Molecular Neuroscience
Protein folding and neurodegeneration
Structure and function of enzyme

​

03/1978-03/1982, Luzhou Medical College, Sichuan (Bachelor in Medicine);

09/1983-09/1986, Institute of Microbiology, Chinese Academy of Sciences (M.S., Cytology);

09/1986-12/1989, Institute of Biophysics, Chinese Academy of Sciences  (Ph.D., biochemistry).

(1) Zhu Li Yuehua outstanding teacher award, 2011

(2) First class, Award for Scientific and technological Advancement, CAS, 1995

1. Wei, Y., Han, C.S., Wang, Y.J., Wu, B.B., Su, T., Liu, Y., He, R.Q.* (2015). Ribosylation triggering Alzheimer’s disease-like Tau hyperphosphorylation via activation of CaMKII. Aging. Cell. 14(5):754-63. (*corresponding author)
2. Wu, B.B., Wei, Y., Wang, Y.J., Su, T., Zhou, L., Liu, Y., He, R.Q.* (2015). Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice. Oncotarget. 6(33):34128-42. (*corresponding author)
3. Tong, Z.Q., Han, C.S., Qiang, M., Wang, W.S., Lv, J.H., Zhang, S.Z., Luo, W.H., Li, H., Luo, H.J., Zhou, J.N., Wu, B.B., Su, T., Yang, X., Wang, X.M., Liu, Y., He, R.Q.* (2015). Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer’s disease. Neurobiol. Aging. 36:100-10. (*corresponding author)
4. Qiang, M., Xiao, R., Su, T., Wu, B.B., Tong, Z.Q., Liu, Y., He, R.Q.* (2014). A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse. J. Alzheimers. Dis. 40(4):1039-53. (*corresponding author)
5. Han, C.S., Lu, Y., Wei, Y.*, Wu, B.B., Liu, Y., He, R.Q.* (2014). D-Ribosylation induces cognitive impairment through RAGE-dependent astrocytic inflammation. Cell. Death. Dis. 5:e1117. (*corresponding author)
6. Yang, M.F., Lu, J., Miao, J.Y., Rizak, J., Yang, J.Z., Zhai, R.W., Zhou, J., Qu, J.G., Wang, J.H., Yang, S.C., Ma, Y.Y., Hu, X.T.*, He, R.Q.* (2014). Alzheimer's Disease and Methanol Toxicity (Part 1): Chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice. J. Alzheimers. Dis. 41(4):1117-29. (*corresponding author)
7. Yang, M.F., Miao, J.Y., Rizak, J., Zhai, R.W., Wang, Z.B., Huma, T., Li, T., Zheng, N., Wu, S.H., Zheng, Y.W., Fan X.N., Yang, J.Z., Wang, J.H., Yang, S.C., Ma, Y.Y., Lv, L.B., He, R.Q.*, Hu, X.T.* (2014). Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol. J. Alzheimers. Dis. 41(4):1131-47. (*corresponding author)
8. Lu, Y., He, H.J., Zhou, J., Miao, J.Y., Lu, J., He, Y.G., Pan, R., Wei, Y.*, Liu, Y., He, R.Q.* (2013). Hyperphosphorylation results in tau dysfunction in DNA folding and protection. J. Alzheimers. Dis. 37:551-63. (*corresponding author)
9. Tong, Z.Q., Han, C.S., Luo, W.H., Li, H., Luo, H.J., Qiang, M., Su, T., Wu, B.B., Liu, Y., Xu, Y., Wan, Y., Cui, D.H.*, He, R.Q.* (2013). Aging-associated excess formaldehyde leads to spatial memory deficits. Sci. Rep. 3:1807. (*corresponding author)
10. Tong, Z.Q., Han, C.S., Luo, W.H., Wang, X.H., Li, H., Luo, H.J., Zhou, J.N., Qi, J.S.*, He, R.Q.* (2013). Accumulated hippocampal formaldehyde induces age-dependent memory decline. AGE. 35:583-96. (*corresponding author)
11. Tong, Z.Q., Zhang, J.L., Luo, W.H., Li, H., Luo, H.J., Wang, W.H., Lu, J., Zhou, J.N., Wan, Y., He, R.Q.* (2011) Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. Neurobiol Aging. 32:31–41. (*corresponding author)
12. Liu, K.L., Liu, Y.*, Mo, W.C., Qiu, R., Wang, X.M., Wu, Y., He, R.Q.* (2011). MiR-124 regulates early neurogenesis in the optic vesicle and forebrain targeting NeuroD1 Nucleic Acid Res. 39: 2869-2879. (*corresponding author)
13. Liu YY, Qiang M, Wei Y, He, R.Q.* (2010). A novel molecular mechanism for nitrated a-synuclein-induced cell death. J Mol Cell Biol. 3:239–249. (*corresponding author)
14. Chen, L., Wei, Y., Wang, X.Q., He, R.Q.* (2009). D-Ribosylated Tau forms globular aggregates with high cytotoxicity. Cell Mol Life Sci. 66(15):2559-2571. (*corresponding author)

Cognitive impairment and imbalance of energetic metabolism. (1) Dysfunction of formaldehyde metabolism and how it plays a role in the age-related cognitive impairments (Pre-MCI, MCI and AD). Attempt to clarify the mechanism of aldehyde-induced cognitive impairment; to establish aldehyde-induced cognitive impaired animal models including mouse, rat and monkey; and to design a new chemical method for diagnosis of age-related cognitive impairment. (2) Metabolic dysfunction of D-ribose and cognitive impairment for Type 2 diabetes mellitus.

Queensland Brain Institute, the University of Queensland, Brisbane, Australia

New York State Institute for Basic Research in Developmental Disabilities, USA

已指导学生

聂春来  01  19184  

华茜  01  19184  

刘铭楠  01  19184  

兰蕾  01  19184  

李文  01  19184  

许亚杰  01  19184  

刘阳  01  19184  

李妲  02  19179  

王东亮  01  19184  

何海进  01  19184  

罗云峰  01  19184  

邱蓉  01  19184  

张金玲  01  19184  

张雪晶  02  19183  

张丽  02  19183  

肖蓉  01  19179  

潘荣  01  19179  

刘开力  01  19183  

魏艳  01  19183  

卢静  01  19183  

莫炜川  01  19183  

李一凝  01  19183  

周园  01  19183  

韩婵帅  01  19183  

周均  02  19182  

张子剑  01  19183  

苗君叶  01  19183  

强敏  01  19179  

苏涛  01  19179  

付晶鹏  01  19179  

王玉婧  01  19179  

吴蓓蓓  01  19179  

李婷  01  19179  

现指导学生

胡平东  02  19179  

于乐祥  02  19179  

陈茜茜  01  19179  

李咏泽  02  19183  

范士超  02  63228  

张海涛  01  19179  

石呈钢  02  19179