基本信息
沈玥 女 博导 其他
电子邮件： shenyue@genomics.cn
通信地址： 深圳市大鹏新区金沙路国家基因库
邮政编码：
电子邮件： shenyue@genomics.cn
通信地址： 深圳市大鹏新区金沙路国家基因库
邮政编码：
招生信息
招生专业
0710Z1-基因组学
0710J3-生物信息学
0710J3-生物信息学
招生方向
合成生物学，DNA合成关键技术与工具，DNA信息存储技术，基因组合成与编辑，生物制造
教育背景
2014-06--2019-07 英国爱丁堡大学 博士
2009-02--2009-12 澳大利亚墨尔本大学 硕士
2004-09--2008-07 华南理工大学 学士
2009-02--2009-12 澳大利亚墨尔本大学 硕士
2004-09--2008-07 华南理工大学 学士
工作经历
工作简历
2019-01~现在, 深圳市合成生物学创新研究院, 客座研究员
2015-09~2019-12,深圳国家基因库, 合成与编辑平台主管
2010-03~现在, 深圳华大生命科学研究院, 首席科学家
2015-09~2019-12,深圳国家基因库, 合成与编辑平台主管
2010-03~现在, 深圳华大生命科学研究院, 首席科学家
社会兼职
2021-01-16-今,《合成生物学丛书》, 编委
2020-02-29-今,深圳先进技术研究院合成基因组学研究中心, 客座研究员
2020-02-25-今,《合成生物学》期刊编辑委员会, 委员
2019-09-30-2023-09-29,中国医药生物技术协会合成生物技术分会, 委员
2019-01-01-今,深圳市合成生物学创新研究院, 客座研究员
2018-10-31-今,中国生物工程学会合成生物学专业委员会（筹）, 委员
2020-02-29-今,深圳先进技术研究院合成基因组学研究中心, 客座研究员
2020-02-25-今,《合成生物学》期刊编辑委员会, 委员
2019-09-30-2023-09-29,中国医药生物技术协会合成生物技术分会, 委员
2019-01-01-今,深圳市合成生物学创新研究院, 客座研究员
2018-10-31-今,中国生物工程学会合成生物学专业委员会（筹）, 委员
专利与奖励
奖励信息
（1） 深圳市科学技术奖自然科学类, 一等奖, 市地级, 2021
（2） 深圳市科学技术青年科技奖, 市地级, 2021
（3） 2019年度天津市自然科学特等奖, 特等奖, 市地级, 2019
（4） 2017年度中国科学十大进展, , 部委级, 2017
（2） 深圳市科学技术青年科技奖, 市地级, 2021
（3） 2019年度天津市自然科学特等奖, 特等奖, 市地级, 2019
（4） 2017年度中国科学十大进展, , 部委级, 2017
专利成果
[1] 付宪, 张浩霖, 沈玥. 一种检测极端嗜盐生物中氨酰-tRNA合成酶和tRNA活性的系统及方法. CN: CN114250243A, 2022-03-29.
[2] 高杨, 刘超, 高峰, 顾颖, 沈玥. 一种体外制备环状DNA的方法. CN: CN114231524A, 2022-03-25.
[3] 孙海汐, 高峰, 顾颖, 沈玥. 一种mRNA 5’3’末端差异的快速检测方法. CN: CN114171121A, 2022-03-11.
[4] 沈玥, 陈泰, 刘龙英, 陈世宏, 王云, 杨焕明. 利用DNA存储文本信息的方法、其解码方法及应用. CN: CN109074424B, 2022-03-11.
[5] 方鑫, 黄小罗, 沈玥, 徐讯. 核酸合成装置和纯化装置、其用途及核酸合成方法和纯化方法. CN: CN113348250A, 2021-09-03.
[6] 平质, 黄小罗, 陈世宏, 柴晨, 沈玥, 徐讯, 杨焕明. 一种定点编辑存储有数据的核酸序列的方法及装置. CN: CN113228193A, 2021-08-06.
[7] 汪建, 徐讯, 汪军, 沈玥, 倪鸣, 章文蔚, 王勇, 江湘儿, 黄小罗. 一种生物芯片及其制备方法与应用. CN: CN113166974A, 2021-07-23.
[8] 郭洁, 孙宝策, 冯利鹤, 王勇, 黄小罗, 沈玥, 倪鸣, 徐讯. 一种微流控芯片及其制备方法和DNA合成方法. CN: CN112969527A, 2021-06-15.
[9] 付宪, 张帆, 林涛, 张浩霖, 沈玥. 基于非天然氨基酸的基因组重排调控系统和方法. CN: CN112553239A, 2021-03-26.
