1. The research of isolation, synthesis, and structure-activity relationship of natural products with biologically significant activities;

2. Bioactive constituents and quality standard of the traditional Chinese medicine;

3. Pharmacological mechanisms of natural products towards the new drug discovery.

Dr. Tan (Haibo Tan) received his B.S. from Huazhong University of Science and Technology in 2009 and Ph.D from Peking University in 2014.

Dr. Tan (Haibo Tan)  joined the Chemical Biology of Plant Resources Lab, South China Botanical Garden, Chinese Academy of Sciences as an assistant researcher from 2014 to 2016 and then promoted as an associate professor since 2016.

[1] Liu, H. X.; Zhao, L. Y.; Yuan, Y. F.; Xu, Z. F.; Chen, K.*; Qiu, S. X.*; Tan, H. B.* Potassium thioacids mediated selective amide and peptide constructions enabled by visible light photoredox catalysis. ACS Catal. 2016, 6, 1732-1736. 

[2] Liu, H. X.; Wei, S. S.; Shi, L. L.; Tan, H. B.* Preparation, structural characterization, and bioactivities of polysaccharides from Psidium guajava: A review. Food Chem. 2023, 395, 135423.

[3] Xiao, Y. Y.#; Tan, H. B.#; Huang, H. T.; Yu, J. Z.; Zeng, L. T.; Liao, Y. Y.; Wu, P.; Yang, Z. Y.* Light synergistically promotes the tea green leafhopper infestation-induced accumulation of linalool oxides and their glucosides in tea (Camellia sinensis). Food Chem. 2022, 394, 133460. 

[4] Zheng, A. Q.; Zhou, T. T.; Wang, S. S.; Zhang, W. G.; Lu, X. X.; Chen, H. Y.*; Tan, H. B.*  Total syntheses of hyperaspidinols A and B enabled by a bioinspired diastereoselective cascade sequence. Chin. Chem. Lett. 2022, 33, 885-889. 

[5] Tan, H. B.#; Liu, H. X.#; Zhao, L. Y.; Yuan, Y.; Li, B. L.; Jiang, Y. M.; Gong, L.*; Qiu, S. X.* Structure-activity relationships and optimization of acyclic acylphloroglucinol analogues as novel antimicrobial agents. Eur. J. Med. Chem. 2017, 125, 492-499. 

[6] Chen, Y.; Wang, H.; Ke, X.; Sang, Z. H.; Kuang, M.; Peng, W. W.; Tan, J. B.; Zheng, Y. T.; Zou, Z. X.*; Tan, H. B.*. Five new secondary metabolites from an endophytic fungus Phomopsis sp. SZSJ-7B. Front. Plant Sci. 2022, ASAP. 

[7] Zhang, X.#; Dong, C. M.#; Wu, G. Y.; Huo, L. Q.; Yuan, Y. F.; Hu, Y. J.*; Liu, H. X.*; Tan, H. B.* The biomimetic total syntheses of the antiplasmodial tomentosones A and B. Org. Lett. 2020, 22, 8007-8011. 

[8] Wang, S. S.*; Song, M. M.; Li, X. G.; Huang, Y. H.; Zhao, T. X.; Wei, Z. J.; Lan, Y. Y.; Tan, H. B.* Synthesis of heterobiaryl 4-aryl furans through a base-promoted decarboxylative propargylation/cycloisomerization annulation. Org. Lett. 2020, 22, 8752–8757. 

[9] Huo, L. Q.; Dong, C. M.; Wang, M. M.; Lu, X. X.; Zhang, W. G.; Yang, B.; Yuan, Y. F.; Qiu, S. X.; Liu, H. X.*; Tan, H. B.* Biomimetic total syntheses of sanctis A-B with structure revision. Org. Lett. 2020, 22, 934-938. 

[10] Liu, H. X.#; Tan, H. B.#; Chen, Y. C.; Guo, X. Y.; Wang, W. X.; Guo, H.; Liu, Z. M.; Zhang, W. M.* Cytorhizins A-D, four highly structure-combined benzophenones from the endophytic fungus Cytospora rhizophorae. Org. Lett. 2019, 21, 1063-1067.

