基本信息
宋默识  女  博导  中国科学院动物研究所
电子邮件: songmoshi@ioz.ac.cn
通信地址: 中国科学院动物研究所
邮政编码: 100101

研究领域

线粒体与心脏疾病
线粒体与心脏衰老

招生信息

   
招生专业
100104-病理学与病理生理学
1001J6-再生医学
071003-生理学

教育背景

2011-08--2015-12   圣路易斯华盛顿大学   理学博士
2009-08--2011-06   卡罗琳斯卡医学院   医学硕士
2005-09--2009-07   北京林业大学   理学学士
学历
研究生

学位
博士

工作经历

   
工作简历
2018-09~现在, 中国科学院大学, 教授
2018-01~现在, 中国科学院动物研究所, 研究员
2016-10~2018-02,斯坦福大学, 博士后
社会兼职
2019-10-19-今,中国老年学和老年医学学会抗衰老分会, 副秘书长
2019-08-24-今,中国动物学会, 理事
2018-05-29-今,中国细胞生物学学会衰老细胞生物学分会, 委员
2015-10-31-今,中国病理生理学会心血管专业委员会会员, 会员
2014-12-31-今,国际心脏病研究会北美分会 (ISHR-NAS), 会员
2012-12-31-今,美国心脏协会 (AHA), 会员

教授课程

分子细胞生物学

荣誉与奖励

   
奖励信息
(1) 中国科学院青年学习标兵, , 院级, 2019
(2) 中国干细胞第八届年会青年论坛最佳人气奖, , 其他, 2018
(3) 中国心脏大会基础研究青年学者奖, , 其他, 2018
(4) 美国心脏协会 (AHA) Postdoctoral Fellowship, , 其他, 2018
(5) EMBO Workshop线粒体质量控制研讨会最佳海报奖, , 其他, 2017
(6) 圣路易斯华盛顿大学Spencer T. and Ann W. Olin Medical Science Fellow奖, , 研究所(学校), 2016
(7) 国家优秀自费留学生奖, , 国家级, 2015
(8) 第35届国际心脏病研究会北美分会 (ISHR-NAS) 年会优秀青年研究学者奖, , 其他, 2015
(9) 美国心脏协会心血管基础研究协会 (BCVS) 年会优秀青年研究学者奖, , 其他, 2015
(10) 圣路易斯华盛顿大学Barbara Jakschik Award奖, , 研究所(学校), 2015
(11) 美国心脏协会 (AHA) Predoctoral Fellowship, , 其他, 2014
(12) Gordon Research Conference心脏调节机制研讨会最佳海报奖, , 其他, 2014
(13) 《Circulation Research》杂志年度最佳论文奖, , 其他, 2014
(14) Keystone symposium心脏重塑、信号通路、基质及功能会议优秀青年研究学者奖, , 其他, 2013

