基本信息
佘准 男 中国科学院高能物理研究所
电子邮件： shezhun@ihep.ac.cn
通信地址： 玉泉路19号乙13号厅206
邮政编码：
电子邮件： shezhun@ihep.ac.cn
通信地址： 玉泉路19号乙13号厅206
邮政编码：
研究领域
重要蛋白质及蛋白质复合物的结构及功能，蛋白质-蛋白质之间的相互作用，蛋白质-核酸的相互作用。
招生信息
招生专业
071010-生物化学与分子生物学
070205-凝聚态物理
071011-生物物理学
070205-凝聚态物理
071011-生物物理学
招生方向
蛋白质晶体学
蛋白质相互所用
蛋白质相互所用
教育背景
学历
2004年9月-2008年7月 郑州大学物理工程学院 应用物理学专业 获理学学士学位
2008年9月-2014年1月 中国科学院大学 凝聚态物理专业 理学博士学位
学位
理学博士
工作经历
2014年4月-2021年9月 中国科学院高能物理研究所 多学科中心 蛋白质中心 助理研究员
2021年9月 至今 中国科学院高能物理研究所 多学科中心 蛋白质中心 副研究员
出版信息
发表论文
[1] Li, YanHua, Hou, HaiFeng, Geng, Zhi, Zhang, Heng, She, Zhun, Dong, YuHui. Structural basis of a multi-functional deaminase in chlorovirus PBCV-1. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS[J]. 2022, 727: http://dx.doi.org/10.1016/j.abb.2022.109339.
[2] Wang, Shuangyue, Geng, Zhi, Zhang, Heng, She, Zhun, Dong, Yuhui. The Pseudomonas aeruginosa PAAR2 cluster encodes a putative VRR-NUC domain-containing effector. FEBS JOURNAL[J]. 2021, 288(19): 5755-5767, http://dx.doi.org/10.1111/febs.15870.
[3] Wen, Haiying, Liu, Guangfeng, Geng, Zhi, Zhang, Heng, Li, Yanhua, She, Zhun, Dong, Yuhui. Structure and SAXS studies unveiled a novel inhibition mechanism of the Pseudomonas aeruginosa T6SS TseT-TsiT complex. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2021, 188: 450-459, http://dx.doi.org/10.1016/j.ijbiomac.2021.08.029.
[4] Wen, Haiying, Geng, Zhi, Gao, Zengqiang, She, Zhun, Dong, Yuhui. Characterization of the Pseudomonas aeruginosa T6SS PldB immunity proteins PA5086, PA5087 and PA5088 explains a novel stockpiling mechanism. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2020, 76(Pt 5): 222-227, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000530263400005.
[5] Zhun She, Zhi Geng, JianHua Xu, YanHua Li, YuHui Dong. Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa. PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY[J]. 2019, 28(5): 971-975,
[6] Xu, BingShuang, Liu, Min, Zhou, Ke, Geng, Zhi, Gao, ZengQiang, Dong, YuHui, She, Zhun, Liu, QuanSheng. Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2019, 514(1): 37-43, http://dx.doi.org/10.1016/j.bbrc.2019.04.061.
[7] She, Zhun, Geng, Zhi, Xu, JianHua, Li, YanHua, Dong, YuHui. Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa. PROTEIN SCIENCE[J]. 2019, 28(5): 971-975,
[8] Yang, XiaoYun, Li, ZongQiang, Gao, ZengQiang, Wang, WenJia, Geng, Zhi, Xu, JianHua, She, Zhun, Dong, YuHui. Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa. PROTEIN SCIENCE[J]. 2017, 26(10): 2083-2091, http://www.corc.org.cn/handle/1471x/2177080.
[9] Yang, XiaoYun, Li, ZongQiang, She, Zhun, Geng, Zhi, Xu, JianHua, Gao, ZengQiang, Dong, YuHui. Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins. FEBS LETTERS[J]. 2016, 590(16): 2787-2796,
[10] Zhang Jiulong, Zhang Heng, Liu Ying, Zhan Lihong, She Zhun, Dong Cheng, Dong Yuhui. Crystallization and preliminary X-ray study of TsiV3 from Vibrio cholerae. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2014, 70(3): 335-338, http://ir.ihep.ac.cn/handle/311005/224794.
[11] Zhang, Jiulong, Zhang, Heng, Liu, Ying, Zhan, Lihong, She, Zhun, Dong, Cheng, Dong, Yuhui. Crystallization and preliminary X-ray study of TsiV3 from Vibrio cholerae. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2014, 70(Pt 3): 335-338, https://www.webofscience.com/wos/woscc/full-record/WOS:000332405600012.
[12] Dong, Cheng, Zhang, Heng, Gao, ZengQiang, Wang, WenJia, She, Zhun, Liu, GuangFeng, Shen, YueQuan, Su, XiaoDong, Dong, YuHui. Structural insights into the inhibition of type VI effector Tae3 by its immunity protein Tai3. BIOCHEMICAL JOURNAL[J]. 2013, 454(1): 59-68, http://ir.ihep.ac.cn/handle/311005/223811.
[13] She, Zhun, Gao, ZengQiang, Liu, Ying, Wang, WenJia, Liu, GuangFeng, Shtykova, Eleonora V, Xu, JianHua, Dong, YuHui. Structural and SAXS analysis of the budding yeast SHU-complex proteins. FEBS LETTERS[J]. 2012, 586(16): 2306-2312, http://dx.doi.org/10.1016/j.febslet.2012.06.024.
