy with Improved Adhesion Strength and Corrosion Resistance. ADVANCED MATERIALS INTERFACES[J]. 2019, 第 9 作者  通讯作者  6(12): http://dx.doi.org/10.1002/admi.201801964.
[27] Weng, Yuchang, Liu, Hanxia, Ji, Shunping, Huang, Qian, Wu, Hao, Li, Zhibin, Wu, Zhongzhen, Wang, Huaiyu, Tong, Liping, Fu, Ricky K Y, Chu, Paul K, Pan, Feng. A promising orthopedic implant material with enhanced osteogenic and antibacterial activity: Al2O3-coated aluminum alloy. APPLIED SURFACE SCIENCE[J]. 2018, 第 9 作者457: 1025-1034, http://ir.siat.ac.cn:8080/handle/172644/14664.
[28] Zhao, Yuetao, Tong, Liping, Li, Zhibin, Yang, Na, Fu, Haidi, Wu, Lie, Cui, Haodong, Zhou, Wenhua, Wang, Jiahong, Wang, Huaiyu, Chu, Paul K, Yu, XueFeng. Stable and Multifunctional Dye-Modified Black Phosphorus Nanosheets for Near-Infrared Imaging-Guided Photothermal Therapy. CHEMISTRY OF MATERIALS[J]. 2017, 第 2 作者29(17): 7131-7139, https://www.webofscience.com/wos/woscc/full-record/WOS:000410868600014.
[29] Tong Liping. Linker-free covalent immobilization of heparin, SDF-1a, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation. Biomaterials. 2017, 第 1 作者  通讯作者  
[30] Gao, Ang, Hang, Ruiqiang, Li, Wan, Zhang, Wei, Li, Penghui, Wang, Guomin, Bai, Long, Yu, XueFeng, Wang, Huaiyu, Tong, Liping, Chu, Paul K. Linker-free covalent immobilization of heparin, SDF-1 alpha, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation. BIOMATERIALS[J]. 2017, 第 10 作者  通讯作者  140: 201-211, https://www.webofscience.com/wos/woscc/full-record/WOS:000405973900018.
[31] Tong, Liping, Zhou, Wenhua, Zhao, Yuetao, Yu, Xuefeng, Wang, Huaiyu, Chu, Paul K. Enhanced cytocompatibility and reduced genotoxicity of polydimethylsiloxane modified by plasma immersion ion implantation. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2016, 第 1 作者148: 139-146, http://dx.doi.org/10.1016/j.colsurfb.2016.08.057.
[32] Zhao, Yuetao, Tong, Liping, Li, Yong, Pan, Haobo, Zhang, Wei, Guan, Min, Li, Weihao, Chen, Yixin, Li, Qing, Li, Zhongjun, Wang, Huaiyu, Yu, XueFeng, Chu, Paul K. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 2 作者8(9): 5813-5820, https://www.webofscience.com/wos/woscc/full-record/WOS:000371945700011.
[33] Shao, Jundong, Tong, Liping, Tang, Siying, Guo, Zhinan, Zhang, Han, Li, Penghui, Wang, Huaiyu, Du, Chang, Yu, XueFeng. PLLA Nanofibrous Paper-Based Plasmonic Substrate with Tailored Hydrophilicity for Focusing SERS Detection. ACS APPLIED MATERIALS & INTERFACES[J]. 2015, 第 2 作者7(9): 5391-5399, https://www.webofscience.com/wos/woscc/full-record/WOS:000350614600044.
[34] Shao Jundong, Tong Liping, Tang Siying, Guo Zhinan, Zhang Han, Li Penghui, Wang Huaiyu, Du Chang, Yu XueFeng. PLLA nanofibrous paper-based plasmonic substrate with tailored hydrophilicity for focusing SERS detection （EI收录）. ACS APPLIED MATERIALS AND INTERFACES[J]. 2015, 第 2 作者7: 5391-5399, http://www.corc.org.cn/handle/1471x/2212371.
[35] Tong, Liping, Yu, K N, Bao, Lingzhi, Wu, Wenqing, Wang, Hongzhi, Han, Wei. Low concentration of exogenous carbon monoxide protects mammalian cells against proliferation induced by radiation-induced bystander effect. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS[J]. 2014, 第 1 作者759(无): 9-15, http://dx.doi.org/10.1016/j.mrfmmm.2013.11.006.
[36] Mei, Shenglin, Wang, Huaiyu, Wang, Wei, Tong, Liping, Pan, Haobo, Ruan, Changshun, Ma, Qianli, Liu, Mengyuan, Yang, Huiling, Zhang, Liang, Cheng, Yicheng, Zhang, Yumei, Zhao, Lingzhou, Chu, Paul K. Antibacterial effects and biocompatibility of titanium surfaces with graded silver incorporation in titania nanotubes. BIOMATERIALS[J]. 2014, 第 4 作者35(14): 4255-4265, http://dx.doi.org/10.1016/j.biomaterials.2014.02.005.
[37] Tong, Liping, Zhang, Wenwen, Hang, Haiying, Yu, Zengliang, Chu, Paul K, Xu, An. Toxicity of Carbon Nanotubes to p21 and hus1 Gene Deficient Mammalian Cells. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY[J]. 2011, 第 1 作者11(12): 11001-11005, http://www.irgrid.ac.cn/handle/1471x/757548.
[38] Wang, Huaiyu, Kwok, Dixon T K, Wang, Wei, Wu, Zhengwei, Tong, Liping, Zhang, Yumei, Chu, Paul K. Osteoblast behavior on polytetrafluoroethylene modified by long pulse, high frequency oxygen plasma immersion ion implantation. BIOMATERIALS[J]. 2010, 第 5 作者31(3): 413-419, http://dx.doi.org/10.1016/j.biomaterials.2009.09.066.
[39] 刘竞男, 童丽萍, 沈童伟, 李杰, 吴李君, 余增亮. Impact of Ion Implantation on Licorice (Glycyrrhiza uralensis Fisch) Growth and Antioxidant Activity Under Drought Stress. 等离子体科学和技术：英文版[J]. 2007, 第 2 作者9(3): 301-306, http://lib.cqvip.com/Qikan/Article/Detail?id=24754725.

