基本信息
朱岩 男 博导 中国科学院天津工业生物技术研究所
电子邮件： zhuyan@tib.cas.cn
通信地址： 天津空港经济区西七道32号中科院天津工业生物技术研究所
邮政编码：
电子邮件： zhuyan@tib.cas.cn
通信地址： 天津空港经济区西七道32号中科院天津工业生物技术研究所
邮政编码：
研究领域
针对重要工业微生物，开展基因组学、转录组学、蛋白质组学、代谢组学、脂质组学、通量组学、相互作用组学以及表型组学分析，解析菌株工业生产和胁迫耐受的分子机制，利用组学数据构建全细胞模型、开发仿真模拟算法，实现虚拟细胞工厂的优化设计。
利用多组学方法解析在微生物菌群结构变化以及成员间相互作用机制。构建虚拟菌群模型，开发菌群成员空间动态协作的计算方法，实现合成微生物组的最优设计。
招生信息
招生专业
071010-生物化学与分子生物学
招生方向
系统生物学
计算生物学
计算生物学
教育背景
2006-09--2013-01 中国科学院大学 博士
2002-09--2006-07 山东大学 学士
2002-09--2006-07 山东大学 学士
工作经历
工作简历
2022-11~现在, 天津工业生物技术研究所, 研究员
2015-01~2022-11,Monash University, 博士后
2013-05~2014-12,University of Queensland, 博士后
2015-01~2022-11,Monash University, 博士后
2013-05~2014-12,University of Queensland, 博士后
出版信息
发表论文
[1] Huang Ying, 朱岩, Yue Hui-Ying, Liu Yi-Yun, Deng Li-Ming, Lv Luchao, Wang Chengzhen, Yang Jun, Liu Jian-Hua. Flavomycin restores colistin susceptibility in multidrug-resistant Gram-negative bacteria. mSystems[J]. 2024, 第 2 作者
[2] Jing Lu, Meiling Han, Heidi H Yu, Phillip J Bergen, Yiyun Liu, Jinxin Zhao, Hasini Wickremasinghe, Xukai Jiang, Yang Hu, Haiyan Du, Yan Zhu, Tony Velkov, Artem S Rogovskyy. Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae. MICROBIOLOGY SPECTRUM[J]. 2023, 第 11 作者11(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433984/.
[3] Jinxin Zhao, Yan Zhu, MeiLing Han, Jing Lu, Heidi H Yu, Hasini Wickremasinghe, Qi Tony Zhou, Phillip Bergen, Gauri Rao, Tony Velkov, YuWei Lin, Jian Li. Model-informed dose optimisation of polymyxin-rifampicin combination therapy against multidrug-resistant Acinetobacter baumannii. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2023, 第 2 作者62(3): http://dx.doi.org/10.1016/j.ijantimicag.2023.106902.
[4] Li, Mengyao, Azad, Mohammad A K, Thompson, Philip E, Roberts, Kade D, Velkov, Tony, Zhu, Yan, Li, Jian. Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells. ANTIBIOTICS-BASEL[J]. 2023, 第 6 作者12(2): http://dx.doi.org/10.3390/antibiotics12020415.
[5] Xia, Di, Tan, Xu, Wang, Li, Li, Zongjun, Hou, Aixiang, Zhu, Yan, Lai, Ling, Wang, Yuanliang. GC-MS Coupled with Rate-All-That-Apply (RATA) to Analyse the Volatile Flavor Substances of Yellow Wine during Fermentation. FOODS[J]. 2023, 第 6 作者12(10): http://dx.doi.org/10.3390/foods12101992.
[6] Jin, Peipei, Dai, Jing, Guo, Yinjuan, Wang, Xuefeng, Lu, Jing, Zhu, Yan, Yu, Fangyou. Genomic Analysis of Mycobacterium abscessus Complex Isolates from Patients with Pulmonary Infection in China. MICROBIOLOGY SPECTRUM[J]. 2022, 第 6 作者 通讯作者 10(4): http://dx.doi.org/10.1128/spectrum.00118-22.