出版信息

   
发表论文
[1] qun chu, Feifei Liu, Yifang He, Xiaoyu Jiang, 蔡雨生, Zeming Wu, yan kaowen, lingling geng, Yichen Zhang, Huyi Feng, zhou kaixin, Si Wang, Weiqi Zhang, Guang-Hui Liu , shuai ma, jing qu, Moshi Song. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein & Cell[J]. 2022, [2] Zunpeng Liu, Wei Li, Lingling Geng, Liang Sun, Qiaoran Wang, Yang Yu, Pengze Yan, Chuqian Liang, Jie Ren, Moshi Song, Qian Zhao, Jinghui Lei, Yusheng Cai, Jiaming Li, Kaowen Yan, Zeming Wu, Qun Chu, Jingyi Li, Si Wang, Chunyi Li, JingDong J Han, Reyna HernandezBenitez, Ng ShyhChang, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, GuangHui Liu. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discovery[J]. 2022, 8: [3] Wei Li, Zhiran Zou, Yusheng Cai, Kuan Yang, Si Wang, Zunpeng Liu, Lingling Geng, Qun Chu, Zhejun Ji, Piu Chan, GuangHui Liu, Moshi Song, Jing Qu, Weiqi Zhang. Low-dose chloroquine treatment extends the lifespan of aged rats. Protein & Cell[J]. 2022, 13(6): 454-461, [4] Chen, Liang, Zhao, Na, Cao, Jiabao, liu xiaolin, Xu, Jiayue, Ma, Yue, Yu, Ying, Zhang, Xuan, Zhang, Wenhui;, Guan, Xiangyu, Yu, Xiaotong, Liu, Zhipeng, Fan, Yanqun, Wang, Yang, Liang, Fan, Wang, Depeng, Zhao, Linhua, song moshi, Wang, Jun. Short- and long-read metagenomics expand individualized structural variations in gut microbiomes.. Nature Communications[J]. 2022, [5] Li, Ting, Lu, Dingyi, Yao, Chengcheng, Li, Tingting, Dong, Hua, Li, Zhan, Xu, Guang, Chen, Jiayi, Zhang, Hao, Yi, Xiaoyu, Zhu, Haizhen, Liu, Guangqin, Wen, Kaiqing, Zhao, Haixin, Gao, Jun, Zhang, Yakun, Han, Qiuying, Li, Teng, Zhang, Weina, Zhao, Jie, Li, Tao, Bai, Zhaofang, Song, Moshi, He, Xinhua, Zhou, Tao, Xia, Qing, Li, Ailing, Pan, Xin. Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-28613-0.
[6] Zhao, Mingming, Wei, Haoran, Li, Chenze, Zhan, Rui, Liu, Changjie, Gao, Jianing, Yi, Yaodong, Cui, Xiao, Shan, Wenxin, Ji, Liang, Pan, Bing, Cheng, Si, Song, Moshi, Sun, Haipeng, Jiang, Huidi, Cai, Jun, GarciaBarrio, Minerva T, Chen, Y Eugene, Meng, Xiangbao, Dong, Erdan, Wang, Dao Wen, Zheng, Lemin. Gut microbiota production of trimethyl-5-aminovaleric acid reduces fatty acid oxidation and accelerates cardiac hypertrophy. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-29060-7.
[7] Hongkai Zhao, Qianzhao Ji, Zeming Wu, Si Wang, Jie Ren, Kaowen Yan, Zehua Wang, Jianli Hu, Qun Chu, Huifang Hu, Yusheng Cai, Qiaoran Wang, Daoyuan Huang, Zhejun Ji, Jingyi Li, Juan Carlos Izpisua Belmonte, Moshi Song, Weiqi Zhang, Jing Qu, Guang-Hui Liu. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging[J]. 2022, [8] shuai ma, Si Wang, yanxia ye, Jie Ren, Ruiqing Chen, Wei Li, Jiaming Li, 赵丽云, Qian Zhao, Guoqiang Sun, ying jing, 左越晟, 熊沐钊, 杨远涵, Qiaoran Wang, 雷敬辉, Shuhui Sun, Xiao Long, Moshi Song, shuyang yu, Piu Chan, Jianwei Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, jing qu, Weiqi Zhang, Guang-Hui Liu . Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.. Cell Stem Cell[J]. 2022, [9] Bo Gou, Xiaojing Chu, Yi Xiao, Pinxuan Liu, Hao Zhang, Zeyu Gao, Moshi Song. Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells. Frontiers in Cardiovascular Medicine[J]. 2022, 9: [10] Kang, Wang, Jin, Tong, Zhang, Tao, Ma, Shuai, Yan, Haoteng, Liu, Zunpeng, Ji, Zhejun, Cai, Yusheng, Wang, Si, Song, Moshi, Ren, Jie, Hu, Baoyang, Zhou, Qi, Zhang, Weiqi, Qu, Jing, Bao, Yiming, Liu, GuangHui. Regeneration Roadmap: database resources for regenerative biology. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(D1): D1085-D1090, [11] Chuqian Liang, Zunpeng Liu, Moshi Song, Wei Li, Zeming Wu, Zehua Wang, Qiaoran Wang, Si Wang, Kaowen Yan, Liang Sun, Tomoaki Hishida, Yanning Cai, Juan Carlos lzpisua Belmonte, Pedro Guillen, Piu Chan, Qi Zhou, Weiqi Zhang, Jing Qu, GuangHui Liu. Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration. CELL RESEARCH[J]. 2021, 31(2): 187-205, http://lib.cqvip.com/Qikan/Article/Detail?id=7104259262.
