沈爱金 女 中国科学院大连化学物理研究所
电子邮件: ajshen@dicp.ac.cn
通信地址: 大连市中山路457号
邮政编码: 116023
电子邮件: ajshen@dicp.ac.cn
通信地址: 大连市中山路457号
邮政编码: 116023
研究领域
主要从事中药药效物质基础研究及天然产物智能解析,构建高效液相色谱串联质谱的中药复杂体系物质组成分离表征新技术及基于人工智能的中药化合物结构解析技术,深度挖掘中药的物质组成结构及中药代谢的关键化学成分,建设中药物质组成信息数据库。
主要研究方向:
1. 基于多级高分辨质谱技术的化合物结构AI解析
2. 中药物质组成分析新技术及新化合物发现
3. 中药的效应代谢物研究
4. 基于AI的中药物质组成信息库建设
招生信息
招生专业
070302-分析化学
招生方向
中药药效物质基础研究
教育背景
2009-09--2015-07 中国科学院大学 理学博士学位
2005-09--2009-07 厦门大学 理学学士学位
2005-09--2009-07 厦门大学 理学学士学位
学历
博士研究生
学位
博士
工作经历
2024.1-至今,中国科学院大连化学物理研究所,本草物质科学研究室 中药组成结构分析研究组(2810组),组长
2020.7-至今,中国科学院大连化学物理研究所,本草物质科学研究室(28室),副研究员
2015.7-2020.7,中国科学院大连化学物理研究所,分离材料化学与组分中药研究组,助理研究员
工作简历
2024-01~现在, 中国科学院大连化学物理研究所, 2810组 组长
2020-07~现在, 中国科学院大连化学物理研究所, 副研究员
2015-07~2020-07,中国科学院大连化学物理研究所, 助理研究员
2020-07~现在, 中国科学院大连化学物理研究所, 副研究员
2015-07~2020-07,中国科学院大连化学物理研究所, 助理研究员
专利与奖励
专利成果
( 1 ) 一种贝母属药材中甾体生物碱富集纯化的方法, 发明专利, 2022, 第 4 作者, 专利号: CN114720576A
( 2 ) 一种清肺排毒汤组方中药材的解析方法, 发明专利, 2022, 第 3 作者, 专利号: CN114624349A
( 3 ) 基于人工神经网络和差谱的中药复方样品色谱分析方法, 发明专利, 2022, 第 5 作者, 专利号: CN114577967A
( 4 ) 一种穿山甲指纹图谱质量监测方法, 发明专利, 2021, 第 3 作者, 专利号: CN112924570A
( 5 ) 一种胆南星定量指纹图谱质量监测方法, 发明专利, 2021, 第 3 作者, 专利号: CN112924569A
( 6 ) 一种双黄连口服液定量指纹图谱质量监测方法, 发明专利, 2021, 第 3 作者, 专利号: CN112858549A
( 7 ) 一种基于HPLC-DAD的六味地黄丸组方解析和质量分析方法, 发明专利, 2021, 第 3 作者, 专利号: CN112684091A
( 8 ) 一种双查尔酮类化合物及其制备方法和用途, 发明授权, 2022, 第 4 作者, 专利号: CN111233648B
( 9 ) 两性离子聚合物固定相及其制备和应用, 发明专利, 2018, 第 4 作者, 专利号: CN108144594A
( 10 ) 一种高效分离纯化高纯度甘草酸的方法, 专利授权, 2018, 第 5 作者, 专利号: CN107759655A
( 11 ) 一种液相色谱固定相及其制备方法, 发明专利, 2015, 第 4 作者, 专利号: CN105148881A
( 12 ) Zwitterionic stationary phase for hydrophilic interaction liquid chromatography and preparation method thereof, 发明专利, 2015, 第 2 作者, 专利号: US9138721B2
( 13 ) 一种强阳离子交换色谱固定相及其制备方法, 发明专利, 2012, 第 3 作者, 专利号: CN102614845A
( 14 ) 一种两性离子亲水色谱固定相及其制备方法, 发明专利, 2012, 第 2 作者, 专利号: CN102614847A
( 2 ) 一种清肺排毒汤组方中药材的解析方法, 发明专利, 2022, 第 3 作者, 专利号: CN114624349A
( 3 ) 基于人工神经网络和差谱的中药复方样品色谱分析方法, 发明专利, 2022, 第 5 作者, 专利号: CN114577967A
( 4 ) 一种穿山甲指纹图谱质量监测方法, 发明专利, 2021, 第 3 作者, 专利号: CN112924570A
( 5 ) 一种胆南星定量指纹图谱质量监测方法, 发明专利, 2021, 第 3 作者, 专利号: CN112924569A
( 6 ) 一种双黄连口服液定量指纹图谱质量监测方法, 发明专利, 2021, 第 3 作者, 专利号: CN112858549A
( 7 ) 一种基于HPLC-DAD的六味地黄丸组方解析和质量分析方法, 发明专利, 2021, 第 3 作者, 专利号: CN112684091A
( 8 ) 一种双查尔酮类化合物及其制备方法和用途, 发明授权, 2022, 第 4 作者, 专利号: CN111233648B
( 9 ) 两性离子聚合物固定相及其制备和应用, 发明专利, 2018, 第 4 作者, 专利号: CN108144594A
( 10 ) 一种高效分离纯化高纯度甘草酸的方法, 专利授权, 2018, 第 5 作者, 专利号: CN107759655A
( 11 ) 一种液相色谱固定相及其制备方法, 发明专利, 2015, 第 4 作者, 专利号: CN105148881A
( 12 ) Zwitterionic stationary phase for hydrophilic interaction liquid chromatography and preparation method thereof, 发明专利, 2015, 第 2 作者, 专利号: US9138721B2
( 13 ) 一种强阳离子交换色谱固定相及其制备方法, 发明专利, 2012, 第 3 作者, 专利号: CN102614845A
( 14 ) 一种两性离子亲水色谱固定相及其制备方法, 发明专利, 2012, 第 2 作者, 专利号: CN102614847A
出版信息
发表论文
(1) 基于UPLC-Q-TOF-MS技术的赤芍单萜类成分研究, 中国中药杂志, 2023, 第 6 作者 通讯作者
(2) 基于超高效液相色谱-四极杆-静电场轨道阱高分辨质谱的刺五加注射液化学成分分析, 色谱, 2023, 第 8 作者 通讯作者
(3) Combining multidimensional chromatography-mass spectrometry and feature-based molecular networking methods for the systematic characterization of compounds in the supercritical fluid extract of Tripterygium wilfordii Hook F, ANALYST, 2022, 第 3 作者 通讯作者
(4) Comprehensive characterization of ingredients in Crocus sativus L. from different origins based on the combination of targeted and nontargeted strategies, FOOD CHEMISTRY, 2022, 第 8 作者 通讯作者
(5) Chemical profiling of Qingfei Paidu Decoction by triplex off-line two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, JOURNAL OF SEPARATION SCIENCE, 2022, 第 1 作者
(6) Integrated strategy for identifying isoflavones in Belamcandae Rhizoma based on the combination of mass defect filtering and neutral-loss-triggered multistage fragmentation, JOURNAL OF CHROMATOGRAPHY A, 2022, 第 8 作者 通讯作者
(7) A strategy for efficient enrichment of steroidal alkaloids from Fritillaria based on fluorinated reversed-phase stationary phase, JOURNAL OF SEPARATION SCIENCE, 2021, 第 8 作者 通讯作者
(8) 基于HPLC-Q-TOF-MS/MS的分子网络技术快速分析夏天无生物碱, Rapid Identification of Alkaloids in the Rhizomes of Corydalis decumbens by Molecular Networking Base on HPLC-Q-TOF-MS/MS, 质谱学报, 2021, 第 4 作者
(9) 穿山甲色谱指纹谱的建立及其在基源鉴别和质量等级区分方面的应用, 色谱, 2020, 第 3 作者 通讯作者
(10) Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 第 9 作者 通讯作者
(11) Synthesis and chromatographic evaluation of a new stationary phase based on mild thiol-Michael addition reaction, JOURNAL OF CHROMATOGRAPHY A, 2020, 第 2 作者
(12) Preparation of glutathione-functionalized zwitterionic silica material for efficient enrichment of sialylated N-glycopeptides, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 第 3 作者
(13) Two-dimensional solid-phase extraction strategy for the selective enrichment of aminoglycosides in milk, JOURNAL OF SEPARATION SCIENCE, 2017, 第 1 作者
(14) Purification of high-purity glycyrrhizin from licorice using hydrophilic interaction solid phase extraction coupled with preparative reversed-phase liquid chromatography, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2017, 第 3 作者
(15) In-Depth Analysis of Glycoprotein Sialylation in Serum Using a Dual-Functional Material with Superior Hydrophilicity and Switchable Surface Charge, ANALYTICAL CHEMISTRY, 2017, 第 6 作者
(16) "Two-dimensional" molecularly imprinted solid-phase extraction coupled with crystallization and high performance liquid chromatography for fast semi-preparative purification of tannins from pomegranate husk extract, JOURNAL OF CHROMATOGRAPHY A, 2017, 第 4 作者
(17) Separation analysis of macrolide antibiotics with good performance on a positively charged C18HCE column, JOURNAL OF SEPARATION SCIENCE, 2016, 第 2 作者
(18) Synthesis and evaluation of sulfobetaine zwitterionic polymer bonded stationary phase, TALANTA, 2016, 第 3 作者
(19) Determination of underivatized glyphosate residues in plant-derived food with low matrix effect by solid phase extraction-liquid chromatography-tandem mass spectrometry, FOOD ANALYTICAL METHODS, 2016, 第 4 作者
(20) 糖类化合物在两性离子亲水作用色谱柱上的保留行为评价, Evaluation of retention behavior of carbohydrate compounds on the zwitterionic hydrophilic interaction liquid chromatographic column, 色谱, 2015, 第 2 作者
(21) A controlled thiol-initiated surface polymerization strategy for the preparation of hydrophilic polymer stationary phases, CHEMICAL COMMUNICATIONS, 2015, 第 2 作者
(22) Preparation and chromatographic evaluation of a newly designedsteviol glycoside modified-silica stationary phase in hydrophilicinteraction liquid chromatography and reversed phase liquidchromatography, JOURNAL OF CHROMATOGRAPHY A, 2015, 第 3 作者
(23) Hydrophilic-subtraction model for the characterization andcomparison of hydrophilic interaction liquid chromatographycolumns, JOURNAL OF CHROMATOGRAPHY A, 2015, 第 3 作者
(24) Preparative separation of a challenging anthocyanin from Lycium ruthenicum Murr. by two-dimensional reversed-phase liquidchromatography/hydrophilic interaction chromatography, RSC ADVANCES, 2015, 第 4 作者
(25) Highly Selective Enrichment of Multi-Phosphopeptides by Click TE-GSH, ACTA CHIMICA SINICA, 2014, 第 2 作者
(26) Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases, PROGRESS IN CHEMISTRY, 2014, 第 1 作者
(27) Highly selective separation of aminoglycoside antibiotics on a zwitterionic Click TE-Cys column, JOURNAL OF SEPARATION SCIENCE, 2014, 第 2 作者
(28) Efficient purification of active bufadienolides by a class separation method based on hydrophilic solid-phase extraction and reversed-phase high performance liquid chromatography, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 3 作者
(29) Sample preparation for mass spectrometric analysis of human serum N-glycans using hydrophilic interaction chromatography-based solid phase extraction, ANALYST, 2014, 第 4 作者
(30) Glutathione-based zwitterionic stationary phase for hydrophilic interaction/cation-exchange mixed-mode chromatography, JOURNAL OF CHROMATOGRAPHY A, 2013, 第 1 作者
(31) 混合模式色谱分离材料的研究及其应用进展, Development and application of separation materials for mixed-mode chromatography, 色谱, 2013, 第 3 作者
(32) Preparation and chromatographic evaluation of a cysteine-bonded zwitterionic hydrophilic interaction liquid chromatography stationary phase, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 1 作者
(33) Hydrophilic interaction/weak cation-exchange mixed-mode chromatography for chitooligosaccharides separation, CARBOHYDRATE RESEARCH, 2012, 第 2 作者
(34) 基于QuEChERS前处理技术和弱阳离子交换色谱的牛奶和奶粉中三聚氰胺的快速检测方法, Rapid analysis of melamine in milk and milk powder using QuEChERS approach coupled with weak cation exchange chromatography, 色谱, 2011, 第 3 作者
(35) A novel zwitterionic HILIC stationary phase based on "thiol-ene" click chemistry between cysteine and vinyl silica, CHEMICAL COMMUNICATIONS, 2011, 第 1 作者
(2) 基于超高效液相色谱-四极杆-静电场轨道阱高分辨质谱的刺五加注射液化学成分分析, 色谱, 2023, 第 8 作者 通讯作者
(3) Combining multidimensional chromatography-mass spectrometry and feature-based molecular networking methods for the systematic characterization of compounds in the supercritical fluid extract of Tripterygium wilfordii Hook F, ANALYST, 2022, 第 3 作者 通讯作者
(4) Comprehensive characterization of ingredients in Crocus sativus L. from different origins based on the combination of targeted and nontargeted strategies, FOOD CHEMISTRY, 2022, 第 8 作者 通讯作者
(5) Chemical profiling of Qingfei Paidu Decoction by triplex off-line two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, JOURNAL OF SEPARATION SCIENCE, 2022, 第 1 作者
(6) Integrated strategy for identifying isoflavones in Belamcandae Rhizoma based on the combination of mass defect filtering and neutral-loss-triggered multistage fragmentation, JOURNAL OF CHROMATOGRAPHY A, 2022, 第 8 作者 通讯作者
(7) A strategy for efficient enrichment of steroidal alkaloids from Fritillaria based on fluorinated reversed-phase stationary phase, JOURNAL OF SEPARATION SCIENCE, 2021, 第 8 作者 通讯作者
(8) 基于HPLC-Q-TOF-MS/MS的分子网络技术快速分析夏天无生物碱, Rapid Identification of Alkaloids in the Rhizomes of Corydalis decumbens by Molecular Networking Base on HPLC-Q-TOF-MS/MS, 质谱学报, 2021, 第 4 作者
(9) 穿山甲色谱指纹谱的建立及其在基源鉴别和质量等级区分方面的应用, 色谱, 2020, 第 3 作者 通讯作者
(10) Combination of multi-model statistical analysis and quantitative fingerprinting in quality evaluation of Shuang-huang-lian oral liquid, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 第 9 作者 通讯作者
(11) Synthesis and chromatographic evaluation of a new stationary phase based on mild thiol-Michael addition reaction, JOURNAL OF CHROMATOGRAPHY A, 2020, 第 2 作者
(12) Preparation of glutathione-functionalized zwitterionic silica material for efficient enrichment of sialylated N-glycopeptides, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2019, 第 3 作者
(13) Two-dimensional solid-phase extraction strategy for the selective enrichment of aminoglycosides in milk, JOURNAL OF SEPARATION SCIENCE, 2017, 第 1 作者
(14) Purification of high-purity glycyrrhizin from licorice using hydrophilic interaction solid phase extraction coupled with preparative reversed-phase liquid chromatography, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2017, 第 3 作者
(15) In-Depth Analysis of Glycoprotein Sialylation in Serum Using a Dual-Functional Material with Superior Hydrophilicity and Switchable Surface Charge, ANALYTICAL CHEMISTRY, 2017, 第 6 作者
(16) "Two-dimensional" molecularly imprinted solid-phase extraction coupled with crystallization and high performance liquid chromatography for fast semi-preparative purification of tannins from pomegranate husk extract, JOURNAL OF CHROMATOGRAPHY A, 2017, 第 4 作者
(17) Separation analysis of macrolide antibiotics with good performance on a positively charged C18HCE column, JOURNAL OF SEPARATION SCIENCE, 2016, 第 2 作者
(18) Synthesis and evaluation of sulfobetaine zwitterionic polymer bonded stationary phase, TALANTA, 2016, 第 3 作者
(19) Determination of underivatized glyphosate residues in plant-derived food with low matrix effect by solid phase extraction-liquid chromatography-tandem mass spectrometry, FOOD ANALYTICAL METHODS, 2016, 第 4 作者
(20) 糖类化合物在两性离子亲水作用色谱柱上的保留行为评价, Evaluation of retention behavior of carbohydrate compounds on the zwitterionic hydrophilic interaction liquid chromatographic column, 色谱, 2015, 第 2 作者
(21) A controlled thiol-initiated surface polymerization strategy for the preparation of hydrophilic polymer stationary phases, CHEMICAL COMMUNICATIONS, 2015, 第 2 作者
(22) Preparation and chromatographic evaluation of a newly designedsteviol glycoside modified-silica stationary phase in hydrophilicinteraction liquid chromatography and reversed phase liquidchromatography, JOURNAL OF CHROMATOGRAPHY A, 2015, 第 3 作者
(23) Hydrophilic-subtraction model for the characterization andcomparison of hydrophilic interaction liquid chromatographycolumns, JOURNAL OF CHROMATOGRAPHY A, 2015, 第 3 作者
(24) Preparative separation of a challenging anthocyanin from Lycium ruthenicum Murr. by two-dimensional reversed-phase liquidchromatography/hydrophilic interaction chromatography, RSC ADVANCES, 2015, 第 4 作者
(25) Highly Selective Enrichment of Multi-Phosphopeptides by Click TE-GSH, ACTA CHIMICA SINICA, 2014, 第 2 作者
(26) Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases, PROGRESS IN CHEMISTRY, 2014, 第 1 作者
(27) Highly selective separation of aminoglycoside antibiotics on a zwitterionic Click TE-Cys column, JOURNAL OF SEPARATION SCIENCE, 2014, 第 2 作者
(28) Efficient purification of active bufadienolides by a class separation method based on hydrophilic solid-phase extraction and reversed-phase high performance liquid chromatography, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 3 作者
(29) Sample preparation for mass spectrometric analysis of human serum N-glycans using hydrophilic interaction chromatography-based solid phase extraction, ANALYST, 2014, 第 4 作者
(30) Glutathione-based zwitterionic stationary phase for hydrophilic interaction/cation-exchange mixed-mode chromatography, JOURNAL OF CHROMATOGRAPHY A, 2013, 第 1 作者
(31) 混合模式色谱分离材料的研究及其应用进展, Development and application of separation materials for mixed-mode chromatography, 色谱, 2013, 第 3 作者
(32) Preparation and chromatographic evaluation of a cysteine-bonded zwitterionic hydrophilic interaction liquid chromatography stationary phase, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 1 作者
(33) Hydrophilic interaction/weak cation-exchange mixed-mode chromatography for chitooligosaccharides separation, CARBOHYDRATE RESEARCH, 2012, 第 2 作者
(34) 基于QuEChERS前处理技术和弱阳离子交换色谱的牛奶和奶粉中三聚氰胺的快速检测方法, Rapid analysis of melamine in milk and milk powder using QuEChERS approach coupled with weak cation exchange chromatography, 色谱, 2011, 第 3 作者
(35) A novel zwitterionic HILIC stationary phase based on "thiol-ene" click chemistry between cysteine and vinyl silica, CHEMICAL COMMUNICATIONS, 2011, 第 1 作者
科研活动
科研项目
( 1 ) 中药化合物高分辨多级质谱库的构建及基于裂解规律的谱图自动化归属, 负责人, 地方任务, 2024-04--2025-03
( 2 ) 基于计算机辅助的夏天无生物碱高效智能表征策略及其应用研究, 负责人, 地方任务, 2023-01--2025-12
( 3 ) 基于多级高分辨质谱技术的异喹啉生物碱人工智能结构解析, 负责人, 研究所自主部署, 2022-01--2024-07
( 4 ) 本草物质组成分析, 负责人, 地方任务, 2021-07--2025-07
( 2 ) 基于计算机辅助的夏天无生物碱高效智能表征策略及其应用研究, 负责人, 地方任务, 2023-01--2025-12
( 3 ) 基于多级高分辨质谱技术的异喹啉生物碱人工智能结构解析, 负责人, 研究所自主部署, 2022-01--2024-07
( 4 ) 本草物质组成分析, 负责人, 地方任务, 2021-07--2025-07
参与会议
(1)中药物质组成分析 中国化学会第十五届全国生物医药色谱质谱及相关技术学术报告会 2024-05-18