1. 线粒体能量代谢

2. 线粒体移植与肿瘤辐射敏感性研究

3. 量子生物技术在肿瘤细胞微环境检测中应用基础研究

4. 细胞内氧化还原平衡与肿瘤辐射敏感性研究

071011-生物物理学

辐射生物学，辐射医学

086000-生物与医药

放疗增敏药物及辐射防护药物研发

2011-11--2014-11   National Institute of Radiological Sciences (NIRS)   共同利用研究员
2010-09--2013-07   中国科学院近代物理研究所   理学博士
2007-09--2010-07   石河子大学   医学硕士

中国科学院研究生院 -- 研究生

中国科学院研究生院 -- 博士

   

2020-01~现在, 中国科学院近代物理研究所, 青年研究员
2019-10~2020-10,National Institutes for Quantum and Radiological Sciences and Technology, 访问学者
2015-11~2019-12,中国科学院近代物理研究所, 副研究员
2013-07~2015-11,中国科学院近代物理研究所, 助理研究员

   

（1） 甘肃省医学科技一等奖, 一等奖, 市地级, 2024
（2） 甘肃省科技进步三等奖, 三等奖, 省级, 2024
（3） 甘肃省医学科技一等奖, 一等奖, 市地级, 2022
（4） 郑集-张昌颖优秀论文奖, 其他, 2018
（5） 甘肃省科学技术进步三等奖, 三等奖, 省级, 2018
（6） 甘肃省科学技术进步三等奖, 三等奖, 省级, 2018
（7） 甘肃省药学发展二等奖, 二等奖, 市地级, 2018
（8） 甘肃省环境科学技术一等奖, 一等奖, 市地级, 2018
（9） 中国科学院近代物理研究所发表文章先进个人奖, 其他, 2017
（10） 甘肃省科学技术进步二等奖, 二等奖, 省级, 2016
（11） 甘肃省科学技术进步二等奖, 二等奖, 省级, 2014

   

