Zhang, Sanguo  Professor
Phone: 86-10-88256077
School of Mathematical Sciences, 
University of CAS
Yuquan Road 19A, Beijing 100049, China

Research Interests

  • High Dimensional Data Analysis
  • Generalized Linear Models
  • Non(or Semi-)parametric Statistics
  • Measurement Errors Models
  • Change Point Analysis
  • Emprical Likelihood
  • Mixed Distributions
  • Machine Learning
  • Applied Statistics


  • Ph. D in Statistics, Department of Mathematics, University of Science and Technology of China (USTC) 2002
  • B.S. in Mathematics, Department of Mathematics, University of Science and Technology of China (USTC) 1998

Working Experience

  • Lecturer, University of CAS, 2002-2003
  • Post-doc, Department of Statistics, Chinese University of Hongkong, 2003-2004
  • Associate Professor, University of CAS, 2005-2007
  • Post-doc, Department of Biostatistics, Vanderbilt University, 2007-2008
  • Associate Professor, University of CAS, 2008-2010 
  • Professor, University of CAS, 2010-present


Selected Papers:


1) Zhang, S. & Chen, X. Consistency of modified MLE in EV model with replicated observations. Science in China (Series A), 304-310,2001.

2) Zhang, S. & Chen, X. Estimation in the polynomial errors-in-variables model. Science in China (Series A), 1-8, 2002.

3) Zhang, S. & Chen, X. Asymptotic normality of parameters estimation in EV model with replicated observations. Acta Mathematica Scientia (Series B), 107-114, 2002.

4) Zhang, S. & Chen, X. On asymptotic normality of parameters in linear EV model. Chinese Annals of Mathematics (Series B), 495-506, 2002.

5) Liu, J. Zhang, S. & Chen, X. Linear EV model with replicable observed independent variables, Science in China Series A: Mathematics, 752-769, 2006.

6) Zhang, S. & Liao, Y. On some problems of weak consistency of quasi-maximum likelihood estimates in generalized linear models, Science in China Series A: Mathematics, 1287-1296, 2008.

7) Jia, Y., Sun, J., Fan, L., Song, D., Tian, S., Yang, Y., Jia, M., Lu, L., Sun, X. Zhang, S., Kulczycki, A. & Vermund, H. S. Estimates of HIV prevalence in a highly endemic area of China: Dehong Prefecture,Yunnan Province, International Journal of Epidemiology, 1287-1296, 2008.

8) Yu, C., Zhang, S., Zhou, C. & Sile, S. A likelihood test of population Hardy Weinberg Equilibrium for case-control studies. Genetic Epidemiology, 275-280, 2009.

9) Ning, W., Zhang, S. & Yu, C. A Moment-based Test for the Homogeneity in Natural Exponential Family with Quadratic Variance Functions, Statistics and Probability Letters, 828-834, 2009.

10) Ning, W., Gupta, A., K., Yu, C. & Zhang, S., A moment-based test for homogeneity in finite mixture models, Communications in Statistics - Theory and Methods, 1371-1382, 2009. 

11) Zhang, B., Halder, K. S., Zhang, S. & Datta, K. P. Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer. Cancer letters, 114-120, 2009.
12) Wang, G., Zhang, S., Joggerst, S. J., McPherson, J. & Zhao, X. D. Effects of the number and interval of balloon inflations during primary PCI on the extent of myocardial injury in patients with STEMI: Does postconditioning exist in real-world practice?  Journal of Invasive Cardiology, 451-455, 2009.

13) Huang, F., Jiang, Z., Zhang, S. & Gao, S. Reliability evaluation of wireless sensor networks using logistic regression, International Conference on Communications and Mobile Computing, IEEE Computer Society, 334-338, 2010.

14) Wang, S., Zhang, S. & Xue, H. Sieve least squares estimator for partial linear models with current status data, Journal of Systems Science and Complexity, 335-346, 2011.

15) Jiang, J., Zhang, S., Guo, T. Russo’s formula, uniqueness of the infinite cluster, and continuous differentiability of free energy for continuum percolation, Journal of  Applied Probability,  597-610, 2011. 

16) Zhang, S., Liao, Y. & Ning, W. Asymptotic properties of quasi-Maximum likelihood estimates in generalized linear models, Communications in Statistics - Theory and Methods, 4417-4430, 2011.