[11] Liu, H. X.; Wang, Y.; Guo, X. Y.; Huo, L. Q.; Xu, Z. F.; Zhang, W. M.; Qiu, S. X.; Yang, B.*; Tan, H. B.* A bioinspired cascade sequence enables facile assembly of methanodibenzo[b,f][1,5]dioxocin flavonoid scaffold. Org. Lett. 2018, 20, 546-549. 

[12] Liu, H. X.; Huo, L. Q.; Yang, B.; Yuan, Y. F.; Zhang, W. M.; Xu, Z. F.; Qiu, S. X.*; Tan, H. B.* Biomimetic-inspired syntheses of myrtucommuacetalone and myrtucommulone J. Org. Lett. 2017, 19, 4786-4789.

[13] Tan, H. B.; Liu, H. X.; Chen, X. Z.; Yuan, Y. F.; Chen, K.*; Qiu, S. X.* Concise construction of the tricyclic core of bullataketals enabled by a biomimetic intermolecular (3+3) type cycloaddition. Org. Lett. 2015, 17, 4050-4053. 

[14] Tan, H. B.#; Zheng, C.#; Liu, Z.; Wang, D. Z.* Biomimetic total syntheses of linderaspirone A and bi-linderone and revisions of their biosynthetic pathways. Org. Lett. 2011, 13, 2192-2195.

[15] Liu, H. X.; Dang, Y. Q.; Yuan, Y. F.; Xu, Z. F.; Qiu, S. X.*; Tan, H. B.* Diacyl disulfide: a reagent for chemoselective acylation of phenols enabled by 4-(N,N-dimethylamino)pyridine catalysis. Org. Lett. 2016, 18, 5584-5587.

[16] Zeng, L. T.#; Tan, H. B.#; Liao, Y. Y.; Jian, G. T.; Kang, M.; Dong, F.; Watanabe,  N.; Yang, Z. Y.* Increasing temperature changes flux into multiple biosynthetic pathways for 2-phenylethanol in model systems of tea (Camellia sinensis) and other plants. J. Agr. Food Chem. 2019, 36, 10145-10154. 

[17] Liao, Y. Y.#; Tan, H. B.#; Jian, G. X.; Zhou, X. C.; Huo, L. Q.; Jia, Y. X.; Zeng, L. T.; Yang, Z. Y.* Herbivore-induced (Z)-3-hexen-1-ol is an airborne signal that promotes direct and indirect defenses in tea (Camellia sinensis) under light. J. Agric. Food Chem. 2021, 69, 12608-12620. 

[18] Kang, F. X.#; Lu, X. X.#; Zhang, S.; Chen, D. K.; Kuang, M.; Peng, W. W.; Tan, J. B.; Xu, K. P.; Zou, Z. X.*; Tan, H. B.* Diaportones A-C, three new metabolites from endophytic fungus Diaporthe foeniculina BZM-15. Front. Chem. 2021, 755351.

[19] Lu, X. X.; Zhang, Y. J.; Zhang, W. G.; Wang, H.; Zhang, J.; Wang, S. S.*; Tan, H. B.* Cyclohexanone and phenolic acid derivatives from endophytic fungus Diaporthe foeniculina. Front. Chem. 2021, 738307.

[20] Liu, H. X.; Liu, Z. M.; Zhang, Y. J.; Chen, Y. C.; Wang, H.; Tan, H. B.*; Zhang, W. M.* Antioxidant aryl-substituted phthalan derivatives produced by endophytic fungus Cytospora rhizophorae. Front. Chem. 2022, 10, 826615.

[21] Zheng, A. Q.; Wang, S. S.; Zhou, T. T.; Chen, Y.; Ke, X.; Chen, H. Y.; Tan, H. B.* Bioinspired syntheses of cryptoflavanones C-D, oboflavanones A-B, and cryptoyunnanones G-H enabled by an acid-triggered cascade sequence. Org. Chem. Front. 2022, 9, 2424-2429. 