[12] Shan, Hezhen, Geng, Lingling, Jiang, Xiaoyu, Song, Moshi, Wang, Jianxun, Liu, Zunpeng, Zhuo, Xiao, Wu, Zeming, Hu, Jianli, Ji, Zhejun, Wang, Si, Chan, Piu, Qu, Jing, Zhang, Weiqi, Liu, GuangHui. Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells. PROTEIN & CELL. 2021, [13] Wang, Yongjun, Han, Dong, Zhou, Tingwen, Chen, Cheng, Cao, Hong, Zhang, Joe Z, Ma, Ning, Liu, Chun, Song, Moshi, Shi, Jiawei, Jin, Xin, Cao, Feng, Dong, Nianguo. DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells. EUROPEAN HEART JOURNAL[J]. 2021, 42(30): 2935-2950, http://dx.doi.org/10.1093/eurheartj/ehab316.
[14] Wang, Si, Cheng, Fang, Ji, Qianzhao, Song, Moshi, Wu, Zeming, Zhang, Yiyuan, Ji, Zhejun, Feng, Huyi, Belmonte, Juan Carlos Izpisua, Zhou, Qi, Qu, Jing, Li, Wei, Liu, GuangHui, Zhang, Weiqi. Hyperthermia differentially affects specific human stem cells and their differentiated derivatives. PROTEIN & CELL. 2021, [15] Ma, Shuai, Sun, Shuhui, Li, Jiaming, Fan, Yanling, Qu, Jing, Sun, Liang, Wang, Si, Zhang, Yiyuan, Yang, Shanshan, Liu, Zunpeng, Wu, Zeming, Zhang, Sheng, Wang, Qiaoran, Zheng, Aihua, Duo, Shuguang, Yu, Yang, Belmonte, Juan Carlos Izpisua, Chan, Piu, Zhou, Qi, Song, Moshi, Zhang, Weiqi, Liu, GuangHui. Single-cell transcriptomic atlas of primate cardiopulmonary aging. CELL RESEARCH[J]. 2021, 31(4): 415-432, http://lib.cqvip.com/Qikan/Article/Detail?id=7104702584.
[16] Li, Jingyi, Zheng, Yuxuan, Yan, Pengze, Song, Moshi, Wang, Si, Sun, Liang, Liu, Zunpeng, Ma, Shuai, Belmonte, Juan Carlos Izpisua, Chan, Piu, Zhou, Qi, Zhang, Weiqi, Liu, GuangHui, Tang, Fuchou, Qu, Jing. A single-cell transcriptomic atlas of primate pancreatic islet aging. NATIONAL SCIENCE REVIEW[J]. 2021, 8(2): 12-26, http://lib.cqvip.com/Qikan/Article/Detail?id=7104077533.
[17] Aging Atlas Consortium, Zhang, Weiqi, Qu, Jing, Bao, Yiming, Liu, GuangHui. Aging Atlas: a multi-omics database for aging biology. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(D1): D825-D830, http://dx.doi.org/10.1093/nar/gkaa894.
[18] Si Wang, Xiaohong Yao, Shuai Ma, Yifang Ping, Yanling Fan, Shuhui Sun, Zhicheng He, Yu Shi, Liang Sun, Shiqi Xiao, Moshi Song, Jun Cai, Jiaming Li, Rui Tang, Liyun Zhao, Chaofu Wang, Qiaoran Wang, Lei Zhao, Huifang Hu, Xindong Liu, Guoqiang Sun, Lu Chen, Guoqing Pan, Huaiyong Chen, Qingrui Li, Peipei Zhang, Yuanyuan Xu, Huyi Feng, GuoGuang Zhao, Tianzi Wen, Yungui Yang, Xuequan Huang, Wei Li, Zhenhua Liu, Hongmei Wang, Haibo Wu, Baoyang Hu, Yong Ren, Qi Zhou, Jing Qu, Weiqi Zhang, GuangHui Liu, XiuWu Bian. A single-cell transcriptomic landscape of the lungs of patients with COVID-19. Nature Cell Biology[J]. 2021, 1-15, [19] Wang, Wei, Zheng, Yuxuan, Sun, Shuhui, Li, Wei, Song, Moshi, Ji, Qianzhao, Wu, Zeming, Liu, Zunpeng, Fan, Yanling, Liu, Feifei, Li, Jingyi, Esteban, Concepcion Rodriguez, Wang, Si, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, Tang, Fuchou, Liu, GuangHui. A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence. SCIENCE TRANSLATIONAL MEDICINE[J]. 2021, 13(575): https://www.webofscience.com/wos/woscc/full-record/WOS:000608364300006.
[20] Diao, Zhiqing, Ji, Qianzhao, Wu, Zeming, Zhang, Weiqi, Cai, Yusheng, Wang, Zehua, Hu, Jianli, Liu, Zunpeng, Wang, Qiaoran, Bi, Shijia, Huang, Daoyuan, Ji, Zhejun, Liu, GuangHui, Wang, Si, Song, Moshi, Qu, Jing. SIRT3 consolidates heterochromatin and counteracts senescence. NUCLEIC ACIDS RESEARCH[J]. 2021, 49(8): 4203-4219, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096253/.