[10] 江媛, 王丹, 章登位, 戴雪辰, 汪晓珏, 纪泽阳, 王琦, 赵静, 李卓坤, 顾颖, 欧阳文杰, 沈玥, 陈奥, 章文蔚, 肖亮. 新型的Cas蛋白、Crispr-Cas系统及其在基因编辑领域中的用途. CN: CN112301018A, 2021-02-02.
[11] 张羽, 沈玥, 王博, 丘璨瑜, 吴燕玲, 郝璋颖. 酿制柠檬风味啤酒的酵母菌株、其制备方法及啤酒酿制方法. CN: CN112011471A, 2020-12-01.
[12] 王勇, 陈世宏, 周超, 孙宝策, 冯利鹤, 黄小罗, 沈玥, 李汉东, 章文蔚, 徐讯. 合成寡核苷酸的方法及系统. CN: CN111479818A, 2020-07-31.
[13] 张焕贵, 汪军, 胡书环, 黄小罗, 倪鸣, 沈玥, 徐讯, 汪建. 合成装置、合成仪及合成方法. CN: CN111359555A, 2020-07-03.
[14] 黄小罗, 陈世宏, 林涛, 陈泰, 沈玥, 徐讯, 尹烨, 杨焕明. 编码/解码方法、编码/解码器和存储方法、装置. CN: CN111279422A, 2020-06-12.
[15] 孙宝策, 王勇, 黄小罗, 陈泰, 谭宏东, 沈玥, 徐讯. 用于核酸合成的微流控芯片. CN: CN111246936A, 2020-06-05.
[16] 夏科科, 章登位, 郝璋颖, 顾颖, 沈玥. 一种兰科植物原生质体的制备及转化方法和应用. CN: CN111197023A, 2020-05-26.
[17] 汪建, 徐讯, 汪军, 沈玥, 倪鸣, 章文蔚, 李汉东, 王勇, 江湘儿, 张焕贵, 胡书环, 冯利鹤, 孙宝策, 黄小罗, 周超. 用于合成具有预先确定的序列的核酸的方法. CN: CN111187797A, 2020-05-22.
[18] 刘田宾, 李静, 孙海汐, 李勇, 顾颖, 沈玥. 用于动物胚胎解离的试剂盒和方法. CN: CN110551682A, 2019-12-10.
[19] 陈泰, 赵宏翠, 范楚珧, 陈世宏, 王云, 沈玥, 徐讯. 一种DNA片段体外组装方法和试剂盒. CN: CN108138189A, 2018-06-08.
[2] 高杨, 刘超, 高峰, 顾颖, 沈玥. 一种体外制备环状DNA的方法. CN: CN114231524A, 2022-03-25.
[3] 孙海汐, 高峰, 顾颖, 沈玥. 一种mRNA 5’3’末端差异的快速检测方法. CN: CN114171121A, 2022-03-11.
[4] 沈玥, 陈泰, 刘龙英, 陈世宏, 王云, 杨焕明. 利用DNA存储文本信息的方法、其解码方法及应用. CN: CN109074424B, 2022-03-11.
[5] 方鑫, 黄小罗, 沈玥, 徐讯. 核酸合成装置和纯化装置、其用途及核酸合成方法和纯化方法. CN: CN113348250A, 2021-09-03.
[6] 平质, 黄小罗, 陈世宏, 柴晨, 沈玥, 徐讯, 杨焕明. 一种定点编辑存储有数据的核酸序列的方法及装置. CN: CN113228193A, 2021-08-06.
[7] 汪建, 徐讯, 汪军, 沈玥, 倪鸣, 章文蔚, 王勇, 江湘儿, 黄小罗. 一种生物芯片及其制备方法与应用. CN: CN113166974A, 2021-07-23.
[8] 郭洁, 孙宝策, 冯利鹤, 王勇, 黄小罗, 沈玥, 倪鸣, 徐讯. 一种微流控芯片及其制备方法和DNA合成方法. CN: CN112969527A, 2021-06-15.
[9] 付宪, 张帆, 林涛, 张浩霖, 沈玥. 基于非天然氨基酸的基因组重排调控系统和方法. CN: CN112553239A, 2021-03-26.
[10] 江媛, 王丹, 章登位, 戴雪辰, 汪晓珏, 纪泽阳, 王琦, 赵静, 李卓坤, 顾颖, 欧阳文杰, 沈玥, 陈奥, 章文蔚, 肖亮. 新型的Cas蛋白、Crispr-Cas系统及其在基因编辑领域中的用途. CN: CN112301018A, 2021-02-02.
[11] 张羽, 沈玥, 王博, 丘璨瑜, 吴燕玲, 郝璋颖. 酿制柠檬风味啤酒的酵母菌株、其制备方法及啤酒酿制方法. CN: CN112011471A, 2020-12-01.