[22] Shi, L. L.#; Wang, S. S.#; Huo, L. Q.; Gao, M. L.; Zhang, W. G.; Lu, X. X.; Qiu, S. X.; Liu, H. X.*; Tan, H. B.*; Diastereoselective construction of the benzannulated spiroketal core of chaetoquadrins enabled by a regiodivergent cascade. Org. Chem. Front. 2020, 7, 2385-2390. 

[23] Liu, H. X.#; Tan, H. B.#; Wang, W. X.; Zhang, W. G.; Chen, Y. C.; Li, S. N.; Liu, Z. M.; Li, H. H.; Zhang, W. M.* Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae. Org. Chem. Front. 2019, 6, 591-596. 

[24] Shi, L. L.; Liu, H. X.; Huo, L. Q.; Dang, Y. Q.; Wang, Y.; Yang, B.; Qiu, S. X.*; Tan, H. B.* Site-selective phenol acylation mediated by thioacids via visible light photoredox catalysis. Org. Chem. Front. 2018, 5, 1312-1319. 

[25] Wang, M. M.; Zhao, L. Y.; Chen, K.; Shang, Y. X.; Wu, J. F.; Guo, X. Y.; Chen, Y. H.; Liu, H. X.; Tan, H. B.*; Qiu, S. X.* Antibacterial sesquiterpenes from the stems and roots of Thuja sutchuenensis. Bioorg. Chem. 2020, 96, 103645. 

[26] Zhao, L. Y.; Liu, H. X.; Wang, L.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Rhodomyrtosone B, a membrane-targeting anti-MRSA natural acylphloroglucinol from Rhodomyrtus tomentosa. J. Ethnopharm. 2019, 228, 50-57. 

[27] Zhao, L. Y.#; Liu, H. X.#; Huo, L. Q.; Wang, M. M.; Yang, B.; Zhang, W. M.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Structural optimization and antibacterial evaluation of rhodomyrtosone B analogues against MRSA strains. MedChemComm. 2018, 9, 1698-1707. 

[28] Xiang, Y. Q.; Liu, H. X.; Zhao, L. Y.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Callistemenonone A, a novel dearomatic dibenzofuran-type acylphloroglucinol with antimicrobial activity from Callistemon viminalis. Sci. Rep. 2017, 7, 2363. 

[29] Yuan, Y.; Wu, J. W.; Li, B. L.; Niu, J.; Tan, H. B.*, Qiu, S. X.* Regulation of signaling pathways involved in the anti-proliferative and apoptosis-inducing effects of M22 against non-small cell lung Adenocarcinoma A549 cells. Sci. Rep. 2018, 8, 992. 

[30] Gong, L.#; Tan, H. B.#; Chen, F.; Li, T. T.; Zhu, J. Y.; Jian, Q. J.; Yuan, D. B.; Xu, L. X.; Hu, W. Z.; Jiang, Y. M.; Duan, X. W. Novel synthesized 2,4-DAPG analogues: antifungal activity, mechanism and toxicology. Sci. Rep. 2016, 6, 32266. 

[31] Zhang, W. G.; Lu, X. X.; Huo, L. Q.; Zhang, S.; Chen, Y.; Zou, Z. X.*; Tan, H. B.* Sesquiterpenes and steroids from an ewndophytic Eutypella scoparia. J. Nat. Prod. 2021, 84, 1715-1724. 

[32] Zhang, X.; Wu, G. Y.; Huo, L. Q.; Guo, X. Y.; Qiu, S. X.; Liu, H. X.*; Tan, H. B.*; Hu, Y. J.* The first racemic total syntheses of the antiplasmodials watsonianones A and B and corymbone B. J. Nat. Prod. 2020, 83, 3-7. 

[33] Liu, H. X.; Zhang, W. M.; Xu, Z. F.; Chen, Y. C.; Tan, H. B.*; Qiu, S. X.* Isolation, synthesis, and biological activity of tomentosenol A from the leaves of Rhodomyrtus tomentosa. RSC Adv. 2016, 6, 25882-25886. 

[34] Liu, H. X.; Chen, K.; Tang, G. H.; Yuan, Y. F.; Tan, H. B.*; Qiu, S. X.* Isolation and biomimetic total synthesis of tomentodiones A-B, terpenoid-conjugated phloroglucinols from the leaves of Rhodomyrtus tomentosa. RSC Adv. 2016, 6, 48231-48236. 