[21] Zou, Zhiran, Long, Xiao, Zhao, Qian, Zheng, Yandong, Song, Moshi, Ma, Shuai, Jing, Yaobin, Wang, Si, He, Yifang, Esteban, Concepcion Rodriguez, Yu, Nanze, Huang, Jiuzuo, Chan, Piu, Chen, Ting, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, Liu, GuangHui. A Single-Cell Transcriptomic Atlas of Human Skin Aging. DEVELOPMENTAL CELL[J]. 2021, 56(3): 383-+, http://dx.doi.org/10.1016/j.devcel.2020.11.002.
[22] Jinghui Lei, Si Wang, Wang Kang, Qun Chu, Zunpeng Liu, Liang Sun, Yun Ji, Concepcion Rodriguez Esteban, Yan Yao, Juan Carlos Izpisua Belmonte, Piu Chan, GuangHui Liu, Weiqi Zhang, Moshi Song, Jing Qu. FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein & Cell[J]. 2021, 12(2): 145-151, [23] Wu, Zeming, Shi, Yue, Lu, Mingming, Song, Moshi, Yu, Zihui, Wang, Jilu, Wang, Si, Ren, Jie, Yang, YunGui, Liu, GuangHui, Zhang, Weiqi, Ci, Weimin, Qu, Jing. METTL3 counteracts premature aging via m(6)A-dependent stabilization of MIS12 mRNA. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(19): 11083-11096, https://www.webofscience.com/wos/woscc/full-record/WOS:000606018400039.
[24] Bi, Shijia, Liu, Zunpeng, Wu, Zeming, Wang, Zehua, Liu, Xiaoqian, Wang, Si, Ren, Jie, Yao, Yan, Zhang, Weiqi, Song, Moshi, Liu, GuangHui, Qu, Jing. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. PROTEIN & CELL[J]. 2020, 11(7): 483-504, http://lib.cqvip.com/Qikan/Article/Detail?id=7102619525.
[25] Yingfeng Zheng, Xiuxing Liu, Wenqing Le, Lihui Xie, He Li, Wen Wen, Si Wang, Shuai Ma, Zhaohao Huang, Jinguo Ye, Wen Shi, Yanxia Ye, Zunpeng Liu, Moshi Song, Weiqi Zhang, JingDong J Han, Juan Carlos Izpisua Belmonte, Chuanle Xiao, Jing Qu, Hongyang Wang, GuangHui Liu, Wenru Su. A human circulating immune cell landscape in aging and COVID-19. Protein & Cell[J]. 2020, 11(10): 740-770, https://doaj.org/article/23cd9fa05c7a4f1f9348ea29fcaf59ef.
[26] Zhang, Zhang, Zhao, Wenming, Xiao, Jingfa, Bao, Yiming, He, Shunmin, Zhang, Guoqing, Li, Yixue, Zhao, Guoping, Chen, Runsheng, Gao, Yang, Zhang, Chao, Yuan, Liyun, Xu, Shuhua, Ning, Zhilin, Lu, Yan, Zeng, Jingyao, Yuan, Na, Zhu, Junwei, Pan, Mengyu, Zhang, Hao, Wang, Qi, Shi, Shuo, Jiang, Meiye, Lu, Mingming, Qian, Qiheng, Gao, Qianwen, Shang, Yunfei, Wang, Jinyue, Du, Zhenglin, Tian, Dongmei, Wang, Pei, Tang, Bixia, Li, Cuiping, Teng, Xufei, Liu, Xiaonan, Zou, Dong, Song, Shuhui, Xiong, Zhuang, Li, Mengwei, Yang, Fei, Ma, Yingke, Sang, Jian, Li, Zhaohua, Li, Rujiao, Wang, Zhonghuang, Zhu, Qianghui, Li, Xin, Zhang, Sisi, Kang, Hailong, Dong, Lili, Ying, Cui, Duan, Guangya, Li, Menghua, Zhi, Xiaoyang, Ling, Yunchao, Cao, Ruifang, Jiang, Zhao, Zhou, Haokui, Lv, Daqing, Liu, Wan, Klenk, HansPeter, Zhang, Yadong, Zhang, Zhewen, Chen, Tingting, Chen, Xu, Wang, Yanqing, Wu, Song, Gong, Zheng, Chen, Meili, Fang, Shuangsang, Zhang, Lili, Guo, Jincheng, Niu, Yiwei, Wu, Yang, Li, Hui, Zhao, Lianhe, Li, Xiyuan, Teng, Xueyi, Sun, Xianhui, Sun, Liang, Zhao, Yi, Wang, Jiajia, Zhang, Peng, Li, Yanyan, Zheng, Yu, Chen, Xiaomin, Xue, Hua, Teng, Yiheng, Kang, Quan, Hao, Yajing, Cao, Jiabao, Liu, Lin, Li, Zhao, Li, Qianpeng, Du, Qiang, Abbasi, Amir A, Shireen, Huma, Pervaiz, Nashaiman, Batool, Fatima, Raza, Rabail Z, Ma, Lina, Niu, Guangyi, Zhang, Yuansheng, Zhu, Tongtong, Hao, Lili, Wang, Guoliang, Yan, Jun, Li, Chen, Wang, Zhennan, Wang, Xiangfeng, Li, Zhonghai, Zhang, Yang, Wang, Houling, Zhang, Yi, Xia, Xinli, Guo, Hongwei, Zhu, Junwen, Zhou, Qing, Kang, Hongen, Lan, Li, Zhang, Xin, Xue, Yongbiao, Sun, Yubin, Zhai, Shuang, Yu, Lei, Sun, Mingyuan, Chen, Huanxin, Hu, Hui, Guo, AnYuan, Lin, Shaofeng, Xue, Yu, Wang, Chenwei, Ning, Wanshan, Zhang, Xinxin, Xiao, Yun, Li, Xia, Tu, Yiran, Wu, Wanying, Ji, Peifeng, Zhao, Fangqing, Luo, Hao, Gao, Feng, Guo, Yaping, Yuan, Hao, Zhang, Yong E, Zhang, Qiong, Zhou, Jiaqi, Huang, Zhou, Cui, Qinghua, Miao, YaRu, Ruan, Chen, Yuan, Chunhui, Chen, Ming, Jin, JinPu, Tian, Feng, Gao, Ge, Shi, Ying, Yao, Lan, Li, Xiangshang, Li, ChuanYun, Tang, Qing, Peng, Di. Database Resources of the National Genomics Data Center in 2020. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(D1): D24-D33, https://www.webofscience.com/wos/woscc/full-record/WOS:000525956700004.
[27] Wang, Si, Zheng, Yuxuan, Li, Jingyi, Yu, Yang, Zhang, Weiqi, Song, Moshi, Liu, Zunpeng, Min, Zheying, Hu, Huifang, Jing, Ying, He, Xiaojuan, Sun, Liang, Ma, Lifang, Esteban, Concepcion Rodriguez, Chan, Piu, Qiao, Jie, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Qu, Jing, Tang, Fuchou, Liu, GuangHui. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. CELL[J]. 2020, 180(3): 585-+, http://dx.doi.org/10.1016/j.cell.2020.01.009.
[28] Hongyu Li, Zeming Wu, Xiaoqian Liu, Sheng Zhang, Qianzhao Ji, Xiaoyu Jiang, Zunpeng Liu, Si Wang, Jing Qu, Weiqi Zhang, Moshi Song, Eli Song, GuangHui Liu. ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells. Protein & Cell[J]. 2020, 11(9): 688-695, https://doaj.org/article/61701b1fdc354b5e85f71770d2316f96.
[29] Ma, Shuai, Sun, Shuhui, Geng, Lingling, Song, Moshi, Wang, Wei, Ye, Yanxia, Ji, Qianzhao, Zou, Zhiran, Wang, Si, He, Xiaojuan, Li, Wei, Esteban, Concepcion Rodriguez, Long, Xiao, Guo, Guoji, Chan, Piu, Zhou, Qi, Belmonte, Juan Carlos Izpisua, Zhang, Weiqi, Qu, Jing, Liu, GuangHui. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. CELL[J]. 2020, 180(5): 984-+, http://dx.doi.org/10.1016/j.cell.2020.02.008.
[30] Zhang, Jiahe, Liu, GuangHui, Qu, Jing, Song, Moshi. Treating osteoarthritis via gene therapy with rejuvenation factors. GENE THERAPYnull. 2020, 27(7-8): 309-311, https://www.webofscience.com/wos/woscc/full-record/WOS:000529076100003.
[31] Yan, Pengze, Liu, Zunpeng, Song, Moshi, Wu, Zeming, Xu, Wei, Li, Kuan, Ji, Qianzhao, Wang, Si, Liu, Xiaoqian, Yan, Kaowen, Esteban, Concepcion Rodriguez, Ci, Weimin, Belmonte, Juan Carlos Izpisua, Xie, Wei, Ren, Jie, Zhang, Weiqi, Sun, Qianwen, Qu, Jing, Liu, GuangHui. Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming. CELL REPORTS[J]. 2020, 32(1): http://dx.doi.org/10.1016/j.celrep.2020.107870.
[32] Hu, Huifang, Ji, Qianzhao, Song, Moshi, Ren, Jie, Liu, Zunpeng, Wang, Zehua, Liu, Xiaoqian, Yan, Kaowen, Hu, Jianli, Jing, Yaobin, Wang, Si, Zhang, Weiqi, Liu, GuangHui, Qu, Jing. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(11): 6001-6018, http://dx.doi.org/10.1093/nar/gkaa425.
[33] Weiqi Zhang, Shu Zhang, Pengze Yan, Jie Ren, Moshi Song, Jingyi Li, Jinghui Lei, Huize Pan, Si Wang, Xibo Ma, Shuai Ma, Hongyu Li, Fei Sun, Haifeng Wan, Wei Li, Piu Chan, Qi Zhou, GuangHui Liu, Fuchou Tang, Jing Qu. A single-cell transcriptomic landscape of primate arterial aging. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-15997-0.
[34] Qu Jing. Deciphering primate retinal aging at single-cell resolution.. Protein Cell. 2020, [35] Yan, Pengze, Li, Qingqing, Wang, Lixia, Lu, Ping, Suzuki, Keiichiro, Liu, Zunpeng, Lei, Jinghui, Li, Wei, He, Xiaojuan, Wang, Si, Ding, Jianjian, Chan, Piu, Zhang, Weiqi, Song, Moshi, Belmonte, Juan Carlos Izpisua, Qu, Jing, Tang, Fuchou, Liu, GuangHui. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. CELL STEM CELL[J]. 2019, 24(3): 447-+, http://dx.doi.org/10.1016/j.stem.2018.12.002.
