Molecular mechanism of synaptic transmission and plasticity; Disease mechanism underlying intrinsically disordered syantpic protein mutations
Research Areas
We are interested in understanding the molecular mechanism of synaptic transmission and plasticity. Specifically, we focus on the synaptic proteins that are intrinsically disordered (IDP). IDP are proteins that lack stable three-dimensional structure and are widespread in human proteome. We ask how these proteins can execute their function without a fixed structure, how they dynamically regulate the efficiency of synaptic transmission and control plasticity? Using genetic modified mice, two-photon imaging, electrophysiology, time resolved electron microscopy, we aim to gain insights into their function and add our knowledge in the molecular mechanism that underlies synaptic plasticity.
Education
2010-2013, PhD, Max Planck Institute for Biophysical Chemistry, Germany
2005-2007, Master in Biochemistry, Yang-Ming University, Taiwan
2001-2005, Bachelor in Life science, Cheng-Kung University, Taiwan
Experience
Work Experience
Since 2020-Associate investigator at Shenzhen Institute for advanced technology (SIAT) CAS, Shenzhen, China
2019-2020, Postdoctoral Fellow, Sickkids Hospital Toronto, Canada
2014-2017, Postdoctoral Fellow, Charite Berlin, Germany
Teaching Experience
Basic electrophysiology, Biology, Neuroscience
Publications
1. Lipstein N, Chang S, Lin K-H, Neher E, Taschenberger H, Brose N. Munc13-1 is a calcium phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission. Neuron.2021
2.Chang S, Trimbuch T, Rosenmund C. Synaptotagmin-1 drives synchronous Ca2+ triggered fusion by C2B domain-mediated slow and rapid vesicle membrane docking. Nat Neuroscience. 2018
3.Camacho-Perez M, Basu J, Trimbuch T, Chang S, Pulido-Lozano C, Chang S-S, Duluvova I, Abo Rady M, Rizo J and Rosenmund C. Heterodimerization of Munc13 C 2 A domain with RIM regulates synaptic vesicle docking and priming. Nat Commum. 2017
4.Vardar G, Chang S, Arancillo M, Wu YJ, Trimbuch T, Rosenmund C. Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons. J Neurosci. 2016
5.Chang S, Reim K, Pedersen M, Neher E, Brose N, Taschenberger H. Complexin stabilizes newly primed synaptic vesicles and prevents their premature fusion at the mouse calyx of held synapse. J Neurosci. 2015