[35] Zhang, Y. J.#; Liu, H. X.#; Chen, Y. C.; Lu, X. X.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Cyophiobiolins A-D, ophiobolin sestertepenoids from Cytospora rhizophorae. Phytochem. 2022, 195, 113352. 

[36] Liu, H. X.#; Zhang, Y. J.#; Chen, Y. C.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Pyrone and isocoumarin derivatives from the endophytic fungus Cytospora rhizophorae. Org. Biomol. Chem. 2022, 20, 4900-4904. 

[37] Zhou, T. T.; Zheng, A. Q.; Zhang, W. G.; Lu, X. X.; Chen, H. Y.*; Tan, H. B.*; Concise total syntheses of two flavans and structure revision assisted by quantum NMR calculations. Org. Biomol. Chem. 2022, 20, 4096-4100. 

[38] Dong, C. M.#; Peng, W. W.#; Wang, H.; Zhang, X.; Zhang, J.; Tan, G. S.; Xu, K. P.*; Zou, Z. X.*; Tan, H. B.* Total syntheses of melodienones by redox isomerization of propargylic alcohols. Org. Biomol. Chem. 2021, 19, 5077-5081.

[39] Liu, H. X.#; Chen, S. C.#; Zhang, X.; Dong, C. M.; Chen, Y. C.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Isolation, structural elucidation, total synthesis, and cytotoxic activity of effphenol A. Org. Biomol. Chem. 2020, 18, 9035-9038. 

[40] Liu, Z. M.#; Tan, H. B.#; Chen, K.; Chen, Y. C.; Zhang, W. G.; Chen, S. C.; Li, H. H.; Zhang, W. M.* Rhizophols A and B, antioxidant and axially chiral benzophenones from the endophytic fungus: Cytospora rhizophorae. Org. Biomol. Chem. 2019, 17, 10009-10012.

[41] Tan, H. B.*; Liu, H. X.; Chen, X. Z.; Chen, H. Y.; Qiu, S. X.* Racemic total synthesis of dactyloidin and demethyldactyloidin through the DL-proline catalyzed Knoevenagel condensation/[4+2] cycloaddition cascade. Org. Biomol. Chem. 2015, 13, 9977-9983. 

[42] Liu, H. X.; Chen, K.; Yuan, Y.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Rhodomentones A and B, novel meroterpenoids with unique NMR characteristics from Rhodomyrtus tomentosa. Org. Biomol. Chem. 2016, 14, 7354-7360. 

[43] Liu, H. X.#; Tan, H. B.#; Chen, K.; Zhao, L. Y.; Chen, Y. C.; Li, S. N.; Li, H. H.; Zhang, W. M.* Cytosporins A-D, novel benzophenone derivatives from the endophytic fungus Cytospora rhizophorae A761. Org. Biomol. Chem. 2019, 17, 2346-2350.

[44] Wu, G. Y.#; Zhang, X.#; Guo, X. Y.; Huo, L. Q.; Liu, H. X.; Shen, X. L.; Qiu, S. X.; Hu, Y. J.*; Tan, H. B.* Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan. Chin. J. Nat. Med. 2019, 5, 381-386. 

[45] Zhang, Y. J.#; Liu, H. X.#; Chen, Y. C.; Liu, Z. M.; Qiu, K. D.; Wei, S. S.; Zhang, W. M.*; Tan, H. B.* Alkyl aromatic derivatives from the endophytic fungus Cytospora rhizophorae. J. Antibiot. 2023, asap. 

[46] Tan, H. B.*; Chen, X. Z.; Chen, H. Y.; Liu, H. X.; Qiu, S. X.* Proline-catalyzed Knoevenagel condensation/[4+2] cycloaddition cascade reaction: application to formal synthesis of averufin. Eur. J. Org. Chem. 2015, 22, 4956-4963. 

[47] Zhang, Y. J.#; Liu, H. X.#; Chen, Y. C.; Wei, S. S.; Zhang, W. M.*; Tan, H. B.* Cytospones E-J from the endophytic fungus Cytospora rhizophorae. Fitoterapia 2022, 163, 105324. 