[7] Chung, Wan Yean, Zhu, Yan, Mahamad Maifiah, Mohd Hafidz, Hawala Shivashekaregowda, Naveen Kumar, Wong, Eng Hwa, Abdul Rahim, Nusaibah. Exogenous metabolite feeding on altering antibiotic susceptibility in Gram-negative bacteria through metabolic modulation: a review. METABOLOMICS. 2022, 第 2 作者18(7):
[8] Roberts, Kade D, Zhu, Yan, Azad, Mohammad A K, Han, MeiLing, Wang, Jiping, Wang, Lynn, Yu, Heidi H, Horne, Andrew S, Pinson, JoAnne, Rudd, David, Voelcker, Nicolas H, Patil, Nitin A, Zhao, Jinxin, Jiang, Xukai, Lu, Jing, Chen, Ke, Lomovskaya, Olga, Hecker, Scott J, Thompson, Philip E, Nation, Roger L, Dudley, Michael N, Griffith, David C, Velkov, Tony, Li, Jian. A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens. NATURE COMMUNICATIONS[J]. 2022, 第 2 作者13(1): https://doaj.org/article/0e3e6c3ab9774848b67a0f077533e996.
[9] Xiao, Chenlu, Zhu, Yan, Yang, Zhitao, Shi, Dake, Ni, Yuxing, Hua, Li, Li, Jian. Prevalence and Molecular Characteristics of Polymyxin-Resistant Pseudomonas aeruginosa in a Chinese Tertiary Teaching Hospital. ANTIBIOTICS-BASEL[J]. 2022, 第 2 作者11(6): http://dx.doi.org/10.3390/antibiotics11060799.
[10] Mohd Kamal, Khairunnisa, Mahamad Maifiah, Mohd Hafidz, Zhu, Yan, Abdul Rahim, Nusaibah, Hashim, Yumi Zuhanis HasYun, Abdullah Sani, Muhamad Shirwan. Isotopic Tracer for Absolute Quantification of Metabolites of the Pentose Phosphate Pathway in Bacteria. METABOLITES. 2022, 第 3 作者12(11): http://dx.doi.org/10.3390/metabo12111085.
[11] Lu, Jing, Zhu, Yan, Parkington, Helena C, Hussein, Maytham, Zhao, Jinxin, Bergen, Phillip, Rudd, David, Deane, Mary A, Oberrauch, Sara, CornthwaiteDuncan, Linda, Allobawi, Rafah, Sharma, Rajnikant, Rao, Gauri, Li, Jian, Velkov, Tony. Transcriptomic Mapping of Neurotoxicity Pathways in the Rat Brain in Response to Intraventricular Polymyxin B. MOLECULAR NEUROBIOLOGY. 2022, 第 2 作者
[12] Maifiah, Mohd Hafidz Mahamad, Zhu, Yan, Tsuji, Brian T, Creek, Darren J, Velkov, Tony, Li, Jian. Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin-rifampicin combination against Pseudomonas aeruginosa. JOURNAL OF BIOMEDICAL SCIENCE[J]. 2022, 第 2 作者29(1): http://dx.doi.org/10.1186/s12929-022-00874-3.
[13] Mengyao Li, Mohammad A K Azad, Maizbha U Ahmed, Yan Zhu, Jiangning Song, Fanfan Zhou, HakKim Chan, Tony Velkov, Qi Tony Zhou, Jian Li, Francesco Imperi. Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells. ANTIBIOTICS[J]. 2022, 第 4 作者11(3):
[14] Lu, Jing, Azad, Mohammad A K, Moreau, Julie L M, Zhu, Yan, Jiang, Xukai, Tonta, Mary, Lam, Rachel, Wickremasinghe, Hasini, Zhao, Jinxin, Wang, Jiping, Coleman, Harold A, Formosa, Luke E, Velkov, Tony, Parkington, Helena C, Combes, Alexander N, Rosenbluh, Joseph, Li, Jian. Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2022, 第 4 作者79(6): http://dx.doi.org/10.1007/s00018-022-04316-z.
