电子邮件: chtan@simm.ac.cn
通信地址: 上海市浦东新区张江高科技园祖冲之路555号
邮政编码: 201203
研究领域
教育背景
工作经历
2009-09~现在, 中国科学院上海药物研究所, 研究员
2005-09~2009-09,中国科学院上海药物研究所, 副研究员
2001-07~2005-08,中国科学院上海药物研究所, 助理研究员
1993-07~1996-08,南昌大学, 助教
教授课程
专利与奖励
1) 谭昌恒,曲世津,高明垚,李牧,谭俊杰,骆宏丰。一种防治酒精性肝损伤的中药复方制剂及其制备方法和用途(申请日2021-03-24,授权日2023-04-18). 202110315877.X,CN115120634B
2) 谭昌恒,李杨,曲世津,郭飞,马玉琴.一类多巴胺D5受体激动剂及其制备和应用. (申请日2018-01-17,授权日2022-07-29),ZL201810044844.4,CN110041318B。
3) 肖凯,谭昌恒,孙铭学,朱大元,赵杰,谭俊杰,孟文琪,杨玉彦,裴志鹏,冯雍炜,桂莉,王毅欣. ZT-1在制备预防沙林中毒药物中的应用(申请日2016-05-12,授权日2020-07-10);ZL201618001687.0(密)
4) 朱大元,左建平,谭昌恒,曲世津,段文虎,王桂凤,孙长海,姚小青. 苯并杂环类化合物及其制备方法和用途. ZL201310423211.1,授权日2016.3.30。
5) 余龙,谭昌恒,刘祖龙,朱恒锐,曲世津,朱大元,唐丽莎,(E)-氮-(4-肉桂酰胺丁基)苯甲酰胺在制备抗肿瘤药物中的应用,CN201210142558.4,授权日2015.08.19。
6) 谭昌恒,谭俊杰,朱大元,胡宗江,黑果枸杞果实提取物及制备方法和应用ZL201310274771.5,授权日2014.12.10。
7) 朱大元,左建平,谭昌恒,曲世津,段文虎,王桂凤,孙长海,姚小青,苯并杂环类化合物及其制备方法和用途,ZL201310423211.1,授权日2013.10.09。
8) 凌益平,朱大元,谭昌恒,谭俊杰,刘武,徐兵勇,骆雅琴,孙媛媛,张晓丽,参麦注射液有效成分测定方法,ZL201010157578.X,授权日2012.09.26。
9) 凌益平,朱大元,谭昌恒,谭俊杰,刘武,骆雅琴,孙媛媛,张晓丽,潘迎锋,一种参麦注射液的质量控制方法,ZL200910155685.6,授权日2012.02.01。
10) 朱大元,黎豫杭,许正宇,箫耀龙,李云森,谭昌恒,蒋福祥,柯嘉敏,文英强,张善飞,柴建国,参麦注射液的化学成分的制备及其在治疗心脑血管疾病中的应用,ZL200710187422.4,授权日2009.01.21。
出版信息
[1] Wang, AiZhu, Han, Hua, Fang, QiangQiang, Tan, ChangHeng. Structurally diverse polycyclic polyprenylated acylphloroglucinols with protective effect on human vein endothelial cells injured by high-glucose from Hypericum acmosepalum N. Robson. PHYTOCHEMISTRY[J]. 2023, 205:113482.
[2] Jin Peng, Kun Jiang, Xiao Sun, Lingzhi Wu, Jiewei Wang, Xiaomei Xi, Xu Tan, Tingbo Liang, Changheng Tan, Pumin Zhang. Identification of a class of potent USP25/28 inhibitors with broad spectrum of anti-tumor activity. Signal Transduction and Targeted Therapy[J]. 2022, 7: 393.
[3] Wang, AiZhu, Fang, QiangQiang, Feng, TongTong, Wei, RenJie, Jiang, Kun, Lu, Qun, Tan, ChangHeng. Acmoxanthones A-E, New Lavandulated Xanthones from Hypericum acmosepalum N. Robson. FITOTERAPIA[J]. 2021, 154: 104923.
[4] Fang, QiangQiang, Feng, TongTong, Wang, AiZhu, He, WanYing, Wei, RenJie, Lu, Qun, Tan, ChangHeng. Structurally diverse polyprenylated acylphloroglucinols from Hypericum uralum Buch.-Ham. ex D. Don. PHYTOCHEMISTRY[J]. 2021, 187: 112771.
[5] Wang, XiaoFeng, Zhu, Zhengdan, Hao, TingTing, Fang, QiangQiang, Jiang, Kun, Qu, ShiJin, Zuo, JiangPin, Zhu, Weiliang, He, ShiJun, Tan, ChangHeng. Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides. BIOORGANIC CHEMISTRY[J]. 2020, 99:103812.
[6] Pan, RuiYuan, Ma, Jun, Kong, XiangXi, Wang, XiaoFeng, Li, ShuoShuo, Qi, XiaoLong, Yan, YuHan, Cheng, Jinbo, Liu, Qingsong, Jin, Wanzhu, Tan, ChangHeng, Yuan, Zengqiang. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance. SCIENCE ADVANCES[J]. 2019, 5(2): eaau6328.
[7] Wang, WanPing, Jiang, Kun, Zhang, Ping, Shen, KaiKai, Qu, ShiJin, Yu, XiaoPing, Tan, ChangHeng. Highly oxygenated and structurally diverse diterpenoids from &ITEuphorbia helioscopia&IT. PHYTOCHEMISTRY[J]. 2018, 145: 93-102.
[8] Liu, Zulong, Zhu, Hengrui, Qu, Shijin, Tang, Lisha, Cao, Lihuan, Yu, Wenbo, Yang, Xianmei, Jiang, Songmin, Zhu, Dayuan, Tan, Changheng, Yu, Long. Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY[J]. 2018, 18(2): 286-294.
[9] Ma, Yaqian, Liu, Menghan, Tan, Ting, Yan, Aiping, Guo, Lan, Jiang, Kun, Tan, Changheng, Wan, Yiqun. Deep eutectic solvents used as extraction solvent for the determination of flavonoids from Camellia oleifera flowers by high-performance liquid chromatography. PHYTOCHEMICAL ANALYSIS[J]. 2018, 29(6): 639-648.
[10] Zhai, YiMing, Jiang, Kun, Qu, ShiJin, Luo, HongFeng, Tan, JunJie, Tan, ChangHeng. Structurally diverse stilbene dimers from Gnetum montanum Markgr.: studies on the H-1 chemical shift differences between dimeric stilbene epimers correlating to the relative configurations. RSC ADVANCES[J]. 2016, 6(55): 50083-50090.
发表著作
合作情况
上海苦草科技有限公司-崇明苦草产品的研究开发
青海启正投资有限公司-黑果枸杞的药用开发研究
正大青春宝药业有限公司-参麦注射液的安全型再评价;
天津红日药业有限公司-抗丙肝药物的研究与开发;
湖南本草药业有限公司-石杉碱甲的资源的替代、原料药及新剂型开发;