[48] Liu, H. X.#; Chen, Y. C.#; Li, S. N.; Zhang, W. G.; Liu, Z. M.; Tan, H. B.*; Zhang, W. M.* Trichothecene macrolides from the endophytic fungus Paramyrothecium roridum and their cytotoxic activity. Fitoterapia 2020, 147, 104768. 

[49] Zhang, W. G., Wang, M. M.; Zhang, S.; Xu, K. P.; Tan, G. S.; Qiu, S. X.; Zou, Z. Z.*; Tan, H. B.* Eutyscoparols A-G, polyketide derivatives from endophytic fungus Eutypella scoparia SCBG-8. Fitoterapia 2020, 146, 104681. 

[50] Li, Y.; Qin, X. B.; Liu, H. X.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Two pairs of enantiomeric propylated flavonoids and a new lignan from the aerial parts of Abrus precatorius. Fitoterapia 2019, 133, 125-129. 

[51] Liu, H. X.#; Tan, H. B.#; Chen, K.; Chen, Y. C.; Li, S. N.; Li, H. H.; Zhang, W. M.* Cerrenins A-C, cerapicane and isohirsutane sesquiterpenoids from the endophytic fungus Cerrena sp. Fitoterapia 2018, 129, 173-178. 

[52] Zou, Z. X.; Tan, G. S.; Huang, Q.; Sun, H. H.; Huo, L. Q.; Zhong, W. Q.; Zhao, L. Y.; Liu, H. X.*; Tan, H. B.* Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative from Leptospermum brachyandrum. Fitoterapia 2018, 130, 184-189. 

[53] Li, C.; Liu, H. X.; Zhao, L. Y.; Zhang, W. M.; Qiu, S. X.; Yang, X. Y.*; Tan, H. B.* Antibacterial neolignans from the leaves of Melaleuca bracteata. Fitoterapia 2017, 120, 171-176. 

[54] Liu, H. X.#; Tan, H. B.#; Liu, Y.; Chen, Y. C.; Li, S. N.; Sun, Z. H.; Li, H. H.; Qiu, S. X.; Zhang, W. M.* Three new highly-oxygenated metabolites from the endophytic fungus Cytospora rhizophorae A761. Fitoterapia 2017, 117, 1-5. 

[55] Liu, H. X.; Chen, K.; Liu, Y.; Li, C.; Wu, J. W.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.* Callviminols A-E, new terpenoid-conjugated phloroglucinols from the leaves of Callistemon viminalis. Fitoterapia 2016, 115, 142-147. 

[56] Liu, H. X.; Chen, Y. C.; Liu, Y.; Zhang, W. M.; Wu, J. W.; Tan, H. B.*; Qiu, S. X.* Acylphloroglucinols from the fruits leaves of Callistemon viminalis. Fitoterapia 2016, 114, 40-44.

[57] Guo, X. Y.; Wang, M. M.; Wu, J. F.; Wu, G. Y.; Zhang, X.; Huo, L. Q.; Liu, H. X.; Chen, Y. H.; Xie, G. W.*; Tan, H. B.*; Qiu, S. X.* Chemical constituents of the trunks and roots of Thuja sutchuenensis. Fitoterapia 2019, 134, 264-269.

[58] Wang, H.; Sang, Z. H.; Chen, Y.; Wei, S. S.; Qiu, K. D.; Liu, Z. Y.; Zhang, J.*; Tan, H. B.* The chemical constituents of endophytic fungus Nigrospora chinensis of Gannan navel orange. Nat. Prod. Res. 2022, 36, ASAP. 

[59] Peng, W. W.; Kuang, M.; Huang, Y. T.; Li, M. F.; Zheng, Y. T.; Xu, L.; Tan, J. B.; Kang, F. H.; Tan, H. B.*; Zou, Z. X.* Pseudocercones A-C, three new polyketide derivatives from the endophytic fungus Pseudocercospora sp. TSS-1. Nat. Prod. Res. 2022, ASAP, https://doi.org/10.1080/14786419.2022.2138874.