[14] Liu, Ying, Gao, ZengQiang, She, Zhun, Qu, Kun, Wang, WenJia, Shtykova, Eleonora V, Xu, JianHua, Ji, ChaoNeng, Dong, YuHui. The structural basis of the response regulator DrRRA from Deinococcus radiodurans. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2012, 417(4): 1206-1212, http://ir.ihep.ac.cn/handle/311005/224117.
[15] Liu ChaoPei, Xu Rui, Gao ZengQiang, Xu JianHua, Hou HaiFeng, Li LiQin, She Zhun, Li LanFen, Su XiaoDong, Liu Peng, Dong YuHui. Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2010, 66(5): 498-502, http://ir.ihep.ac.cn/handle/311005/237726.
[2] Wang, Shuangyue, Geng, Zhi, Zhang, Heng, She, Zhun, Dong, Yuhui. The Pseudomonas aeruginosa PAAR2 cluster encodes a putative VRR-NUC domain-containing effector. FEBS JOURNAL[J]. 2021, 288(19): 5755-5767, http://dx.doi.org/10.1111/febs.15870.
[3] Wen, Haiying, Liu, Guangfeng, Geng, Zhi, Zhang, Heng, Li, Yanhua, She, Zhun, Dong, Yuhui. Structure and SAXS studies unveiled a novel inhibition mechanism of the Pseudomonas aeruginosa T6SS TseT-TsiT complex. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2021, 188: 450-459, http://dx.doi.org/10.1016/j.ijbiomac.2021.08.029.
[4] Wen, Haiying, Geng, Zhi, Gao, Zengqiang, She, Zhun, Dong, Yuhui. Characterization of the Pseudomonas aeruginosa T6SS PldB immunity proteins PA5086, PA5087 and PA5088 explains a novel stockpiling mechanism. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2020, 76(Pt 5): 222-227, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000530263400005.
[5] Zhun She, Zhi Geng, JianHua Xu, YanHua Li, YuHui Dong. Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa. PROTEIN SCIENCE : A PUBLICATION OF THE PROTEIN SOCIETY[J]. 2019, 28(5): 971-975,
[6] Xu, BingShuang, Liu, Min, Zhou, Ke, Geng, Zhi, Gao, ZengQiang, Dong, YuHui, She, Zhun, Liu, QuanSheng. Conformational changes of antitoxin HigA from Escherichia coli str. K-12 upon binding of its cognate toxin HigB reveal a new regulation mechanism in toxin-antitoxin systems. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2019, 514(1): 37-43, http://dx.doi.org/10.1016/j.bbrc.2019.04.061.
[7] She, Zhun, Geng, Zhi, Xu, JianHua, Li, YanHua, Dong, YuHui. Structural characterization of the Imm52 family protein TsiT in Pseudomonas aeruginosa. PROTEIN SCIENCE[J]. 2019, 28(5): 971-975,
[8] Yang, XiaoYun, Li, ZongQiang, Gao, ZengQiang, Wang, WenJia, Geng, Zhi, Xu, JianHua, She, Zhun, Dong, YuHui. Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa. PROTEIN SCIENCE[J]. 2017, 26(10): 2083-2091, http://www.corc.org.cn/handle/1471x/2177080.
[9] Yang, XiaoYun, Li, ZongQiang, She, Zhun, Geng, Zhi, Xu, JianHua, Gao, ZengQiang, Dong, YuHui. Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins. FEBS LETTERS[J]. 2016, 590(16): 2787-2796,
[10] Zhang Jiulong, Zhang Heng, Liu Ying, Zhan Lihong, She Zhun, Dong Cheng, Dong Yuhui. Crystallization and preliminary X-ray study of TsiV3 from Vibrio cholerae. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2014, 70(3): 335-338, http://ir.ihep.ac.cn/handle/311005/224794.
[11] Zhang, Jiulong, Zhang, Heng, Liu, Ying, Zhan, Lihong, She, Zhun, Dong, Cheng, Dong, Yuhui. Crystallization and preliminary X-ray study of TsiV3 from Vibrio cholerae. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS[J]. 2014, 70(Pt 3): 335-338, https://www.webofscience.com/wos/woscc/full-record/WOS:000332405600012.
[12] Dong, Cheng, Zhang, Heng, Gao, ZengQiang, Wang, WenJia, She, Zhun, Liu, GuangFeng, Shen, YueQuan, Su, XiaoDong, Dong, YuHui. Structural insights into the inhibition of type VI effector Tae3 by its immunity protein Tai3. BIOCHEMICAL JOURNAL[J]. 2013, 454(1): 59-68, http://ir.ihep.ac.cn/handle/311005/223811.
[13] She, Zhun, Gao, ZengQiang, Liu, Ying, Wang, WenJia, Liu, GuangFeng, Shtykova, Eleonora V, Xu, JianHua, Dong, YuHui. Structural and SAXS analysis of the budding yeast SHU-complex proteins. FEBS LETTERS[J]. 2012, 586(16): 2306-2312, http://dx.doi.org/10.1016/j.febslet.2012.06.024.
[14] Liu, Ying, Gao, ZengQiang, She, Zhun, Qu, Kun, Wang, WenJia, Shtykova, Eleonora V, Xu, JianHua, Ji, ChaoNeng, Dong, YuHui. The structural basis of the response regulator DrRRA from Deinococcus radiodurans. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2012, 417(4): 1206-1212, http://ir.ihep.ac.cn/handle/311005/224117.
[15] Liu ChaoPei, Xu Rui, Gao ZengQiang, Xu JianHua, Hou HaiFeng, Li LiQin, She Zhun, Li LanFen, Su XiaoDong, Liu Peng, Dong YuHui. Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS[J]. 2010, 66(5): 498-502, http://ir.ihep.ac.cn/handle/311005/237726.