基本信息
上官棣华 男 博导
电子邮件：sgdh@iccas.ac.cn
联系电话：010-62528509
手机号码：
通信地址：北京市海淀区中关村北一街2号
邮政编码：100190
电子邮件：sgdh@iccas.ac.cn
联系电话：010-62528509
手机号码：
通信地址：北京市海淀区中关村北一街2号
邮政编码：100190
研究领域
生化分析
分子识别
复杂体系的分离分析
教育及工作简历
教育背景
1988-1992 中国药科大学 理学学士
1995-1998 中国医学科学院中国协和医科大学医药生物技术研究所 理学硕士
1998-2001 中国科学院化学研究所 理学博士
1995-1998 中国医学科学院中国协和医科大学医药生物技术研究所 理学硕士
1998-2001 中国科学院化学研究所 理学博士
工作经历
1992-1995 同济医科大学附属协和医院 药师
2001-2003 中国科学院化学研究所 助理研究员
2003-2006 佛罗里达大学化学系 博士后
2007-至今 中国科学院化学研究所 研究员
2001-2003 中国科学院化学研究所 助理研究员
2003-2006 佛罗里达大学化学系 博士后
2007-至今 中国科学院化学研究所 研究员
专利与奖励
奖励信息
2002年度中国分析测试协会科学技术奖（CAIA奖）一等奖。
研究项目“生物物质的高灵敏度检测” （排名第一）
参加人员：上官棣华 熊少祥 赵睿 马明生 党福全 韩慧婉 陈义 刘国诠
研究项目“生物物质的高灵敏度检测” （排名第一）
参加人员：上官棣华 熊少祥 赵睿 马明生 党福全 韩慧婉 陈义 刘国诠
专利成果
[1] 上官棣华, 张祥茹, 张楠, 邴涛, 刘祥军. 一种靶向c-MET的双特异性核酸适体的构建及应用. CN: CN117778399A, 2024-03-29.
[2] 上官棣华. 识别并结合细胞朊蛋白的核酸适体及其应用. 202211353867.6, 2022-11-01.
[3] 上官棣华. 识别CD171 的核酸适体及其应用. 202211277460.X, 2022-10-19.
[4] 上官棣华, 邴涛, 李胜男, 刘祥军, 张楠. 靶标为碱性磷酸酶异源二聚体的核酸适体及其衍生物和应用. CN: CN115058429A, 2022-09-16.
[5] 上官棣华. 靶标为碱性磷酸酶异源二聚体的核酸适体及其衍生物和应用. 202210732686.8, 2022-06-24.
[6] 上官棣华, 张楠, 隆振豪, 刘祥军. 识别并结合c-MET蛋白的核酸适体及其应用. CN: CN117165593A, 2023-12-05.
[7] 上官棣华. 识别并结合c-MET蛋白的核酸适体及其应用. 2022110573556.4, 2022-05-24.
[8] 上官棣华. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. 202111507125.X, 2021-12-10.
[9] 上官棣华, 刘祥军, 刘静, 张楠. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. CN: CN114436960A, 2022-05-06.
[10] 上官棣华, 刘祥军, 刘静, 张楠. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. CN: CN114436960B, 2024-03-26.
[11] 上官棣华, 刘祥军, 刘静, 张楠. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. CN: CN114436960A, 2022-05-06.
[12] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适体识别并结合整合素α3亚基及其相关功能. CN: CN114058623A, 2022-02-18.
[13] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适配体识别并结合PTPRF及其相关功能的应用研究. CN: CN113817740B, 2024-07-09.
[14] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适配体识别并结合PTPRF及其相关功能的应用研究. CN: CN113817740A, 2021-12-21.
[15] 上官棣华, 卢珊珊, 张楠, 魏涌标, 刘祥军. 一种基于苯并噻唑联杂环的半花菁类化合物及其制备方法与应用. CN: CN111217806B, 2021-06-01.
[16] 上官棣华, 张楠, 王妍, 刘祥军, 邴涛. 一种基于萘酰亚胺-吲哚衍生物的细胞内质网荧光探针及其应用. CN: CN112010838B, 2021-07-13.
[17] 上官棣华, 邴涛, 沈璐瑶, 汪俊彦, 肖潇, 刘祥军, 张楠. 基于核酸适配体的肿瘤检测方法及试剂盒. CN: CN109682973A, 2019-04-26.
[18] 上官棣华, 邴涛, 沈璐瑶, 汪俊彦, 刘祥军, 张楠. 核酸适配体在识别并结合碱性磷酸酶异源二聚体中的应用. CN: CN109554369A, 2019-04-02.