[12] 王勇, 陈世宏, 周超, 孙宝策, 冯利鹤, 黄小罗, 沈玥, 李汉东, 章文蔚, 徐讯. 合成寡核苷酸的方法及系统. CN: CN111479818A, 2020-07-31.
[13] 张焕贵, 汪军, 胡书环, 黄小罗, 倪鸣, 沈玥, 徐讯, 汪建. 合成装置、合成仪及合成方法. CN: CN111359555A, 2020-07-03.
[14] 黄小罗, 陈世宏, 林涛, 陈泰, 沈玥, 徐讯, 尹烨, 杨焕明. 编码/解码方法、编码/解码器和存储方法、装置. CN: CN111279422A, 2020-06-12.
[15] 孙宝策, 王勇, 黄小罗, 陈泰, 谭宏东, 沈玥, 徐讯. 用于核酸合成的微流控芯片. CN: CN111246936A, 2020-06-05.
[16] 夏科科, 章登位, 郝璋颖, 顾颖, 沈玥. 一种兰科植物原生质体的制备及转化方法和应用. CN: CN111197023A, 2020-05-26.
[17] 汪建, 徐讯, 汪军, 沈玥, 倪鸣, 章文蔚, 李汉东, 王勇, 江湘儿, 张焕贵, 胡书环, 冯利鹤, 孙宝策, 黄小罗, 周超. 用于合成具有预先确定的序列的核酸的方法. CN: CN111187797A, 2020-05-22.
[18] 刘田宾, 李静, 孙海汐, 李勇, 顾颖, 沈玥. 用于动物胚胎解离的试剂盒和方法. CN: CN110551682A, 2019-12-10.
[19] 陈泰, 赵宏翠, 范楚珧, 陈世宏, 王云, 沈玥, 徐讯. 一种DNA片段体外组装方法和试剂盒. CN: CN108138189A, 2018-06-08.
出版信息
发表论文
[1] Tiantian Chang, Weichao Ding, Shirui Yan, Yun Wang, Haoling Zhang, Yu Zhang, Zhi Ping, Huiming Zhang, Yijian Huang, Jiahui Zhang, Dan Wang, Wenwei Zhang, Xun Xu, Yue Shen, Xian Fu. A robust yeast biocontainment system with two-layered regulation switch dependent on unnatural amino acid. NATURE COMMUNICATIONS[J]. 2023, 第 14 作者 通讯作者 14(1): 1-13, http://dx.doi.org/10.1038/s41467-023-42358-4.
[2] Yue Shen, Feng Gao, Yun Wang, Yuerong Wang, Ju Zheng, Jianhui Gong, Jintao Zhang, Zhouqing Luo, Daniel Schindler, Yang Deng, Weichao Ding, Tao Lin, Reem Swidah, Hongcui Zhao, Shuangying Jiang, Cheng Zeng, Shihong Chen, Tai Chen, Yong Wang, Yisha Luo, Leslie Mitchell, Joel S Bader, Guojie Zhang, Xia Shen, Jian Wang, Xian Fu, Junbiao Dai, Jef D Boeke, Huanming Yang, Xun Xu, Yizhi Cai. Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast. CELL GENOMICS[J]. 2023, 第 1 作者 通讯作者 3(11): http://dx.doi.org/10.1016/j.xgen.2023.100364.
[3] Zhang, Haolin, Gong, Xuemei, Zhao, Qianqian, Mukai, Takahito, VargasRodriguez, Oscar, Zhang, Huiming, Zhang, Yuxing, Wassel, Paul, Amikura, Kazuaki, MaupinFurlow, Julie, Ren, Yan, Xu, Xun, Wolf, Yuri, I, Makarova, Kira S, Koonin, Eugene, V, Shen, Yue, Soll, Dieter, Fu, Xian. The tRNA discriminator base defines the mutual orthogonality of two distinct pyrrolysyl-tRNA synthetase/tRNA(Pyl) pairs in the same organism. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 16 作者 通讯作者 50(8): 4601-4615, http://dx.doi.org/10.1093/nar/gkac271.
[4] 沈玥. Towards Practical and Robust DNA-Based Data Archiving Using ‘Yin-Yang Codec’System. Nature Computational Science[J]. 2022, 第 1 作者 通讯作者
[5] Xian Fu, Yijian Huang, Yue Shen. Improving the Efficiency and Orthogonality of Genetic Code Expansion. BIODESIGNRESEARCH[J]. 2022, 第 3 作者https://doaj.org/article/377ce4d4945d43399dbcd978a4fc0862.
[6] Ping, Zhi, Yang, Huanming, Shen, Yue. A new era of mass data storage in artificial chromosome. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 第 3 作者 通讯作者 65(7): 1477-1478, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7300730&detailType=1.
