谭立课题组致力于对癌症、炎症或神经退行性疾病背景下异常的蛋白质稳态进行化学干预：针对E3泛素连接酶和去泛素化酶等潜在治疗靶点研制首创型调控剂；基于新型共价反应官能团和化学蛋白质组学技术研制新型的共价抑制剂；针对RIPK1所介导的炎症和细胞死亡相关疾病进行新药创制。

   

0703Z1-化学生物学
100701-药物化学

化学生物学，药物化学

2004-09--2009-07   中国科学院上海有机化学研究所   博士
2000-09--2004-06   南京大学   学士

   

2015-04~2016-05,哈佛医学院Dana-Farber癌症研究所, Research Scientist
2010-04~2015-03,哈佛医学院Dana-Farber癌症研究所, 博士后
2009-07~2009-12,中国科学院上海有机化学研究所, 助理研究员

   

（ 1 ） 一类细胞程序性坏死抑制剂及其制备方法和用途, 发明专利, 2022, 第 1 作者, 专利号: CN114262322A

（ 2 ） 一类基于有机砷的II型丙酮酸激酶抑制剂及其制备方法和用途, 发明专利, 2021, 第 1 作者, 专利号: CN113801163A

（ 3 ） 去泛素化酶活性探针及其制备和应用, 发明专利, 2021, 第 1 作者, 专利号: CN112794878A

（ 4 ） 一类基于有机胂的CDK抑制剂及其制备方法和用途, 发明专利, 2021, 第 1 作者, 专利号: CN112574255A

（ 5 ） 一类细胞程序性坏死抑制剂及其制备方法和用途, 发明专利, 2020, 第 1 作者, 专利号: CN111978311A

（ 6 ） 一类细胞程序性坏死抑制剂及其制备方法和用途, 发明专利, 2023, 第 1 作者, 专利号: 202310819087.4

（ 7 ） 细胞周期依赖性激酶降解剂及其制备方法和用途, 发明专利, 2024, 第 1 作者, 专利号: 202410074991.1

   

[1] Ying Qin, Dekang Li, Chunting Qi, Huaijiang Xiang, Huyan Meng, Jingli Liu, Shaoqing Zhou, Xinyu Gong, Ying Li, Guifang Xu, Rui Zu, Hang Xie, Yechun Xu, Gang Xu, Zheng Zhang, Shi Chen, Lifeng Pan, Ying Li, Li Tan. Structure-based development of potent and selective type-II kinase inhibitors of RIPK1. ACTA PHARMACEUTICA SINICA B[J]. 2024, 第 19 作者  通讯作者  14(1): 319-334, http://dx.doi.org/10.1016/j.apsb.2023.10.021.
[2] Science Advances. 2023,   通讯作者  
[3] Tao, Youqi, Xia, Wencheng, Zhao, Qinyue, Xiang, Huaijiang, Han, Chao, Zhang, Shenqing, Gu, Wei, Tang, Wenjun, Li, Ying, Tan, Li, Li, Dan, Liu, Cong. Structural mechanism for specific binding of chemical compounds to amyloid fibrils. NATURE CHEMICAL BIOLOGY. 2023, 第 10 作者http://dx.doi.org/10.1038/s41589-023-01370-x.
[4] Wang, Jingyao, Zhou, Shaoqing, Cheng, Yan, Cheng, Lin, Qin, Ying, Zhang, Zhenfeng, Bi, Aiwei, Xiang, Huaijiang, He, Xinheng, Tian, Xiaoxu, Liu, Wenbin, Zhang, Jian, Peng, Chao, Zhu, Zhengjiang, Huang, Min, Li, Ying, Zhuang, Guanglei, Tan, Li. Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2023, 第 18 作者  通讯作者  66(4): http://dx.doi.org/10.1021/acs.jmedchem.2c01563.
[5] Lin, Lifeng, Shi, Kaixuan, Zhou, Shaoqing, MeiChun Cai, Zhang, Caiyan, Sun, Yunheng, Zang, Jingyu, Cheng, Lin, Ye, Kaiyan, Ma, Pengfei, Shen, Peiye, Zhang, Meiying, Cheng, Yan, Qi, Chunting, Li, Ying, Yin, Xia, Zheng, Yiyan, Tan, Li, Zhuang, Guanglei, Zang, Rongyu. SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer. ONCOGENE[J]. 2022, 第 18 作者  通讯作者  41(12): 1767-1779, http://dx.doi.org/10.1038/s41388-022-02210-3.
[6] Guo, Chenchen, Wan, Ruijie, He, Yayi, Lin, ShuHai, Cao, Jiayu, Qiu, Ying, Zhang, Tengfei, Zhao, Qiqi, Niu, Yujia, Jin, Yujuan, Huang, HsinYi, Wang, Xue, Tan, Li, Thomas, Roman K, Zhang, Hua, Chen, Luonan, Wong, KwokKin, Hu, Liang, Ji, Hongbin. Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer. NATURE CANCER[J]. 2022, 第 13 作者3(5): 614-+, http://dx.doi.org/10.1038/s43018-022-00358-1.
[7] Zhuang, Guanglei, Chen, Gang, Tan, Li, Tan, Lingli, Shan, Hengyue, Han, Chao, Zhang, Zhenfeng, Shen, Jiali, Zhang, Xiao, Xiang, Huaijiang, Lu, Kuankuan, Qi, Chunting, Li, Ying. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 3 作者  通讯作者  65(20): 13645-13659, http://dx.doi.org/10.1021/acs.jmedchem.2c00408.
[8] Cheng, Lin, Zhou, Shichao, Zhou, Shaoqing, Shi, Kaixuan, Cheng, Yan, Cai, MeiChun, Ye, Kaiyan, Lin, Lifeng, Zhang, Zhenfeng, Jia, Chenqiang, Xiang, Huaijiang, Zang, Jingyu, Zhang, Meiying, Yin, Xia, Li, Ying, Di, Wen, Zhuang, Guanglei, Tan, Li. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer. CANCER RESEARCH[J]. 2022, 第 18 作者  通讯作者  82(19): 3588-3602, http://dx.doi.org/10.1158/0008-5472.CAN-22-0222.
[9] Meng, Huyan, Wu, Guowei, Zhao, Xinsuo, Wang, Anhui, Li, Dekang, Tong, Yilun, Jin, Taijie, Cao, Ye, Shan, Bing, Hu, Shichen, Li, Ying, Pan, Lifeng, Tian, Xiaoxu, Wu, Ping, Peng, Chao, Yuan, Junying, Li, Guohui, Tan, Li, Wang, Zhaoyin, Li, Ying. Discovery of a cooperative mode of inhibiting RIPK1 kinase. CELL DISCOVERY[J]. 2021, 第 18 作者  通讯作者  7(1): 
[10] Shan, Hengyue, Liu, Jianping, Shen, Jiali, Dai, Jialin, Xu, Gang, Lu, Kuankuan, Han, Chao, Wang, Yaru, Xu, Xiaolong, Tong, Yilun, Xiang, Huaijiang, Ai, Zhiyuan, Zhuang, Guanglei, Hu, Junhao, Zhang, Zheng, Li, Ying, Pan, Lifeng, Tan, Li. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. CELL CHEMICAL BIOLOGY[J]. 2021, 第 18 作者  通讯作者  28(6): 855-+, http://dx.doi.org/10.1016/j.chembiol.2021.04.020.
[11] Guang Yang, Jinhua Wang, Li Tan, Manit Munshi, Xia Liu, Amanda Kofides, Jiaji G Chen, Nicholas Tsakmaklis, Maria G Demos, Maria Luisa Guerrera, Lian Xu, Zachary R Hunter, Jinwei Che, Christopher J Patterson, Kirsten Meid, Jorge J Castillo, Nikhil C Munshi, Kenneth C Anderson, Michael Cameron, Sara J Buhrlage, Nathanael S Gray, Steven P Treon. The HCK/BTK inhibitor KIN-8194 is active in MYD88 driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance.. BLOOD[J]. 2021, 第 3 作者http://dx.doi.org/10.1182/blood.2021011405.
[12] Pinch, Benika J, Doctor, Zainab M, Nabet, Behnam, Browne, Christopher M, Seo, HyukSoo, Mohardt, Mikaela L, Kozono, Shingo, Lian, Xiaolan, Manz, Theresa D, Chun, Yujin, Kibe, Shin, Zaidman, Daniel, Daitchman, Dina, Yeoh, Zoe C, Vangos, Nicholas E, Geffken, Ezekiel A, Tan, Li, Ficarro, Scott B, London, Nir, Marto, Jarrod A, Buratowski, Stephen, DhePaganon, Sirano, Zhou, Xiao Zhen, Lu, Kun Ping, Gray, Nathanael S. Identification of a potent and selective covalent Pin1 inhibitor. NATURE CHEMICAL BIOLOGY[J]. 2020, 第 17 作者16(9): 979-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442691/.
[13] Yin, Xia, Bi, Rui, Ma, Pengfei, Zhang, Shengzhe, Zhang, Yang, Sun, Yunheng, Zhang, Yi, Jing, Ying, Yu, Minhua, Wang, Wenjing, Tan, Li, Di, Wen, Zhuang, Guanglei, Cai, MeiChun. Multiregion whole-genome sequencing depicts intratumour heterogeneity and punctuated evolution in ovarian clear cell carcinoma. JOURNAL OF MEDICAL GENETICS[J]. 2020, 第 11 作者57(9): 605-609, https://www.webofscience.com/wos/woscc/full-record/WOS:000567008800004.
[14] Donovan, Katherine A, Ferguson, Fleur M, Bushman, Jonathan W, Eleuteri, Nicholas A, Bhunia, Debabrata, Ryu, SeongShick, Tan, Li, Shi, Kun, Yue, Hong, Liu, Xiaoxi, Dobrovolsky, Dennis, Jiang, Baishan, Wang, Jinhua, Hao, Mingfeng, You, Inchul, Teng, Mingxing, Liang, Yanke, Hatcher, John, Li, Zhengnian, Manz, Theresa D, Groendyke, Brian, Hu, Wanyi, Nam, Yunju, Sengupta, Sandip, Cho, Hanna, Shin, Injae, Agius, Michael P, Ghobrial, Irene M, Ma, Michelle W, Che, Jianwei, Buhrlage, Sara J, Sim, Taebo, Gray, Nathanael S, Fischer, Eric S. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. CELL[J]. 2020, 第 7 作者183(6): 1714-+, http://dx.doi.org/10.1016/j.cell.2020.10.038.
[15] Gu, Jinge, Liu, Zhenying, Zhang, Shengnan, Li, Yichen, Xia, Wencheng, Wang, Chen, Xiang, Huaijiang, Liu, Zhijun, Tan, Li, Fang, Yanshan, Liu, Cong, Li, Dan. Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2020, 第 9 作者117(49): 31123-31133, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7733851/.
[16] Xu, Daichao, Zhao, Heng, Jin, Minzhi, Zhu, Hong, Shan, Bing, Geng, Jiefei, Dziedzic, Slawomir A, Amin, Palak, Mifflin, Lauren, Naito, Masanori Gomi, Najafov, Ayaz, Xing, Jing, Yan, Lingjie, Liu, Jianping, Qin, Ying, Hu, Xinqian, Wang, Huibing, Zhang, Mengmeng, Manuel, Vica Jean, Tan, Li, He, Zhuohao, Sun, Zhenyu J, Lee, Virginia M Y, Wagner, Gerhard, Yuan, Junying. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. NATURE[J]. 2020, 第 20 作者587(7832): 133-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000572352700003.
[17] Cai, MeiChun, Zhao, Xiaojing, Cao, Min, Ma, Pengfei, Chen, Minjiang, Wu, Jie, Jia, Chenqiang, He, Chunming, Fu, Yujie, Tan, Li, Xue, Xinying, Yu, Zhuang, Zhuang, Guanglei. T-cell exhaustion interrelates with immune cytolytic activity to shape the inflamed tumor microenvironment. JOURNAL OF PATHOLOGY[J]. 2020, 第 10 作者251(2): 147-159, http://dx.doi.org/10.1002/path.5435.