[36] Moshi Song, Juan Carlos Izpisua Belmonte, GuangHui Liu. Age-related cardiopathies gene editing. Aging (Albany NY). 2019, 11(5): 1327-1328, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428092/.
[37] Geng, Lingling, Liu, Zunpeng, Zhang, Weiqi, Li, Wei, Wu, Zeming, Wang, Wei, Ren, Ruotong, Su, Yao, Wang, Peichang, Sun, Liang, Ju, Zhenyu, Chan, Piu, Song, Moshi, Qu, Jing, Liu, GuangHui. Chemical screen identifies a geroprotective role of quercetin in premature aging. PROTEIN & CELL[J]. 2019, 10(6): 417-435, http://lib.cqvip.com/Qikan/Article/Detail?id=7002265644.
[38] He, Xiaojuan, Song, Moshi, Qu, Jing, Guo, Yansu, Cao, Heqi, Sun, Ruijuan, Liu, GuangHui, Shen, Yong, Major Program Expert Grp. Basic and translational aging research in China: present and future. PROTEIN & CELL[J]. 2019, 10(7): 476-484, http://lib.cqvip.com/Qikan/Article/Detail?id=7002649433.
[39] Cheng, Fang, Wang, Si, Song, Moshi, Liu, Zunpeng, Liu, Ping, Wang, Lei, Wang, Yanjiang, Zhao, Qian, Yan, Kaowen, Chan, Piu, Zhang, Weiqi, Qu, Jing, Liu, GuangHui. DJ-1 is dispensable for human stem cell homeostasis. PROTEIN & CELLnull. 2019, 10(11): 846-853, http://lib.cqvip.com/Qikan/Article/Detail?id=7100511677.
[40] Ling, Chen, Liu, Zunpeng, Song, Moshi, Zhang, Weiqi, Wang, Si, Liu, Xiaoqian, Ma, Shuai, Sun, Shuhui, Fu, Lina, Chu, Qun, Belmonte, Juan Carlos Izpisua, Wang, Zhaoxia, Qu, Jing, Yuan, Yun, Liu, GuangHui. Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. PROTEIN & CELL[J]. 2019, 10(4): 249-271, http://lib.cqvip.com/Qikan/Article/Detail?id=7001745320.
[41] Lina Fu, Yuqiong Hu, Moshi Song, Zunpeng Liu, Weiqi Zhang, FaXing Yu, Jun Wu, Si Wang, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, Fuchou Tang, GuangHui Liu. Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.. PLoS Biology[J]. 2019, 17(4): https://doaj.org/article/bc32e11a824146e3a288cacfa0d43eda.
[42] Wang, Yuhan, Li, Yujing, He, Chuting, Gou, Bo, Song, Moshi. Mitochondrial regulation of cardiac aging. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASEnull. 2019, 1865(7): 1853-1864, http://dx.doi.org/10.1016/j.bbadis.2018.12.008.
[43] Zhang, Xing, Liu, Zunpeng, Liu, Xiaoqian, Wang, Si, Zhang, Yiyuan, He, Xiaojuan, Sun, Shuhui, Ma, Shuai, Ng ShyhChang, Liu, Feng, Wang, Qiang, Wang, Xiaoqun, Liu, Lin, Zhang, Weiqi, Song, Moshi, Liu, GuangHui, Qu, Jing. Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. PROTEIN & CELL[J]. 2019, 10(9): 649-667, http://lib.cqvip.com/Qikan/Article/Detail?id=7002965332.
[44] Geng, Lingling, Liu, Zunpeng, Wang, Si, Sun, Shuhui, Ma, Shuai, Liu, Xiaoqian, Chan, Piu, Sun, Liang, Song, Moshi, Zhang, Weiqi, Liu, GuangHui, Qu, Jing. Low-dose quercetin positively regulates mouse healthspan. PROTEIN & CELLnull. 2019, 10(10): 770-775, http://lib.cqvip.com/Qikan/Article/Detail?id=7100271929.
[45] Seidlmayer, Lea K, Mages, Christine, Berbner, Annette, EderNegrin, Petra, AriasLoza, Paula Anahi, Kaspar, Mathias, Song, Moshi, Dorn, Gerald W, II, Kohlhaas, Michael, Frantz, Stefan, Maack, Christoph, Gerull, Brenda, Dedkova, Elena N. Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes. FRONTIERS IN PHYSIOLOGY[J]. 2019, 10: https://doaj.org/article/39da39d0c63a46f4b4186d34884f37e3.
[46] Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang, Pedro Guillen, Juan Carlos Izpisua Belmonte, Piu Chan, Jing Qu, GuangHui Liu. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nature Communications[J]. 2019, 10(1): 1-16, http://dx.doi.org/10.1038/s41467-019-10831-8.