17) Shi, Y. Li, T. Wang, Y. Gao, Q. Zhang, S. & Li, H. Optical image encryption via ptychography, Optics Letters, 1425-1427, 2013.

18) Liu,J. Chang,N. Zhang,S. & Lei,Z. Recognizing and characterizing dynamics of cellular devices in cellular data network through massive data analysis,International Journal of Communication Systems,28:1884–1897, 2015.

19) Wu,X. Zhang,Q. & Zhang, S. Detecting difference between coeficients in linear model using jackknife empirical likelihood,Journal of Systems Science and Complexity,29:542-556, 2016.

20) Zhang, Q., Zhang, S. Liu, J. Huang, J. & Ma, S. Panelized integrative analysis under the accelerated failure time model, Statistica Sinica, 26:493-508, 2016.

21) Wu,X. Zhang,S. Zhang, Q. & Ma,S. Detecting change point in linear regression using jackknife empirical likelihood,Statistics and its interface,9: 113–122, 2016.

22)Zang, Y. Zhang, S.  Li, Q. Zhang, Q. Jackknife empirical likelihood test for high-dimensional regression coefficients, Computational Statistics & Data Analysis, 94:302–316, 2016.

23) Hu, X., Zhang W, Zhang S, Ma S, & Li. Q. Group-combined p-values with applications to genetic association studies. Bioinformatics, 32, 2737–2743, 2016.

24) Zang, Y., Zhao, Y., Zhang, Q., Cai, H., Zhang, S. & Ma, S. Identifying Gene-Environment Interactions with a Least Relative Error Approach, Statistical Applications from Clinical Trials and Personalized Medicine to Finance and Business Analytics: Selected Papers from the 2015 ICSA/Graybill Applied Statistics Symposium, Colorado State University, Fort Collins[M]. Springer, 305-321, 2016.

25) Zang, Y. Zhang, Q., Zhang, S.  Li, Q. & Ma, S. Empirical likelihood test for high dimensional generalized linear models. Invited book chapter. Big and Complex Data Analysis: Statistical Methodologies and Applications, Springer, 29-50, 2017. 

26) Wang, G., Zhang, Q., Zang, Y., Zhang, S. & Ma, S. Identifying gene-environment interactions associated with prognosis using penalized robust regression. Invited book chapter. Big and Complex Data Analysis: Statistical Methodologies and Applications, Springer. 347-367, 2017. 

27) Hu, X., Duan, X., Pan, D., Zhang, S., & Li, Q. A Model-embedded Trend Test with Incorporating Hardy-Weinberg Equilibrium Information. Journal of Systems Science and Complexity, 101-110, 2017.

28) Huang, Y., Zhang, Q., Zhang, S., Huang, J. & Ma, S. Promoting similarity of sparsity structures in intergrative analysis with penalization. Journal of American Statistical Association,  342-350, 2017.

29) Wu,X. Zhang,S. & Zhang,Q. A note on the two sample mean problem based on jackknife empirical likelihood,Communications in Statistics - Theory and Methods,7827-7836, 2017. 

30) Wang, G., Zhang,S., & Dai, P. A Robust image denoising algorithm based on Exponential squared loss and SELO penalty,Acta Mathematicae Applicatae Sinica, English Series,753-770, 2017. 

31) Zang, Y., Zhao, Q., Zhang, Q., Li, Y., Zhang,S. & Ma, S. Inferring gene regulatory relations using high-dimensional robust estimation. Genetic Epidemiology, 437-454, 2017. 

32) Wu, M.,Zang, Y., Zhang,S., Huang, J. & Ma, S. Accommodating missingness in environmental measurements in gene-environment interaction analysis. Genetic Epidemiology, 523-554, 2017. 

33) Fu, S., Zhang, S. & Liu, Y. Adaptively weighted large-margin angle-based classifiers,  Journal of multivariate analysis, 282-299, 2018.

34) Li, J., Zhang, W., Zhang, S. & Li, Q. A theoretic study of a distance-based regression model, Science China Mathematics, 979-998, 2019.

35) Fu, S., He, Q., Zhang, S. & Liu, Y. Robust outcome weighted learning for optimal individualized treatment rules,  Journal of biopharmaceutical statistics, 606-624, 2019.

36) Xue, Y., Wang, J., Ding, J., Zhang, S. & Li, Q. A powerful test for ordinal trait genetic association analysis,  Statistical Applications in Genetics and Molecular Biology, vol. 18, issue 2, 2019.

