基本信息
谭曙光 男 博导 中国科学院微生物研究所
电子邮件： tansg@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码：
电子邮件： tansg@im.ac.cn
通信地址： 北京市朝阳区北辰西路1号院3号
邮政编码：
研究领域
T细胞免疫识别与肿瘤免疫治疗
招生信息
招生专业
100102-免疫学
086000-生物与医药
086000-生物与医药
招生方向
分子免疫学
教育背景
2008-09--2014-01 中国科学院大学 博士
2004-09--2008-06 中国海洋大学 本科
2004-09--2008-06 中国海洋大学 本科
工作经历
工作简历
2022-11~现在, 中国科学院微生物研究所, 项目研究员
2017-09~2022-11,中国科学院微生物研究所, 副研究员
2014-03~2017-09,中国科学院微生物研究所, 助理研究员
2017-09~2022-11,中国科学院微生物研究所, 副研究员
2014-03~2017-09,中国科学院微生物研究所, 助理研究员
教授课程
生物药物研究与开发
专利与奖励
奖励信息
（1） 中国免疫学会青年学者奖, 其他, 2017
专利成果
[1] 高福, 蒋敏, 谭曙光, 孙文桥. WT1抗原特异性T细胞受体及其抗肿瘤用途. CN: CN114853880A, 2022-08-05.
[2] 高福, 吴燕, 李世华, 张根, 谭曙光. 一种新型冠状病毒及其突变体的单克隆抗体及其应用. CN: CN113929774A, 2022-01-14.
[3] 高福, 吴燕, 李世华, 张根, 谭曙光. 一种新型冠状病毒及其突变体的单克隆抗体及其应用. CN: CN113929774B, 2023-05-02.
[4] 高福, 吴燕, 李世华, 张根, 谭曙光. 一种新型冠状病毒及其突变体的单克隆抗体及其应用. CN: CN113943368B, 2023-07-14.
[5] 高福, 吴燕, 李世华, 黎朝晖, 谭曙光. 一种抗新型冠状病毒的双特异性抗体及其应用. CN: CN113563475A, 2021-10-29.
[6] 高福, 谭曙光, 孙文桥, 蒋敏. 结核诊断细胞因子及其应用. CN: CN115598349A, 2023-01-13.
[7] 高福, 谭曙光, 蒋敏, 孙文桥. 结核鉴别诊断细胞因子及其在结核感染风险评估中的应用. CN: CN115598041A, 2023-01-13.
[8] 高福, 孙萌, 谭曙光, 张贺琳, 王杰. 人乳头瘤病毒特异性T细胞受体及其抗肿瘤用途. CN: CN112480239A, 2021-03-12.
[9] 高福, 张贺琳, 谭曙光, 孙萌. NY-ESO-1特异性T细胞受体筛选及其抗肿瘤用途. CN: CN112375136A, 2021-02-19.
[10] 高福, 谭曙光, 卢丹. KRAS突变特异性T细胞受体筛选及抗肿瘤用途. CN: CN112300269A, 2021-02-02.
[11] 严景华, 史瑞, 谭曙光, 高福, 马素芳. 一种非红细胞凝集的抗PD-L1/CD47双特异抗体及其在抗肿瘤治疗中的应用. CN: CN113372449A, 2021-09-10.
[12] 严景华, 郭俐静, 谭曙光, 史瑞, 高福. 一种抗PD-L1抗体及其在抗肿瘤治疗中的应用. CN: CN109232740A, 2019-01-18.
[13] 严景华, 陈丹青, 谭曙光, 仝舟, 高福. 一种PD-1特异性抗体及其抗肿瘤应用. CN: CN108840932B, 2022-03-29.
[14] 严景华, 陈丹青, 谭曙光, 仝舟, 高福. 一种PD-1特异性抗体及其抗肿瘤应用. CN: CN108840932A, 2018-11-20.
[15] 严景华, 陈丹青, 谭曙光, 仝舟, 高福. 一种靶向PD-1的肿瘤抑制性抗体及其应用. CN: CN109336975A, 2019-02-15.
