海洋微生物天然产物化学及生物合成研究

海洋生物医 药

070703-海洋生物学
100705-微生物与生化药学
070303-有机化学

微生物天然活性物质的分离鉴定

2007-09--2010-06   中国科学院大学（中国科学院昆明植物研究所）   药物化学专业博士
2004-09--2007-06   河南大学药学院   生药学专业硕士
1999-09--2002-06   河南大学药学院   药学专业专科毕业

药物化学专业博士

理学博士

2022/12–至今，中国科学院南海海洋研究所热带海洋生物资源与生态重点实验室，研究员。

2012/12–2022/12，中国科学院南海海洋研究所热带海洋生物资源与生态重点实验室，副研究员。

2010/08–2012/12，中国科学院南海海洋研究所海洋生物资源可持续利用重点实验室，助理研究员。

2004/07–2003/09，郑州市致和药业公司任滴眼剂车间主任，主要从事氯霉素滴眼剂、色甘酸钠滴眼剂的生产工作。

2003/09–2002/07，河南省仲景药业公司工程技术中心任技术员，从事新药开发工作。

2012-12~现在, 中国科学院南海海洋研究所, 副研究员
2010-07~2012-11,中国科学院南海海洋研究所, 助理研究员
2003-10~2004-08,郑州市致和药业公司, 滴眼剂工段长
2002-07~2003-09,河南省仲景药业公司, 技术员

1. Lijuan Wang^#, Mengyi Zhu^#, Qingbo Zhang, Shilan Zhai, Yiguang Zhu, Haibo Zhang*, and Changsheng Zhang*. Biosynthetic diversification of fidaxomicin aglycones by heterologous expression and promoter refactoring. Journal of Natural Products, 2023, 86 (4): 986–993.

2. Haibo Zhang, Liping Zhang, Imran Khan, Guangtao Zhang, Yiguang Zhu & Changsheng Zhang.* A simple and facile iodination method of didechlorotiacumicin B and aromatic compounds. SCIENCE CHINA Chemistry, 2021, DOI: 10.1007/s11426-021-1072-6. Epub 2021 Aug 31.

3. Xinya Zhang,^# Siqiang Chen,^# Liping Zhang, Qingbo Zhang, Wenjun Zhang, Yuchan Chen, Weimin Zhang, Haibo Zhang,* and Changsheng Zhang.* Dassonmycins A and B, Polycyclic thioalkaloids from a marine sponge-derived Nocardiopsis dassonvillei SCSIO 40065. Organic Letters, 2021, 23 (8): 2858–2862. ( Front Cover paper )

4. Imran Khan, Jing Peng, Zhuangjie Fang, Wei Liu, Wenjun Zhang, Qingbo Zhang, Liang Ma, Guangtao Zhang, Changsheng Zhang* and Haibo Zhang.* Cylindromicin from arctic-derived fungus Tolypocladium sp. SCSIO 40433. Molecules, 2021, 26, 1080.

5. Imran Khan, Haibo Zhang,* Wei Liu, Liping Zhang, Fang Peng, Yuchan Chen, Qingbo Zhang, Guangtao Zhang, Weimin Zhang, and Changsheng Zhang.* Identification and bioactivity evaluation of secondary metabolites from Antarctic-derived Penicillium chrysogenum CCTCC M 2020019. RSC Advances, 2020, 10 (35): 20738-20744.

6. Haibo Zhang, Xiaoxing Tian, Xiaohui Pu, Qingbo Zhang, Wenjun Zhang, and Changsheng Zhang*, Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant，Journal of Natural Products，2018, 81: 1219-1224.

7. Haibo Zhang(共同第一), Kumar Saurav(共同第一), Ziquan Yu，Attila Mándi, Tibor Kurtán，Jie Li，Xinpeng Tian, Qingbo Zhang，Wenjun Zhang，Changsheng Zhang*,α‑Pyrones with Diverse Hydroxy Substitutions from Three Marine Derived Nocardiopsis Strains，Journal of Natural Products，2016, 79(6):1610~1618.

8. Ruidong Chen (共同第一)，Haibo Zhang (共同第一), Gaiyun Zhang, Sumei Li，Guangtao Zhang, Yiguang Zhu，Jinsong Liu, Changsheng Zhang*，Characterizing Amosamine Biosynthesis in Amicetin Reveals AmiG as a Reversible Retaining lycosyltransferase，Journal of the American Chemical Society, 2013, 135(33):12152~12155.

9.Gaiyun Zhang^†, Haibo Zhang^†, (共同第一) Sumei Li, Ji Xiao, Guangtao Zhang, Yiguang Zhu, Siwen Niu, Jianhua Ju and, Chang-Sheng Zhang*; Characterization of the Amicetin Biosynthesis Gene Cluster from Streptomyces vinaceusdrappus NRRL 2363 Implicates Two Alternative Strategies for Amide Bond Formation, Applied and Environmental Microbiology, 2012, 78(7): 2393-2401.

10. Hai-Bo Zhang, Jian-Xin Pu, Yong Zhao, Fei He, Xiao-Nian Li, Xiao Luo, Li-Guang Lou, Han-Dong Sun*, Bisleuconins A-D: A Pair of Epimeric ent-Kauranoid Dimers and Two New Asymmetric Analogues Isolated from Isodon leucophyllus, Tetrahedron Letters, 2011，52：6061–6066.

11. Hai-Bo Zhang, Xue Du, Jian-Xin Pu, Yuan-Yuan Wang, Fei He, Yong Zhao, Xiao-Nian Li, Xiao Luo, Wei-Lie Xiao, Yan Li Han-Dong Sun*, Two novel diterpenoids from Isodon rubescens var. lushanensis，Tetrahedron Letters, 2010, 51: 4225–4228.

12. Hai-Bo ZHANG, Jian-Xin PU, Yuan-Yuan WANG, Fei HE, Yong ZHAO, Xiao-Nian LI, Xiao LUO, Wei-Lie XIAO, Yan LI, and Han-Dong SUN*, Four New ent-Kauranoids from Isodon rubescens var. lushanensis and Data Reassignment of Dayecrystal B, Chemical ＆ Pharmaceutical Bulletin, 2010, 58(1): 56-60.

13. Hai Bo Zhang, Jian Xin Pu, Yong Zhao, Fei He, Wei Zhao, Li Guang Lou, Wei Lie Xiao and Han Dong Sun*, Three New 18-Oxygenated ent-Kaurane Diterpenoids from Isodon leucophyllus, Natural Product Communications, 2010, 5(12): 1873-1876.