[47] Ren, Xiaoqing, Hu, Boqiang, Song, Moshi, Ding, Zhichao, Dang, Yujiao, Liu, Zunpeng, Zhang, Weiqi, Ji, Qianzhao, Ren, Ruotong, Ding, Jianjian, Chan, Piu, Jiang, Changtao, Ye, Keqiong, Qu, Jing, Tang, Fuchou, Liu, GuangHui. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. CELL REPORTS[J]. 2019, 26(13): 3643-+, http://dx.doi.org/10.1016/j.celrep.2019.02.088.
[48] Zhang, Weiqi, Song, Moshi, Qu, Jing, Liu, GuangHui. Epigenetic Modifications in Cardiovascular Aging and Diseases. CIRCULATION RESEARCH[J]. 2018, 123(7): 773-786, https://www.webofscience.com/wos/woscc/full-record/WOS:000444478800004.
[49] Wang, Ping, Liu, Zunpeng, Zhang, Xiaoqian, Li, Jingyi, Sun, Liang, Ju, Zhenyu, Li, Jian, Chan, Piu, Liu, GuangHui, Zhang, Weiqi, Song, Moshi, Qu, Jing. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-B/RelA in maintaining the homeostasis of human vascular cells. PROTEIN & CELL[J]. 2018, 9(11): 945-965, http://lib.cqvip.com/Qikan/Article/Detail?id=676820273.
[50] Wu, Zeming, Zhang, Weiqi, Song, Moshi, Wang, Wei, Wei, Gang, Li, Wei, Lei, Jinghui, Huang, Yu, Sang, Yanmei, Chan, Piu, Chen, Chang, Qu, Jing, Suzuki, Keiichiro, Belmonte, Juan Carlos Izpisua, Liu, GuangHui. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. PROTEIN & CELL[J]. 2018, 9(4): 333-350, https://doaj.org/article/fa5e38d6b9c94afd97abd5c6d669be4f.
[51] Song, Moshi, Franco, Antonietta, Fleischer, Julie A, Zhang, Lihong, Dorn, Gerald W, II. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. CELL METABOLISM[J]. 2017, 26(6): 872-+, http://dx.doi.org/10.1016/j.cmet.2017.09.023.
[52] Bhandari, Poonam, Song, Moshi, Dorn, Gerald W, II. Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY[J]. 2015, 80: 71-80, https://www.webofscience.com/wos/woscc/full-record/WOS:000355389800008.
[53] Gong, Guohua, Song, Moshi, Csordas, Gyorgy, Kelly, Daniel P, Matkovich, Scot J, Dorn, Gerald W, II. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. SCIENCE[J]. 2015, 350(6265): [54] Song, Moshi, Mihara, Katsuyoshi, Chen, Yun, Scorrano, Luca, Dorn, Gerald W, II. Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts. CELL METABOLISM[J]. 2015, 21(2): 273-285, http://dx.doi.org/10.1016/j.cmet.2014.12.011.
[55] Moshi Song, Scot J Matkovich, Yan Zhang, Daniel J Hammer, Gerald W Dorn. Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth. Science signaling. 2015, 8(373): ra39-ra39, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677479/.
[56] Song, Moshi, Gong, Guohua, Burelle, Yan, Gustafsson, Asa B, Kitsis, Richard N, Matkovich, Scot J, Dorn, Gerald W, II. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. CIRCULATION RESEARCH[J]. 2015, 117(4): 346-351, https://www.webofscience.com/wos/woscc/full-record/WOS:000369253500011.
[57] Dorn, Gerald W, II, Song, Moshi, Walsh, Kenneth. Functional implications of mitofusin 2-mediated mitochondrial-SR tethering. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGYnull. 2015, 78: 123-128, https://www.webofscience.com/wos/woscc/full-record/WOS:000348484400015.
[58] Shirihai, Orian S, Song, Moshi, Dorn, Gerald W, II. How Mitochondrial Dynamism Orchestrates Mitophagy. CIRCULATION RESEARCHnull. 2015, 116(11): 1835-1849, https://www.webofscience.com/wos/woscc/full-record/WOS:000354861500015.
[59] Song, Moshi, Dorn, Gerald W, II. Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart. CELL METABOLISMnull. 2015, 21(2): 195-205, http://dx.doi.org/10.1016/j.cmet.2014.12.019.
[60] Song, Moshi, Chen, Yun, Gong, Guohua, Murphy, Elizabeth, Rabinovitch, Peter S, Dorn, Gerald W, II. Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy. CIRCULATION RESEARCH[J]. 2014, 115(3): 348-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000339272700006.