[18] Schroeder, Martin, Tan, Li, Wang, Jinhua, Liang, Yanke, Gray, Nathanael S, Knapp, Stefan, Chaikuad, Apirat. Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. CELL CHEMICAL BIOLOGY[J]. 2020, 第 2 作者27(10): 1285-+, http://dx.doi.org/10.1016/j.chembiol.2020.07.014.
[19] Pinch, Benika, Doctor, Zainab, Browne, Christopher M, Seo, HyukSoo, Nabet, Behnam, Kozono, Shingo, Lian, Xiaolan, Zaidman, Daniel, Daitchman, Dina, London, Nir, Gong, Lu, Manz, Theresa, Chun, Yujin, Tan, Li, Marto, Jarrod, Buratowski, Stephen, DhePaganon, Sirano, Zhou, Xiao, Lu, Kun Ping, Gray, Nathanael S. Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine. CANCER RESEARCH. 2019, 第 14 作者79(13): https://www.webofscience.com/wos/woscc/full-record/WOS:000488279401207.
[20] Rao, Suman, Gurbani, Deepak, Du, Guangyan, Everley, Robert A, Browne, Christopher M, Chaikuad, Apirat, Tan, Li, Schroeder, Martin, Gondi, Sudershan, Ficarro, Scott B, Sim, Taebo, Kim, Nam Doo, Berberich, Matthew J, Knapp, Stefan, Marto, Jarrod A, Westover, Kenneth D, Sorger, Peter K, Gray, Nathanael S. Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. CELL CHEMICAL BIOLOGY[J]. 2019, 第 7 作者26(6): 818-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000472159700005.
[21] Rusan, Maria, Li, Kapsok, Li, Yvonne, Christensen, Camilla L, Abraham, Brian J, Kwiatkowski, Nicholas, Buczkowski, Kevin A, Bockorny, Bruno, Chen, Ting, Li, Shuai, Rhee, Kevin, Zhang, Haikuo, Chen, Wankun, Terai, Hideki, Tavares, Tiffany, Leggett, Alan L, Li, Tianxia, Wang, Yichen, Zhang, Tinghu, Kim, TaeJung, Hong, SookHee, PoudelNeupane, Neermala, Silkes, Michael, Mudianto, Tenny, Tan, Li, Shimamura, Takeshi, Meyerson, Matthew, Bass, Adam J, Watanabe, Hideo, Gray, Nathanael S, Young, Richard A, Wong, KwokKin, Hammerman, Peter S. Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression. CANCER DISCOVERY[J]. 2018, 第 25 作者8(1): 59-73, http://dx.doi.org/10.1158/2159-8290.CD-17-0461.
[22] Huang, HaiTsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L, Doctor, Zainab M, Buckley, Dennis L, Cho, JoongHeui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D, Li, Ying, Treon, Steven P, Fischer, Eric S, Bradner, James E, Tan, Li, Gray, Nathanael S. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. CELL CHEMICAL BIOLOGY[J]. 2018, 第 18 作者  通讯作者  25(1): 88-+, http://dx.doi.org/10.1016/j.chembiol.2017.10.005.
[23] Powell, Chelsea E, Gao, Yang, Tan, Li, Donovan, Katherine A, Nowak, Radoslaw P, Loehr, Amanda, Bahcall, Magda, Fischer, Eric S, Janne, Pasi A, George, Rani E, Gray, Nathanael S. Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK). JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 第 3 作者61(9): 4249-4255, https://www.webofscience.com/wos/woscc/full-record/WOS:000432204800033.
[24] Bockorny, Bruno, Rusan, Maria, Chen, Wankun, Liao, Rachel G, Li, Yvonne, Piccioni, Federica, Wang, Jun, Tan, Li, Thorner, Aaron R, Li, Tianxia, Zhang, Yanxi, Miao, Changhong, Ovesen, Therese, Shapiro, Geoffrey I, Kwiatkowski, David J, Gray, Nathanael S, Meyerson, Matthew, Hammerman, Peter S, Bass, Adam J. RAS-MAPK Reactivation Facilitates Acquired Resistance in FGFR1-Amplified Lung Cancer and Underlies a Rationale for Upfront FGFR-MEK Blockade. MOLECULAR CANCER THERAPEUTICS[J]. 2018, 第 8 作者17(7): 1526-1539, https://www.webofscience.com/wos/woscc/full-record/WOS:000437274600016.