[15] Han, MeiLing, Nang, Sue C, Lin, YuWei, Zhu, Yan, Yu, Heidi H, Wickremasinghe, Hasini, Barlow, Christopher K, Creek, Darren J, Crawford, Simon, Rao, Gauri, Dai, Chongshan, Barr, Jeremy J, Chan, Kim, Schooley, Robert Turner, Velkov, Tony, Li, Jian. Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2022, 第 4 作者20: 485-495, https://doaj.org/article/2a60c041def3434ca1a2990b05797555.
[16] Nang, Sue C, Li, Mengyao, Harper, Marina, Mandela, Eric, Bergen, Phillip J, Rolain, JeanMarc, Zhu, Yan, Velkov, Tony, Li, Jian. Polymyxin causes cell envelope remodelling and stress responses in mcr-1-harbouring Escherichia coli. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS[J]. 2022, 第 7 作者59(2): http://dx.doi.org/10.1016/j.ijantimicag.2021.106505.
[17] Kho, Zhi Ying, Azad, Mohammad A K, Han, MeiLing, Zhu, Yan, Huang, Cheng, Schittenhelm, Ralf B, Naderer, Thomas, Velkov, Tony, Selkrig, Joel, Zhou, Qi Tony, Li, Jian. Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages. PLOS PATHOGENS[J]. 2022, 第 4 作者18(3): http://dx.doi.org/10.1371/journal.ppat.1010308.
[18] Chung, Wan Yean, Abdul Rahim, Nusaibah, Mahamad Maifiah, Mohd Hafidz, Hawala Shivashekaregowda, Naveen Kumar, Zhu, Yan, Wong, Eng Hwa. In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae. FRONTIERS IN PHARMACOLOGY[J]. 2022, 第 5 作者 通讯作者 13: http://dx.doi.org/10.3389/fphar.2022.880352.
[19] Hasini Wickremasinghe, Heidi H Yu, Mohammad A K Azad, Jinxin Zhao, Phillip J Bergen, Tony Velkov, Qi Tony Zhou, Yan Zhu, Jian Li, Giovanna Batoni. Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant Pseudomonas aeruginosa and Minimize Biofilm Formation. ANTIBIOTICS. 2021, 第 8 作者10(4): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8069709/.
[20] Rahim, Nusaibah Abdul, Zhu, Yan, Cheah, SoonEe, Johnson, Matthew D, Yu, Heidi H, Sidjabat, Hanna E, Butler, Mark S, Cooper, Matthew A, Fu, Jing, Paterson, David L, Nation, Roger L, Boyce, John D, Creek, Darren J, Bergen, Phillip J, Velkov, Tony, Li, Jian. Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-beta-Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol. ACS INFECTIOUS DISEASES[J]. 2021, 第 2 作者7(6): 1584-1595, http://dx.doi.org/10.1021/acsinfecdis.0c00661.
[21] Lu Jing, He Huan, Miao JunYe, Zhu Yan, Li Ting, Chen XiXi, Tong ZhiQian, He RongQiao, Liu Ying. Reversal of Memory Deficit Correlates to Formaldehyde Reduction in A beta PPLon/Swe Mice. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2021, 第 4 作者48(11): 1337-1347, http://dx.doi.org/10.16476/j.pibb.2020.0403.
[22] Dai, Zongjie, Zhu, Yan, Dong, Hongjun, Zhao, Chunhua, Zhang, Yanping, Li, Yin. Enforcing ATP hydrolysis enhanced anaerobic glycolysis and promoted solvent production in Clostridium acetobutylicum. MICROBIAL CELL FACTORIES[J]. 2021, 第 2 作者20(1): http://dx.doi.org/10.1186/s12934-021-01639-7.
[23] Bin Hafeez, Ahmer, Jiang, Xukai, Bergen, Phillip J, Zhu, Yan. Antimicrobial Peptides: An Update on Classifications and Databases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021, 第 4 作者 通讯作者 22(21): http://dx.doi.org/10.3390/ijms222111691.
[24] Aichem, Michael, Czauderna, Tobias, Zhu, Yan, Zhao, Jinxin, Klapperstueck, Matthias, Klein, Karsten, Li, Jian, Schreiber, Falk. Visual exploration of large metabolic models. BIOINFORMATICS[J]. 2021, 第 3 作者37(23): 4460-4468, http://dx.doi.org/10.1093/bioinformatics/btab335.
[25] Gunther Eysenbach, Lorraine Buis, Marc Scheetz, Kabelo Leonard Mauco, Xueliang Hua, Chen Li, Jason M Pogue, Varun S Sharma, Ilias Karaiskos, Keith S Kaye, Brian T Tsuji, Phillip J Bergen, Yan Zhu, Jiangning Song, Jian Li. ColistinDose, a Mobile App for Determining Intravenous Dosage Regimens of Colistimethate in Critically Ill Adult Patients: Clinician-Centered Design and Development Study. JMIR MHEALTH AND UHEALTH. 2020, 第 13 作者8(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7748388/.
[26] Liu, YiYun, Zhu, Yan, Wickremasinghe, Hasini, Bergen, Phillip J, Lu, Jing, Zhu, XiaoQing, Zhou, QiaoLi, Azad, Mohammad, Nang, Sue C, Han, MeiLing, Lei, Tao, Li, Jian, Liu, JianHua. Metabolic Perturbations Caused by the Over-Expression of mcr-1 in Escherichia coli. FRONTIERS IN MICROBIOLOGY[J]. 2020, 第 2 作者11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581681/.
[27] Chung, Wan Yean, Zhu, Yan, Maifiah, Mohd Hafidz Mahamad, Shivashekaregowda, Naveen Kumar Hawala, Wong, Eng Hwa, Rahim, Nusaibah Abdul. Novel antimicrobial development using genome-scale metabolic model of Gram-negative pathogens: a review. JOURNAL OF ANTIBIOTICS. 2020, 第 2 作者https://www.webofscience.com/wos/woscc/full-record/WOS:000567453300001.
[28] Li, Fuyi, Fan, Cunshuo, MarquezLago, Tatiana T, Leier, Andre, Revote, Jerico, Jia, Cangzhi, Zhu, Yan, Smith, A Ian, Webb, Geoffrey, I, Liu, Quanzhong, Wei, Leyi, Li, Jian, Song, Jiangning. PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact. BRIEFINGS IN BIOINFORMATICS[J]. 2020, 第 7 作者21(3): 1069-1079, http://dx.doi.org/10.1093/bib/bbz050.
[29] Jiang, Xukai, Yang, Kai, Yuan, Bing, Han, Meiling, Zhu, Yan, Roberts, Kade D, Patil, Nitin A, Li, Jingliang, Gong, Bin, Hancock, Robert E W, Velkov, Tony, Schreiber, Falk, Wang, Lushan, Li, Jian. Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY[J]. 2020, 第 5 作者75(12): 3534-3543, http://dx.doi.org/10.1093/jac/dkaa376.
[30] Hussein, Maytham, Han, MeiLing, Zhu, Yan, Zhou, Qi, Lin, YuWei, Hancock, Robert E W, Hoyer, Daniel, Creek, Darren J, Li, Jian, Velkov, Tony. Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2020, 第 3 作者64(1): http://dx.doi.org/10.1128/AAC.01587-19.
[31] Hussein, Maytham, Karas, John A, SchneiderFutschik, Elena K, Chen, Fan, Swarbrick, James, Paulin, Olivia K A, Hoyer, Daniel, Baker, Mark, Zhu, Yan, Li, Jian, Velkov, Tony. The Killing Mechanism of Teixobactin against Methicillin-Resistant Staphylococcus aureus: an Untargeted Metabolomics Study. MSYSTEMS[J]. 2020, 第 9 作者5(3): https://doaj.org/article/66160a865d9c40c4b1b2ff70db52d073.
[32] Zhu, Yan, Lu, