生化分析
分子识别
复杂体系的分离分析

1988-1992 中国药科大学 理学学士
1995-1998 中国医学科学院中国协和医科大学医药生物技术研究所 理学硕士
1998-2001 中国科学院化学研究所 理学博士

1992-1995  同济医科大学附属协和医院 药师
2001-2003   中国科学院化学研究所 助理研究员
2003-2006  佛罗里达大学化学系 博士后
2007-至今   中国科学院化学研究所 研究员

   

2002年度中国分析测试协会科学技术奖（CAIA奖）一等奖。
研究项目“生物物质的高灵敏度检测” （排名第一）
参加人员：上官棣华 熊少祥 赵睿 马明生 党福全 韩慧婉 陈义 刘国诠

[1] 上官棣华. 识别并结合细胞朊蛋白的核酸适体及其应用. 202211353867.6, 2022-11-01.
[2] 上官棣华. 识别CD171 的核酸适体及其应用. 202211277460.X, 2022-10-19.
[3] 上官棣华. 靶标为碱性磷酸酶异源二聚体的核酸适体及其衍生物和应用. 202210732686.8, 2022-06-24.
[4] 上官棣华. 识别并结合c-MET蛋白的核酸适体及其应用. 2022110573556.4, 2022-05-24.
[5] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适体识别并结合整合素α3亚基及其相关功能. CN: CN114058623A, 2022-02-18.
[6] 上官棣华, 邴涛, 甄笑笑, 吕静. 一种核酸适配体识别并结合PTPRF及其相关功能的应用研究. CN: CN113817740A, 2021-12-21.
[7] 上官棣华. 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途. 202111507125.X, 2021-12-10.
[8] 上官棣华, 张楠, 王妍, 刘祥军, 邴涛. 一种基于萘酰亚胺-吲哚衍生物的细胞内质网荧光探针及其应用. CN: CN112010838B, 2021-07-13.
[9] 上官棣华, 卢珊珊, 张楠, 魏涌标, 刘祥军. 一种基于苯并噻唑联杂环的半花菁类化合物及其制备方法与应用. CN: CN111217806B, 2021-06-01.
[10] 上官棣华, 王林林, 邴涛, 刘祥军, 张楠, 沈璐瑶. 一种核酸适体识别并结合CD171及其相关功能的应用研究. CN: CN109913462A, 2019-06-21.
[11] 上官棣华, 邴涛, 沈璐瑶, 汪俊彦, 肖潇, 刘祥军, 张楠. 基于核酸适配体的肿瘤检测方法及试剂盒. CN: CN109682973A, 2019-04-26.
[12] 上官棣华, 邴涛, 沈璐瑶, 汪俊彦, 刘祥军, 张楠. 核酸适配体在识别并结合碱性磷酸酶异源二聚体中的应用. CN: CN109554369A, 2019-04-02.
[13] 上官棣华, 魏涌标, 刘祥军, 沈璐瑶, 张鑫, 邴涛. 方酸染料类化合物、制备方法及用途. CN: CN108070275A, 2018-05-25.
[14] 上官棣华, 张楠, 邴涛, 刘祥军, 沈璐瑶. 一种识别并结合人转铁蛋白受体的核酸适体序列及其应用. CN: CN106191069A, 2016-12-07.
[15] 上官棣华, 柳影, 周进, 王林林, 刘祥军. HQO作为监测活细胞中线粒体自噬过程荧光探针的应用. CN: CN105838354A, 2016-08-10.
[16] 上官棣华, 邴涛, 汪寅生, 刘祥军. 核酸适配体在识别并结合L选择素中的应用. CN: CN105044322A, 2015-11-11.
[17] 上官棣华, 邴涛, 汪寅生, 刘祥军. 核酸适配体在识别并结合整合素α4中的应用. CN: CN104988154A, 2015-10-21.
[18] 上官棣华, 刘祥军, 吴尚荣, 王林林. 2,9-双苯乙烯取代的邻菲罗啉类化合物及其制备方法与应用. CN: CN104693199A, 2015-06-10.