[60] Yu, Z. H.#; Lu, X. X.#; Choi, J.; Deng, S. L.; Xiong, B. H.; Zhang, W. G.; Wang, H.; Wang, S. S.*; Tan, H. B.* 2-Pyrones from endophytic fungus Diaporthe foeniculina BZM-15. Nat. Prod. Res. 2022, 36, 4853-4861. 

[61] Wu, G. Y.; Zhu, Z. Y.; Zhang, X.; Wang, M. M.; Li, J. X.; Hu, Y. J.*; Tan, H. B.* Chemical constituents from the Streptomyces morookaensis strain Sm4-1986. Nat. Prod. Res. 2022, 36, 3681-3688. 

[62] Wang, M. M.; Huo, L. Q.; Liu, H. X.; Zhao, L. Y.; Xu, Z. F.; Tan, H. B.*; Qiu, S. X.*  Thujasutchins N-O, two new compounds from the stems and roots of Thuja sutchuenensis. Nat. Prod. Res. 2022, 36, 2356-2362. 

[63] Zhang, Q.; Liu, H. X.; Tan, H. B.*; Qiu, S. X.* Novel highly oxygenated and rare B-ring-seco-ent-diterpene glucosides from the seeds of Prinsepia utilis. Tetrahedron 2015, 71, 9415-9419.

[64] Liu, H. X.#; Tan, H. B.#; He, M. T.; Li, L.; Wang, Y. H.*; Long, C. L.* Isolation and synthesis of two hydroxychavicol heterodimers from Piper nudibaccatum. Tetrahedron 2015, 71, 2369-2375. 

[65] Tan, H. B.; Chen, X. Z.; Liu, Z.; Wang, D. Z.* Total synthesis of angelone enabled by a remarkable biomimetic sequence. Tetrahedron 2012, 68, 3952-3955.

[66] Zhang, W. G.; Lu, X. X.; Wang, H.; Chen, Y.; Zhang, J.; Zou, Z. X.*; Tan, H. B.* Antibacterial secondary metabolites from the endophytic fungus Eutypella scoparia SCBG-8. Tetrahedron Lett. 2021, 153314.

[67] Li, C. C.; Chang, X. Y.; Huo, L. Q.; Tan, H. B.; Xing, X. Y.*; Xu, C.* Hydration of cyanohydrins by highly active cationic Pt catalysts: mechanism and scope. ACS Catal. 2021, 11, 8716-8726. 

[68] Chen, S. S.#; Liu, H. X.#; Li, S. N.; Chen, Y. C.; Ye, W.; Li, H. H.; Tan, H. B.; Li, D. L.; Liu, Z. M.*; Zhang, W. M.* Hawanoids A-E, unprecedented diterpenoids with PAF-induced platelet aggregation inhibitory activities from the deep-sea-derived fungus Paraconiothyrium hawaiiense. Chin. Chem. Lett. 2022, 34, 107513.

[69] Xu, J. L.; Tan, H. B.; Chen, Y. C.; Li, S. N.; Huang, Z. L.; Li, H. H.; Gao, X. X.; Liu, H. X.*; Zhang, W. M.* Lithocarpinols A and B, a pair of diastereomeric antineoplastic tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508. Chin. Chem. Lett. 2019, 30, 439-442.

[70] Chen, S. C.; Liu, Z. M.; Chen, Y. C.; Tan, H. B.; Li, S. N.; Liu, H. X.*; Zhang, W. M.* and Zhu, S.* Highly substituted phenol derivatives with nitric oxide inhibitory activities from the deep-sea-derived fungus Trichobotrys effuse FS524. Mar. Drugs 2020, 18, 134. 

[71] Chen, S. C.; Liu, Z. M.; Tan, H. B.; Chen, Y. C.; Li, S. N.; Li, H. H.; Guo, H.; Zhu, S.; Liu, H. X.*; Zhang, W. M.* Tersones A-G, new pyridone alkaloids from the deep-sea fungus phomopsis tersa. Mar. Drugs 2019, 17, 394. 