37) Xue, Y., Ding, J., Wang, J.,Zhang, S. & Pan, D. Two-phase SSU and SKAT in genetic association studies. Journal of Genetics, 99:9, 2020.

38) Zhang, S., Xue, Y., Zhang, Q., Ma, C., Wu, M. & Ma, S. Identification of gene–environment interactions with marginal penalization. Genetic Epidemiology, 44:159–196, 2020.

39) Bu, D., Yang, Q., Meng, Z., Zhang, S. & Li, Q. Truncated tests for combining evidence of summary statistics. Genetic Epidemiology. 44:687–701, 2020.

40) Liu, Y., Zhang, S., Ma, S. & Zhang, Q. Tests for regression coefficients in high dimensional partially linear models. Statistics and Probability Letters, 163: 108772-108777, 2020.

41) Zhang, S., Fan, Y., Zhong, T. & Ma, S. Histopathological imaging features‑ versus molecular measurements‑based cancer prognosis modeling. Scientific Reports, 10:15030-15038, 2020.

42) Sun, X., Zhang, S., Ma, R., Tao, Y., Zhu, Y., Yang, D. & Shi, Y. Natural speckle-based watermarking with random-like illuminated decoding.  Optics Express,  31832-31843, 2020.

43) Ren, M., Zhang, S. & Zhang, Q., Robust high-dimensional regression for data with anomalous responses, Annals of the Institute of Statistical Mathematics, 

 703-736, 2021.

44) Liu, Y., Ren, M., & Zhang, S.  Empirical likelihood test for regression coefficients in high dimensional partially linear models. Journal of Systems Science and Complexity, 1135-1155, 2021.

45) Ren, M., Zhang, S., Zhang, Q. & Ma, S., HeteroGGM: an R package for Gaussian graphical model-based heterogeneity analysis, Bioinformatics, 3073-3074, 2021.

46) Zhang, S., Hu, X., Luo, Z., Jiang, Yu., Sun, Y. & Ma, S., Biomarker-guided heterogeneity analysis of genetic regulations via multivariate sparse fusion, Statistics in Medicine, 3915-3936, 2021. 

47) Ren, M., Zhang, Q., Zhang, S., Zhong, T., Huang, J. & Ma, S., Hierarchical cancer heterogeneity analysis based on histopathological imaging features, Biometrics, 1579-1591, 2021.

48) Ren, M., Zhang, S., Ma, S. & Zhang, Q., Gene-environment interaction identification via penalized robust divergence, Biometrical Journal, 461-480, 2022.

49) Ren, M., Zhang, S., Zhang, Q. & Ma, S., Gaussian graphical model-based heterogeneity analysis via penalized fusion, Biometrics, 524-535, 2022.

50) Sun, X., Zhang, S., & Shi, Y.  Cryptanalysis of an optical cryptosystem with uncertainty quantification in a probabilistic model. Applied Optics, 5567-5574, 2022.

51) Li, S. , Ren, M., Gan, J., Zhang, S.., Kang, M, Li, H.,  Machine learning to determine risk factors for myopia progression in primary school children: the anyang childhood eye study. Ophthalmology and Therapy, 573-585, 2022.

52) Fan, Y., Zhang, S., & Ma, S.  Survival Analysis with High-Dimensional Omics Data Using a Threshold Gradient Descent Regularization-Based Neural Network Approach. Genes, 13(9) 1674, 2022.

53) Bu, D., Zhang, S., & Li, N.  Analyzing Multiple Phenotypes Based on Principal Component Analysis. Acta Mathematicae Applicatae Sinica, English Series,  843-860, 2022.

54) Ren, M., Zhang, S., & Wang, J.  Consistent estimation of the number of communities via regularized network embedding, Biometrics,, 2022.

55) Yang, Y., Zhang, S.,  Local offset point cloud transformer based implicit surface reconstruction, Computer Graphics Forum,, 2023.

56) Li, X., Zhang, X., He, W., Bu, D., & Zhang, S. Gene expression prediction based on neighbour connection neural network utilizing gene interaction graphs. Plos one, 18(2), e0281286, 2023.

57) Yan, H., Zhang, S., & Ma, S. Hierarchy‐assisted gene expression regulatory network analysis. Statistical Analysis and Data Mining: The ASA Data Science Journal,