[16] 高福, 谭曙光. 可用于结核分枝杆菌感染检测的表位多肽及其应用. CN: CN102516356A, 2012-06-27.
[17] 严景华, 毕晓珊, 史瑞, 谭曙光, 高福. 一种抗SIRPα抗体及其应用. CN: CN113735973A, 2021-12-03.
[18] 刘映霞, 吴燕, 沈晨光",null,null,null,null,"高福. 一种抗新型冠状病毒的单克隆抗体及其应用. CN: CN113354730A, 2021-09-07.
[19] 严景华, 史瑞, 谭曙光, 马素芳, 高福. 一种抗CD47抗体及其应用. CN: CN109265547A, 2019-01-25.
[20] 高福, 严景华, 谭曙光, 仝舟, 陈丹青. 一种抗PD‑1抗体及其应用. CN: CN107043420A, 2017-08-15.
[21] 高福, 谭曙光, 范盘生, 张宁, 万康林. 一种结核诊断组合物及其应用. CN: CN102608333A, 2012-07-25.
[2] 高福, 吴燕, 李世华, 张根, 谭曙光. 一种新型冠状病毒及其突变体的单克隆抗体及其应用. CN: CN113929774A, 2022-01-14.
[3] 高福, 吴燕, 李世华, 张根, 谭曙光. 一种新型冠状病毒及其突变体的单克隆抗体及其应用. CN: CN113929774B, 2023-05-02.
[4] 高福, 吴燕, 李世华, 张根, 谭曙光. 一种新型冠状病毒及其突变体的单克隆抗体及其应用. CN: CN113943368B, 2023-07-14.
[5] 高福, 吴燕, 李世华, 黎朝晖, 谭曙光. 一种抗新型冠状病毒的双特异性抗体及其应用. CN: CN113563475A, 2021-10-29.
[6] 高福, 谭曙光, 孙文桥, 蒋敏. 结核诊断细胞因子及其应用. CN: CN115598349A, 2023-01-13.
[7] 高福, 谭曙光, 蒋敏, 孙文桥. 结核鉴别诊断细胞因子及其在结核感染风险评估中的应用. CN: CN115598041A, 2023-01-13.
[8] 高福, 孙萌, 谭曙光, 张贺琳, 王杰. 人乳头瘤病毒特异性T细胞受体及其抗肿瘤用途. CN: CN112480239A, 2021-03-12.
[9] 高福, 张贺琳, 谭曙光, 孙萌. NY-ESO-1特异性T细胞受体筛选及其抗肿瘤用途. CN: CN112375136A, 2021-02-19.
[10] 高福, 谭曙光, 卢丹. KRAS突变特异性T细胞受体筛选及抗肿瘤用途. CN: CN112300269A, 2021-02-02.
[11] 严景华, 史瑞, 谭曙光, 高福, 马素芳. 一种非红细胞凝集的抗PD-L1/CD47双特异抗体及其在抗肿瘤治疗中的应用. CN: CN113372449A, 2021-09-10.
[12] 严景华, 郭俐静, 谭曙光, 史瑞, 高福. 一种抗PD-L1抗体及其在抗肿瘤治疗中的应用. CN: CN109232740A, 2019-01-18.
[13] 严景华, 陈丹青, 谭曙光, 仝舟, 高福. 一种PD-1特异性抗体及其抗肿瘤应用. CN: CN108840932B, 2022-03-29.
[14] 严景华, 陈丹青, 谭曙光, 仝舟, 高福. 一种PD-1特异性抗体及其抗肿瘤应用. CN: CN108840932A, 2018-11-20.
[15] 严景华, 陈丹青, 谭曙光, 仝舟, 高福. 一种靶向PD-1的肿瘤抑制性抗体及其应用. CN: CN109336975A, 2019-02-15.
[16] 高福, 谭曙光. 可用于结核分枝杆菌感染检测的表位多肽及其应用. CN: CN102516356A, 2012-06-27.
[17] 严景华, 毕晓珊, 史瑞, 谭曙光, 高福. 一种抗SIRPα抗体及其应用. CN: CN113735973A, 2021-12-03.
