基本信息
单淳敏 男 中国科学院微生物研究所
电子邮件： shancm@im.ac.cn
通信地址： 北辰西路1号院3号中科院微生物所H919
邮政编码： 100101
电子邮件： shancm@im.ac.cn
通信地址： 北辰西路1号院3号中科院微生物所H919
邮政编码： 100101
招生信息
招生专业
071007-遗传学
071010-生物化学与分子生物学
071010-生物化学与分子生物学
招生方向
表观遗传学
微生物遗传学与基因组学
植物病原真菌
微生物遗传学与基因组学
植物病原真菌
教育背景
2007-09--2014-07 中国科学院大学 理学博士
2003-09--2007-07 南京大学 理学学士
2003-09--2007-07 南京大学 理学学士
工作经历
工作简历
2021-10~现在, 中国科学院微生物研究所, 项目研究员
2019-10~2021-09,美国哥伦比亚大学, 副研究科学家
2014-10~2019-09,美国哥伦比亚大学, 博士后研究员
2019-10~2021-09,美国哥伦比亚大学, 副研究科学家
2014-10~2019-09,美国哥伦比亚大学, 博士后研究员
专利与奖励
专利成果
[1] 陈晓亚, 赵波, 单淳敏, 上官小霞, 王凌健. 棉花GhTCP4基因及其在改良棉纤维长度中的应用. CN: CN107630020A, 2018-01-26.
[2] 陈晓亚, 赵波, 单淳敏, 上官小霞, 杨长青, 王凌健. GhPRE1基因及其在改良棉纤维品质中的应用. CN: CN107151669A, 2017-09-12.
[3] 陈晓亚, 单淳敏, 关雪莹, 上官小霞, 王水, 王凌健. HOX3基因在改良棉纤维伸长性状中的用途. CN: CN106191073A, 2016-12-07.
[4] 陈晓亚, 徐冰, 林芝萍, 王凌健, 上官小霞, 单淳敏. 提高植物产量的基因工程方法及材料. CN: CN102732553A, 2012-10-17.
[2] 陈晓亚, 赵波, 单淳敏, 上官小霞, 杨长青, 王凌健. GhPRE1基因及其在改良棉纤维品质中的应用. CN: CN107151669A, 2017-09-12.
[3] 陈晓亚, 单淳敏, 关雪莹, 上官小霞, 王水, 王凌健. HOX3基因在改良棉纤维伸长性状中的用途. CN: CN106191073A, 2016-12-07.
[4] 陈晓亚, 徐冰, 林芝萍, 王凌健, 上官小霞, 单淳敏. 提高植物产量的基因工程方法及材料. CN: CN102732553A, 2012-10-17.
出版信息
发表论文
[1] Shan, ChunMin, Fang, Yimeng, Jia, Songtao. Leaving histone unturned for epigenetic inheritance. FEBS JOURNAL. 2023, 第 1 作者290(2): 310-320,
[2] Miao, Zepu, Wang, Haiting, Tu, Xinyu, Huang, Zhengshen, Huang, Shujing, Zhang, Xinxin, Wang, Fan, Huang, Zhishen, Li, Huihui, Jiao, Yue, Gao, Song, Zhou, Zhipeng, Shan, ChunMin, Li, Jing, Yue, JiaXing. GetPrimers: A generalized PCR-based genetic targeting primer designer enabling easy and standardized targeted gene modification across multiple systems. YEAST. 2023, 第 13 作者 通讯作者 http://dx.doi.org/10.1002/yea.3916.
[3] Bao, Kehan, Shan, ChunMin S, Chen, Xiao, Raiymbek, Gulzhan, Monroe, Jeremy E, Fang, Yimeng, Toda, Takenori M, Koutmou, Kristin, Ragunathan, Kaushik M, Lu, Chao, Berchowitz, Luke M, Jia, Songtao. The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly. PLOS GENETICS[J]. 2022, 18(2): http://dx.doi.org/10.1371/journal.pgen.1010049.
[4] Du, Wenlong, Shi, Guojun, Shan, ChunMin, Li, Zhiming, Zhu, Bing, Jia, Songtao, Li, Qing, Zhang, Zhiguo. Mechanisms of chromatin-based epigenetic inheritance. SCIENCE CHINA-LIFE SCIENCES. 2022, 第 3 作者65(11): 2162-2190, http://dx.doi.org/10.1007/s11427-022-2120-1.
[5] Shan, ChunMin, Fang, Yimeng, Jia, Songtao. Leaving histone unturned for epigenetic inheritance. FEBS JOURNAL. 2021, 第 1 作者
[6] Shan, ChunMin, Kim, JinKwang, Wang, Jiyong, Bao, Kehan, Sun, Yadong, Chen, Huijie, Yue, JiaXing, Stirpe, Alessandro, Zhang, Zhiguo, Lu, Chao, Schalch, Thomas, Liti, Gianni, Nagy, Peter L, Tong, Liang, Qiao, Feng, Jia, Songtao. The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin. CELL REPORTS[J]. 2021, 第 1 作者35(7): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167812/.
[7] Cao, JunFeng, Zhao, Bo, Huang, ChaoChen, Chen, ZhiWen, Zhao, Ting, Liu, HongRu, Hu, GuanJing, Shangguan, XiaoXia, Shan, ChunMin, Wang, LingJian, Zhang, TianZhen, Wendel, Jonathan F, Guan, XueYing, Chen, XiaoYa. The miR319-Targeted GhTCP4 Promotes the Transition from Cell Elongation to Wall Thickening in Cotton Fiber. MOLECULAR PLANT[J]. 2020, 第 9 作者13(7): 1063-1077, http://lib.cqvip.com/Qikan/Article/Detail?id=7102831443.
[8] Shan, ChunMin, Bao, Kehan, Diedrich, Jolene, Chen, Xiao, Lu, Chao, Yates, John R, III, Jia, Songtao. The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin. CELL REPORTS[J]. 2020, 第 1 作者33(13): 108561-108561, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896557/.
[9] Bao, Kehan, Shan, ChunMin, Moresco, James, Yates, John, III, Jia, Songtao. Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin. GENES & DEVELOPMENT[J]. 2019, 第 2 作者33(1-2): 116-126,
[10] Zhang, Yinglu, Shan, ChunMin, Wang, Jiyong, Bao, Kehan, Tong, Liang, Jia, Songtao. Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. SCIENTIFIC REPORTS[J]. 2017, 第 2 作者7: https://www.webofscience.com/wos/woscc/full-record/WOS:000396171300001.
[11] Shan, ChunMin, Wang, Jiyong, Xu, Ke, Chen, Huijie, Yue, JiaXing, Andrews, Stuart, Moresco, James J, Yates, John R, III, Nagy, Peter L, Tong, Liang, Jia, Songtao. A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. ELIFE[J]. 2016, 第 1 作者5: https://doaj.org/article/04ee4764c55949d7a952403e1f5ec89d.
[12] Liu, Xia, Zhao, Bo, Zheng, HuaJun, Hu, Yan, Lu, Gang, Yang, ChangQing, Chen, JieDan, Chen, JunJian, Chen, DianYang, Zhang, Liang, Zhou, Yan, Wang, LingJian, Guo, WangZhen, Bai, YuLin, Ruan, JuXin, Shangguan, XiaoXia, Mao, YingBo, Shan, ChunMin, Jiang, JianPing, Zhu, YongQiang, Jin, Lei, Kang, Hui, Chen, ShuTing, He, XuLin, Wang, Rui, Wang, YueZhu, Chen, Jie, Wang, LiJun, Yu, ShuTing, Wang, BiYun, Wei, Jia, Song, SiChao, Lu, XinYan, Gao, ZhengChao, Gu, WenYi, Deng, Xiao, Ma, Dan, Wang, Sen, Liang, WenHua, Fang, Lei, Cai, CaiPing, Zhu, XieFei, Zhou, BaoLiang, Chen, Z Jeffrey, Xu, ShuHua, Zhang, YuGao, Wang, ShengYue, Zhang, TianZhen, Zhao, GuoPing, Chen, XiaoYa. Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites. SCIENTIFIC REPORTS[J]. 2015, 第 18 作者5: http://dx.doi.org/10.1038/srep14139.
[13] Yu, ZongXia, Wang, LingJian, Zhao, Bo, Shan, ChunMin, Zhang, YuHua, Chen, DongFang, Chen, XiaoYa. Progressive Regulation of Sesquiterpene Biosynthesis in Arabidopsis and Patchouli (Pogostemon cablin) by the miR156-Targeted SPL Transcription Factors. MOLECULAR PLANT[J]. 2015, 第 4 作者8(1): 98-110, http://dx.doi.org/10.1016/j.molp.2014.11.002.
[14] Liu, Xia, Zhao, Bo, Zheng, HuaJun, Hu, Yan, Lu, Gang, Yang, ChangQing, Chen, JieDan, Chen, JunJian, Chen, DianYang, Zhang, Liang, Zhou, Yan, Wang, LingJian, Guo, WangZhen, Bai, YuLin, Ruan, JuXin, Shangguan, XiaoXia, Mao, YingBo, Shan, ChunMin, Jiang, JianPing, Zhu, YongQiang, Jin, Lei, Kang, Hui, Chen, ShuTing, He, XuLin, Wang, Rui, Wang, YueZhu, Chen, Jie, Wang, LiJun, Yu, ShuTing, Wang, BiYun, Wei, Jia, Song, SiChao, Lu, XinYan, Gao, ZhengChao, Gu, WenYi, Deng, Xiao, Ma, Dan, Wang, Sen, Liang, WenHua, Fang, Lei, Cai, CaiPing, Zhu, XieFei, Zhou, BaoLiang, Chen, Z Jeffrey, Xu, ShuHua, Zhang, YuGao, Wang, ShengYue, Zhang, TianZhen, Zhao, GuoPing, Chen, XiaoYa. Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites. SCIENTIFIC REPORTS[J]. 2015, 第 18 作者5: http://dx.doi.org/10.1038/srep14139.
[15] Shan, ChunMin, Shangguan, XiaoXia, Zhao, Bo, Zhang, XiuFang, Chao, Lumen, Yang, ChangQing, Wang, LingJian, Zhu, HuaYu, Zeng, YanDa, Guo, WangZhen, Zhou, BaoLiang, Hu, GuanJing, Guan, XueYing, Chen, Z Jeffrey, Wendel, Jonathan F, Zhang, TianZhen, Chen, XiaoYa. Control of cotton fibre elongation by a homeodomain transcription factor GhHOX3. NATURE COMMUNICATIONS[J]. 2014, 第 1 作者5: https://www.webofscience.com/wos/woscc/full-record/WOS:000345913300004.
[16] Yu, Nan, Cai, WenJuan, Wang, Shucai, Shan, ChunMin, Wang, LingJian, Chen, XiaoYa. Temporal Control of Trichome Distribution by MicroRNA156-Targeted SPL Genes in Arabidopsis thaliana. PLANT CELL[J]. 2010, 第 4 作者22(7): 2322-2335, http://www.corc.org.cn/handle/1471x/2405659.
[17] Guan, XueYing, Li, QianJin, Shan, ChunMin, Wang, Shui, Mao, YingBo, Wang, LingJian, Chen, XiaoYa. The HD-Zip IV gene GaHOX1 from cotton is a functional homologue of the Arabidopsis GLABRA2. PHYSIOLOGIA PLANTARUM[J]. 2008, 第 3 作者134(1): 174-182, https://www.webofscience.com/wos/woscc/full-record/WOS:000258411200016.
[2] Miao, Zepu, Wang, Haiting, Tu, Xinyu, Huang, Zhengshen, Huang, Shujing, Zhang, Xinxin, Wang, Fan, Huang, Zhishen, Li, Huihui, Jiao, Yue, Gao, Song, Zhou, Zhipeng, Shan, ChunMin, Li, Jing, Yue, JiaXing. GetPrimers: A generalized PCR-based genetic targeting primer designer enabling easy and standardized targeted gene modification across multiple systems. YEAST. 2023, 第 13 作者 通讯作者 http://dx.doi.org/10.1002/yea.3916.