[19] 上官棣华, 王林林, 邴涛, 刘祥军, 张楠, 沈璐瑶. 一种核酸适体识别并结合CD171及其相关功能的应用研究. CN: CN109913462A, 2019-06-21.
[20] 上官棣华, 魏涌标, 刘祥军, 沈璐瑶, 张鑫, 邴涛. 方酸染料类化合物、制备方法及用途. CN: CN108070275A, 2018-05-25.
[21] 上官棣华, 张楠, 邴涛, 刘祥军, 沈璐瑶. 一种识别并结合人转铁蛋白受体的核酸适体序列及其应用. CN: CN106191069A, 2016-12-07.
[22] 上官棣华, 柳影, 周进, 王林林, 刘祥军. HQO作为监测活细胞中线粒体自噬过程荧光探针的应用. CN: CN105838354A, 2016-08-10.
[23] 上官棣华, 邴涛, 汪寅生, 刘祥军. 核酸适配体在识别并结合整合素α4中的应用. CN: CN104988154A, 2015-10-21.
[24] 上官棣华, 邴涛, 汪寅生, 刘祥军. 核酸适配体在识别并结合L选择素中的应用. CN: CN105044322A, 2015-11-11.
[25] 上官棣华, 刘祥军, 吴尚荣, 王林林. 2,9-双苯乙烯取代的邻菲罗啉类化合物及其制备方法与应用. CN: CN104693199A, 2015-06-10.
[26] 上官棣华, 柳影, 刘祥军, 王林林. N,N-二戊烷取代的喹吖啶酮类化合物及其制备方法与应用. CN: CN104650080A, 2015-05-27.
[27] 上官棣华, 张楠, 邴涛, 刘祥军. 一种识别耐阿霉素乳腺癌细胞的核酸适体及其筛选方法和应用. CN: CN104498500A, 2015-04-08.
[28] 上官棣华, 金冰, 刘祥军, 王林林, 张楠. 二苯并咪唑联咔唑类化合物在用于特异性结合核酸G-四链体结构及在抗肿瘤药物中的应用. CN: CN103728294A, 2014-04-16.
[29] 高新, 上官棣华, 罗云, 邴涛, 王元元. 一种核酸适配体及其筛选方法、在检测前列腺癌细胞株中的应用. CN: CN103642810A, 2014-03-19.
[30] 上官棣华, 乞萃, 刘祥军, 邴涛. 特异性识别玉米素的核酸适体及其筛选方法和应用. CN: CN102732523A, 2012-10-17.
[31] 上官棣华, 梅宏成, 刘祥军, 邴涛. 识别含对硝基苯磺酰胺基的化合物的核酸适体及其应用. CN: CN102618546A, 2012-08-01.
[32] 上官棣华, 周进, 刘祥军, 方灿良. 并杂环萘酰亚胺及其制备方法与应用. CN: CN102344449A, 2012-02-08.
[33] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 一种用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101914543A, 2010-12-15.
[34] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101955939A, 2011-01-26.
[35] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101538570A, 2009-09-23.
[36] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的一种核酸适体及其筛选方法. CN: CN101914542A, 2010-12-15.
[37] 上官棣华, 刘祥军, 乞萃. 胸腺嘧啶作为特异性汞离子吸附剂的应用. CN: CN101306350A, 2008-11-19.
[38] 刘国诠, 毛建军, 赵睿, 上官棣华. 一种夹心型液芯波导结构检测池. CN: CN101000299A, 2007-07-18.
[2] 上官棣华. 识别并结合细胞朊蛋白的核酸适体及其应用. 202211353867.6, 2022-11-01.
[3] 上官棣华. 识别CD171 的核酸适体及其应用. 202211277460.X, 2022-10-19.
[4] 上官棣华, 邴涛, 李胜男, 刘祥军, 张楠. 靶标为碱性磷酸酶异源二聚体的核酸适体及其衍生物和应用. CN: CN115058429A, 2022-09-16.
[5] 上官棣华. 靶标为碱性磷酸酶异源二聚体的核酸适体及其衍生物和应用. 202210732686.8, 2022-06-24.
[6] 上官棣华, 张楠, 隆振豪, 刘祥军. 识别并结合c-MET蛋白的核酸适体及其应用. CN: CN117165593A, 2023-12-05.
[7] 上官棣华. 识别并结合c-MET蛋白的核酸适体及其应用. 2022110573556.4, 2022-05-24.
[8] 上官棣华. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. 202111507125.X, 2021-12-10.