[7] Zhang, Huiming, Fu, Xian, Gong, Xuemei, Wang, Yun, Zhang, Haolin, Zhao, Yu, Shen, Yue. Systematic dissection of key factors governing recombination outcomes by GCE-SCRaMbLE. NATURE COMMUNICATIONS[J]. 2022, 第 7 作者 通讯作者 13(1): http://dx.doi.org/10.1038/s41467-022-33606-0.
[8] 江湘儿, 王勇, 沈玥. DNA 合成技术与仪器研发进展概述. 集成技术[J]. 2021, 第 3 作者10(5): 80-95, https://jcjs.siat.ac.cn/jcjs/article/abstract/202105009?st=article_issue.
[9] Yu Zhang, TsanYu Chiu, JinTao Zhang, ShuJie Wang, ShuWen Wang, LongYing Liu, Zhi Ping, Yong Wang, Ao Chen, WenWei Zhang, Tai Chen, Yun Wang, Yue Shen. Systematical Engineering of Synthetic Yeast for Enhanced Production of Lycopene. BIOENGINEERING[J]. 2021, 第 13 作者8(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833358/.
[10] 钱珑, 沈玥, 元英进, 欧阳颀, 杨焕明. DNA数字信息存储：造梦、追梦与圆梦. 合成生物学[J]. 2021, 第 2 作者2(3): 303-304, http://lib.cqvip.com/Qikan/Article/Detail?id=7105090020.
[11] 平质, 张颢龄, 陈世宏, 倪鸣. Chamaeleo：DNA存储碱基编解码算法的可拓展集成与系统评估平台. 合成生物学[J]. 2021, http://synbioj.cip.com.cn/CN/abstract/abstract212.shtml.
[12] 付宪, 林涛, 张帆, 张惠铭, 章文蔚, 杨焕明, 朱师达, 徐讯, 沈玥. 基因密码子拓展技术的方法原理和前沿应用研究进展. 合成生物学[J]. 2020, 第 9 作者1(1): 103-119, http://lib.cqvip.com/Qikan/Article/Detail?id=7102233263.
[13] Song, Wenchen, Sun, HaiXi, Zhang, Carolyn, Cheng, Li, Peng, Ye, Deng, Ziqing, Wang, Dan, Wang, Yun, Hu, Ming, Liu, Wenen, Yang, Huanming, Shen, Yue, Li, Junhua, You, Lingchong, Xiao, Minfeng. Prophage Hunter: an integrative hunting tool for active prophages. NUCLEIC ACIDS RESEARCH[J]. 2019, 第 12 作者47(W1): W74-W80, http://dx.doi.org/10.1093/nar/gkz380.
[14] Wu, Tian, Li, Linzhou, Jiang, Xiaosen, Yang, Yong, Song, Yanzi, Chen, Liang, Xu, Xun, Shen, Yue, Gu, Ying. Sequencing and comparative analysis of three Chlorella genomes provide insights into strain-specific adaptation to wastewater. SCIENTIFIC REPORTS[J]. 2019, 第 8 作者 通讯作者 9(1): http://dx.doi.org/10.1038/s41598-019-45511-6.
[15] Ping, Zhi, Ma, Dongzhao, Huang, Xiaoluo, Chen, Shihong, Liu, Longying, Guo, Fei, Zhu, Sha Joe, Shen, Yue. Carbon-based archiving: current progress and future prospects of DNA-based data storage. GIGASCIENCE. 2019, 第 8 作者 通讯作者 8(6):
[16] Zhang, Panpan, Kang, Bin, Xie, Guoyun, Li, Shaolei, Gu, Ying, Shen, Yue, Zhao, Xin, Ma, Yuanyuan, Li, Fuqiang, Si, Jiahui, Wang, Jian, Chen, Jinfeng, Yang, Huanming, Xu, Xun, Yang, Yue. Genomic sequencing and editing revealed the GRM8 signaling pathway as potential therapeutic targets of squamous cell lung cancer. CANCER LETTERS[J]. 2019, 第 6 作者442: 53-67, http://dx.doi.org/10.1016/j.canlet.2018.10.035.
[17] Chang, Zhiguang, Lang, Yue, Lang, Qi, Zheng, Hai, Tokuyasu, Taku A, Huang, Shuqiang, Liu, Chenli. Microfluidic Synchronizer Using a Synthetic Nanoparticle-Capped Bacterium. ACS SYNTHETIC BIOLOGY[J]. 2019, 8(5): 962-967,
[18] Zhouqing Luo, Lihui Wang, Yun Wang, Weimin Zhang, Yakun Guo, Yue Shen, Linghuo Jiang, Qingyu Wu, Chong Zhang, Yizhi Cai, Junbiao Dai. Identifying and characterizing SCRaMbLEd synthetic yeast using ReSCuES. NATURE COMMUNICATIONS[J]. 2018, 第 6 作者9(1): http://ir.siat.ac.cn:8080/handle/172644/13429.
[19] Wang, Yueqiang, Shen, Yue, Gu, Ying, Zhu, Shida, Yin, Ye. Genome Writing: Current Progress and Related Applications. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2018, 第 2 作者16(1): 10-16, http://lib.cqvip.com/Qikan/Article/Detail?id=674913590.
[20] Liu, Wei, Luo, Zhouqing, Wang, Yun, Pham, Nhan T, Tuck, Laura, PerezPi, Irene, Liu, Longying, Shen, Yue, French, Chris, Auer, Manfred, MarlesWright, Jon, Dai, Junbiao, Cai, Yizhi. Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods. NATURE COMMUNICATIONS[J]. 2018, 第 8 作者9(1): http://ir.siat.ac.cn:8080/handle/172644/13428.
[21] Zhang, Weimin, Zhao, Guanghou, Luo, Zhouqing, Lin, Yicong, Wang, Lihui, Guo, Yakun, Wang, Ann, Jiang, Shuangying, Jiang, Qingwen, Gong, Jianhui, Wang, Yun, Hou, Sha, Huang, Jing, Li, Tianyi, Qin, Yiran, Dong, Junkai, Qin, Qin, Zhang, Jiaying, Zou, Xinzhi, He, Xi, Zhao, Li, Xiao, Yibo, Xu, Meng, Cheng, Erchao, Huang, Ning, Zhou, Tong, Shen, Yue, Walker, Roy, Luo, Yisha, Kuang, Zheng, Mitchell, Leslie A, Yang, Kun, Richardson, Sarah M, Wu, Yi, Li, BingZhi, Yuan, YingJin, Yang, Huanming, Lin, Jiwei, Chen, GuoQiang, Wu, Qingyu, Bader, Joel S, Cai, Yizhi, Boeke, Jef D, Dai, Junbiao. Engineering the ribosomal DNA in a megabase synthetic chromosome. SCIENCE[J]. 2017, 第 27 作者355(6329): http://dx.doi.org/10.1126/science.aaf3981.
[22] Mercy, Guillaume, Mozziconacci, Julien, Scolari, Vittore F, Yang, Kun, Zhao, Guanghou, Thierry, Agnes, Luo, Yisha, Mitchell, Leslie A, Shen, Michael, Shen, Yue, Walker, Roy, Zhang, Weimin, Wu, Yi, Xie, ZeXiong, Luo, Zhouqing, Cai, Yizhi, Dai, Junbiao, Yang, Huanming, Yuan, YingJin, Boeke, Jef D, Bader, Joel S, Muller, Heloise, Koszul, Romain. 3D organization of synthetic and scrambled chromosomes. SCIENCE[J]. 2017, 第 10 作者355(6329): http://dx.doi.org/10.1126/science.aaf4597.
[23] Xie, ZeXiong, Liu, Duo, Li, BingZhi, Zhao, Meng, Zeng, BoXuan, Wu, Yi, Shen, Yue, Lin, Tao, Yang, Ping, Dai, Junbiao, Cai, Yizhi, Yang, Huanming, Yuan, YingJin. Design and chemical synthesis of eukaryotic chromosomes. CHEMICAL SOCIETY REVIEWS[J]. 2017, 第 7 作者46(23): 7191-7207, http://dx.doi.org/10.1039/c7cs00208d.
[24] Xie, ZeXiong, Li, BingZhi, Mitchell, Leslie A, Wu, Yi, Qi, Xin, Jin, Zhu, Jia, Bin, Wang, Xia, Zeng, BoXuan, Liu, HuiMin, Wu, XiaoLe, Feng, Qi, Zhang, WenZheng, Liu, Wei, Ding, MingZhu, Li, Xia, Zhao, GuangRong, Qiao, JianJun, Cheng, JingSheng, Zhao, Meng, Kuang, Zheng, Wang, Xuya, Martin, J Andrew, Stracquadanio, Giovanni, Yang, Kun, Bai, Xue, Zhao, Juan, Hu, MengLong, Lin, QiuHui, Zhang, WenQian, Shen, MingHua, Chen, Si, Su, Wan, Wang, EnXu, Guo, Rui, Zhai, Fang, Guo, XueJiao, Du, HaoXing, Zhu, JiaQing, Song, TianQing, Dai, JunJun, Li, FeiFei, Jiang, GuoZhen, Han, ShiLei, Liu, ShiYang, Yu, ZhiChao, Yang, XiaoNa, Chen, Ken, Hu, Cheng, Li, DaShuai, Jia, Nan, Liu, Yue, Wang, LinTing, Wang, Su, Wei, XiaoTong, Fu, MeiQing, Qu, LanMeng, Xin, SiYu, Liu, Ting, Tian, KaiRen, Li, XueNan, Zhang, JinHua, Song, LiXiang, Liu, JinGui, Lv, JiaFei, Xu, Hang, Tao, Ran, Wang, Yan, Zhang, TingTing, Deng, YeXuan, Wang, YiRan, Li, Ting, Ye, GuangXin, Xu, XiaoRan, Xia, ZhengBao, Zhang, Wei, Yang, ShiLan, Liu, YiLin, Ding, WenQi, Liu, ZhenNing, Zhu, JunQi, Liu, NingZhi, Walker, Roy, Luo, Yisha, Wang, Yun, Shen, Yue, Yang, Huanming, Cai, Yizhi, Ma, PingSheng, Zhang, ChunTing, Bader, Joel S, Boeke, Jef D, Yuan, YingJin. "Perfect" designer chromosome V and behavior of a ring derivative. SCIENCE[J]. 2017, 第 86 作者355(6329): http://dx.doi.org/10.1126/science.aaf4704.
