基本信息

谭昌恒 男 硕导 中国科学院上海药物研究所
电子邮件: chtan@simm.ac.cn
通信地址: 上海市浦东新区张江高科技园祖冲之路555号
邮政编码: 201203
电子邮件: chtan@simm.ac.cn
通信地址: 上海市浦东新区张江高科技园祖冲之路555号
邮政编码: 201203
研究领域
从事药学基础研究和创新药物研发,主要包括中草药、民间药和其他天然产物的活性物质基础研究,以及天然活性成分的结构优化研究。
招生信息
招生专业
100701-药物化学070303-有机化学100800-中药学
招生方向
天然药物化学食品化学中药化学
教育背景
1996-08--2001-07 中国科学院上海药物研究所 博士1989-09--1993-07 南昌大学 学士
学历
中国科学院上海药物研究所 -- 研究生
学位
中国科学院上海药物研究所 -- 博士
工作经历
工作简历
2009-09~现在, 中国科学院上海药物研究所, 研究员2005-09~2005-09,中国科学院上海药物研究所, 副研究员2001-07~2005-08,中国科学院上海药物研究所, 助理研究员1993-07~1996-08,南昌大学, 助教
教授课程
有机化合物波谱解析有机结构分析
专利与奖励
专利成果
( 1 ) 一种龙脑苷在控制参麦注射液质量时的用途, 发明, 2012, 第 3 作者, 专利号: 200910155685.6( 2 ) 苯并杂环类化合物及其制备方法和用途, 发明, 2013, 第 5 作者, 专利号: 201010149856.7( 3 ) 参麦注射液的化学成分的制备及其在治疗心脑血管疾病中的应用, 发明, 2009, 第 5 作者, 专利号: 200710187422.4( 4 ) 参麦注射液有效成分测定方法, 发明, 2012, 第 3 作者, 专利号: 201010157578.X( 5 ) 苯并杂环类化合物及其制备方法和用途, 发明, 2016, 第 3 作者, 专利号: 201310423211.1( 6 ) (E)-氮-(4-肉桂酰胺丁基)苯甲酰胺在制备抗肿瘤药物中的应用, 发明, 2015, 第 2 作者, 专利号: 201210142558.4( 7 ) 黑果枸杞果实提取物及制备方法和应用, 发明, 2014, 第 1 作者, 专利号: 201310274771.5( 8 ) 黑果枸杞果实提取物在制药中的应用, 发明, 2016, 第 1 作者, 专利号: 201410058204.0
出版信息
发表论文
[1] Liu, QuanWen, Chen, CaiHua, Wang, XiaoFeng, Jiang, Kun, Qu, ShiJin, Dai, YiRu, Tan, ChangHeng. Triterpenoids, megastigmanes and hydroxycinnamic acid derivatives from Anisomeles indica. NATURAL PRODUCT RESEARCH[J]. 2019, 33(1): 41-46, http://www.corc.org.cn/handle/1471x/2165157.[2] Wang WanPing, Jiang Kun, Zhang Ping, Shen KaiKai, Qu ShiJin, Yu XiaoPing, Tan ChangHeng. Highly oxygenated and structurally diverse diterpenoids from Euphorbia helioscopia. Phytochemistry[J]. 2018, [3] Liu, Zulong, Zhu, Hengrui, Qu, Shijin, Tang, Lisha, Cao, Lihuan, Yu, Wenbo, Yang, Xianmei, Jiang, Songmin, Zhu, Dayuan, Tan, Changheng, Yu, Long. Pyramidatine (Z88) Sensitizes Vincristine-Resistant Human Oral Cancer (KB/VCR) Cells to Chemotherapeutic Agents by Inhibition of P-glycoprotein. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY[J]. 2018, 18(2): 286-294, https://www.webofscience.com/wos/woscc/full-record/WOS:000430724600012.[4] Ma, YaQian, Jiang, Kun, Deng, Yi, Guo, Lan, Wan, YiQun, Tan, ChangHeng. Mexicanolide-type limonoids from the seeds of Swietenia macrophylla. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2018, 20(4): 299-305, https://www.webofscience.com/wos/woscc/full-record/WOS:000435527900001.[5] Ma YaQian, Zhai YiMing, Deng Yi, Guo Lan, Wan YiQun, Tan ChangHeng. Stilbeno-phenylpropanoids from Gnetum montanum Markgr.. Phytochemistry Letters[J]. 2017, [6] Deng, Yi, Jiang, Kun, Cai, MaoJun, Qu, ShiJin, Dai, YiRu, Tan, ChangHeng. The synthesis of dendroflorin. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2017, 19(6): 602-609, https://www.webofscience.com/wos/woscc/full-record/WOS:000401984100009.[7] Chang-Heng Tan. Structurally diverse stilbene dimers from Gnetum montanum Markgr.: studies on the 1H chemical shift differences between dimeric stilbene epimers correlating to the relative configurations.. RSC Advances. 2016, [8] 谭昌恒. 天然来源的乙型和丙型肝炎病毒抑制剂的研究进展. 药学进展. 2016, [9] Zhang, Chao, Jiang, Kun, Qu, ShiJin, Zhai, YiMing, Tan, JunJie, Tan, ChangHeng. Triterpenoids from the barks of Terminalia chebula. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2015, 17(10): 996-1001, https://www.webofscience.com/wos/woscc/full-record/WOS:000363659800006.[10] Chang-Heng Tan. noids and their glycosides from Gynuraprocumbens. Helvetica Chimica Acta. 2014, [11] Chang-Heng Tan. hree New 24-Nortriterpenoids from the roots of Ilex asprella.. Helvetica Chimica Acta. 2014, [12] Qiu, YiHua, Yang, YanFang, Tan, JunMing, Tan, ChangHeng, Chang, Jun. Laggeric acid, a novel seco-eudesmane sesquiterpenoid from Laggera crispata. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2014, 16(3): 318-322, https://www.webofscience.com/wos/woscc/full-record/WOS:000329899200015.[13] Feng, TianXiang, Qu, ShiJin, Tan, JunJie, Jiang, Kun, Tan, ChangHeng, Lin, ShuangJun. The resolution of aglinin A epimers and their NMR assignments. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2013, 15(1): 89-93, https://www.webofscience.com/wos/woscc/full-record/WOS:000314452400014.[14] Bai, JunQi, Jiang, Kun, Tan, JunJie, Qiu, XiaoHui, Tan, ChangHeng, Chang, Jun, Zhu, DaYuan. Chemical constituents from Chonemorpha griffithii. BIOCHEMICAL SYSTEMATICS AND ECOLOGY[J]. 2013, 51: 171-174, http://dx.doi.org/10.1016/j.bse.2013.08.025.[15] Yang, LiJun, Jiang, Kun, Tan, JunJie, Qu, ShiJin, Luo, HongFeng, Tan, ChangHeng, Zhu, DaYuan. Prenylated Benzene Metabolites from Melicope pteleifolia. HELVETICA CHIMICA ACTA[J]. 2013, 96(1): 119-123, http://dx.doi.org/10.1002/hlca.201200211.[16] Qu, ShiJin, Tan, JunJie, Cai, JianGuo, Ling, YiPing, Zhang, ShanFei, Tan, ChangHeng, Zhu, DaYuan. Minor dammarane saponins from the hongshen extract of Shenmai injection. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2011, 13(2): 178-181, http://dx.doi.org/10.1080/10286020.2010.545055.[17] Fan, QiuLing, Tan, ChangHeng, Liu, Jing, Zhao, MingMing, Han, FuSen, Zhu, DaYuan. Iridoid glycosides and glycosidic constituents from Eriophyton wallichii Benth. PHYTOCHEMISTRY[J]. 2011, 72(14-15): 1927-1932, http://dx.doi.org/10.1016/j.phytochem.2011.04.019.[18] Qu, ShiJin, Tan, ChangHeng, Liu, ZuLong, Jiang, ShanHao, Yu, Long, Zhu, DaYuan. Diterpenoid alkaloids from Aconitum tanguticum. PHYTOCHEMISTRY LETTERS[J]. 2011, 4(2): 144-146, http://dx.doi.org/10.1016/j.phytol.2011.02.003.[19] Fu, WenWei, Tan, ChangHeng, Zhuang, PengYu, Yang, ShuMin, Luo, HongFeng, Tan, JunJie, Liu, Ping, Zhu, DaYuan. PURINIUM DERIVATIVES WITH ANTITUMOR ACTIVITIES FROM HETEROSTEMMA ALATUM WIGHT. HETEROCYCLES[J]. 2011, 83(6): 1405-1408, http://www.corc.org.cn/handle/1471x/2302069.[20] Qu, ShiJin, Wang, GuiFeng, Duan, WenHu, Yao, ShanYan, Zuo, JianPing, Tan, ChangHeng, Zhu, DaYuan. Tryptamine derivatives as novel non-nucleosidic inhibitors against hepatitis B virus. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2011, 19(10): 3120-3127, http://dx.doi.org/10.1016/j.bmc.2011.04.004.[21] Tan, XingQi, Guo, LiangJun, Qiu, YiHua, Chen, HaiSheng, Tan, ChangHeng. Chemical constituents of Trachelospermum jasminoides. NATURAL PRODUCT RESEARCH[J]. 2010, 24(13): 1248-1252, https://www.webofscience.com/wos/woscc/full-record/WOS:000280057100007.[22] Lan, MingSheng, Ma, JianXiong, Tan, Chang Heng, Wei, Song, Zhu, DaYuan. Chemical Constituents of Phyllanthus reticulatus. HELVETICA CHIMICA ACTA[J]. 2010, 93(11): 2276-2280, http://dx.doi.org/10.1002/hlca.201000168.[23] Zhang, Yang, Tan, ChangHeng, Tan, JunJie, Yang, PeiMing, Jiang, ShanHao, Ni, Xiang, Zhu, DaYuan. Glycosidic Constituents of Celastrus orbiculatus. HELVETICA CHIMICA ACTA[J]. 2010, 93(7): 1407-1412, https://www.webofscience.com/wos/woscc/full-record/WOS:000280724700019.[24] Zhang, Ling, Zhang, JianHui, Yang, ShuMing, Tan, ChangHeng, Luo, HongFeng, Zhu, DaYuan. Chemical constituents from the leaves of Aglaia perviridis. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2010, 12(3): 215-219, http://www.corc.org.cn/handle/1471x/2316579.[25] Yang, YanFang, Qu, ShiJin, Xiao, Kai, Jiang, ShanHao, Tan, JunJie, Tan, ChangHeng, Zhu, DaYuan. Lycopodium alkaloids from Huperzia serrata. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2010, 12(11): 1005-1009, http://dx.doi.org/10.1080/10286020.2010.522180.[26] Zou, Yanping, Tan, Changheng, Wang, Baode, Jiang, Shanhao, Zhu, Dayuan. PHENOLIC COMPOUNDS FROM Ranunculus chinensis. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2010, 46(1): 19-21, https://www.webofscience.com/wos/woscc/full-record/WOS:000278574600006.[27] Zou, Yanping, Tan, Changheng, Zhu, Dayuan. A New Acetylated Flavonoid Glycoside from Myrsine africana L. BULLETIN OF THE KOREAN CHEMICAL SOCIETY[J]. 2009, 30(9): 2111-2113, [28] Wang, HengBin, Tan, ChangHeng, Tan, JunJie, Qu, ShiJin, Chen, YiLei, Li, YiMing, Jiang, ShanHao, Zhu, DaYuan. Two new N-oxide Lycopodium alkaloids from Huperzia serrata. NATURAL PRODUCT RESEARCH[J]. 2009, 23(15): 1363-1366, https://www.webofscience.com/wos/woscc/full-record/WOS:000270545800001.[29] Chen, YiLei, Tan, ChangHeng, Tan, JunJie, Zhao, XueMei, Jiang, ShanHao, zhu, DaYuan. Two New Diterpenoid Glucosides from Clerodendrathus spicatus. HELVETICA CHIMICA ACTA[J]. 2009, 92(12): 2802-2807, http://ir.simm.ac.cn/handle/153631/1323.
发表著作
(1) 天然活性产物药物化学, Medicinal Chemistry of Bioactive Natural Products, Wiley, 2006-03, 第 2 作者(2) 生物碱化学, Alkaloids, 化学工业出版社, 2008-02, 第 2 作者
科研活动
科研项目
( 1 ) 神经性毒剂预防药物ZT-1的临床前研究, 主持, 国家级, 2008-01--2010-12( 2 ) 非核苷类抗乙肝病毒天然活性化合物的构效关系研究, 主持, 国家级, 2011-01--2013-12( 3 ) 甘草和蛇足石杉珍稀药用植物人工替代品规模化生产关键技术, 主持, 国家级, 2007-10--2010-09( 4 ) 参麦注射液活性物质的作用机理及其质量标准的研究, 主持, 国家级, 2006-10--2009-09( 5 ) 民间草药猫须草和白枪杆抗痛风化学成分及其构效关系研究, 主持, 国家级, 2007-01--2009-12( 6 ) 靶向多巴胺D5受体的抗注意力缺陷多动症的先导化合物发现, 主持, 部委级, 2016-01--2017-12( 7 ) 黑果枸杞的药用开发, 主持, 院级, 2012-03--2017-12( 8 ) 石杉碱甲替代资源规模化生产关键技术研究, 主持, 省级, 2008-01--2010-12( 9 ) 抗HCV一类新药QH-197的临床前研究, 主持, 院级, 2013-01--2015-12( 10 ) 丹酚酸A原料药的质量研究, 主持, 院级, 2013-07--2014-12( 11 ) 浙麦冬药材的质量研究, 主持, 院级, 2013-04--2014-09( 12 ) 泽漆治疗慢性支气管炎的药效基础研究, 主持, 院级, 2014-10--2015-12
合作情况
正大青春宝药业有限公司-“参麦注射液的安全型再评价”;
天津红日药业有限公司-“抗丙肝药物的研究与开发”
湖南本草药业有限公司-“石杉碱甲的资源的替代、原料药及新剂型开发”
指导学生
已指导学生
杨艳芳 硕士研究生 077901-药物化学
杨利军 硕士研究生 077901-药物化学
张超 硕士研究生 105500-药学
邓毅 硕士研究生 105500-药学
现指导学生
房强强 硕士研究生 078001-药物化学
王琪琪 硕士研究生 078001-药物化学
刘亚男 硕士研究生 105500-药学