[25] Weir, Mark C, Shu, Sherry T, Patel, Ravi K, Hellwig, Sabine, Chen, Li, Tan, Li, Gray, Nathanael S, Smithgall, Thomas E. Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo. ACS CHEMICAL BIOLOGY[J]. 2018, 第 6 作者13(6): 1551-1559, https://www.webofscience.com/wos/woscc/full-record/WOS:000435746200018.
[26] Tan, Li, Gray, Nathanael S. When Kinases Meet PROTACs. CHINESE JOURNAL OF CHEMISTRY[J]. 2018, 第 1 作者  通讯作者  36(10): 971-977, http://lib.cqvip.com/Qikan/Article/Detail?id=676614923.
[27] Zwang, Yaara, Jonas, Oliver, Chen, Casandra, Rinne, Mikael L, Doench, John G, Piccioni, Federica, Tan, Li, Huang, HaiTsang, Wang, Jinhua, Ham, Young Jin, OConnell, Joyce, Bhola, Patrick, Doshi, Mihir, Whitman, Matthew, Cima, Michael, Letai, Anthony, Root, David E, Langer, Robert S, Gray, Nathanael, Hahn, William C. Synergistic interactions with PI3K inhibition that induce apoptosis. ELIFE[J]. 2017, 第 7 作者6: https://doaj.org/article/e53a69f812244f4b946e1569b458a6f8.
[28] Tan, Li, Gurbani, Deepak, Weisberg, Ellen L, Jones, Douglas S, Rao, Suman, Singer, William D, Bernard, Faviola M, Mowafy, Samar, Jenney, Annie, Du, Guangyan, Nonami, Atsushi, Griffin, James D, Lauffenburger, Douglas A, Westover, Kenneth D, Sorger, Peter K, Gray, Nathanael S. Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2017, 第 1 作者25(4): 1320-1328, http://dx.doi.org/10.1016/j.bmc.2016.11.034.
[29] Tan, Li, Gurbani, Deepak, Weisberg, Ellen L, Hunter, John C, Li, Lianbo, Jones, Douglas S, Ficarro, Scott B, Mowafy, Samar, Tam, ChunPong, Rao, Suman, Du, Guangyan, Griffin, James D, Sorger, Peter K, Marto, Jarrod A, Westover, Kenneth D, Gray, Nathanael S. Structure-guided development of covalent TAK1 inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2017, 第 1 作者25(3): 838-846, http://dx.doi.org/10.1016/j.bmc.2016.11.035.
[30] Weir, Mark C, Hellwig, Sabine, Tan, Li, Liu, Yao, Gray, Nathanael S, Smithgall, Thomas E. Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth. PLOS ONE[J]. 2017, 第 3 作者12(7): https://doaj.org/article/e2dbe4e0bdf64805bb692be55cbeac4f.
[31] Amato, Katherine R, Wang, Shan, Tan, Li, Hastings, Andrew K, Song, Wenqiang, Lovly, Christine M, Meador, Catherine B, Ye, Fei, Lu, Pengcheng, Balko, Justin M, Colvin, Daniel C, Cates, Justin M, Pao, William, Gray, Nathanael S, Chen, Jin. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. CANCER RESEARCH[J]. 2016, 第 3 作者76(2): 305-318, https://www.webofscience.com/wos/woscc/full-record/WOS:000368628000015.
[32] Yang, Guang, Buhrlage, Sara J, Tan, Li, Liu, Xia, Chen, Jie, Xu, Lian, Tsakmaklis, Nicholas, Chen, Jiaji G, Patterson, Christopher J, Brown, Jennifer R, Castillo, Jorge J, Zhang, Wei, Zhang, Xiaofeng, Liu, Shuai, Cohen, Philip, Hunter, Zachary R, Gray, Nathanael, Treon, Steven P. HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib. BLOOD[J]. 2016, 第 3 作者127(25): 3237-3252, http://dx.doi.org/10.1182/blood-2016-01-695098.
[33] Tan, Li, Akahane, Koshi, McNally, Randall, Reyskens, Kathleen M S E, Ficarro, Scott B, Liu, Suhu, HerterSprie, Grit S, Koyama, Shohei, Pattison, Michael J, Labella, Katherine, Johannessen, Liv, Akbay, Esra A, Wong, KwokKin, Frank, David A, Marto, Jarrod A, Look, Thomas A, Arthur, J Simon C, Eck, Michael J, Gray, Nathanael S. Development of Selective Covalent Janus Kinase 3 Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2015, 第 1 作者58(16): 6589-6606, https://www.webofscience.com/wos/woscc/full-record/WOS:000360415800021.
