微生物能够产生结构多样和活性丰富的次级代谢产物，是现代药物发现和创新的重要源泉。本课题组针对微生物天然产物开展化学和生物学等多领域交叉研究，研究内容主要包含以下方面：

1. 微生物活性天然产物的发现、结构改造与新药研发

基于多种沉默基因簇激活策略，发现具有新颖结构的微生物次级代谢产物，运用化学合成和合成生物学等手段对其进行结构改造与优化，为新药开发提供丰富的化合物资源。

2. 微生物次级代谢产物的生物合成及其调控与合成生物学应用

从基因和蛋白水平对微生物中重要次级代谢产物的生物合成机制进行解析，为合理设计、改造及构建新的代谢途径以获得更多结构多样的衍生物奠定基础；对于生物合成途径中的关键酶或蛋白，深入理解其结构与功能，通过理性设计及改造，开发其在合成生物学上的应用。同时，围绕微生物信号分子及其介导的次级代谢调控系统，深入探索信号分子调控次级代谢产物生成的机制及其生物合成规律，从而开发有效策略提高次级代谢产物产量和激活沉默基因簇。

   

100705-微生物与生化药学
071005-微生物学
071010-生物化学与分子生物学

微生物次级代谢产物的生物合成与调控
微生物药物开发与合成生物学

2012-10--2016-09   英国华威大学   博士
2009-09--2012-03   上海交通大学   硕士
2004-09--2008-06   中国药科大学   学士

   

2022-04~现在, 中国科学院微生物研究所, 研究员
2016-10~2022-02,英国华威大学, 博士后
2008-07~2009-08,深圳一致药业集团致君制药有限公司, QA

   

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