基本信息
邵璇 男 硕导 中国科学院动物研究所
电子邮件： shaoxuan@ioz.ac.cn
通信地址： 北京市朝阳区大屯路甲3号
邮政编码：100101
研究领域
主要从事妊娠适应性调节和滋养层细胞代谢相关研究，以此为切入点研究胎盘内分泌功能和代谢机能的调节机制和子痫前期等妊娠疾病的胎盘源性机制。具体的研究内容包括：胎盘营养传输功能单元的构建及其调控机制；子痫前期、胎儿生长受限等重要妊娠疾病的病因学。以一作／并列一作/通讯/共同通讯等身份在PNAS、Journal of Pineal Research、Journal of Biomedical Science、Cell Chemical Biology、Hypertension、Genomics Proteomics Bioinformatics、Cell Proliferation等杂志上发表论文15篇；获得国家发明专利1项和国际PCT专利1项；目前担任Advanced Science、Communications Biology、Cell Biology and Toxicology、Frontiers in Cell and Developmental Biology、Frontiers in Endocrinology、Biology of Reproduction、Placenta、BMC Pregnancy and Childbirth等杂志的审稿人。在读硕士研究生1名。
招生信息
招生专业
100104-病理学与病理生理学
招生方向
病理学与病理生理学
教育背景
2010-09--2014-06 中国科学院动物研究所 理学博士
2007-09--2010-06 军事医学科学院 理学硕士
2002-09--2006-06 河北大学 理学学士
2007-09--2010-06 军事医学科学院 理学硕士
2002-09--2006-06 河北大学 理学学士
工作经历
工作简历
2023-08~现在, 中国科学院动物研究所, 副研究员
2017-07~2021-08,中国科学院动物研究所, 助理研究员
2014-07~2017-06,中国科学院动物研究所, 博士后
2017-07~2021-08,中国科学院动物研究所, 助理研究员
2014-07~2017-06,中国科学院动物研究所, 博士后
专利与奖励
专利成果
（ 1 ） 纤溶酶抑制因子的抑制剂用于预防或治疗子痫前期或子痫的用途, 发明专利, 2021, 第 2 作者, 专利号: CN112675307A
出版信息
发表论文
[1] Jiang, Liyuan, Wang, Xin, Wang, Leyun, Ma, Sinan, Ding, Yali, Liu, Chao, Wang, Siqi, Shao, Xuan, Zhang, Ying, Li, Zhikun, Li, Wei, Feng, Guihai, Zhou, Qi. Deciphering the placental abnormalities associated with somatic cell nuclear transfer at single-nucleus resolution. PROTEIN & CELL[J]. 2023, 第 8 作者pwad030: http://dx.doi.org/10.1093/procel/pwad030.
[2] Shao, Xuan, Yang, Yun, Liu, Yanlei, Wang, Yongqing, Zhao, Yangyu, Yu, Xin, Liu, Juan, Li, YuXia, Wang, YanLing. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta. JOURNAL OF PINEAL RESEARCH[J]. 2023, 第 1 作者75(4): http://dx.doi.org/10.1111/jpi.12913.
[3] Shao, Xuan, Yu, Wenzhe, Yang, Yun, Wang, Feiyang, Yu, Xin, Wu, Hongyu, Ma, Yeling, Cao, Bin, Wang, YanLing. The mystery of the life tree: the placentas(dagger). BIOLOGY OF REPRODUCTION[J]. 2022, 第 1 作者107(1): 301-316, http://dx.doi.org/10.1093/biolre/ioac095.
[4] Li, Guanlin, Wang, Yongqing, Cao, Guangming, Ma, Yeling, Li, YuXia, Zhao, Yangyu, Shao, Xuan, Wang, YanLing. Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia. JOURNAL OF BIOMEDICAL SCIENCE[J]. 2022, 第 7 作者 通讯作者 29(1): http://dx.doi.org/10.1186/s12929-022-00791-5.
[5] Xin Yu, Hongyu Wu, Yun Yang, Feiyang Wang, YanLing Wang, Xuan Shao. Placental Development and Pregnancy-Associated Diseases. MATERNAL-FETAL MEDICINE[J]. 2022, 第 6 作者 通讯作者 4(1): 36-51, https://doaj.org/article/fa6d6c487e1f40a1b1bbf52e9e5f0b0c.
[6] Du, Lili, 王雁玲, Shao, Xuan, Wang, Xiaoyi, Yu, Wenzhe, Bi, Shilei, Chen, Dexiong, Pan, Xingfei, Zeng, Shanshan, Huang, Lijun, Liang, Yingyu, Li, Yulian, Chen, Rufang, Xue, Fengwu, Li, Xiuying, Wang, Shouping, Zhuang, Manli, Liu, Mingxing, Lin, Lin, Yan, Hao, He, Fang, Yu, Lin, Jiang, Qingping, Xiong, Zhongtang, Zhang, Lizi, Cao, Bin, Wang, YanLing, Chen, Dunjin. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at midgestation highlights the defective impacts on foetal health. CELL PROLIFERATION[J]. 2022, 第 3 作者55(4): http://dx.doi.org/10.1111/cpr.13204.
[7] 朱玥霖, 李倩倩, 王雁玲, 邵璇. 胎盘发育和子痫前期. 生物医学转化[J]. 2022, 第 4 作者 通讯作者 3(4): 22-29, http://lib.cqvip.com/Qikan/Article/Detail?id=7108612266.
[8] Shao Xuan, Cao Guangming, Chen Dunjin, Liu Juan, Yu Bolan, Liu Ming, Li YuXia, Cao Bin, Sadovsky Yoel, Wang YanLing. PLACENTAL TROPHOBLAST SYNCYTIALIZATION POTENTIATES MACROPINOCYTOSIS VIA MTOR SIGNALING TO ADAPT TO REDUCED AMINO ACID SUPPLY. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 第 1 作者118(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826386/.
[9] Ma, Yeling, Yu, Xin, Zhang, Lanmei, Liu, Juan, Shao, Xuan, Li, Yuxia, Wang, YanLing. Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy. BIOLOGY OF REPRODUCTION[J]. 2021, 第 5 作者104(3): 624-637, http://dx.doi.org/10.1093/biolre/ioaa208.
[10] Yang, Qian, Ma, Yeling, Liu, Yanlei, Shao, Xuan, Jia, Wentong, Yu, Xin, Li, Yuxia, Yang, Long, Gu, Wenwen, Wang, Haibin, Wang, Jian, Wang, YanLing. MNSF beta regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness. CELL PROLIFERATION[J]. 2021, 第 4 作者54(12): http://dx.doi.org/10.1111/cpr.13145.
[11] Bian, Xiaotao, Liu, Juan, Yang, Qian, Liu, Yanlei, Jia, Wentong, Zhang, Xiaodong, Li, YuXia, Shao, Xuan, Wang, YanLing. MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy. BIOLOGY OF REPRODUCTION[J]. 2021, 第 8 作者 通讯作者 104(2): 418-429, https://www.webofscience.com/wos/woscc/full-record/WOS:000637015600018.
[12] Liu, Juan, Shao, Xuan, Qin, Wei, Zhang, Yanling, Dang, Feihong, Yang, Qian, Yu, Xin, Li, YuXia, Chen, Xing, Wang, Chu, Wang, YanLing. Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine gamma-lyase (CSE) represses trophoblast syncytialization. CELL CHEMICAL BIOLOGY[J]. 2021, 第 2 作者28(6): 788-+,
[13] Wang, Feiyang, Jia, Wentong, Fan, Mengjie, Shao, Xuan, Li, Zhilang, Liu, Yongjie, Ma, Yeling, Li, YuXia, Li, Rong, Tu, Qiang, Wang, YanLing. Single-cell Immune Landscape of Human Recurrent Miscarriage. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2021, 第 4 作者19(2): 208-222, https://doaj.org/article/fb619ef6a70444ebb02f3c91a8f1af31.
[14] Ma, Yeling, Yang, Qian, Fan, Mengjie, Zhang, Lanmei, Gu, Yan, Jia, Wentong, Li, Zhilang, Wang, Feiyang, Li, Yuxia, Wang, Jian, Li, Rong, Shao, Xuan, Wang, YanLing. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. CELL PROLIFERATION[J]. 2020, 第 12 作者 通讯作者 53(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000525834200001.
[15] Xu, Peng, Li, Zhilang, Wang, Yongqing, Yu, Xin, Shao, Xuan, Li, Yuxia, Peng, Chun, Zhao, Yangyu, Wang, YanLing. miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-beta Signaling. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 第 5 作者22: 542-556, http://dx.doi.org/10.1016/j.omtn.2020.09.019.
[16] Wang, Hao, Zhao, Yangyu, Luo, Rongcan, Bian, Xiaotao, Wang, Yongqing, Shao, Xuan, Li, YuXia, Liu, Ming, Wang, YanLing. A positive feedback self-regulatory loop between miR-210 and HIF-1 alpha mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia. BIOLOGY OF REPRODUCTION[J]. 2020, 第 6 作者102(3): 560-570, http://dx.doi.org/10.1093/biolre/ioz196.
[17] Li, Zhilang, Bian, Xiaotao, Ma, Yeling, Yang, Qian, Jia, Wentong, Liu, Juan, Wang, Feiyang, Liu, Ming, Li, YuXia, Shao, Xuan, Wang, YanLing. Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids. ENDOCRINOLOGY[J]. 2020, 第 10 作者 通讯作者 161(11): http://dx.doi.org/10.1210/endocr/bqaa174.
[18] 邵璇, 王雁玲. 胎盘发育研究的突破与展望. 中华围产医学杂志[J]. 2019, 第 1 作者22(10): 694-697, http://lib.cqvip.com/Qikan/Article/Detail?id=7003089538.
[19] Shao, Xuan, Wang, Yongqing, Liu, Yanlei, Guo, Xuejiang, Li, Dong, Huo, Ran, Jia, Wentong, Cao, Guangming, Li, YuXia, Liu, Ming, Sha, Jiahao, Zhao, Yangyu, Wang, YanLing. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. JOURNAL OF HYPERTENSION[J]. 2019, 第 1 作者37(1): 197-205, https://www.webofscience.com/wos/woscc/full-record/WOS:000467336300029.
[20] Liu, Ming, Wang, Yongqing, Lu, Huifen, Wang, Hao, Shi, Xiaoming, Shao, Xuan, Li, Yuxia, Zhao, Yangyu, Wang, YanLing. mir-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MaPK signal. FRONTIERS IN ENDOCRINOLOGY[J]. 2018, 第 6 作者9: https://doaj.org/article/45219cf280844a38bee46ca4b89a0e66.
[21] Liu, Juan, Dang, Feihong, Liu, Ming, Li, Yuxia, Xuan, Shao, Wang, YanLing. H2S SYNTHETASE CYSTATHIONINE gamma-LYASE INHIBITS TROPHOBLAST CELLS SYNCYTIALIZATION THROUGH BLOCKING AR DIMERAZATION. PLACENTA. 2018, 第 5 作者69: E89-E89, https://www.webofscience.com/wos/woscc/full-record/WOS:000444236500308.
[22] Shao, Xuan, Wang, Yongqing, Liu, Yanlei, Guo, Xuejiang, Li, Dong, Huo, Ran, Jia, Wentong, Cao, Guangming, Li, YuXia, Liu, Ming, Sha, Jiahao, Zhao, Yangyu, Wang, YanLing. ASSOCIATION OF STEROID HORMONE IMBALANCE WITH COAGULATORY FACTOR SERPINF2 EXCESS IN PREECLAMPTIC PLACENTA. PLACENTA. 2018, 第 1 作者69: E81-E81, https://www.webofscience.com/wos/woscc/full-record/WOS:000444236500281.
[23] Li, Guanlin, Ma, Liyang, Lu, Huifen, Cao, Guangming, Shao, Xuan, Liu, Yanlei, Li, Yuxia, Liu, Ming, Yang, Huixia, Wang, Yanling. Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia. JOURNAL OF HYPERTENSION[J]. 2018, 第 5 作者36(11): 2215-2225, https://www.webofscience.com/wos/woscc/full-record/WOS:000452654200014.
[24] Qin, Ke, Zhu, Yuntao, Qin, Wei, Gao, Jinjun, Shao, Xuan, Wang, Yanling, Zhou, Wen, Wang, Chu, Chen, Xing. Quantitative Profiling of Protein O-GIcNAcylation Sites by an Isotope-Tagged Cleavable Linker. ACS CHEMICAL BIOLOGY[J]. 2018, 第 5 作者13(8): 1983-1989, https://www.webofscience.com/wos/woscc/full-record/WOS:000442452300011.
[25] Shao, Xuan, Tan, Cheng, Chen, Dunjin, Wang, YanLing. Placental defects are involved in most gene mutations that cause embryonic and fetal death. BIOLOGY OF REPRODUCTION. 2018, 第 1 作者99(3): 476-478, https://www.webofscience.com/wos/woscc/full-record/WOS:000446336600002.
[26] Liu, Yanlei, Lu, Huifen, Jia, Wentong, Dang, Feihong, Ma, Liyang, Li, Yuxia, Shao, Xuan, Wang, Yanling. INFLAMMATORY FACTOR TNF alpha INDUCES SERPINF2 UPREGULATION AND EXCESSIVE HYPER-COAGULATION IN PREECLAMPSIA. PLACENTA. 2018, 第 7 作者69: E80-E80, https://www.webofscience.com/wos/woscc/full-record/WOS:000444236500277.
[27] Shao, Xuan, Liu, Yanlei, Liu, Ming, Wang, Yongqing, Yan, Liying, Wang, Hao, Ma, Liyang, Li, Yuxia, Zhao, Yangyu, Wang, Yanling. Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia. HYPERTENSION[J]. 2017, 第 1 作者69(4): 721-730, https://www.webofscience.com/wos/woscc/full-record/WOS:000395750800031.
[28] Shao, Xuan, Lu, Huifen, Li, Dong, Huo, Ran, Liu, Ming, Liu, Yanlei, Guo, Xuejiang, Cao, Guangming, Li, Yuxia, Sha, Jiahao, Wang, Yanling. REGULATION OF THE PRO-COAGULATION FACTOR SERPINF2 BY PLACENTA-SYNTHESIZED STEROID HORMONES: IMPLICATIONS FOR PREGNANCY ADAPTATION OF THE MATERNAL COAGULATION SYSTEM. PLACENTA[J]. 2016, 第 1 作者45: 94-94, http://dx.doi.org/10.1016/j.placenta.2016.06.116.
[29] Luo, Rongcan, Wang, Yongqing, Xu, Peng, Cao, Guangming, Zhao, Yangyu, Shao, Xuan, Li, Yuxia, Chang, Cheng, Peng, Chun, Wang, Yanling. Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. SCIENTIFIC REPORTS[J]. 2016, 第 6 作者6: http://dx.doi.org/10.1038/srep19588.
[30] 芦慧芬, 刘艳蕾, 邵璇, 王雁玲. 妊娠过程中血液稳态变化的研究进展. 发育医学电子杂志[J]. 2015, 第 3 作者68-73, http://lib.cqvip.com/Qikan/Article/Detail?id=70898968504849534850484851.
[31] Luo, Rongcan, Shao, Xuan, Xu, Peng, Liu, Yanlei, Wang, Yongqing, Zhao, Yangyu, Liu, Ming, Ji, Lei, Li, Yuxia, Chang, Cheng, Qiao, Jie, Peng, Chun, Wang, Yanling. MicroRNA-210 Contributes to Preeclampsia by Downregulating Potassium Channel Modulatory Factor 1. HYPERTENSION[J]. 2014, 第 2 作者64(4): 839-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000341988000024.
[32] Liu, Ming, Wang, Yongqing, Zhao, Yangyu, Shao, Xuan, Ji, Lei, Li, Yuxia, Redman, Christopher, Qiao, Jie, Wang, Yanling. IDENTIFICATION OF A NOVEL BIOMARKER RELIABLY PREDICTING THE RISK FOR SEVERE PREECLAMPSIA. PLACENTA[J]. 2014, 第 4 作者35(9): A77-A78, http://dx.doi.org/10.1016/j.placenta.2014.06.250.
[33] Peng Xu, Zhilang Li, Yongqing Wang, Xin Yu, Xuan Shao, Yuxia Li, Chun Peng, Yangyu Zhao, YanLing Wang. MiR-18a contributes to preeclampsia by downregulating Smad2 (full-length) and reducing transforming growth factor-β signaling. MOLECULAR THERAPY - NUCLEIC ACIDS. 第 5 作者http://dx.doi.org/10.1016/j.omtn.2020.09.019.
[2] Shao, Xuan, Yang, Yun, Liu, Yanlei, Wang, Yongqing, Zhao, Yangyu, Yu, Xin, Liu, Juan, Li, YuXia, Wang, YanLing. Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta. JOURNAL OF PINEAL RESEARCH[J]. 2023, 第 1 作者75(4): http://dx.doi.org/10.1111/jpi.12913.
[3] Shao, Xuan, Yu, Wenzhe, Yang, Yun, Wang, Feiyang, Yu, Xin, Wu, Hongyu, Ma, Yeling, Cao, Bin, Wang, YanLing. The mystery of the life tree: the placentas(dagger). BIOLOGY OF REPRODUCTION[J]. 2022, 第 1 作者107(1): 301-316, http://dx.doi.org/10.1093/biolre/ioac095.
[4] Li, Guanlin, Wang, Yongqing, Cao, Guangming, Ma, Yeling, Li, YuXia, Zhao, Yangyu, Shao, Xuan, Wang, YanLing. Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia. JOURNAL OF BIOMEDICAL SCIENCE[J]. 2022, 第 7 作者 通讯作者 29(1): http://dx.doi.org/10.1186/s12929-022-00791-5.
[5] Xin Yu, Hongyu Wu, Yun Yang, Feiyang Wang, YanLing Wang, Xuan Shao. Placental Development and Pregnancy-Associated Diseases. MATERNAL-FETAL MEDICINE[J]. 2022, 第 6 作者 通讯作者 4(1): 36-51, https://doaj.org/article/fa6d6c487e1f40a1b1bbf52e9e5f0b0c.
[6] Du, Lili, 王雁玲, Shao, Xuan, Wang, Xiaoyi, Yu, Wenzhe, Bi, Shilei, Chen, Dexiong, Pan, Xingfei, Zeng, Shanshan, Huang, Lijun, Liang, Yingyu, Li, Yulian, Chen, Rufang, Xue, Fengwu, Li, Xiuying, Wang, Shouping, Zhuang, Manli, Liu, Mingxing, Lin, Lin, Yan, Hao, He, Fang, Yu, Lin, Jiang, Qingping, Xiong, Zhongtang, Zhang, Lizi, Cao, Bin, Wang, YanLing, Chen, Dunjin. Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at midgestation highlights the defective impacts on foetal health. CELL PROLIFERATION[J]. 2022, 第 3 作者55(4): http://dx.doi.org/10.1111/cpr.13204.
[7] 朱玥霖, 李倩倩, 王雁玲, 邵璇. 胎盘发育和子痫前期. 生物医学转化[J]. 2022, 第 4 作者 通讯作者 3(4): 22-29, http://lib.cqvip.com/Qikan/Article/Detail?id=7108612266.
[8] Shao Xuan, Cao Guangming, Chen Dunjin, Liu Juan, Yu Bolan, Liu Ming, Li YuXia, Cao Bin, Sadovsky Yoel, Wang YanLing. PLACENTAL TROPHOBLAST SYNCYTIALIZATION POTENTIATES MACROPINOCYTOSIS VIA MTOR SIGNALING TO ADAPT TO REDUCED AMINO ACID SUPPLY. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2021, 第 1 作者118(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826386/.
[9] Ma, Yeling, Yu, Xin, Zhang, Lanmei, Liu, Juan, Shao, Xuan, Li, Yuxia, Wang, YanLing. Uterine decidual niche modulates the progressive dedifferentiation of spiral artery vascular smooth muscle cells during human pregnancy. BIOLOGY OF REPRODUCTION[J]. 2021, 第 5 作者104(3): 624-637, http://dx.doi.org/10.1093/biolre/ioaa208.
[10] Yang, Qian, Ma, Yeling, Liu, Yanlei, Shao, Xuan, Jia, Wentong, Yu, Xin, Li, Yuxia, Yang, Long, Gu, Wenwen, Wang, Haibin, Wang, Jian, Wang, YanLing. MNSF beta regulates placental development by conjugating IGF2BP2 to enhance trophoblast cell invasiveness. CELL PROLIFERATION[J]. 2021, 第 4 作者54(12): http://dx.doi.org/10.1111/cpr.13145.
[11] Bian, Xiaotao, Liu, Juan, Yang, Qian, Liu, Yanlei, Jia, Wentong, Zhang, Xiaodong, Li, YuXia, Shao, Xuan, Wang, YanLing. MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy. BIOLOGY OF REPRODUCTION[J]. 2021, 第 8 作者 通讯作者 104(2): 418-429, https://www.webofscience.com/wos/woscc/full-record/WOS:000637015600018.
[12] Liu, Juan, Shao, Xuan, Qin, Wei, Zhang, Yanling, Dang, Feihong, Yang, Qian, Yu, Xin, Li, YuXia, Chen, Xing, Wang, Chu, Wang, YanLing. Quantitative chemoproteomics reveals O-GlcNAcylation of cystathionine gamma-lyase (CSE) represses trophoblast syncytialization. CELL CHEMICAL BIOLOGY[J]. 2021, 第 2 作者28(6): 788-+,
[13] Wang, Feiyang, Jia, Wentong, Fan, Mengjie, Shao, Xuan, Li, Zhilang, Liu, Yongjie, Ma, Yeling, Li, YuXia, Li, Rong, Tu, Qiang, Wang, YanLing. Single-cell Immune Landscape of Human Recurrent Miscarriage. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2021, 第 4 作者19(2): 208-222, https://doaj.org/article/fb619ef6a70444ebb02f3c91a8f1af31.
[14] Ma, Yeling, Yang, Qian, Fan, Mengjie, Zhang, Lanmei, Gu, Yan, Jia, Wentong, Li, Zhilang, Wang, Feiyang, Li, Yuxia, Wang, Jian, Li, Rong, Shao, Xuan, Wang, YanLing. Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation. CELL PROLIFERATION[J]. 2020, 第 12 作者 通讯作者 53(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000525834200001.
[15] Xu, Peng, Li, Zhilang, Wang, Yongqing, Yu, Xin, Shao, Xuan, Li, Yuxia, Peng, Chun, Zhao, Yangyu, Wang, YanLing. miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-beta Signaling. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 第 5 作者22: 542-556, http://dx.doi.org/10.1016/j.omtn.2020.09.019.
[16] Wang, Hao, Zhao, Yangyu, Luo, Rongcan, Bian, Xiaotao, Wang, Yongqing, Shao, Xuan, Li, YuXia, Liu, Ming, Wang, YanLing. A positive feedback self-regulatory loop between miR-210 and HIF-1 alpha mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsia. BIOLOGY OF REPRODUCTION[J]. 2020, 第 6 作者102(3): 560-570, http://dx.doi.org/10.1093/biolre/ioz196.
[17] Li, Zhilang, Bian, Xiaotao, Ma, Yeling, Yang, Qian, Jia, Wentong, Liu, Juan, Wang, Feiyang, Liu, Ming, Li, YuXia, Shao, Xuan, Wang, YanLing. Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids. ENDOCRINOLOGY[J]. 2020, 第 10 作者 通讯作者 161(11): http://dx.doi.org/10.1210/endocr/bqaa174.
[18] 邵璇, 王雁玲. 胎盘发育研究的突破与展望. 中华围产医学杂志[J]. 2019, 第 1 作者22(10): 694-697, http://lib.cqvip.com/Qikan/Article/Detail?id=7003089538.
[19] Shao, Xuan, Wang, Yongqing, Liu, Yanlei, Guo, Xuejiang, Li, Dong, Huo, Ran, Jia, Wentong, Cao, Guangming, Li, YuXia, Liu, Ming, Sha, Jiahao, Zhao, Yangyu, Wang, YanLing. Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia. JOURNAL OF HYPERTENSION[J]. 2019, 第 1 作者37(1): 197-205, https://www.webofscience.com/wos/woscc/full-record/WOS:000467336300029.
[20] Liu, Ming, Wang, Yongqing, Lu, Huifen, Wang, Hao, Shi, Xiaoming, Shao, Xuan, Li, Yuxia, Zhao, Yangyu, Wang, YanLing. mir-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MaPK signal. FRONTIERS IN ENDOCRINOLOGY[J]. 2018, 第 6 作者9: https://doaj.org/article/45219cf280844a38bee46ca4b89a0e66.
[21] Liu, Juan, Dang, Feihong, Liu, Ming, Li, Yuxia, Xuan, Shao, Wang, YanLing. H2S SYNTHETASE CYSTATHIONINE gamma-LYASE INHIBITS TROPHOBLAST CELLS SYNCYTIALIZATION THROUGH BLOCKING AR DIMERAZATION. PLACENTA. 2018, 第 5 作者69: E89-E89, https://www.webofscience.com/wos/woscc/full-record/WOS:000444236500308.
[22] Shao, Xuan, Wang, Yongqing, Liu, Yanlei, Guo, Xuejiang, Li, Dong, Huo, Ran, Jia, Wentong, Cao, Guangming, Li, YuXia, Liu, Ming, Sha, Jiahao, Zhao, Yangyu, Wang, YanLing. ASSOCIATION OF STEROID HORMONE IMBALANCE WITH COAGULATORY FACTOR SERPINF2 EXCESS IN PREECLAMPTIC PLACENTA. PLACENTA. 2018, 第 1 作者69: E81-E81, https://www.webofscience.com/wos/woscc/full-record/WOS:000444236500281.
[23] Li, Guanlin, Ma, Liyang, Lu, Huifen, Cao, Guangming, Shao, Xuan, Liu, Yanlei, Li, Yuxia, Liu, Ming, Yang, Huixia, Wang, Yanling. Transactivation of Met signalling by semaphorin4D in human placenta: implications for the pathogenesis of preeclampsia. JOURNAL OF HYPERTENSION[J]. 2018, 第 5 作者36(11): 2215-2225, https://www.webofscience.com/wos/woscc/full-record/WOS:000452654200014.
[24] Qin, Ke, Zhu, Yuntao, Qin, Wei, Gao, Jinjun, Shao, Xuan, Wang, Yanling, Zhou, Wen, Wang, Chu, Chen, Xing. Quantitative Profiling of Protein O-GIcNAcylation Sites by an Isotope-Tagged Cleavable Linker. ACS CHEMICAL BIOLOGY[J]. 2018, 第 5 作者13(8): 1983-1989, https://www.webofscience.com/wos/woscc/full-record/WOS:000442452300011.
[25] Shao, Xuan, Tan, Cheng, Chen, Dunjin, Wang, YanLing. Placental defects are involved in most gene mutations that cause embryonic and fetal death. BIOLOGY OF REPRODUCTION. 2018, 第 1 作者99(3): 476-478, https://www.webofscience.com/wos/woscc/full-record/WOS:000446336600002.
[26] Liu, Yanlei, Lu, Huifen, Jia, Wentong, Dang, Feihong, Ma, Liyang, Li, Yuxia, Shao, Xuan, Wang, Yanling. INFLAMMATORY FACTOR TNF alpha INDUCES SERPINF2 UPREGULATION AND EXCESSIVE HYPER-COAGULATION IN PREECLAMPSIA. PLACENTA. 2018, 第 7 作者69: E80-E80, https://www.webofscience.com/wos/woscc/full-record/WOS:000444236500277.
[27] Shao, Xuan, Liu, Yanlei, Liu, Ming, Wang, Yongqing, Yan, Liying, Wang, Hao, Ma, Liyang, Li, Yuxia, Zhao, Yangyu, Wang, Yanling. Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia. HYPERTENSION[J]. 2017, 第 1 作者69(4): 721-730, https://www.webofscience.com/wos/woscc/full-record/WOS:000395750800031.
[28] Shao, Xuan, Lu, Huifen, Li, Dong, Huo, Ran, Liu, Ming, Liu, Yanlei, Guo, Xuejiang, Cao, Guangming, Li, Yuxia, Sha, Jiahao, Wang, Yanling. REGULATION OF THE PRO-COAGULATION FACTOR SERPINF2 BY PLACENTA-SYNTHESIZED STEROID HORMONES: IMPLICATIONS FOR PREGNANCY ADAPTATION OF THE MATERNAL COAGULATION SYSTEM. PLACENTA[J]. 2016, 第 1 作者45: 94-94, http://dx.doi.org/10.1016/j.placenta.2016.06.116.
[29] Luo, Rongcan, Wang, Yongqing, Xu, Peng, Cao, Guangming, Zhao, Yangyu, Shao, Xuan, Li, Yuxia, Chang, Cheng, Peng, Chun, Wang, Yanling. Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. SCIENTIFIC REPORTS[J]. 2016, 第 6 作者6: http://dx.doi.org/10.1038/srep19588.
[30] 芦慧芬, 刘艳蕾, 邵璇, 王雁玲. 妊娠过程中血液稳态变化的研究进展. 发育医学电子杂志[J]. 2015, 第 3 作者68-73, http://lib.cqvip.com/Qikan/Article/Detail?id=70898968504849534850484851.
[31] Luo, Rongcan, Shao, Xuan, Xu, Peng, Liu, Yanlei, Wang, Yongqing, Zhao, Yangyu, Liu, Ming, Ji, Lei, Li, Yuxia, Chang, Cheng, Qiao, Jie, Peng, Chun, Wang, Yanling. MicroRNA-210 Contributes to Preeclampsia by Downregulating Potassium Channel Modulatory Factor 1. HYPERTENSION[J]. 2014, 第 2 作者64(4): 839-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000341988000024.
[32] Liu, Ming, Wang, Yongqing, Zhao, Yangyu, Shao, Xuan, Ji, Lei, Li, Yuxia, Redman, Christopher, Qiao, Jie, Wang, Yanling. IDENTIFICATION OF A NOVEL BIOMARKER RELIABLY PREDICTING THE RISK FOR SEVERE PREECLAMPSIA. PLACENTA[J]. 2014, 第 4 作者35(9): A77-A78, http://dx.doi.org/10.1016/j.placenta.2014.06.250.
[33] Peng Xu, Zhilang Li, Yongqing Wang, Xin Yu, Xuan Shao, Yuxia Li, Chun Peng, Yangyu Zhao, YanLing Wang. MiR-18a contributes to preeclampsia by downregulating Smad2 (full-length) and reducing transforming growth factor-β signaling. MOLECULAR THERAPY - NUCLEIC ACIDS. 第 5 作者http://dx.doi.org/10.1016/j.omtn.2020.09.019.
科研活动
科研项目
（ 1 ） 糖代谢调节胎盘滋养层细胞合体化的机制研究, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 灵长类胚外组织发育与反复妊娠失败, 参与, 国家任务, 2022-01--2026-12
（ 3 ） 胎盘滋养层细胞通过合体化增强巨胞饮能力以应对不良营养微环境的机制, 负责人, 国家任务, 2019-01--2021-12
（ 4 ） 母胎界面免疫耐受形成的时空图谱解析, 参与, 国家任务, 2022-12--2027-11
（ 5 ） 胎盘形成的分子机制, 参与, 国家任务, 2018-12--2021-12
（ 2 ） 灵长类胚外组织发育与反复妊娠失败, 参与, 国家任务, 2022-01--2026-12
（ 3 ） 胎盘滋养层细胞通过合体化增强巨胞饮能力以应对不良营养微环境的机制, 负责人, 国家任务, 2019-01--2021-12
（ 4 ） 母胎界面免疫耐受形成的时空图谱解析, 参与, 国家任务, 2022-12--2027-11
（ 5 ） 胎盘形成的分子机制, 参与, 国家任务, 2018-12--2021-12