[19] 上官棣华, 柳影, 刘祥军, 王林林. N,N-二戊烷取代的喹吖啶酮类化合物及其制备方法与应用. CN: CN104650080A, 2015-05-27.
[20] 上官棣华, 张楠, 邴涛, 刘祥军. 一种识别耐阿霉素乳腺癌细胞的核酸适体及其筛选方法和应用. CN: CN104498500A, 2015-04-08.
[21] 上官棣华, 金冰, 刘祥军, 王林林, 张楠. 二苯并咪唑联咔唑类化合物在用于特异性结合核酸G-四链体结构及在抗肿瘤药物中的应用. CN: CN103728294A, 2014-04-16.
[22] 高新, 上官棣华, 罗云, 邴涛, 王元元. 一种核酸适配体及其筛选方法、在检测前列腺癌细胞株中的应用. CN: CN103642810A, 2014-03-19.
[23] 上官棣华, 乞萃, 刘祥军, 邴涛. 特异性识别玉米素的核酸适体及其筛选方法和应用. CN: CN102732523A, 2012-10-17.
[24] 上官棣华, 梅宏成, 刘祥军, 邴涛. 识别含对硝基苯磺酰胺基的化合物的核酸适体及其应用. CN: CN102618546A, 2012-08-01.
[25] 上官棣华, 周进, 刘祥军, 方灿良. 并杂环萘酰亚胺及其制备方法与应用. CN: CN102344449A, 2012-02-08.
[26] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101955939A, 2011-01-26.
[27] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 一种用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101914543A, 2010-12-15.
[28] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的一种核酸适体及其筛选方法. CN: CN101914542A, 2010-12-15.
[29] 方晓红, 赵子龙, 徐丽, 上官棣华, 谭蔚泓. 用于不同亚型非小细胞肺癌分型的核酸适体及其筛选方法. CN: CN101538570A, 2009-09-23.
[30] 上官棣华, 刘祥军, 乞萃. 胸腺嘧啶作为特异性汞离子吸附剂的应用. CN: CN101306350A, 2008-11-19.
[31] 刘国诠, 毛建军, 赵睿, 上官棣华. 一种夹心型液芯波导结构检测池. CN: CN101000299A, 2007-07-18.

   

[1] Yi, Mengwen, Zhang, Nan, Liu, Xiangjun, Liu, Jing, Zhang, Xiangru, Wei, Yongbiao, Shangguan, Dihua. A mitochondria-targeted fluorescent probe for imaging of endogenous carbon monoxide in living cells. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY[J]. 2023, 291: http://dx.doi.org/10.1016/j.saa.2023.122377.
[2] Lv, Jing, Zhen, Xiaoxiao, Li, Dandan, Liao, Guomiao, Long, Zhenhao, Zhang, Nan, Liu, Xiangjun, Bing, Tao, Shangguan, Dihua. Generation of an Aptamer Targeting Receptor-Type Tyrosine-Protein Phosphatase F. ANALYTICAL CHEMISTRY[J]. 2023, 95(2): 1228-1233, http://dx.doi.org/10.1021/acs.analchem.2c03988.
[3] Long, Zhenhao, Bing, Tao, Zhang, Xiangru, Sheng, Jing, Zu, Shuang, Li, Weiwei, Liu, Xiangjun, Zhang, Nan, Shangguan, Dihua. Structural Optimization and Interaction Study of a DNA Aptamer to L1 Cell Adhesion Molecule. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 24(10): http://dx.doi.org/10.3390/ijms24108612.
[4] 钟世龙, 张玲玲, 刘静, 刘祥军, 常天俊, 上官棣华. 基于碳量子点的新型介孔纳米荧光探针的合成及用于铜离子的检测. 分析化学[J]. 2022, 50(1): 47-53, http://lib.cqvip.com/Qikan/Article/Detail?id=7106362324.
[5] Sun, Yue, Zhang, Zhicheng, Bing, Tao, Liu, Jing, Li, Weiwei, Liu, Xiangjun, Zhang, Nan, Shu, Yang, Wang, Jianhua, Shangguan, Dihua. Aptamer-Based Cell Nucleus Imaging via Expansion Microscopy br. ANALYTICAL CHEMISTRY[J]. 2022, 94(15): 6044-6049, http://dx.doi.org/10.1021/acs.analchem.2c00773.
[6] Jing Lv, tao bing, Shangguan, Dihua. Characterization and identification of aptamers against CD49c for the detection, capture and release of cancer cells. ACS APPLIED BIO MATERIALS[J]. 2022, 5(7): 3461-4, https://doi.org/10.1021/acsabm.2c00389.
[7] Zhang, Nan, Wang, Junyan, Bing, Tao, Liu, Xiangjun, Shangguan, Dihua. Transferrin receptor-mediated internalization and intracellular fate of conjugates of a DNA aptamer. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2022, 27: 1249-1259, https://doaj.org/article/1dd2a2eeb706498b8662a331d305d580.
[8] tianjun chang, Li, Guangping, Shangguan, Dihua. Potential G-quadruplexes within the Promoter Nuclease Hypersensitive Sites of the Heat-Responsive Genes in Rice. CHEMBIOCHEM[J]. 2022, 23(20): e202200405-, [9] Yi, Mengwen, Liu, Xiangjun, Liu, Jing, Li, Shengnan, Li, Dandan, Zhang, Xiangru, Zhang, Nan, Wei, Yongbiao, Shangguan, Dihua. A mitochondria-targeted near-infrared fluorescent probe for detection and imaging of HSO3- in living cells. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY[J]. 2022, 278: http://dx.doi.org/10.1016/j.saa.2022.121305.
[10] Zhang, Lingling, Yi, Mengwen, Zhong, Shilong, Liu, Jing, Liu, Xiangjun, Bing, Tao, Zhang, Nan, Wei, Yongbiao, Shangguan, Dihua. p-Aminostyryl thiazole orange derivatives for monitoring mitochondrial viscosity in live cells. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY[J]. 2022, 265: http://dx.doi.org/10.1016/j.saa.2021.120394.
[11] Liu Jing, Liu Xiangjun, Yi Mengwen, Sun Yue, Bing Tao, Zhang Nan, Shangguan Dihua. A photo-activated aptamer-drug conjugate for targeted drug delivery. Chemical Communications[J]. 2022, 58: 10797-10800, [12] Zhang, Nan, Bing, Tao, Shen, Luyao, Feng, Le, Liu, Xiangjun, Shangguan, Dihua. A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2021, 22(16): http://dx.doi.org/10.3390/ijms22168923.
[13] 上官棣华. 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity.. Chem. Commun.. 2021, [14] Liu, Jing, Zhong, Shilong, Zhang, Lingling, Yi, Mengwen, Liu, Xiangjun, Bing, Tao, Zhang, Nan, Shangguan, Dihua. A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity. CHEMICAL COMMUNICATIONS[J]. 2021, 57(53): 6558-6561, http://dx.doi.org/10.1039/d1cc01847g.
[15] Li, Wanming, Bing, Tao, Wang, Rui, Jin, Sihan, Shangguan, Dihua, Chen, Hang. Cell-SELEX-based selection of ssDNA aptamers for specifically targeting BRAF V600E-mutated melanoma. ANALYST[J]. 2021, 147(1): 187-195, http://dx.doi.org/10.1039/d1an01579f.
[16] Wang, Junyan, Bing, Tao, Zhang, Nan, Liu, Xiangjun, Shangguan, Dihua. FnCas12a/crRNA assisted dumbbell-PCR detection of IsomiRs with terminal and inner sequence variants. CHEMICAL COMMUNICATIONS[J]. 2020, 56(69): 10038-10041, http://dx.doi.org/10.1039/d0cc04348f.
[17] Zhang, Lingling, Liu, Xiangjun, Lu, Shanshan, Liu, Jing, Zhong, Shilong, Wei, Yongbiao, Bing, Tao, Zhang, Nan, Shangguan, Dihua. Thiazole Orange Styryl Derivatives as Fluorescent Probes for G-Quadruplex DNA. ACS APPLIED BIO MATERIALS[J]. 2020, 3(5): 2643-2650, [18] 常天俊, 武俐, 卞文秀, 邴涛, 赵同谦, 上官棣华. 凝胶原位探测c-Myc G-四链体的结构多态性. 分析化学[J]. 2020, 48(3): 323-331, http://lib.cqvip.com/Qikan/Article/Detail?id=7100959266.
[19] Bing, Tao, Wang, Junyan, Shen, Luyao, Liu, Xiangjun, Shangguan, Dihua. Prion Protein Targeted by a Prostate Cancer Cell Binding Aptamer, a Potential Tumor Marker?. ACS APPLIED BIO MATERIALS[J]. 2020, 3(5): 2658-2665, http://dx.doi.org/10.1021/acsabm.0c00024.
[20] Shen, Luyao, Jia, Keke, Bing, Tao, Zhang, Zhibao, Zhen, Xiaoxiao, Liu, Xiangjun, Zhang, Nan, Shangguan, Dihua. Detection of Circulating Tumor-Related Materials by Aptamer Capturing and Endogenous Enzyme-Signal Amplification. ANALYTICAL CHEMISTRY[J]. 2020, 92(7): 5370-5378, http://dx.doi.org/10.1021/acs.analchem.0c00051.
[21] Feng, Le, Xiao, Xiao, Liu, Jing, Wang, Junyan, Zhang, Nan, Bing, Tao, Liu, Xiangjun, Zhang, Ziping, Shangguan, Dihua. Immunomodulatory Effects of Lycium barbarum Polysaccharide Extract and Its Uptake Behaviors at the Cellular Level. MOLECULES[J]. 2020, 25(6): http://dx.doi.org/10.3390/molecules25061351.
[22] Liu, Jing, Liu, Xiangjun, Lu, Shanshan, Zhang, Lingling, Feng, Le, Zhong, Shilong, Zhang, Nan, Bing, Tao, Shangguan, Dihua. Ratiometric detection and imaging of hydrogen sulfide in mitochondria based on a cyanine/naphthalimide hybrid fluorescent probe. ANALYST[J]. 2020, 145(20): 6549-6555, http://dx.doi.org/10.1039/d0an01314e.
[23] Liu, Xiangjun, Wang, Linlin, Bing, Tao, Zhang, Nan, Shangguan, Dihua. A Mitochondria-Targeted Ratiometric Fluorescent pH Probe. ACSAPPLIEDBIOMATERIALS[J]. 2019, 2(3): 1368-1375, [24] Shen, Luyao, Bing, Tao, Zhang, Nan, Wang, LinLin, Wang, Junyan, Liu, Xiangjun, Shangguan, Dihua. A Nucleus-Targeting DNA Aptamer for Dead Cell Indication. ACS SENSORS[J]. 2019, 4(6): 1612-1618, https://www.webofscience.com/wos/woscc/full-record/WOS:000473827800019.
[25] He, Junqing, Wang, Junyan, Zhang, Nan, Shen, Luyao, Wang, Linlin, Xiao, Xiao, Wang, Yan, Bing, Tao, Liu, Xiangjun, Li, Songqing, Shangguan, Dihua. In vitro selection of DNA aptamers recognizing drug-resistant ovarian cancer by cell-SELEX. TALANTA[J]. 2019, 194: 437-445, http://dx.doi.org/10.1016/j.talanta.2018.10.028.
[26] Bing, Tao, Shen, Luyao, Wang, Junyan, Wang, Linlin, Liu, Xiangjun, Zhang, Nan, Xiao, Xiao, Shangguan, Dihua. Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers. ADVANCED SCIENCE[J]. 2019, 6(11): https://doaj.org/article/3698e4db1b5b46aca7231e49b5b2b2ab.