（1） Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases, Biology (Basel) , 2026, 
（2） Absolute dynamic and relative static: the relationship of glycolysis and OXPHOS in cancer development, Cell Death and Discovery, 2026, 
（3） Apigenin Enhances the Radiosensitivity of TNBC Cells by Improving cGAS-STING Pathway Activity, Radiation Research, 2026, 
（4） Cancer-Associated Fibroblasts as the "Architect" of the Lung Cancer Immune Microenvironment: Multidimensional Roles and Synergistic Regulation with Radiotherapy, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 第 4 作者
（5） Genistein Implications in Radiotherapy: Kill Two Birds with One Stone, MOLECULES, 2025, 第 8 作者  通讯作者
（6） Mitochondrial Reverse Electron Transport: Mechanisms, Pathophysiological Roles, and Therapeutic Potential, Biology (Basel) , 2025, 
（7） The Research Progress of Mitochondrial Transplantation in the Treatment of Mitochondrial Defective Diseases, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 第 4 作者  通讯作者
（8） Feedback loop between hypoxia and energy metabolic reprogramming aggravates the radioresistance of cancer cells, Exp Hematol Oncol, 2024, 
（9） Mitochondrial-Targeted Antioxidant MitoQ-Mediated Autophagy: A Novel Strategy for Precise Radiation Protection, ANTIOXIDANTS, 2023, 第 11 作者  通讯作者
（10） Hyperthermia ablation combined with transarterial chemoembolization versus monotherapy for hepatocellular carcinoma: A systematic review and meta-analysis, CANCER MEDICINE, 2021, 第 11 作者
（11） The crosstalk between HIFs and mitochondrial dysfunctions in cancer development, CELL DEATH & DISEASE, 2021, 第 7 作者  通讯作者
（12） Crosstalk of the Caspase Family and Mammalian Target of Rapamycin Signaling, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 第 6 作者
（13） Biomarkers of Brain Damage Induced by Radiotherapy, DOSE-RESPONSE, 2020, 第 2 作者
（14） A Minireview on Gastrointestinal Microbiota and Radiosusceptibility, DOSE-RESPONSE, 2020, 第 2 作者
（15） Phycocyanin Ameliorates Radiation-Induced Acute Intestinal Toxicity by Regulating the Effect of the Gut Microbiota on the TLR4/Myd88/NF-kappa B Pathway, JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2020, 第 3 作者
（16） Altered Response to Total Body Irradiation of C57BL/6-Tg (CAG-EGFP) Mice, DOSE-RESPONSE, 2020, 第 8 作者
（17） Carbon ion combined with tigecycline inhibits lung cancer cell proliferation by inducing mitochondrial dysfunction, LIFE SCIENCES, 2020, 第 10 作者
（18） The effects of the Wnt/beta-catenin signaling pathway on apoptosis in HeLa cells induced by carbon ion irradiation, ONCOLOGY REPORTS, 2020, 第 7 作者
（19） MicroRNA-29b-3p enhances radiosensitivity through modulating WISP1-mediated mitochondrial apoptosis in prostate cancer cells, JOURNAL OF CANCER, 2020, 第 8 作者
（20） Phycocyanin Ameliorates Radiation-Induced Acute Intestinal Toxicity by Regulating the Effect of the Gut Microbiota on the TLR4/Myd88/NF-κB Pathway, JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2020, 第 3 作者
（21） Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers, CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2020, 第 3 作者
（22） Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity, THERANOSTICS, 2019, 第 1 作者
（23） microRNA-16-5p enhances radiosensitivity through modulating Cyclin D1/E1-pRb-E2F1 pathway in prostate cancer cells, JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 第 9 作者
（24） Mitochondrial proteomics reveals the mechanism of spermatogenic cells apoptosis induced by carbon ion radiation in zebrafish, JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 第 5 作者
（25） Function, clinical application, and strategies of Pre-mRNA splicing in cancer, CELL DEATH AND DIFFERENTIATION, 2019, 第 8 作者
（26） Radiation-induced lung injury: latest molecular developments, therapeutic approaches, and clinical guidance, CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 第 2 作者
（27） Exogenous melatonin modulates carbon ion radiation-induced immune dysfunction in mice, TOXICOLOGY, 2019, 第 8 作者
（28） Research progress on therapeutic targeting of quiescent cancer cells, ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2019, 第 6 作者
（29） Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 第 5 作者
（30） 线粒体移植在治疗线粒体缺陷疾病中的研究进展, Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases, 生物化学与生物物理进展, 2018, 第 2 作者
（31） Exosomes as drug carriers for clinical application, ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 第 8 作者
（32） 线粒体移植增强人神经胶质瘤U87细胞的辐射敏感性, Mitochondrial Transplantation Enhances Radiosensitivity of Human Glioma U87 Cells, 中国生物化学与分子生物学报, 2018, 第 2 作者
（33） Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion Fe-56 radiation induced brain injury in mice, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 第 5 作者
（34） Advances of Mitochondrial Transplantation Therapy for The Mitochondrial Deficiency Diseases, PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2018, 第 2 作者
（35） MitoQ regulates autophagy by inducing a pseudo-mitochondrial membrane potential, AUTOPHAGY, 2017, 第 1 作者
（36） NADPH Oxidase Activation Contributes to Heavy Ion Irradiation–Induced Cell Death, DOSE-RESPONSE, 2017, 第 6 作者
（37） Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 第 1 作者
（38） Suppression of radiation-induced migration of non-small cell lung cancer through inhibition of Nrf2-Notch Axis, ONCOTARGET, 2017, 第 6 作者
（39） MitoQ Regulates Autophagy by Inducing Pseudo-Mitochondrial Membrane Potential (PMMP), Autophagy, 2017, 
（40） Contribution of caspase-independent pathway to apoptosis in malignant glioma induced by carbon ion beams, ONCOLOGY REPORTS, 2017, 第 6 作者
