Design and self-assembly of functional peptides, nanomaterials and nanodrugs, and applications in the field of biomedicine

2012.09-2017.07   YanShan University/Institute of Process Engineering (IPE), Chinese Academy of Sciences (CAS)           Ph.D
2008.09-2012.07   YanShan University             Bachelor

2023.09-Now      Institute of Process Engineering (IPE), Chinese Academy of Sciences (CAS)        Associate Professor; Doctoral supervisor

2019.07-2023.08   Institute of Process Engineering (IPE), Chinese Academy of Sciences (CAS)      Associate Professor; Master's supervisor
2017.07-2019.07   Institute of Process Engineering (IPE), Chinese Academy of Sciences (CAS)      Assistant Professor

   

1.M. Shabbir, A. Atiq, J. Wang, M. Atiq, N. Saeed, I. Yildiz, X. Yan, R. Xing*, M. Abbas*, Metal-coordinated amino acid/peptide/protein-based supramolecular self-assembled nanomaterials for anticancer applications. Aggregates, 2024, e672. 10.1002/agt2.672
2.S. Li, Y. Li, M. Shi, R. Xing*, J. C. M. Van Hest, X. Yan. Assembly-enhanced indocyanine green nanoparticles for fluorescence imaging-guided photothermal therapy. Journal of Materials Chemistry B (J. Mater. Chem. B), 2024, XXX. 10.1039/D4TB01604A
3.R. Chang, C. Yuan, P. Zhou, R. Xing*, X. Yan*, Peptide self-assembly: from ordered to disordered. Accounts of Chemical Research (Acc. Chem. Res.), 2024, 57, 289−301. 10.1021/acs.accounts.3c00592
4.R. Chang, R. Xing*, X. Yan*, Green and biorecyclable materials based on peptide noncovalent chemistry.  Chinese Journal of Chemical Engineering, 2024, 75 (4), 1317-1332. 10.11949/0438-1157.20231293
5.S. Li, R. Chang, L. Zhao, R. Xing*, J. van Hest, X. Yan*, Two-photon nanoprobes based on bioorganic nanoarchitectonics with a photooxidation enhanced emission mechanism. Nature Communications (Nat. Commun.), 2023, 14, 5227. 10.1038/s41467-023-40897-4
6.C. Yuan, Q. Li, R. Xing*, J. Li*, X. Yan*, Peptide self-assembly through liquid-liquid phase separation. Chem, 2023, 9, 2425-2445. 10.1016/j.chempr.2023.05.009
7.W. Zhang, S. Li, Y. Liu, Z. Jin*, R. Xing*, H. Xue*, X. Yan*, Immunosuppressive microenvironment improvement and treatment of aggressive malignancy pancreatic ductal adenocarcinoma based on local administration of injectable hydrogel. Nano Today, 2023, 50, 101832. 10.1016/j.nantod.2023.101832
8.R. Chang, L. Zhao, R. Xing*, J. Li*, X. H. Yan*, Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications. Chemical Society Reviews (Chem. Soc. Rev.), 2023, 52, 2688-2712. 10.1039/D2CS00675H
9.R. Xing, C. Yuan, W. Fan, X. Ren, X. Yan*, Biomolecular glass with amino acid and peptide nanoarchitectonics. Science Advances (Sci. Adv.), 2023, 9, eadd8105. 10.1126/sciadv.add810
10.Y. Liu, R. Chang, R. Xing*, X. H. Yan*, Bioactive peptide nanodrugs based on supramolecular assembly for boosting immunogenic cell death-induced cancer immunotherapy. Small Methods., 2023, 7(5): e2201708. 10.1002/smtd.202201708
11.Y. Liu, R. Xing*, J. B. Li, X. H. Yan*, Covalently-triggered self-assembly of peptide-based nanodrugs for cancer theranostics, iScience, 2023, 26(1): 105789. 10.1016/j.isci.2022.105789
12.Y. Z. Liu, R. Xing*, X. Yan*, Peptide-based assemblies and their application in photothermal immunotherapy of cancer. Acta Polymerica Sinica (Acta. Polym. Sin.), 2023, 53 (10), 1173-1186. 10.11777/j.issn1000-3304.2022.22221
13.M. Shi, X. Ren, L. Li, R. Xing*, T. Jiao*, Tyrosinase-triggered formation of fluorescent pigments based on Y-peptide. Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids Surf. A Physicochem. Eng. Asp.), 2023, 661, 130932. 10.1016/j.colsurfa.2022.129406