[34] Huang, Zhifeng, Tan, Li, Wang, Huiyan, Liu, Yang, Blais, Steven, Deng, Jingjing, Neubert, Thomas A, Gray, Nathanael S, Li, Xiaokun, Mohammadi, Moosa. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors. ACS CHEMICAL BIOLOGY[J]. 2015, 第 2 作者10(1): 299-309, 
[35] Terai, Hideki, Tan, Li, Beauchamp, Ellen M, Hatcher, John M, Liu, Qingsong, Meyerson, Matthew, Gray, Nathanael S, Hammerman, Peter S. Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer. ACS CHEMICAL BIOLOGY[J]. 2015, 第 2 作者10(12): 2687-2696, https://www.webofscience.com/wos/woscc/full-record/WOS:000366875400004.
[36] Tan, Li, Nomanbhoy, Tyzoon, Gurbani, Deepak, Patricelli, Matthew, Hunter, John, Geng, Jiefei, Herhaus, Lina, Zhang, Jianming, Pauls, Eduardo, Ham, Youngjin, Choi, Hwan Geun, Xie, Ting, Deng, Xianming, Buhrlage, Sara J, Sim, Taebo, Cohen, Philip, Sapkota, Gopal, Westover, Kenneth D, Gray, Nathanael S. Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). JOURNAL OF MEDICINAL CHEMISTRY[J]. 2015, 第 1 作者58(1): 183-196, https://www.webofscience.com/wos/woscc/full-record/WOS:000347743700011.
[37] Miao, Benchun, Ji, Zhenyu, Tan, Li, Taylor, Michael, Zhang, Jianming, Choi, Hwan Geun, Frederick, Dennie T, Kumar, Raj, Wargo, Jennifer A, Flaherty, Keith T, Gray, Nathanael S, Tsao, Hensin. EPHA2 Is a Mediator of Vemurafenib Resistance and a Novel Therapeutic Target in Melanoma. CANCER DISCOVERY[J]. 2015, 第 3 作者5(3): 274-287, https://www.webofscience.com/wos/woscc/full-record/WOS:000352371900024.
[38] Canning, Peter, Tan, Li, Chu, Kiki, Lee, Sam W, Gray, Nathanael S, Bullock, Alex N. Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors. JOURNAL OF MOLECULAR BIOLOGY[J]. 2014, 第 2 作者426(13): 2457-2470, http://dx.doi.org/10.1016/j.jmb.2014.04.014.
[39] Tan, Li, Wang, Jun, Tanizaki, Junko, Huang, Zhifeng, Aref, Amir R, Rusan, Maria, Zhu, SuJie, Zhang, Yiyun, Ercan, Dalia, Liao, Rachel G, Capelletti, Marzia, Zhou, Wenjun, Hur, Wooyoung, Kim, NamDoo, Sim, Taebo, Gaudet, Suzanne, Barbie, David A, Yeh, JingRuey Joanna, Yun, CaiHong, Hammerman, Peter S, Mohammadi, Moosa, Jaenne, Pasi A, Gray, Nathanael S. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 1 作者111(45): E4869-E4877, https://www.webofscience.com/wos/woscc/full-record/WOS:000344526800011.
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（ 1 ） 去泛素化酶USP14的新型小分子抑制剂的研发, 负责人, 国家任务, 2018-01--2021-12
（ 2 ） 神经退行性疾病中细胞死亡机理和干预的研究, 参与, 国家任务, 2016-06--2021-05
（ 3 ） 基于有机砷化合物的新型抗肿瘤靶向药物的研发, 负责人, 地方任务, 2017-07--2019-06
（ 4 ） 新型细胞程序性坏死调控因子与化学干预, 参与, 国家任务, 2019-01--2023-12
（ 5 ） 细胞程序死亡过程中重要蛋白质复合体的动态调 控机制与结构生物学基础, 参与, 地方任务, 2018-12--2021-11
（ 6 ） 新型BACE1抑制剂的研制及其对衰老相关疾病的干预, 负责人, 中国科学院计划, 2020-01--2024-12
（ 7 ） PLpro-RIPK1联合抑制剂对重症新冠肺炎的协同疗效及其机制, 参与, 国家任务, 2022-01--2023-12
（ 8 ） 靶向病毒感染炎症因子风暴的治疗新技术, 负责人, 国家任务, 2023-11--2025-10

（1）Development of Novel Selective and Covalent Inhibitors based on Arylfluorosulfate Warheads   2023中国药物化学学术会议   2024-10-08
（2）新型共价抑制剂的研制与应用   第十二届全国化学生物学学术会议   2023-04-17
（3）Discovery of Novel Organoarsenic Covalent Inhibitors   第十一届全国化学生物学学术会议   2019-11-18
（4）Discovery of Kinase Inhibitors with Novel Inhibitory Mechanisms   2019-10-28
（5）A Shotgun Approach to Inquire Degradable Kinome   2017-10-17