[72] Guo, H.; Liu, Z. M.; Chen, Y. C.; Tan, H. B.; Li, S. N.; Li, H. H.; Gao, X. X.*; Liu, H. X.*; Zhang, W. M.* Chromone-derived polyketides from the deep-sea fungus Diaporthe phaseolorum FS431. Mar. Drugs 2019, 17, 182.

[73] Xu, J. L.#; Liu, H. X.#; Chen, Y. C.; Tan, H. B.; Guo, H.; Xu, L. Q.; Li, S. N.; Huang, Z. L.; Li, H. H.; Gao, X. X.*; Zhang, W. M.* Highly substituted benzophenone aldehydes and eremophilane derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508. Mar. Drugs 2018, 16, 329.

[74] Li, J.; Zhang, J.; Tan, H. B.; Wang, D. Z.* Visible-light-promoted vinylation of tetrahydrofuran with alkynes through direct C-H bond functionalization. Org. Lett. 2015, 17, 2522-2525.

[75] Zhou, T. T.; Zheng, A. Q.; Huo, L. Q.; Li, C. G.; Tan, H. B.; Wang, S. S.; Chen, H. Y. Total syntheses of ericifolione and its analogues via a biomimetic inverse-electron-demand Diels-Alder reaction. Chem. Commun. 2022, 58, 270-273.

[76] Yin, C. X.#; Liu, H. X.#; Shan, Y.; Guptad, V. K.*; Jiang, Y. M.; Zhang, W. M.*; Tan, H. B; Gong, L.* Cytosporone B as a biological preservative: purification, fungicidal activity and mechanism of action against Geotrichum citriaurantii. Biomolecules 2019, 9, 125.

[77] Zeng, L. T.; Wang, X. Q.; Tan, H. B.; Liao, Y. Y.; Xu, P.; Kang, M.; Dong, F.; Yang, Z. Y.* Alternative pathway to the formation of trans-cinnamic acid derived from l-phenylalanine in tea (Camellia sinensis) plants and other plants. J. Agr. Food Chem. 2020, 68, 3415-3414.

[78] Liao, Y. Y.; Zeng, L. T.; Tan, H. B.; Cheng, S. H.; Dong, F.; Yang, Z. Y.* Biochemical pathway of benzyl nitrile derived from l-phenylalanine in tea (Camellia sinensis) and its formation in response to postharvest stresses. J. Agr. Food Chem. 2020, 68, 1397-1404.

[79] Xu, J. L.; Tan, H. B.; Chen, Y. C.; Li, S. N.; Huang, Z. L.; Guo, H.; Gao, X. X.; Liu, H. X.*; Zhang, W. M.* Lithocarpins A-D, four tenellone-macrolide conjugated [4+2] hetero-adducts from the deep-sea derived fungus Phomopsis lithocarpus FS508. Org. Chem. Front. 2018, 5, 1792-1797.

[80] Chen, S. C.; Liu, Z. M.; Tan, H. B.; Chen, Y. C.; Li, S. N.; Li, H. H.; Zhu, S.; Liu, H. X.*; Zhang, W. M.* Potent cytotoxic meroterpenoids with diverse skeletons from the deep-sea derived fungus Phomopsis tersa FS441. Org. Chem. Front. 2020, 7, 557-562. 

[81] Xu, J. L.#; Liu, Z. M.; Chen, Y. C.; Tan, H. B.; Li, H. H.; Li, S. N.; Guo, H.; Huang, Z. L.; Gao, X. X.*; Liu, H. X.*; Zhang, W. M.* Lithocarols A-F, six tenellone derivatives from the deep-sea derived fungus Phomopsis lithocarpus FS508. Bioorg. Chem. 2019, 87, 728-735.

[82] Song, J. L.; Yuan, Y.; Tan, H. B.; Wu, J. W.; Huang, R. M.; Li, H.; Xu, Z. F.; Na, N.*; Qiu, S. X.* Euryachins A and B, a new type of diterpenoids from Eurya chinensis with potent NO production inhibitory activity. RSC Adv. 2016, 6, 85958-85961.

[83] Wang, X. B.; Zhang, Y. B.; Tan, H. B.; Wang, Y. C.; Han, P.; Wang, D. Z.* Enantioselective organocatalytic Mannich reactions with autocatalysts and their mimics. J. Org. Chem. 2010, 75, 2403-2406.