   

（ 1 ） 退火处理对医用二氧化钛纳米管表面细胞行为的影响及机理研究, 负责人, 国家任务, 2012-01--2015-12
（ 2 ） 糖尿病体征下骨修复支架的降解、表面改性及促成骨研究, 负责人, 国家任务, 2014-07--2016-04
（ 3 ） 糖尿病体征下可降解骨替代支架与机体相互作用研究及促成骨修饰, 负责人, 地方任务, 2015-10--2017-09
（ 4 ） 表面促成骨的新型聚醚醚酮骨科植入材料关键技术研发, 负责人, 地方任务, 2016-07--2018-06
（ 5 ） 医用仿生钛合金研发与产业化团队, 参与, 地方任务, 2016-10--2021-09
（ 6 ） 高分子骨科植入材料表面等离子体改性及其促成骨性能与机制研究, 负责人, 地方任务, 2019-04--2022-08
（ 7 ） 中国科学院青年创新促进会项目, 负责人, 中国科学院计划, 2020-01--2023-12
（ 8 ） 黑磷复合支架的构建及其光调控骨免疫介导原位多重功能与机理研究, 负责人, 国家任务, 2022-01--2025-12
（ 9 ） 视觉响应植入器件的设计与加工, 参与, 国家任务, 2018-05--2023-04
（ 10 ） 精准生物适配型骨再生修复材料及关键技术, 参与, 国家任务, 2021-12--2025-11

现指导学生

区佩妍  硕士研究生  071000-生物学  

徐瑶瑶  硕士研究生  085600-材料与化工  

王紫辉  硕士研究生  086000-生物与医药  

闫磊  硕士研究生  086000-生物与医药  

王志勇  博士研究生  071010-生物化学与分子生物学  

鹿天乐  硕士研究生  086000-生物与医药