[25] Junbiao Dai, Caiyue Xu, Yan Liu, Qingyu Wu, Jianhui Gong, Jef D Boeke, Yue Shen, Yun Wang, Shuangying Jiang. Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library. GENETICS SOCIETY OF AMERICA. 2017, 第 7 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902193418164ZK.
[26] Shen, Yue, Wang, Yun, Chen, Tai, Gao, Feng, Gong, Jianhui, Abramczyk, Dariusz, Walker, Roy, Zhao, Hongcui, Chen, Shihong, Liu, Wei, Luo, Yisha, Mueller, Carolin A, PaulDuboisTaine, Adrien, Alver, Bonnie, Stracquadanio, Giovanni, Mitchell, Leslie A, Luo, Zhouqing, Fan, Yanqun, Zhou, Baojin, Wen, Bo, Tan, Fengji, Wang, Yujia, Zi, Jin, Xie, Zexiong, Li, Bingzhi, Yang, Kun, Richardson, Sarah M, Jiang, Hui, French, Christopher E, Nieduszynski, Conrad A, Koszul, Romain, Marston, Adele L, Yuan, Yingjin, Wang, Jian, Bader, Joel S, Dai, Junbiao, Boeke, Jef D, Xu, Xun, Cai, Yizhi, Yang, Huanming. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome. SCIENCE[J]. 2017, 第 1 作者355(6329): http://dx.doi.org/10.1126/science.aaf4791.
[27] Shen, Yue, Stracquadanio, Giovanni, Wang, Yun, Yang, Kun, Mitchell, Leslie A, Xue, Yaxin, Cai, Yizhi, Chen, Tai, Dymond, Jessica S, Kang, Kang, Gong, Jianhui, Zeng, Xiaofan, Zhang, Yongfen, Li, Yingrui, Feng, Qiang, Xu, Xun, Wang, Jun, Wang, Jian, Yang, Huanming, Boeke, Jef D, Bader, Joel S. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes. GENOME RESEARCH[J]. 2016, 第 1 作者26(1): 36-49, https://www.webofscience.com/wos/woscc/full-record/WOS:000367597000004.
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[20] Liu, Wei, Luo, Zhouqing, Wang, Yun, Pham, Nhan T, Tuck, Laura, PerezPi, Irene, Liu, Longying, Shen, Yue, French, Chris, Auer, Manfred, MarlesWright, Jon, Dai, Junbiao, Cai, Yizhi. Rapid pathway prototyping and engineering using in vitro and in vivo synthetic genome SCRaMbLE-in methods. NATURE COMMUNICATIONS[J]. 2018, 第 8 作者9(1): http://ir.siat.ac.cn:8080/handle/172644/13428.
[21] Zhang, Weimin, Zhao, Guanghou, Luo, Zhouqing, Lin, Yicong, Wang, Lihui, Guo, Yakun, Wang, Ann, Jiang, Shuangying, Jiang, Qingwen, Gong, Jianhui, Wang, Yun, Hou, Sha, Huang, Jing, Li, Tianyi, Qin, Yiran, Dong, Junkai, Qin, Qin, Zhang, Jiaying, Zou, Xinzhi, He, Xi, Zhao, Li, Xiao, Yibo, Xu, Meng, Cheng, Erchao, Huang, Ning, Zhou, Tong, Shen, Yue, Walker, Roy, Luo, Yisha, Kuang, Zheng, Mitchell, Leslie A, Yang, Kun, Richardson, Sarah M, Wu, Yi, Li, BingZhi, Yuan, YingJin, Yang, Huanming, Lin, Jiwei, Chen, GuoQiang, Wu, Qingyu, Bader, Joel S, Cai, Yizhi, Boeke, Jef D, Dai, Junbiao. Engineering the ribosomal DNA in a megabase synthetic chromosome. SCIENCE[J]. 2017, 第 27 作者355(6329): http://dx.doi.org/10.1126/science.aaf3981.