[3] Bao, Kehan, Shan, ChunMin S, Chen, Xiao, Raiymbek, Gulzhan, Monroe, Jeremy E, Fang, Yimeng, Toda, Takenori M, Koutmou, Kristin, Ragunathan, Kaushik M, Lu, Chao, Berchowitz, Luke M, Jia, Songtao. The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly. PLOS GENETICS[J]. 2022, 18(2): http://dx.doi.org/10.1371/journal.pgen.1010049.
[4] Du, Wenlong, Shi, Guojun, Shan, ChunMin, Li, Zhiming, Zhu, Bing, Jia, Songtao, Li, Qing, Zhang, Zhiguo. Mechanisms of chromatin-based epigenetic inheritance. SCIENCE CHINA-LIFE SCIENCES. 2022, 第 3 作者65(11): 2162-2190, http://dx.doi.org/10.1007/s11427-022-2120-1.
[5] Shan, ChunMin, Fang, Yimeng, Jia, Songtao. Leaving histone unturned for epigenetic inheritance. FEBS JOURNAL. 2021, 第 1 作者
[6] Shan, ChunMin, Kim, JinKwang, Wang, Jiyong, Bao, Kehan, Sun, Yadong, Chen, Huijie, Yue, JiaXing, Stirpe, Alessandro, Zhang, Zhiguo, Lu, Chao, Schalch, Thomas, Liti, Gianni, Nagy, Peter L, Tong, Liang, Qiao, Feng, Jia, Songtao. The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin. CELL REPORTS[J]. 2021, 第 1 作者35(7): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167812/.
[7] Cao, JunFeng, Zhao, Bo, Huang, ChaoChen, Chen, ZhiWen, Zhao, Ting, Liu, HongRu, Hu, GuanJing, Shangguan, XiaoXia, Shan, ChunMin, Wang, LingJian, Zhang, TianZhen, Wendel, Jonathan F, Guan, XueYing, Chen, XiaoYa. The miR319-Targeted GhTCP4 Promotes the Transition from Cell Elongation to Wall Thickening in Cotton Fiber. MOLECULAR PLANT[J]. 2020, 第 9 作者13(7): 1063-1077, http://lib.cqvip.com/Qikan/Article/Detail?id=7102831443.
[8] Shan, ChunMin, Bao, Kehan, Diedrich, Jolene, Chen, Xiao, Lu, Chao, Yates, John R, III, Jia, Songtao. The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin. CELL REPORTS[J]. 2020, 第 1 作者33(13): 108561-108561, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896557/.
[9] Bao, Kehan, Shan, ChunMin, Moresco, James, Yates, John, III, Jia, Songtao. Anti-silencing factor Epe1 associates with SAGA to regulate transcription within heterochromatin. GENES & DEVELOPMENT[J]. 2019, 第 2 作者33(1-2): 116-126,
[10] Zhang, Yinglu, Shan, ChunMin, Wang, Jiyong, Bao, Kehan, Tong, Liang, Jia, Songtao. Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. SCIENTIFIC REPORTS[J]. 2017, 第 2 作者7: https://www.webofscience.com/wos/woscc/full-record/WOS:000396171300001.
[11] Shan, ChunMin, Wang, Jiyong, Xu, Ke, Chen, Huijie, Yue, JiaXing, Andrews, Stuart, Moresco, James J, Yates, John R, III, Nagy, Peter L, Tong, Liang, Jia, Songtao. A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. ELIFE[J]. 2016, 第 1 作者5: https://doaj.org/article/04ee4764c55949d7a952403e1f5ec89d.
[12] Liu, Xia, Zhao, Bo, Zheng, HuaJun, Hu, Yan, Lu, Gang, Yang, ChangQing, Chen, JieDan, Chen, JunJian, Chen, DianYang, Zhang, Liang, Zhou, Yan, Wang, LingJian, Guo, WangZhen, Bai, YuLin, Ruan, JuXin, Shangguan, XiaoXia, Mao, YingBo, Shan, ChunMin, Jiang, JianPing, Zhu, YongQiang, Jin, Lei, Kang, Hui, Chen, ShuTing, He, XuLin, Wang, Rui, Wang, YueZhu, Chen, Jie, Wang, LiJun, Yu, ShuTing, Wang, BiYun, Wei, Jia, Song, SiChao, Lu, XinYan, Gao, ZhengChao, Gu, WenYi, Deng, Xiao, Ma, Dan, Wang, Sen, Liang, WenHua, Fang, Lei, Cai, CaiPing, Zhu, XieFei, Zhou, BaoLiang, Chen, Z Jeffrey, Xu, ShuHua, Zhang, YuGao, Wang, ShengYue, Zhang, TianZhen, Zhao, GuoPing, Chen, XiaoYa. Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites. SCIENTIFIC REPORTS[J]. 2015, 第 18 作者5: http://dx.doi.org/10.1038/srep14139.