14.X. Ren, L. Zhao, C. Yuan, M. Shi, R. Xing*, X. Yan*, Enzyme-driven oxygen-fuelled pathway selectivity of tyrosine-containing peptide oxidation evolution. Chemical Engineering Journal (Chem. Eng. J.), 2022, 450 (3), 138293. 10.1016/j.cej.2022.138293
15.X. Ma, H. Gong, Y. Liu, Y. Liu, K. Ogino*, R. Xing*, X. Yan*, Orally administered covalently-assembled antioxidative peptide nanoparticles for inflammatory bowel disease therapy. Journal Of Colloid And Interface Science (J. Colloid Interface Sci.), 2022, 626, 156-166. 10.1016/j.jcis.2022.06.088
16.M. Shi, N. Li, R. Xing*, T. Jiao*, Peroxidase-triggered formation of fluorescent peptide-based nanoarchitectonics. Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids Surf. A Physicochem. Eng. Asp.), 2022, 648, 129406. 10.1016/j.colsurfa.2022.129406
17.X. Ma, H. Gong, K. Ogino*, X. Yan, R. Xing*, Coordination-assembled myricetin nanoarchitectonics for sustainably scavenging free radicals. Beilstein Journal of Nanotechnology (Beilstein J. Nanotechnol.), 2022, 13, 284-291. 10.3762/bjnano.13.23
18.R. Chang, Q. Zou, L. Zhao, Y. Liu, R. Xing*, X. Yan*, Amino acid-encoded supramolecular photothermal nanomedicine for enhanced cancer therapy. Advanced Materials (Adv. Mater.), 2022, 34, 2200139. 10.1002/adma.202200139
19.M. Abbas, M. Ovais, A. Atiq, T. Ansari, R. Xing*, E. Spruijt*, X. Yan*, Tailoring supramolecular short peptide nanomaterials for antibacterial applications. Coordination Chemistry Reviews (Coord. Chem. Rev.), 2022, 460, 214481. 10.1016/j.ccr.2022.214481
20.S. Li, W. Zhang, R. Xing*, C. Yuan, H. Xue*, X. Yan*, Supramolecular nanofibrils formed by coassembly of clinically approved drugs for tumor photothermal immunotherapy. Advanced Materials (Adv. Mater.), 2021, 33, 2100595. 10.1002/adma.202100595
21.K. Zhao, R. Xing*, X. Yan*, Cyclic dipeptides: Biological activities and self-assembled materials. Peptide Science (Pept. Sci.), 2021, 113, e24202. 10.1002/pep2.24184
22.W. Su, J. Yin, R. Wang, M. Shi, P. Liu, Z. Qin, R. Xing*, T. Jiao*, Self-assembled natural biomacromolecular fluorescent hydrogels with tunable red edge effects. Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids Surf. A Physicochem. Eng. Asp.), 2021, 612, 125993. 10.1016/j.colsurfa.2020.125993
23.S. Li, W. Zhang, H. Xue*, R. Xing*, X. Yan*, Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly. Chemical Science (Chem. Sci.), 2020, 11, 8644-8656. 10.1039/D0SC02937H
25.R. Xing, Q. Zou, X. Yan*, Peptide-based supramolecular colloids. Acta Physico-chimica Sinica (Acta Phys. -Chim. Sin.), 2020, 36, 1909048. 10.3866/PKU.WHXB201909048
26.R. Xing, Q. Zou, C. Yuan, L. Zhao, R. Chang, X. Yan*, Self-assembling endogenous biliverdin as a versatile near-infrared photothermal nanoagent for cancer theranostics. Advanced Materials (Adv. Mater.), 2019, 31, 1900822. 10.1002/adma.201900822
27.M. Cao#*, R. Xing#, R. Chang, Y. Wang, X. Yan*, Peptide-coordination self-assembly for the precise design of theranostic nanodrugs. Coordination Chemistry Reviews (Coord. Chem. Rev.), 2019, 397, 14-27. 10.1016/j.ccr.2019.06.013
28.R. Xing, Y. Liu, Q. Zou, X. H. Yan*, Self-assembled injectable biomolecular hydrogels towards phototherapy. Nanoscale 2019, 11, 22182-22195. 10.1039/c9nr06266a
29.E. Mei, S. Li, J. Song, R. Xing*, Z. Li*, X. Yan*, Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy. Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids Surf. A Physicochem. Eng. Asp.), 2019, 577, 570-575. 10.1016/j.colsurfa.2019.06.023
30.M. Yang#, R. Xing#, G. Shen, C. Yuan, X. Yan*, A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions. Colloids and Surfaces A: Physicochemical and Engineering Aspects (Colloids Surf. A Physicochem. Eng. Asp.), 2019, 572, 259-265. 10.1016/j.colsurfa.2019.04.020