[22] Mercy, Guillaume, Mozziconacci, Julien, Scolari, Vittore F, Yang, Kun, Zhao, Guanghou, Thierry, Agnes, Luo, Yisha, Mitchell, Leslie A, Shen, Michael, Shen, Yue, Walker, Roy, Zhang, Weimin, Wu, Yi, Xie, ZeXiong, Luo, Zhouqing, Cai, Yizhi, Dai, Junbiao, Yang, Huanming, Yuan, YingJin, Boeke, Jef D, Bader, Joel S, Muller, Heloise, Koszul, Romain. 3D organization of synthetic and scrambled chromosomes. SCIENCE[J]. 2017, 第 10 作者355(6329): http://dx.doi.org/10.1126/science.aaf4597.
[23] Xie, ZeXiong, Liu, Duo, Li, BingZhi, Zhao, Meng, Zeng, BoXuan, Wu, Yi, Shen, Yue, Lin, Tao, Yang, Ping, Dai, Junbiao, Cai, Yizhi, Yang, Huanming, Yuan, YingJin. Design and chemical synthesis of eukaryotic chromosomes. CHEMICAL SOCIETY REVIEWS[J]. 2017, 第 7 作者46(23): 7191-7207, http://dx.doi.org/10.1039/c7cs00208d.
[24] Xie, ZeXiong, Li, BingZhi, Mitchell, Leslie A, Wu, Yi, Qi, Xin, Jin, Zhu, Jia, Bin, Wang, Xia, Zeng, BoXuan, Liu, HuiMin, Wu, XiaoLe, Feng, Qi, Zhang, WenZheng, Liu, Wei, Ding, MingZhu, Li, Xia, Zhao, GuangRong, Qiao, JianJun, Cheng, JingSheng, Zhao, Meng, Kuang, Zheng, Wang, Xuya, Martin, J Andrew, Stracquadanio, Giovanni, Yang, Kun, Bai, Xue, Zhao, Juan, Hu, MengLong, Lin, QiuHui, Zhang, WenQian, Shen, MingHua, Chen, Si, Su, Wan, Wang, EnXu, Guo, Rui, Zhai, Fang, Guo, XueJiao, Du, HaoXing, Zhu, JiaQing, Song, TianQing, Dai, JunJun, Li, FeiFei, Jiang, GuoZhen, Han, ShiLei, Liu, ShiYang, Yu, ZhiChao, Yang, XiaoNa, Chen, Ken, Hu, Cheng, Li, DaShuai, Jia, Nan, Liu, Yue, Wang, LinTing, Wang, Su, Wei, XiaoTong, Fu, MeiQing, Qu, LanMeng, Xin, SiYu, Liu, Ting, Tian, KaiRen, Li, XueNan, Zhang, JinHua, Song, LiXiang, Liu, JinGui, Lv, JiaFei, Xu, Hang, Tao, Ran, Wang, Yan, Zhang, TingTing, Deng, YeXuan, Wang, YiRan, Li, Ting, Ye, GuangXin, Xu, XiaoRan, Xia, ZhengBao, Zhang, Wei, Yang, ShiLan, Liu, YiLin, Ding, WenQi, Liu, ZhenNing, Zhu, JunQi, Liu, NingZhi, Walker, Roy, Luo, Yisha, Wang, Yun, Shen, Yue, Yang, Huanming, Cai, Yizhi, Ma, PingSheng, Zhang, ChunTing, Bader, Joel S, Boeke, Jef D, Yuan, YingJin. "Perfect" designer chromosome V and behavior of a ring derivative. SCIENCE[J]. 2017, 第 86 作者355(6329): http://dx.doi.org/10.1126/science.aaf4704.
[25] Junbiao Dai, Caiyue Xu, Yan Liu, Qingyu Wu, Jianhui Gong, Jef D Boeke, Yue Shen, Yun Wang, Shuangying Jiang. Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library. GENETICS SOCIETY OF AMERICA. 2017, 第 7 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902193418164ZK.
