宋默识，博士，研究员，中国科学院动物研究所团委副书记，膜生物学国家重点实验室职工党支部书记。入选中国科学院BR计划（2018），国家海外高层次人才引进计划青年项目（2019）、国家优秀青年科学基金项目（2019）、北京市杰出青年科学基金项目（2020）。 

​2011年于瑞典卡罗琳斯卡医学院获医学硕士学位，2015年于美国圣路易斯华盛顿大学获理学博士学位，2016-2018年于美国斯坦福大学从事博士后研究，2018年至今任中国科学院动物研究所研究员（PI）。

1. 解析心脏衰老及相关疾病的分子机制

2. 开发心脏衰老及相关疾病的干预策略

​中国细胞生物学学会衰老细胞生物学分会秘书长、中国老年学和老年医学学会抗衰老分会副总干事、中国动物学会理事、中国细胞生物学学会理事、中国生物物理学会自由基生物学与自由基医学分会委员、中国生物物理学会线粒体生物学分会委员。《Life Medicine》编委、《Translational Medicine of Aging》编委。

北京市科学技术奖自然科学奖二等奖（2023），中华医学科技奖医学科学技术奖二等奖（2021），中国科学十大进展（2020），中国生命科学十大进展（2020），中国科学院杰出科技成就奖（2020）。

代表论著：

Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J*, Song M*. Prophylactic supplementation with Bifidobacterium infantis or its metabolite inosine attenuates cardiac injury after ischemia/reperfusion. iMeta. 2024 (in press)
Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*.Prophylactic supplementation with Lactobacillus reuteri or its metabolite GABA protects against acute ischemic cardiac injury. Adv Sci. 2024 May;11(18):e2307233.
Liu X, Ma Y, Yu Y, Zhang W, Shi J, Zhang X, Dai M, Wang Y, Zhang H, Zhang J, Shen J, Zhang F*, Song M*, Wang J*. Gut microbial methionine impacts circadian clock gene expression and reactive oxygen species level in host gastrointestinal tract. Protein Cell. 2023 Apr 21;14(4):309-313.
He Y, Ji Q, Wu Z, Cai Y, Yin J, Zhang Y, Zhang S, Liu X, Zhang W, Liu GH*, Wang S*, Song M*, Qu J*. 4E-BP1 counteracts human mesenchymal stem cell senescence via maintaining mitochondrial homeostasis. Protein Cell. 2023 Apr 13;14(3):202-216.
Gou B, Chu X, Xiao Y, Liu P, Zhang H, Gao Z, Song M. Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells. Front Cardiovasc Med. 2022 May 9;9:900978.
Shen J, Liu GH*, Song M*. Potential approaches for intervening aging. National Science Open. 2022; 1(2):20220021.
Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nat Aging. 2022 Apr;2(4):303-316.
Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein Cell. 2022 Sep;13(9):676-682.
Li W, Zou Z, Cai Y, Yang K, Wang S, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH*, Song M*, Qu J*, Zhang W*. Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell. 2022 Jun;13(6):454-461.
Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, Hu J, Liu Z, Wang Q, Bi S, Huang D, Ji Z, Liu GH*, Wang S*, Song M*, Qu J*. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Res. 2021 May 7;49(8):4203-4219.
Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Res. 2021 Apr;31(4):415-432.
Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein Cell. 2021 Feb;12(2):145-151.
Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W*, Song M*, Liu GH*, Qu J*. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020 Jul;11(7):483-504.
Zhang J, Liu GH*, Qu J*, Song M*. Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Ther. 2020 Aug;27(7-8):309-311.
Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020 Mar 5;180(5):984-1001.e22.
Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell. 2019 Jun;10(6):417-435.
Wang Y, Li Y, He C, Gou B, Song M. Mitochondrial regulation of cardiac aging. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1853-1864.
Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH*, Zhang W*, Song M*, Qu J*. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell. 2018 Nov;9(11):945-965.
Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab. 2017 Dec 5;26(6):872-883.e5.
Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science. 2015 Dec 4;350(6265):aad2459.
Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. 2015 Jul 31;117(4):346-51.
Song M#, Matkovich SJ#, Zhang Y, Hammer DJ, Dorn GW 2nd. Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth. Sci Signal. 2015 Apr 21;8(373):ra39. 
Song M, Dorn GW 2nd. Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart. Cell Metab. 2015 Feb 3;21(2):195-205.
Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metab. 2015 Feb 3;21(2):273-286.
Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circ Res. 2014 Jul 18;115(3):348-53.