基本信息

宋乡飞 男 硕导 中国科学院青岛生物能源与过程研究所
电子邮件: songxf@qibebt.ac.cn
通信地址: 青岛市崂山区松岭路189号
邮政编码:
电子邮件: songxf@qibebt.ac.cn
通信地址: 青岛市崂山区松岭路189号
邮政编码:
研究领域
1.蛋白质结构和动态性的研究
2.酶催化机理解析和理性设计
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
蛋白质结构和动态性的研究酶催化机理解析和理性设计
教育背景
2017-09--2020-12 中国科学院大学 博士2007-09--2010-06 南京师范大学 硕士2003-09--2007-06 湖南文理学院 本科
学历
研究生
学位
博士
工作经历
工作简历
2023-05~现在, 中国科学院青岛生物能源与过程研究所, 蛋白质设计研究组副组长2018-12~现在, 中国科学院青岛生物能源与过程研究所, 副研究员2013-12~2018-12,中国科学院青岛生物能源与过程研究所, 助理研究员2011-03~2013-12,中国科学院青岛生物能源与过程研究所, 研究研习员
专利与奖励
专利成果
( 1 ) 具有高酶活性与高热稳定性的葡聚糖单加氧酶及其制备方法与应用, 发明专利, 2023, 第 3 作者, 专利号: 202310083991.3( 2 ) 一种改良性能的纤维素内切酶Cel7B突变体, 发明专利, 2015, 第 2 作者, 专利号: CN104560922A( 3 ) 一种改良性能的黄素单核苷酸结合荧光蛋白质, 发明专利, 2013, 第 2 作者, 专利号: CN103421096A
出版信息
发表论文
[1] Berhe, Miesho Hadush, Song, Xiangfei, Yao, Lishan. Improving the Enzymatic Activity and Stability of a Lytic Polysaccharide Monooxygenase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 第 2 作者24(10): http://dx.doi.org/10.3390/ijms24108963.[2] Wang, Mengting, Song, Xiangfei, Chen, Jingfei, Chen, Xiaoxu, Zhang, Xueying, Yang, Ying, Liu, Zhijun, Yao, Lishan. Intracellular environment can change protein conformational dynamics in cells through weak interactions. SCIENCE ADVANCES[J]. 2023, 第 2 作者9(29): http://dx.doi.org/10.1126/sciadv.adg9141.[3] Song xiangfei, Wang mengting, Chen xiaoxu, Zhang xueying, Yang ying, Liu zhijun, Yao lishan. Quantifying Protein Electrostatic Interactions in Cells by Nuclear Magnetic Resonance Spectroscopy. J. Am. Chem. Soc[J]. 2021, 第 1 作者143: 19606-19613, [4] Song, Xiangfei, An, Liaoyuan, Wang, Mengting, Chen, Jingfei, Liu, Zhijun, Yao, Lishan. Osmolytes Can Destabilize Proteins in Cells by Modulating Electrostatics and Quinary Interactions. ACS CHEMICAL BIOLOGY[J]. 2021, 第 1 作者16(5): 864-871, http://dx.doi.org/10.1021/acschembio.1c00024.[5] Song, Xiangfei, Lv, Tianhang, Chen, Jingfei, Wang, Jia, Yao, Lishan. Characterization of Residue Specific Protein Folding and Unfolding Dynamics in Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 1 作者141(29): 11363-11366, [6] Zhang, Ning, Wang, Yefei, An, Liaoyuan, Song, Xiangfei, Huang, Qingshan, Liu, Zhijun, Yao, Lishan. Entropy Drives the Formation of Salt Bridges in the Protein GB3. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 4 作者56(26): 7601-7604, http://www.irgrid.ac.cn/handle/1471x/1755774.[7] Xiangfei Song, Shujun Zhang, Yefei Wang, Jingwen Li, Chunyan He, Lishan Yao. Corrigendum to ‘A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis’ Enzyme Microb. Technol. 87–88 (2016) 9–16. ENZYME AND MICROBIAL TECHNOLOGY. 2016, 第 1 作者92: 117-117, http://dx.doi.org/10.1016/j.enzmictec.2016.08.008.[8] Wang, Yefei, Zhang, Shujun, Song, Xiangfei, Yao, Lishan. Cellulose Chain Binding Free Energy Drives the Processive Move of Cellulases on the Cellulose Surface. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2016, 第 3 作者113(9): 1873-1880, http://ir.qibebt.ac.cn/handle/337004/8479.[9] Song, Xiangfei, Zhang, Shujun, Wang, Yefei, Li, Jingwen, He, Chunyan, Yao, Lishan. A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis. ENZYME AND MICROBIAL TECHNOLOGY[J]. 2016, 第 1 作者87-88(1): 9-16, http://dx.doi.org/10.1016/j.enzmictec.2016.02.008.[10] Wang, Yefei, Song, Xiangfei, Zhang, Shujun, Li, Jingwen, Shu, Zhiyu, He, Chunyan, Huang, Qingshan, Yao, Lishan. Improving the activity of Trichoderma reesei cel7B through stabilizing the transition state. BIOTECHNOLOGY AND BIOENGINEERING[J]. 