（41） Xanthohumol induces paraptosis of leukemia cells through p38 mitogen activated protein kinase signaling pathway, ONCOTARGET, 2017, 第 3 作者
（42） Downregulation of Nrf2 promotes radiation-induced apoptosis through Nrf2 mediated Notch signaling in non-small cell lung cancer cells, INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 第 4 作者
（43） Genistein sensitizes sarcoma cells in vitro and in vivo by enhancing apoptosis and by inhibiting DSB repair pathways., JOURNAL OF RADIATION RESEARCH, 2016, 
（44） Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta, ACTA PHARMACOLOGICA SINICA, 2016, 第 6 作者
（45） Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region, ONCOTARGET, 2016, 第 2 作者
（46） miR-449a enhances radiosensitivity through modulating pRb/E2F1 in prostate cancer cells, TUMOR BIOLOGY, 2016, 第 6 作者
（47） MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells, SCIENTIFIC REPORTS, 2016, 第 4 作者
（48） MST-312对人肝癌HepG2细胞辐射敏感性影响研究, Effects of telomerase inhibitor MST-312 on human hepatoma HepG2 cells radiosensitivity, 中华肿瘤防治杂志, 2015, 第 2 作者
（49） Disturbance of redox status enhances radiosensitivity of hepatocellular carcinoma, AMERICAN JOURNAL OF CANCER RESEARCH, 2015, 第 1 作者
（50） Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation, ONCOLOGY LETTERS, 2015, 第 3 作者
（51） DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation, JOURNAL OF CELLULAR PHYSIOLOGY, 2015, 第 4 作者
（52） Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice, BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2015, 第 5 作者
（53） Diallyl disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/Delta Np73 via mitochondrial pathway, SCIENTIFIC REPORTS, 2015, 第 6 作者
（54） Diallyl disulfide enhances carbon ion beams-induced apoptotic cell death in cervical cancer cells through regulating Tap73/Delta Np73, CELL CYCLE, 2015, 第 2 作者
（55） Radiation-induced hyperproliferation of intestinal crypts results in elevated genome instability with inactive p53-related genomic surveillance, LIFE SCIENCES, 2015, 第 4 作者
（56） Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice, Protective Effects of Shikonin on Brain Injury Induced by Carbon Ion Beam Irradiation in Mice, 生物医学与环境科学：英文版, 2015, 第 5 作者
（57） Radiosensitization to X-ray radiation by telomerase inhibitor MST-312 in human hepatoma HepG2 cells, LIFE SCIENCES, 2015, 第 2 作者
（58） Effects of carbon-ion beam irradiation on the angiogenic response in lung adenocarcinoma A549 cells, CELL BIOLOGY INTERNATIONAL, 2014, 第 4 作者
（59） Carbon Ion Beams Induce Hepatoma Cell Death by NADPH Oxidase-Mediated Mitochondrial Damage, JOURNAL OF CELLULAR PHYSIOLOGY, 2014, 第 1 作者
（60） microRNA Expression and Biogenesis in Cellular Response to Ionizing Radiation, DNA AND CELL BIOLOGY, 2014, 第 5 作者
（61） Carbon Ion Radiation Inhibits Glioma and Endothelial Cell Migration Induced by Secreted VEGF, PLOS ONE, 2014, 第 3 作者
（62） 重离子与X射线照射肺癌细胞A549的生物学效应比较, 中华放射医学与防护杂志, 2014, 第 5 作者
（63） Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status, CELL BIOCHEMISTRY AND BIOPHYSICS, 2013, 第 1 作者
（64） Mechanisms, function and clinical applications of DNp73, CELL CYCLE, 2013, 第 6 作者
（65） Genistein Enhances the Radiosensitivity of Breast Cancer Cells via G2/M Arrest, Molecules, 2013, 第 1 作者
（66） Effects of carbon-ion beam or X-ray irradiation on anti-apoptosis Delta Np73 expression in HeLa cells, GENE, 2013, 第 7 作者
（67） 12C6+离子束辐照对大鼠离体主动脉环内皮依赖性舒张功能的影响, Effects of 12C6+Ion Beams Irradiation on Endothelial Dependent Relaxation in Isolated Rat Aortic Rings, 原子核物理评论, 2013, 第 4 作者
（68） Genistein Enhances the Radiosensitivity of Breast Cancer Cells via G(2)/M Cell Cycle Arrest and Apoptosis, MOLECULES, 2013, 第 2 作者
（69） 重离子和X射线对人微血管内皮细胞血管生成的抑制作用, Inhibitory Effect of ~(12)C~(6+) Ion and X-ray on Angiogenesis in HMEC-1, 原子核物理评论, 2013, 第 4 作者
（70） Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage, Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage, 生物医学与环境科学：英文版, 2013, 第 5 作者
（71） Simulated Microgravity Conditions and Carbon Ion Irradiation Induce Spermatogenic Cell Apoptosis and Sperm DNA Damage, BIOMEDICAL AND ENVIRONMENTAL SCIENCES, 2013, 第 5 作者
（72） 二烯丙基二硫对荷S180肉瘤小鼠的辐射增敏效应, Radiosensitizing Effect of Diallyl Disulfide on S180 Sarcoma-Bearing Mice, 激光生物学报, 2013, 第 6 作者
（73） Effects of carbon ion beam irradiation on lung injury and pulmonary fibrosis in mice, EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2013, 第 8 作者
（74） Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status, CELL BIOCHEMISTRY AND BIOPHYSICS, 2013, 第 1 作者
（75） Genistein Enhances the Radiosensitivity of Breast Cancer Cells via G2/M Cell Cycle Arrest and Apoptosis, MOLECULES, 2013, 第 2 作者
（76） Corrigendum to "Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721" Food Chem. Toxicol. 50 (2012) 1962–1968, FOOD AND CHEMICAL TOXICOLOGY, 2012, 第 2 作者
（77） Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells, PHYTOMEDICINE, 2012, 第 1 作者
（78） Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721, FOOD AND CHEMICAL TOXICOLOGY, 2012, 第 2 作者
（79） Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721, FOOD AND CHEMICAL TOXICOLOGY, 2012, 第 2 作者
（80） Mechanism of apoptotosis induced by ortho-topolin riboside in human hepatoma cell line SMMC-7721 (vol 50, pg 1962, 2012), FOOD AND CHEMICAL TOXICOLOGY, 2012, 第 2 作者
（81） Chromosomal aberrations in the bone marrow cells of mice induced by accelerated C-12(6+) ions, MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2011, 第 7 作者

现指导学生

胡翠兰  硕士研究生  071011-生物物理学  

包炎玉  硕士研究生  071011-生物物理学