[61] Bhandari, Poonam, Song, Moshi, Chen, Yun, Burelle, Yan, Dorn, Gerald W, II. Mitochondrial Contagion Induced by Parkin Deficiency in Drosophila Hearts and Its Containment by Suppressing Mitofusin. CIRCULATION RESEARCH[J]. 2014, 114(2): 257-265, https://www.webofscience.com/wos/woscc/full-record/WOS:000335587100013.
[62] Gastaldello, Stefano, Callegari, Simone, Coppotelli, Giuseppe, Hildebrand, Sebastian, Song, Moshi, Masucci, Maria G. Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2012, 4(4): 242-251, https://www.webofscience.com/wos/woscc/full-record/WOS:000307173900007.
[63] Boon, Hanneke, Kostovski, Emil, Pirkmajer, Sergej, Song, Moshi, Lubarski, Irina, Iversen, Per O, Hjeltnes, Nils, Widegren, Ulrika, Chibalin, Alexander V. Influence of chronic and acute spinal cord injury on skeletal muscle Na+-K+-ATPase and phospholemman expression in humans. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM[J]. 2012, 302(7): E864-E871, https://www.webofscience.com/wos/woscc/full-record/WOS:000302342100012.
[64] Eschenbacher, William H, Song, Moshi, Chen, Yun, Bhandari, Poonam, Zhao, Peter, Jowdy, Casey C, Engelhard, John T, Dorn, Gerald W, II. Two Rare Human Mitofusin 2 Mutations Alter Mitochondrial Dynamics and Induce Retinal and Cardiac Pathology in Drosophila. PLOS ONE[J]. 2012, 7(9): https://doaj.org/article/71f7223d383946cebf9db25c193667f9.
[65] Li, Ben, Sheng, Xia, Song, Moshi, Zhang, Haolin, Weng, Jiaju, Zhang, Mengyuan, Hu, Xiao, Zhou, Jiao, Xu, Meiyu, Weng, Qiang, Watanabe, Gen, Taya, Kazuyoshi. Expression of nerve growth factor and its receptors TrkA and p75 in the uterus of wild female ground squirrel (Citellus dauricus Brandt). GENERAL AND COMPARATIVE ENDOCRINOLOGY[J]. 2012, 176(1): 62-69, http://dx.doi.org/10.1016/j.ygcen.2011.12.024.
[66] Sheng, Xia, Zhang, Haolin, Zhang, Mengyuan, Zhang, Wei, Hu, Xiao, Song, Moshi, Zhou, Jiao, Xu, Meiyu, Weng, Qiang, Watanabe, Gen, Taya, Kazuyoshi. Seasonal Changes in Immunoreactivity of Activin Signaling Component Proteins in Wild Ground Squirrel Testes. JOURNAL OF REPRODUCTION AND DEVELOPMENT[J]. 2012, 58(1): 126-131, https://www.webofscience.com/wos/woscc/full-record/WOS:000302106100018.
[67] 李犇, 李秀雯, 宋默识, 张巍, 胡德夫, 张志翔, 骆有庆, 翁强. 神经生长因子及其受体在雌性哺乳动物生殖系统中的作用. 科技资讯. 2009, 9-10, http://lib.cqvip.com/Qikan/Article/Detail?id=29968755.
[68] 张巍, 宋默识, 张浩林, 盛夏, 张梦远, 李犇, 王宇, 翁强. 达乌尔黄鼠精子形成和细胞色素芳香化酶免疫位置的季节变化. 畜牧与兽医. 2009, 41(1): 28-31, http://lib.cqvip.com/Qikan/Article/Detail?id=29168024.
[69] Sheng, Xia, Zhang, Haolin, Zhang, Wei, Song, Moshi, Zhang, Mengyuan, Li, Ben, Weng, Qiang, Watanabe, Gen, Taya, Kazuyoshi. Seasonal Changes in Spermatogenesis and Immunolocalization of Inhibin/Activin Subunits in the Wild Male Ground Squirrel (Citellus dauricus Brandt). JOURNAL OF REPRODUCTION AND DEVELOPMENT[J]. 2008, 54(6): 460-464, https://www.webofscience.com/wos/woscc/full-record/WOS:000262113500010.
[70] Ying Yu, Bin Liu, Xiaolin Liu, Xuan Zhang, Wenhui Zhang, He Tian, Guanghou Shui, Wenzhao Wang, Moshi Song, Jun Wang. Mesenteric lymph system constitutes the second route in gut-liver axis and transports metabolism-modulating gut microbial metabolites. Journal of Genetics and Genomics. 

科研活动

   
科研项目
( 1 ) 线粒体质量控制在心血管疾病和衰老中的作用研究, 主持, 市地级, 2018-03--2019-12
( 2 ) American Heart Association Postdoctoral Fellowship, 主持, 研究所(学校), 2018-07--2018-07
( 3 ) American Heart Association Predoctoral Fellowship, 主持, 研究所(学校), 2014-01--2015-12
( 4 ) 心脏衰老和再生的代谢调控, 参与, 部委级, 2018-09--2022-12
( 5 ) 线粒体质量控制保护心肌缺血再灌注损伤的机制研究, 主持, 国家级, 2019-01--2022-12
( 6 ) 增龄相关健康减损的细胞分子机制研究, 参与, 国家级, 2018-12--2022-12
( 7 ) 线粒体与心脏衰老, 主持, 国家级, 2020-01--2022-12
( 8 ) 衰老机制及调控, 参与, 国家级, 2020-01--2024-12
( 9 ) 王宽诚率先人才计划“卢嘉锡国家团队”项目, 参与, 部委级, 2020-01--2023-01