[27] Xiao Xiao, Wei Ren, Nan Zhang, Tao Bing, Xiangjun Liu, Zhenwen Zhao, Dihua Shangguan. Comparative Study of the Chemical Constituents and Bioactivities of the Extracts from Fruits, Leaves and Root Barks of Lycium barbarum. MOLECULES[J]. 2019, 24(8): https://doaj.org/article/170dbee6a73745d2b6a79e7ac18aa145.
[28] Wang, Yan, Zhang, Nan, Lu, Shanshan, Wang, Junyan, Bing, Tao, Liu, Xiangjun, Chen, Chunyan, Shangguan, Dihua. Dual-Monitoring Glycosylation and Local pH in Live Cells by Metabolic Oligosaccharide Engineering with a Ratiometric Fluorescent Tag. ANALYTICAL CHEMISTRY[J]. 2019, 91(21): 13720-13728, http://dx.doi.org/10.1021/acs.analchem.9b03047.
[29] Wang, Junyan, Bing, Tao, Zhang, Nan, Shen, Luyao, He, Junqing, Liu, Xiangjun, Wang, Linlin, Shangguan, Dihua. The Mechanism of the Selective Antiproliferation Effect of Guanine-Based Biomolecules and Its Compensation. ACS CHEMICAL BIOLOGY[J]. 2019, 14(6): 1164-1173, https://www.webofscience.com/wos/woscc/full-record/WOS:000473115900014.
[30] Qiao, Na, Li, Jing, Wu, Xiao, Diao, Donglin, Zhao, Jiaxing, Li, Jiyuan, Ren, Xijiao, Ding, Xiaofan, Shangguan, Dihua, Lou, Xinhui. Speeding up in Vitro Discovery of Structure-Switching Aptamers via Magnetic Cross-Linking Precipitation. ANALYTICAL CHEMISTRY[J]. 2019, 91(21): 13383-13389, http://dx.doi.org/10.1021/acs.analchem.9b00081.
[31] Bing, Tao, Zhang, Nan, Shangguan, Dihua. Cell-SELEX, an Effective Way to the Discovery of Biomarkers and Unexpected Molecular Events. ADVANCED BIOSYSTEMS[J]. 2019, 3(12): http://dx.doi.org/10.1002/adbi.201900193.
[32] Qiao, Juan, Chen, Chuanfang, Shangguan, Dihua, Mu, Xiaoyu, Wang, Shutao, Jiang, Lei, Qi, Li. Simultaneous Monitoring of Mitochondrial Temperature and ATP Fluctuation Using Fluorescent Probes in Living Cells. ANALYTICAL CHEMISTRY[J]. 2018, 90(21): 12553-12558, https://www.webofscience.com/wos/woscc/full-record/WOS:000449722500033.
[33] Shen, Luyao, Bing, Tao, Liu, Xiangjun, Wang, Junyan, Wang, Linlin, Zhang, Nan, Shangguan, Dihua. Flow Cytometric Bead Sandwich Assay Based on a Split Aptamer. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(3): 2312-2318, https://www.webofscience.com/wos/woscc/full-record/WOS:000423496500016.
[34] Wang, Linlin, Liu, Ying, Qi, Cui, Shen, Luyao, Wang, Junyan, Liu, Xiangjun, Zhang, Nan, Bing, Tao, Shangguan, Dihua. Oxidative degradation of polyamines by serum supplement causes cytotoxicity on cultured cells. SCIENTIFIC REPORTS[J]. 2018, 8(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000438024500016.
[35] Jin, Ming, Liu, Xiangjun, Zhang, Xin, Wang, Linlin, Bing, Tao, Zhang, Nan, Zhang, Yun, Shangguan, Dihua. Thiazole Orange-Modified Carbon Dots for Ratiometric Fluorescence Detection of G-Quadruplex and Double-Stranded DNA. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(30): 25166-25173, https://www.webofscience.com/wos/woscc/full-record/WOS:000440956000025.
[36] Ma, Tiancong, Hou, Yi, Zeng, Jianfeng, Liu, Chunyan, Zhang, Peisen, Jing, Lihong, Shangguan, Dihua, Gao, Mingyuan. Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH &ITin Vivo&IT. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(1): 211-218, https://www.webofscience.com/wos/woscc/full-record/WOS:000422813300047.
[37] Wang, Linlin, Bing, Tao, Liu, Ying, Zhang, Nan, Shen, Luyao, Liu, Xiangjun, Wang, Junyan, Shangguan, Dihua. Imaging of Neurite Network with an Anti-L1CAM Aptamer Generated by Neurite-SELEX. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(51): 18066-18073, [38] Bing, Tao, Zheng, Wei, Zhang, Xin, Shen, Luyao, Liu, Xiangjun, Wang, Fuyi, Cui, Jie, Cao, Zehui, Shangguan, Dihua. Triplex-quadruplex structural scaffold: a new binding structure of aptamer. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/66bf06ddf9874127a55d9fc01428cf86.
[39] Chen, Waner, Yang, Yan, Shangguan, Dihua, Wu, Yuejing, Liu, Zhe. Multifunctional hard-shelled microbubbles for differentiating imaging, cavitation and drug release by ultrasound. RSC ADVANCES[J]. 2017, 7(42): 25892-25896, https://www.webofscience.com/wos/woscc/full-record/WOS:000401815800014.
[40] Xin Zhang, Yongbiao Wei, Tao Bing, Xiangjun Liu, Nan Zhang, Junyan Wang, Junqing He, Bing Jin, Dihua Shangguan. Development of squaraine based G-quadruplex ligands using click chemistry. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/7e85dac7107b4a2da4b7cc78844c3336.
[41] Liu, Xiangjun, Bing, Tao, Shangguan, Dihua. Microbead-Based Platform for Multiplex Detection of DNA and Protein. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(11): 9462-9469, https://www.webofscience.com/wos/woscc/full-record/WOS:000397478100028.
[42] Chang, Tianjun, Li, Weiguo, Ding, Zhan, Cheng, Shaofei, Liang, Kun, Liu, Xiangjun, Bin, Tao, Shangguan, Dihua. Detection of G-Quadruplex Structures Formed by G-Rich Sequences from Rice Genome and Transcriptome Using Combined Probes. ANALYTICAL CHEMISTRY[J]. 2017, 89(15): 8162-8169, https://www.webofscience.com/wos/woscc/full-record/WOS:000406982500050.
[43] Liu, Ying, Hu, Xiaoxiao, Wang, Linlin, Liu, Xiangjun, Bing, Tao, Tan, Weihong, Shangguan, Dihua. Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo. DYES AND PIGMENTS[J]. 2017, 145: 168-173, http://dx.doi.org/10.1016/j.dyepig.2017.06.003.
[44] Wei Yongbiao, Hu Xiaoxiao, Shen Luyao, Jin Bing, Liu Xiangjun, Tan Weihong, Shangguan Dihua. Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo. EBIOMEDICINE[J]. 2017, [45] Wei, Yongbiao, Hu, Xiaoxiao, Shen, Luyao, Jin, Bing, Liu, Xiangjun, Tan, Weihong, Shangguan, Dihua. Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo. EBIOMEDICINE[J]. 2017, 23(C): 25-33, https://doaj.org/article/bd00cc26a2524072be2a9e8fcff4d0e8.
[46] Zhang, Xin, Jin, Bing, Zheng, Wei, Zhang, Nan, Liu, Xiangjun, Bing, Tao, Wei, Yongbiao, Wang, Fuyi, Shangguan, Dihua. Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes. DYES AND PIGMENTS[J]. 2016, 132: 405-411, http://dx.doi.org/10.1016/j.dyepig.2016.05.009.
[47] Lyu, Yifan, Chen, Guang, Shangguan, Dihua, Zhang, Liqin, Wan, Shuo, Wu, Yuan, Zhang, Hui, Duan, Lian, Liu, Chao, You, Mingxu, Wang, Jie, Tan, Weihong. Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX. THERANOSTICS[J]. 2016, 6(9): 1440-1452, http://dx.doi.org/10.7150/thno.15666.