31.R. Xing, C. Yuan, S. Li, J. Song, J. Li, X. Yan*, Charge-induced secondary structure transformation of amyloid-derived dipeptide assemblies from β-sheet to α-helix. Angewandte Chemie International Edition (Angew. Chem. Int. Ed.), 2018, 57, 1537-1542. 10.1002/anie.201710642 ###高被引论文
32.J. Song#, R. Xing#, T. Jiao*, Q. Peng, C. Yuan*, H. Möhwald, X. Yan*, Crystalline dipeptide nanobelts based on solid-solid phase transformation self-assembly and their polarization imaging of cells. ACS Applied Materials & Interfaces (ACS Appl. Mater. Interfaces), 2018, 10, 2368-2376. 10.1021/acsami.7b17933
33.R. Xing, S. Li, N. Zhang, G. Shen, H. Möhwald, X. Yan*, Self-assembled injectable peptide hydrogels capable of triggering antitumor immune response. Biomacromolecules 2017, 18, 3514-3523. 10.1021/acs.biomac.7b00787
34.R. Xing, W. Wang, T. Jiao*, K. Ma, Q. Zhang, W. Hong, Q. Hui, J. Zhou, L. Zhang, Q. Peng, Bioinspired polydopamine sheathed nanofibers containing carboxylate graphene oxide nanosheet for high-efficient dyes scavenger. ACS Sustainable Chemistry & Engineering (ACS Sustain. Chem. Eng.), 2017, 5, 4948-4956. 10.1021/acssuschemeng.7b00343 ###高被引论文
35.R. Zhang#, R. Xing#, T. Jiao*, K. Ma, C. Chen*, G. Ma, X. Yan*, Carrier-free, chemo-photodynamic dual nanodrugs via self-assembly for synergistic antitumor therapy. ACS Applied Materials & Interfaces (ACS Appl. Mater. Interfaces), 2016, 8, 13262-13269. 10.1021/acsami.6b02416
36.R. Xing, T. Jiao*, K. Ma, G. Ma, H. Möhwald, X. Yan*, Regulating cell apoptosis on layer-by-layer assembled multilayers of photosensitizer-coupled polypeptides and gold nanoparticles. Scientific Reports (Sci. Rep.), 2016, 6, 26506. 10.1038/srep26506
37.R. Xing, T. Jiao*, Y. Liu, K. Ma, Q. Zou*, G. Ma, X. Yan*, Co-assembly of graphene oxide and albumin/photosensitizer nanohybrids towards enhanced photodynamic therapy. Polymers, 2016, 8, 181. 10.3390/polym8050181
38.R. Xing, K. Liu, T. Jiao*, N. Zhang, K. Ma, R. Zhang, Q. Zou*, G. Ma, X. Yan*, An injectable self-assembling collagen-gold hybrid hydrogel for combinatorial antitumor photothermal/photodynamic therapy. Advanced Materials (Adv. Mater.), 2016, 28, 3669-3676. 10.1002/adma.201600284 ###高被引论文
39.K. Liu#, R. Xing#, Q. Zou, G. Ma, H. Möhwald, X. Yan*, Simple peptide-tuned self-assembly of photosensitizers towards anticancer photodynamic therapy. Angewandte Chemie International Edition (Angew. Chem. Int. Ed.), 2016, 55, 3036-3039. 10.1002/anie.201509810 ###高被引论文
40.R. Xing, T. Jiao*, J. Zhou, Q. Zhang, Q. Peng, Preparation and photocatalytic property of silver nanoparticles using cationic pyridine derivative. Integrated Ferroelectrics (Integr. Ferroelectr.), 2016, 169, 15-21. 10.1080/10584587.2016.1162258
41.R. Xing, T. Jiao*, L. Yan, G. Ma, L. Liu*, L. Dai, J. Li, H. Möhwald, X. Yan*, Colloidal gold-collagen protein core–shell nanoconjugate: one-step biomimetic synthesis, layer-by-layer assembled film, and controlled cell growth. ACS Applied Materials & Interfaces (ACS Appl. Mater. Interfaces), 2015, 7, 24733-24740. 10.1021/acsami.5b07453
42.K. Liu#, R. Xing#, C. Chen, G. Shen, L. Yan, Q. Zou, G. Ma, H. Möhwald, X. Yan*, Peptide-induced hierarchical long-range order and photocatalytic activity of porphyrin assemblies. Angewandte Chemie International Edition (Angew. Chem. Int. Ed.), 2015, 54, 500-505. 10.1002/anie.201409149
43.R. Xing, T. Jiao*, L. Feng, Q. Zhang, Q. Zou, X. Yan*, J. Zhou, F. Gao, Photothermally-induced molecular assembly of macroscopic peptide-inorganic hybrid films. Science of Advanced Materials (Sci. Adv. Mater.), 2015, 7, 1701-1707. 10.1166/sam.2015.2411