[26] Shen, Yue, Wang, Yun, Chen, Tai, Gao, Feng, Gong, Jianhui, Abramczyk, Dariusz, Walker, Roy, Zhao, Hongcui, Chen, Shihong, Liu, Wei, Luo, Yisha, Mueller, Carolin A, PaulDuboisTaine, Adrien, Alver, Bonnie, Stracquadanio, Giovanni, Mitchell, Leslie A, Luo, Zhouqing, Fan, Yanqun, Zhou, Baojin, Wen, Bo, Tan, Fengji, Wang, Yujia, Zi, Jin, Xie, Zexiong, Li, Bingzhi, Yang, Kun, Richardson, Sarah M, Jiang, Hui, French, Christopher E, Nieduszynski, Conrad A, Koszul, Romain, Marston, Adele L, Yuan, Yingjin, Wang, Jian, Bader, Joel S, Dai, Junbiao, Boeke, Jef D, Xu, Xun, Cai, Yizhi, Yang, Huanming. Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome. SCIENCE[J]. 2017, 第 1 作者355(6329): http://dx.doi.org/10.1126/science.aaf4791.
[27] Shen, Yue, Stracquadanio, Giovanni, Wang, Yun, Yang, Kun, Mitchell, Leslie A, Xue, Yaxin, Cai, Yizhi, Chen, Tai, Dymond, Jessica S, Kang, Kang, Gong, Jianhui, Zeng, Xiaofan, Zhang, Yongfen, Li, Yingrui, Feng, Qiang, Xu, Xun, Wang, Jun, Wang, Jian, Yang, Huanming, Boeke, Jef D, Bader, Joel S. SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes. GENOME RESEARCH[J]. 2016, 第 1 作者26(1): 36-49, https://www.webofscience.com/wos/woscc/full-record/WOS:000367597000004.
[28] 范楚珧, 刘龙英, 沈玥, 陈泰, 曾筱凡, 杨焕明. 吗啡的合成生物学研究和工业化生产. 科学通报[J]. 2016, 第 3 作者61(13): 1436-1444, https://www.sciengine.com/doi/10.1360/N972015-01206.
[29] Kanigowska, Paulina, Shen, Yue, Zheng, Yijing, Rosser, Susan, Cai, Yizhi. Smart DNA Fabrication Using Sound Waves: Applying Acoustic Dispensing Technologies to Synthetic Biology. JALA[J]. 2016, 第 2 作者21(1): 49-56, http://dx.doi.org/10.1177/2211068215593754.
[30] 谢泽雄, 李炳志, 沈玥, 戴俊彪, 杨焕明, 元英进. 酵母基因组工程. 中国科学. 生命科学[J]. 2015, 第 3 作者45(10): 985-992, https://www.sciengine.com/doi/10.1360/N052015-00052.
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[32] Guo, Yakun, Dong, Junkai, Zhou, Tong, Auxillos, Jamie, Li, Tianyi, Zhang, Weimin, Wang, Lihui, Shen, Yue, Luo, Yisha, Zheng, Yijing, Lin, Jiwei, Chen, GuoQiang, Wu, Qingyu, Cai, Yizhi, Dai, Junbiao. YeastFab: the design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae. NUCLEIC ACIDS RESEARCH[J]. 2015, 第 8 作者43(13): e88-e88, http://dx.doi.org/10.1093/nar/gkv464.
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科研活动
科研项目
（ 1 ） 人工酵母染色体上稀有密码子特性及其替换规律探索, 负责人, 国家任务, 2019-01--2021-12
（ 2 ） DNA存储技术与应用开发, 负责人, 其他任务, 2019-09--2020-06
（ 3 ） 拟南芥微型人工染色体的设计与合成, 负责人, 研究所自选, 2019-09--2022-10
（ 4 ） 高通量合成生物模块化平台开发, 负责人, 地方任务, 2019-06--2022-05
（ 5 ） 基20180216 药用植物药效单体的合成生物学制造, 参与, 地方任务, 2019-03--2022-09
（ 6 ） 基于DNA 原理的高密度安全存储系统研发与生物大数据应用示范, 负责人, 国家任务, 2021-12--2024-11
（ 2 ） DNA存储技术与应用开发, 负责人, 其他任务, 2019-09--2020-06
（ 3 ） 拟南芥微型人工染色体的设计与合成, 负责人, 研究所自选, 2019-09--2022-10
（ 4 ） 高通量合成生物模块化平台开发, 负责人, 地方任务, 2019-06--2022-05
（ 5 ） 基20180216 药用植物药效单体的合成生物学制造, 参与, 地方任务, 2019-03--2022-09
（ 6 ） 基于DNA 原理的高密度安全存储系统研发与生物大数据应用示范, 负责人, 国家任务, 2021-12--2024-11
指导学生
现指导学生
张惠铭 博士研究生 0710Z1-基因组学
龚雪梅 博士研究生 0710Z1-基因组学
陈颖 硕士研究生 0710J3-生物信息学
张家惠 硕士研究生 086000-生物与医药
陈碧燕 硕士研究生 0710Z1-基因组学
李百涛 硕士研究生 071007-遗传学
陈宇婷 硕士研究生 086000-生物与医药