[84] Hu, J. H.; Zhang, W. G.; Tan, H. B. Li, S. N.; Gao, X. X.; Liu, Z. M.; Wang, Y. L.; Liu, H. X.*; Zhang, W. M.* Neocucurbins A-G, novel macrocyclic diterpenes and their derivatives from Neocucurbitaria unguis-hominis FS685. Org. Biomol. Chem. 2022, ASAP.

[85] Liu, H. B.; Liu, Z. M.; Li, H. H.; Tan, H. B.; Zhang, Q. B.; Li, D. L.; Liu, H. X.*; Zhang, W. M.* Lithocaldehydes A and B, polyketones from the deep sea-derived fungus Phomopsis lithocarpus FS508. Org. Biomol. Chem. 2020, 18, 7326-7329.

[86] Chen, S. C.; Liu, Z. M.; Tan, H. B.; Chen, Y. C.; Zhu, S.; Liu, H. X.*; Zhang, W. M.*  Photeroids A and B, unique phenol-sesquiterpene meroterpenoids from the deep-sea-derived fungus Phomopsis tersa. Org. Biomol. Chem. 2020, 18, 642-645.

[87] Liu, H. B.; Liu, Z. M.; Chen, Y. C.; Tan, H. B.; Li, S. N.; Li, D. L.; Liu, H. X.*; Zhang, W. M.* Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus. Chin. J. Nat. Med. 2021, 19, 874-880. 

[88] Liu, H. B.; Chen, Y. C.; Li, H. H.; Li, S. N. Tan, H. B.; Liu, Z. M.; Li, D. L.; Liu, H. X.*; Zhang, W. M.* Four new metabolites from the endophytic fungus Diaporthe lithocarpus A740. Fitoterapia 2019, 137, 104260.

[89] Zhang, J. Y.; Liang, Y.; He, L.; Kaliaperumal, K.; Tan, H. B.; Jiang, Y. M.; Zhong, B. L.; Zhang, J.* Effects of storage time and temperature on the chemical composition and organoleptic quality of Gannan navel orange (Citrus sinensis Osbeck cv. Newhall). J. Food Meas. Charact. 2022, 16, 935-944.

[90] Liu, H. X.; Tan, H. B.; Chen, Y. C.; Li, S. N.; Li, H. H.; Zhang, W. M.* Cytotoxic triquinane-type sesquiterpenoids from the endophytic fungus Cerrena sp. A593. Nat. Prod. Res. 2020, 34, 2430-2436.

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[93] Chen, S. C.; Liu, Z. M.; Chen, Y. C.; Tan, H. B.; Liu, H. X.*; Zhang, W. M.* Tersaphilones A-E, cytotoxic chlorinated azaphilones from the deep-sea-derived fungus Phomopsis tersa FS441. Tetrahedron 2021, 76, 131806.

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[96] Liu, H. X.; He, M. T.; Tan, H. B.; Gu, W.; Yang, S. X.; Wang, Y. H.; Li, L.; Long, C. L. Xanthine oxidase inhibitors isolated from Piper nudibaccatum. Phytochem. Lett. 2015, 12, 133-137.

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[101] Song, J. L.; Yuan, Y.; Tan, H. B.; Huang, R. M.; Liu, H. X.; Xu, Z. F.; Qiu, S. X.* Anti-inflammatory and antimicrobial coumarins from the stems of Eurya chinensis. J. Asian Nat. Prod. Res. 2017, 19, 222-228.

1. Natural product chemistry,

2. Total synthesis,

3. Pharmacological mechanisms,

4. Drug discovery.

已指导学生

陆秀响  硕士研究生  071010-生物化学与分子生物学  

张文歌  硕士研究生  085238-生物工程  

霍璐琼  硕士研究生  085238-生物工程  

张艳江  硕士研究生  071010-生物化学与分子生物学  

现指导学生

韦珊珊  硕士研究生  071010-生物化学与分子生物学  

邱凯笛  硕士研究生  086000-生物与医药  

赖佳潆  硕士研究生  086000-生物与医药