[13] Yu, ZongXia, Wang, LingJian, Zhao, Bo, Shan, ChunMin, Zhang, YuHua, Chen, DongFang, Chen, XiaoYa. Progressive Regulation of Sesquiterpene Biosynthesis in Arabidopsis and Patchouli (Pogostemon cablin) by the miR156-Targeted SPL Transcription Factors. MOLECULAR PLANT[J]. 2015, 第 4 作者8(1): 98-110, http://dx.doi.org/10.1016/j.molp.2014.11.002.
[14] Liu, Xia, Zhao, Bo, Zheng, HuaJun, Hu, Yan, Lu, Gang, Yang, ChangQing, Chen, JieDan, Chen, JunJian, Chen, DianYang, Zhang, Liang, Zhou, Yan, Wang, LingJian, Guo, WangZhen, Bai, YuLin, Ruan, JuXin, Shangguan, XiaoXia, Mao, YingBo, Shan, ChunMin, Jiang, JianPing, Zhu, YongQiang, Jin, Lei, Kang, Hui, Chen, ShuTing, He, XuLin, Wang, Rui, Wang, YueZhu, Chen, Jie, Wang, LiJun, Yu, ShuTing, Wang, BiYun, Wei, Jia, Song, SiChao, Lu, XinYan, Gao, ZhengChao, Gu, WenYi, Deng, Xiao, Ma, Dan, Wang, Sen, Liang, WenHua, Fang, Lei, Cai, CaiPing, Zhu, XieFei, Zhou, BaoLiang, Chen, Z Jeffrey, Xu, ShuHua, Zhang, YuGao, Wang, ShengYue, Zhang, TianZhen, Zhao, GuoPing, Chen, XiaoYa. Gossypium barbadense genome sequence provides insight into the evolution of extra-long staple fiber and specialized metabolites. SCIENTIFIC REPORTS[J]. 2015, 第 18 作者5: http://dx.doi.org/10.1038/srep14139.
[15] Shan, ChunMin, Shangguan, XiaoXia, Zhao, Bo, Zhang, XiuFang, Chao, Lumen, Yang, ChangQing, Wang, LingJian, Zhu, HuaYu, Zeng, YanDa, Guo, WangZhen, Zhou, BaoLiang, Hu, GuanJing, Guan, XueYing, Chen, Z Jeffrey, Wendel, Jonathan F, Zhang, TianZhen, Chen, XiaoYa. Control of cotton fibre elongation by a homeodomain transcription factor GhHOX3. NATURE COMMUNICATIONS[J]. 2014, 第 1 作者5: https://www.webofscience.com/wos/woscc/full-record/WOS:000345913300004.
[16] Yu, Nan, Cai, WenJuan, Wang, Shucai, Shan, ChunMin, Wang, LingJian, Chen, XiaoYa. Temporal Control of Trichome Distribution by MicroRNA156-Targeted SPL Genes in Arabidopsis thaliana. PLANT CELL[J]. 2010, 第 4 作者22(7): 2322-2335, http://www.corc.org.cn/handle/1471x/2405659.
[17] Guan, XueYing, Li, QianJin, Shan, ChunMin, Wang, Shui, Mao, YingBo, Wang, LingJian, Chen, XiaoYa. The HD-Zip IV gene GaHOX1 from cotton is a functional homologue of the Arabidopsis GLABRA2. PHYSIOLOGIA PLANTARUM[J]. 2008, 第 3 作者134(1): 174-182, https://www.webofscience.com/wos/woscc/full-record/WOS:000258411200016.