[18] 刘映霞, 吴燕, 沈晨光",null,null,null,null,"高福. 一种抗新型冠状病毒的单克隆抗体及其应用. CN: CN113354730A, 2021-09-07.
[19] 严景华, 史瑞, 谭曙光, 马素芳, 高福. 一种抗CD47抗体及其应用. CN: CN109265547A, 2019-01-25.
[20] 高福, 严景华, 谭曙光, 仝舟, 陈丹青. 一种抗PD‑1抗体及其应用. CN: CN107043420A, 2017-08-15.
[21] 高福, 谭曙光, 范盘生, 张宁, 万康林. 一种结核诊断组合物及其应用. CN: CN102608333A, 2012-07-25.
出版信息
发表论文
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[3] Guan, Jiawei, Liu, Hongchuan, Chai, Yan, Yu, Jie, Yao, Jian, Wang, Jing, Pan, Zhiwei, Zhang, Jing, Zhou, Yuehua, Liu, Hui, Yao, Sheng, Qi, Jianxun, Feng, Hui, Gao, George F F, Wang, Qihui, Shi, Yi, Tan, Shuguang. Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer. MABS[J]. 2023, 15(1): http://dx.doi.org/10.1080/19420862.2022.2153409.
[4] Li, Hui, Zhao, Min, Zhang, Hangjie, Quan, Chuansong, Zhang, Dannie, Liu, Yingmei, Liu, Meng, Xue, Chunxue, Tan, Shuguang, Guo, Yaxin, Zhao, Yingze, Wu, Guizhen, Gao, George F, Cao, Bin, Liu, William J. Pneumonia Severity and Phase Linked to Virus-Specific T Cell Responses with Distinct Immune Checkpoints during pH1N1 Infection. JOURNAL OF IMMUNOLOGY[J]. 2022, 208(9): 2154-2162, http://dx.doi.org/10.4049/jimmunol.2101021.
[5] Li, Zhaohui, Li, Shihua, Zhang, Gen, Peng, Weiyu, Chang, Zhen, Zhang, Xue, Fan, Zheng, Chai, Yan, Wang, Feiran, Zhao, Xin, Li, Dedong, Zhang, Rong, He, Zhanlong, Zou, Weiwei, Xu, Ke, Lei, Wenwen, Liu, Peipei, Hao, Junfeng, Zhang, Jingjing, Sun, Litao, Wu, Guizhen, Tan, Shuguang, Gao, George Fu, Gao, Feng, Wu, Yan. An engineered bispecific human monoclonal antibody against SARS-CoV-2. NATURE IMMUNOLOGY[J]. 2022, 23(3): 423-+, http://dx.doi.org/10.1038/s41590-022-01138-w.
[6] Zhao, Yan, Huang, Fengming, Zou, Zhen, Bi, Yuhai, Yang, Yang, Zhang, Cong, Liu, Qiang, Shang, Daozhen, Yan, Yiwu, Ju, Xiangwu, Mei, Song, Xie, Peng, Li, Xiao, Tian, Mingyao, Tan, Shuguang, Lu, Huijun, Han, Zongsheng, Liu, Kangtai, Zhang, Yuqing, Liang, Junbo, Liang, Zhu, Zhang, Qingchao, Chang, Jiahui, Liu, William J, Feng, Cong, Li, Tanshi, Zhang, Michael Q, Wang, Xiaoyue, Gao, George F, Liu, Yingxia, Jin, Ningyi, Jiang, Chengyu. Avian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2022, 19(6): 702-714, http://dx.doi.org/10.1038/s41423-022-00843-8.
[7] Lu, Dan, Xu, Zepeng, Zhang, Ding, Jiang, Min, Liu, Kefang, He, Juanhua, Ma, Dongli, Ma, Xiaopeng, Tan, Shuguang, Gao, George F, Chai, Yan. PD-1 N58-Glycosylation-Dependent Binding of Monoclonal Antibody Cemiplimab for Immune Checkpoint Therapy. FRONTIERS IN IMMUNOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fimmu.2022.826045.
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[10] Zhao, Min, Fu, Lijun, Chai, Yan, Sun, Meng, Li, Yan, Wang, Shuo, Qi, Jianxun, Zeng, Bin, Kang, Le, Gao, George F, Tan, Shuguang. Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation. CELL REPORTS[J]. 2021, 36(12): http://dx.doi.org/10.1016/j.celrep.2021.109734.
[11] Zhang, Helin, Sun, Meng, Wang, Jie, Zeng, Bin, Cao, Xiaoqing, Han, Yi, Tan, Shuguang, Gao, George F. Identification of NY-ESO-1(157-165) Specific Murine T Cell Receptors With Distinct Recognition Pattern for Tumor Immunotherapy. FRONTIERS IN IMMUNOLOGY[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021954/.
[12] Liu, Kefang, Tan, Shuguang, Niu, Sheng, Wang, Jia, Wu, Lili, Sun, Huan, Zhang, Yanfang, Pan, Xiaoqian, Qu, Xiao, Du, Pei, Meng, Yumin, Jia, Yunfei, Chen, Qian, Deng, Chuxia, Yan, Jinghua, Wang, HongWei, Wang, Qihui, Qi, Jianxun, Gao, George Fu. Cross-species recognition of SARS-CoV-2 to bat ACE2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 118(1): http://dx.doi.org/10.1073/pnas.2020216118.
[13] Huang, Qingrui, Ji, Kai, Tian, Siyu, Wang, Fengze, Huang, Baoying, Tong, Zhou, Tan, Shuguang, Hao, Junfeng, Wang, Qihui, Tan, Wenjie, Gao, George F, Yan, Jinghua. A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858593/.
[14] Sun, Meng, Zhang, Helin, Jiang, Min, Chai, Yan, Qi, Jianxun, Gao, George F, Tan, Shuguang. Structural insights into the cis and trans assembly of human trophoblast cell surface antigen 2. ISCIENCE[J]. 2021, 24(10): http://dx.doi.org/10.1016/j.isci.2021.103190.
[15] Liu, Kefang, Pan, Xiaoqian, Li, Linjie, Yu, Feng, Zheng, Anqi, Du, Pei, Han, Pengcheng, Meng, Yumin, Zhang, Yanfang, Wu, Lili, Chen, Qian, Song, Chunli, Jia, Yunfei, Niu, Sheng, Lu, Dan, Qiao, Chengpeng, Chen, Zhihai, Ma, Dongli, Ma, Xiaopeng, Tan, Shuguang, Zhao, Xin, Qi, Jianxun, Gao, George F, Wang, Qihui. Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species. CELL[J]. 2021, 184(13): 3438-+, http://dx.doi.org/10.1016/j.cell.2021.05.031.
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[17] Wang, Qihui, Song, Hao, Cheng, Hao, Qi, Jianxun, Nam, Gol, Tan, Shuguang, Wang, Junzhi, Fang, Min, Shi, Yi, Tian, Zhigang, Cao, Xuetao, An, Zhiqiang, Yan, Jinghua, Gao, George F. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2020, 17(9): 966-975, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609294/.
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[22] Sun, Huan, Li, Yan, Liu, Peipei, Qiao, Chengpeng, Wang, Xiaomin, Wu, Lianao, Liu, Kefang, Hu, Yu, Su, Chao, Tan, Shuguang, Zou, Shumei, Wu, Guizhen, Yan, Jinghua, Gao, George Fu, Qi, Jianxun, Wang, Qihui. Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry. EMERGING MICROBES & INFECTIONSnull. 2020, 9(1): 1238-1241, http://dx.doi.org/10.1080/22221751.2020.1770631.
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科研活动
科研项目
（ 1 ） 免疫识别与免疫治疗策略研究, 负责人, 国家任务, 2023-01--2025-12
（ 2 ） 针对重要病原的免疫原设计, 参与, 国家任务, 2021-10--2024-09
（ 2 ） 针对重要病原的免疫原设计, 参与, 国家任务, 2021-10--2024-09
指导学生
现指导学生
梁婷 硕士研究生 077802-免疫学
晏妮 硕士研究生 077802-免疫学