[9] 上官棣华, 刘祥军, 刘静, 张楠. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. CN: CN114436960A, 2022-05-06.
[10] 上官棣华, 刘祥军, 刘静, 张楠. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. CN: CN114436960B, 2024-03-26.
[11] 上官棣华, 刘祥军, 刘静, 张楠. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. CN: CN114436960A, 2022-05-06.
[12] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适体识别并结合整合素α3亚基及其相关功能. CN: CN114058623A, 2022-02-18.
[13] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适配体识别并结合PTPRF及其相关功能的应用研究. CN: CN113817740B, 2024-07-09.
[14] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适配体识别并结合PTPRF及其相关功能的应用研究. CN: CN113817740A, 2021-12-21.
[15] 上官棣华, 卢珊珊, 张楠, 魏涌标, 刘祥军. 一种基于苯并噻唑联杂环的半花菁类化合物及其制备方法与应用. CN: CN111217806B, 2021-06-01.
[16] 上官棣华, 张楠, 王妍, 刘祥军, 邴涛. 一种基于萘酰亚胺-吲哚衍生物的细胞内质网荧光探针及其应用. CN: CN112010838B, 2021-07-13.
[17] 上官棣华, 邴涛, 沈璐瑶, 汪俊彦, 肖潇, 刘祥军, 张楠. 基于核酸适配体的肿瘤检测方法及试剂盒. CN: CN109682973A, 2019-04-26.
[18] 上官棣华, 邴涛, 沈璐瑶, 汪俊彦, 刘祥军, 张楠. 核酸适配体在识别并结合碱性磷酸酶异源二聚体中的应用. CN: CN109554369A, 2019-04-02.
[19] 上官棣华, 王林林, 邴涛, 刘祥军, 张楠, 沈璐瑶. 一种核酸适体识别并结合CD171及其相关功能的应用研究. CN: CN109913462A, 2019-06-21.
[20] 上官棣华, 魏涌标, 刘祥军, 沈璐瑶, 张鑫, 邴涛. 方酸染料类化合物、制备方法及用途. CN: CN108070275A, 2018-05-25.
[21] 上官棣华, 张楠, 邴涛, 刘祥军, 沈璐瑶. 一种识别并结合人转铁蛋白受体的核酸适体序列及其应用. CN: CN106191069A, 2016-12-07.
[22] 上官棣华, 柳影, 周进, 王林林, 刘祥军. HQO作为监测活细胞中线粒体自噬过程荧光探针的应用. CN: CN105838354A, 2016-08-10.
[23] 上官棣华, 邴涛, 汪寅生, 刘祥军. 核酸适配体在识别并结合整合素α4中的应用. CN: CN104988154A, 2015-10-21.
[24] 上官棣华, 邴涛, 汪寅生, 刘祥军. 核酸适配体在识别并结合L选择素中的应用. CN: CN105044322A, 2015-11-11.
[25] 上官棣华, 刘祥军, 吴尚荣, 王林林. 2,9-双苯乙烯取代的邻菲罗啉类化合物及其制备方法与应用. CN: CN104693199A, 2015-06-10.
[26] 上官棣华, 柳影, 刘祥军, 王林林. N,N-二戊烷取代的喹吖啶酮类化合物及其制备方法与应用. CN: CN104650080A, 2015-05-27.
[27] 上官棣华, 张楠, 邴涛, 刘祥军. 一种识别耐阿霉素乳腺癌细胞的核酸适体及其筛选方法和应用. CN: CN104498500A, 2015-04-08.
[28] 上官棣华, 金冰, 刘祥军, 王林林, 张楠. 二苯并咪唑联咔唑类化合物在用于特异性结合核酸G-四链体结构及在抗肿瘤药物中的应用. CN: CN103728294A, 2014-04-16.
[29] 高新, 上官棣华, 罗云, 邴涛, 王元元. 一种核酸适配体及其筛选方法、在检测前列腺癌细胞株中的应用. CN: CN103642810A, 2014-03-19.
[30] 上官棣华, 乞萃, 刘祥军, 邴涛. 特异性识别玉米素的核酸适体及其筛选方法和应用. CN: CN102732523A, 2012-10-17.
[31] 上官棣华, 梅宏成, 刘祥军, 邴涛. 识别含对硝基苯磺酰胺基的化合物的核酸适体及其应用. CN: CN102618546A, 2012-08-01.
[32] 上官棣华, 周进, 刘祥军, 方灿良. 并杂环萘酰亚胺及其制备方法与应用. CN: CN102344449A, 2012-02-08.