2016, 第 2 作者113(6): 1171-1177, http://dx.doi.org/10.1002/bit.25887.[11] Chen, Chao, Cui, Zhenling, Song, Xiangfei, Liu, YaJun, Cui, Qiu, Feng, Yingang. Integration of bacterial expansin-like proteins into cellulosome promotes the cellulose degradation. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 3 作者100(5): 2203-2212, http://www.irgrid.ac.cn/handle/1471x/1059896.[12] Song, Xiangfei, Zhang, Shujun, Wang, Yefei, Li, Jingwen, He, Chunyan, Yao, Lishan. A kinetic study of Trichoderma reesei Cel7B catalyzed cellulose hydrolysis (vol 87, pg 9, 2016). ENZYME AND MICROBIAL TECHNOLOGY. 2016, 第 1 作者92: 117-117, http://ir.qibebt.ac.cn/handle/337004/8486.[13] Song, Xiangfei, Wang, Yefei, Zhang, Shujun, Yan, Shihai, Li, Tong, Yao, Lishan. Characterization of the Dielectric Constant in the Trichoderma reesei Cel7B Active Site. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2015, 第 1 作者55(7): 1369-1376, https://www.webofscience.com/wos/woscc/full-record/WOS:000358821300010.[14] Zhang, Shujun, Wang, Yefei, Song, Xiangfei, Hong, Jingbo, Zhang, Yu, Yao, Lishan. Improving Trichoderma reesei Cel7B Thermostability by Targeting the Weak Spots. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2014, 第 3 作者54(10): 2826-2833, http://dx.doi.org/10.1021/ci500339v.[15] Song, Xiangfei, Wang, Yefei, Shu, Zhiyu, Hong, Jingbo, Li, Tong, Yao, Lishan. Engineering a More Thermostable Blue Light Photo Receptor Bacillus subtilis YtvA LOV Domain by a Computer Aided Rational Design Method. PLOS COMPUTATIONAL BIOLOGY[J]. 2013, 第 1 作者 通讯作者 9(7): http://www.irgrid.ac.cn/handle/1471x/830045.[16] Wang, Shan, Cui, GuZhen, Song, XiangFei, Feng, Yingang, Cui, Qiu. Efficiency and Stability Enhancement of Cis-epoxysuccinic Acid Hydrolase by Fusion with a Carbohydrate Binding Module and Immobilization onto Cellulose. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2012, 第 3 作者168(3): 708-717, http://www.irgrid.ac.cn/handle/1471x/519013.[17] Song, Xiangfei, Xue, Yemin, Wang, Qilei, Wu, Xixi. Comparison of Three Thermostable beta-Glucosidases for Application in the Hydrolysis of Soybean Isoflavone Glycosides. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2011, 第 1 作者59(5): 1954-1961, http://dx.doi.org/10.1021/jf1046915.[18] Xue, Yemin, Song, Xiangfei, Yu, Jinjin. Overexpression of beta-glucosidase from Thermotoga maritima for the production of highly purified aglycone isoflavones from soy flour. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY[J]. 2009, 第 2 作者25(12): 2165-2172, http://dx.doi.org/10.1007/s11274-009-0121-4.[19] Xue, Yemin, Yu, Jinjin, Song, Xiangfei, Peng, Jingjing, Shao, Weilan. Over-expression of xylanolytic alpha-glucuronidase from Thermotoga maritima in the pHsh system of Escherichia coli for the production of xylobiose from xylan. AFRICAN JOURNAL OF BIOTECHNOLOGY[J]. 2008, 第 3 作者7(14): 2454-2461, https://www.webofscience.com/wos/woscc/full-record/WOS:000258333100025.
科研活动
科研项目
( 1 ) 中国科学院青年创新促进会项目, 负责人, 中国科学院计划, 2020-01--2023-12( 2 ) 外切葡聚糖酶CBH II 水解纤维素的作用机制研究和理性设计, 负责人, 地方任务, 2021-01--2023-12( 3 ) 细胞内超氧化物歧化酶的致病机理研究及药物筛选方法发展, 负责人, 研究所自主部署, 2021-06--2023-06( 4 ) 葡聚糖单加氧酶催化水解纤维素作用机制的研究, 负责人, 研究所自主部署, 2021-05--2023-05( 5 ) 细胞内蛋白质动态性影响机制的核磁共振研究, 负责人, 国家任务, 2022-01--2025-12( 6 ) 蛋白质“原位”结构和动态性的检测研究, 负责人, 地方任务, 2023-01--2025-12
参与会议
(1)细胞内蛋白质折叠动力学的研究 2020年中科院微生物所生理与代谢工程重点实验室与青能所生物能源第二党支部“科技尖兵”交流大会 2020-10-15