[48] Liu, Fang, Bing, Tao, Shangguan, Dihua, Zhao, Meiping, Shao, Na. Ratiometric Fluorescent Biosensing of Hydrogen Peroxide and Hydroxyl Radical in Living Cells with Lysozyme-Silver Nanoclusters: Lysozyme as Stabilizing Ligand and Fluorescence Signal Unit. ANALYTICAL CHEMISTRY[J]. 2016, 88(21): 10631-10638, https://www.webofscience.com/wos/woscc/full-record/WOS:000386991200043.
[49] Zhang, Nan, Bing, Tao, Shen, Luyao, Song, Rusheng, Wang, Linlin, Liu, Xiangjun, Liu, Meirong, Li, Juan, Tan, Weihong, Shangguan, Dihua. Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(12): 3914-3918, https://www.webofscience.com/wos/woscc/full-record/WOS:000372660400007.
[50] Chang, Tianjun, Gong, Hongmei, Ding, Pi, Liu, Xiangjun, Li, Weiguo, Bing, Tao, Cao, Zehui, Shangguan, Dihua. Activity Enhancement of G-Quadruplex/Hemin DNAzyme by Flanking d(CCC). CHEMISTRY-A EUROPEAN JOURNAL[J]. 2016, 22(12): 4015-4021, https://www.webofscience.com/wos/woscc/full-record/WOS:000372526500018.
[51] Wu, Shangrong, Wang, Linlin, Zhang, Nan, Liu, Ying, Zheng, Wei, Chang, Ang, Wang, Fuyi, Li, Songqin, Shangguan, Dihua. A Bis(methylpiperazinylstyryl)phenanthroline as a Fluorescent Ligand for G-Quadruplexes. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2016, 22(17): 6037-6047, https://www.webofscience.com/wos/woscc/full-record/WOS:000374542900035.
[52] Liu, Ying, Zhou, Jin, Wang, Linlin, Hu, Xiaoxiao, Liu, Xiangjun, Liu, Meirong, Cao, Zehui, Shangguan, Dihua, Tan, Weihong. A Cyanine Dye to Probe Mitophagy: Simultaneous Detection of Mitochondria and Autolysosomes in Live Cells. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2016, 138(38): 12368-12374, http://dx.doi.org/10.1021/jacs.6b04048.
[53] 上官棣华. A Bis-methylpiperazin-styryl Phenanthroline as a Fluorescent Ligand for G-Quadruplexes. Chem. Eur. J.. 2016, [54] 常昂, 吴尚荣, 柳影, 张鑫, 魏涌标, 李松青, 刘祥军, 上官棣华. 基于新铜试剂的Cu~（2+）荧光探针的合成及性能研究. 分析科学学报[J]. 2016, 32(1): 58-62, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5638677&detailType=1.
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[56] Liu, Ying, Wang, Linlin, Zhou, Jin, Wu, Shangrong, Wei, Yongbiao, Chang, Ang, Liu, Xiangjun, Shangguan, Dihua. DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives. DYES AND PIGMENTS[J]. 2015, 121: 328-335, http://dx.doi.org/10.1016/j.dyepig.2015.05.035.
[57] Zhang, Nan, Bing, Tao, Liu, Xiangjun, Qi, Cui, Shen, Luyao, Wang, Linlin, Shangguan, Dihua. Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides. CHEMICAL SCIENCE[J]. 2015, 6(7): 3831-3838, http://ir.iccas.ac.cn/handle/121111/27967.
[58] Li, Juan, Hong, ChengYi, Wu, ShuXian, Liang, Hong, Wang, LiPing, Huang, Guoming, Chen, Xian, Yang, HuangHao, Shangguan, Dihua, Tan, Weihong. Facile Phase Transfer and Surface Biofunctionalization of Hydrophobic Nanoparticles Using Janus DNA Tetrahedron Nanostructures. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 137(35): 11210-11213, http://ir.iccas.ac.cn/handle/121111/28387.