[33] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 一种用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101914543A, 2010-12-15.
[34] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101955939A, 2011-01-26.
[35] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101538570A, 2009-09-23.
[36] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的一种核酸适体及其筛选方法. CN: CN101914542A, 2010-12-15.
[37] 上官棣华, 刘祥军, 乞萃. 胸腺嘧啶作为特异性汞离子吸附剂的应用. CN: CN101306350A, 2008-11-19.
[38] 刘国诠, 毛建军, 赵睿, 上官棣华. 一种夹心型液芯波导结构检测池. CN: CN101000299A, 2007-07-18.
出版信息
部分发表论文
[1] Xiangru Zhang, Nan Zhang, Haojun Sun, Dandan Li, Zhenhao Long, Jing Sheng, Shuang Zu, Tao Bing, Dihua Shangguan. A Bispecific Chimeric Aptamer Design Platform Based on c-MET Aptamer with a Replaceable Redundant Region. ChemBioChem[J]. 2024, 第 9 作者 通讯作者 25(17): e202400501, https://doi.org/10.1002/cbic.202400501.
[2] Jing Liu, Pu Yan, Xiangjun Liu, Zhenhao Long, Tao Bing, Nan Zhang, Dihua Shangguan. Heptamethine Cyanine-Based Molecule Release Triggered by Mitochondrial ROS. ACS applied bio materials[J]. 2024, 第 7 作者 通讯作者 7(1): 362-368,
[3] Shuang Zu, Zhenhao Long, Xiangru Zhang, Jing Sheng, Yang Xu, Haojun Sun, Xiangjun Liu, Dihua Shangguan. A Comparative Study on the DNA Interactions and Biological Activities of Benzophenanthridine and Protoberberine Alkaloids. JOURNAL OF NATURAL PRODUCTS[J]. 2024, 第 8 作者 通讯作者 87(9): 2170-2179, https://doi.org/10.1021/acs.jnatprod.4c00416.
[4] Li, Yiwei, Zhang, Nan, Wang, Yan, Lu, Shanshan, Sheng, Jing, Liu, Xiangjun, Wei, Yongbiao, Shangguan, Dihua. A naphthalimide-based fluorescent platform for endoplasmic reticulum targeted imaging. CHEMICAL COMMUNICATIONS[J]. 2024, 第 8 作者 通讯作者 60(65): 8565-8568, http://dx.doi.org/10.1039/d4cc02882a.
[5] Yi, Mengwen, Zhang, Nan, Liu, Xiangjun, Liu, Jing, Zhang, Xiangru, Wei, Yongbiao, Shangguan, Dihua. A mitochondria-targeted fluorescent probe for imaging of endogenous carbon monoxide in living cells. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY[J]. 2023, 第 7 作者 通讯作者 291: http://dx.doi.org/10.1016/j.saa.2023.122377.
[6] Sheng, Jing, Zhang, Nan, Long, Zhenhao, Zhang, Xiangru, Zu, Shuang, Liu, Xiangjun, Shangguan, Dihua. DNA Aptamer Binding Octapeptide Repeat Region of Cellular Prion Protein. ANALYTICAL CHEMISTRY[J]. 2023, 第 7 作者 通讯作者 95(50): 18595-18602, http://dx.doi.org/10.1021/acs.analchem.3c04557.
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[79] 常天俊, 李刚, 赵可旭, 班琳, 卞文秀, 邴涛, 上官棣华. 连接环、末端碱基及-价阳离子对G-四链体结构的影响. 高等学校化学学报[J]. 2014, 第 7 作者35(12): 2556-2562, http://lib.cqvip.com/Qikan/Article/Detail?id=663144599.
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指导学生
已毕业学生
邴涛 博士
程晓宏 博士
方灿良 博士
杨晓娟 博士
在读学生
梅宏成 博士研究生 070302-分析化学 80032-化学研究所
常天俊 博士研究生 070302-分析化学 80032-化学研究所
乞萃 博士研究生 070302-分析化学 80032-化学研究所
周进 硕士研究生 070302-分析化学 80032-化学研究所
严景丽 博士研究生 070302-分析化学 80032-化学研究所
张楠 硕士研究生 070302-分析化学 80032-化学研究所
常天俊 博士研究生 070302-分析化学 80032-化学研究所
乞萃 博士研究生 070302-分析化学 80032-化学研究所
周进 硕士研究生 070302-分析化学 80032-化学研究所
严景丽 博士研究生 070302-分析化学 80032-化学研究所
张楠 硕士研究生 070302-分析化学 80032-化学研究所