[59] Wei, Yongbiao, Zhang, Xin, Wang, Linlin, Liu, Ying, Bing, Tao, Liu, Xiangjun, Shangguan, Dihua. Interaction of bisbenzimidazole-substituted carbazole derivatives with G-quadruplexes and living cells. RSC ADVANCES[J]. 2015, 5(93): 75911-75917, http://ir.iccas.ac.cn/handle/121111/28373.
[60] Zhou, Jin, Fang, Canliang, Liu, Ying, Zhao, Yao, Zhang, Nan, Liu, Xiangjun, Wang, Fuyi, Shangguan, Dihua. Visible-light-induced cleavage of 4-alpha-amino acid substituted naphthalimides and its application in DNA photocleavage. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 13(13): 3931-3935, http://dx.doi.org/10.1039/c5ob00302d.
[61] Bing, Tao, Shangguan, Dihua, Wang, Yinsheng. Facile Discovery of Cell-Surface Protein Targets of Cancer Cell Aptamers. MOLECULAR & CELLULAR PROTEOMICS[J]. 2015, 14(10): 2692-2700, http://dx.doi.org/10.1074/mcp.M115.051243.
[62] Li, Lin, Wang, Linlin, Shangguan, Dihua, Wei, Yanbo, Han, Juanjuan, Xiong, Shaoxiang, Zhao, Zhenwen. Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells. JOURNAL OF CHROMATOGRAPHY A[J]. 2015, 1381: 140-148, http://dx.doi.org/10.1016/j.chroma.2015.01.013.
[63] Hou, Yi, Zhou, Jin, Gao, Zhenyu, Sun, Xiaoyu, Liu, Chunyan, Shangguan, Dihua, Yang, Wensheng, Gao, Mingyuan. Protease-Activated Ratio metric Fluorescent Probe for pH Mapping of Malignant Tumors. ACS NANO[J]. 2015, 9(3): 3199-3205, http://ir.iccas.ac.cn/handle/121111/28479.
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[70] 常天俊, 李刚, 赵可旭, 班琳, 卞文秀, 邴涛, 上官棣华. 连接环、末端碱基及-价阳离子对G-四链体结构的影响. 高等学校化学学报[J]. 2014, 35(12): 2556-2562, http://lib.cqvip.com/Qikan/Article/Detail?id=663144599.
[71] Jin, Bing, Zhang, Xin, Zheng, Wei, Liu, Xiangjun, Zhou, Jin, Zhang, Nan, Wang, Fuyi, Shangguan, Dihua. Dicyanomethylene-Functionalized Squaraine as a Highly Selective Probe for Parallel G-Quadruplexes. ANALYTICAL CHEMISTRY[J]. 2014, 86(14): 7063-7070, https://www.webofscience.com/wos/woscc/full-record/WOS:000339227400047.
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[73] Zhou, Jin, Chang, Ang, Wang, Linlin, Liu, Ying, Liu, Xiangjun, Shangguan, Dihua. Effects of side chains on DNA binding, cell permeability, nuclear localization and cytotoxicity of 4-aminonaphthalimides. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2014, 12(45): 9207-9215, http://dx.doi.org/10.1039/c4ob01274g.
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[94] Yang, Xiaojuan, Bing, Tao, Mei, Hongcheng, Fang, Canliang, Cao, Zehui, Shangguan, Dihua. Characterization and application of a DNA aptamer binding to L-tryptophan. ANALYST[J]. 2011, 136(3): 577-585, http://www.irgrid.ac.cn/handle/1471x/898398.
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邴涛 博士 
程晓宏 博士
方灿良 博士
杨晓娟 博士

梅宏成 博士研究生 070302-分析化学 80032-化学研究所 
常天俊 博士研究生 070302-分析化学 80032-化学研究所
乞萃 博士研究生 070302-分析化学 80032-化学研究所 
周进 硕士研究生 070302-分析化学 80032-化学研究所
严景丽 博士研究生 070302-分析化学 80032-化学研究所
张楠 硕士研究生 070302-分析化学 80032-化学研究所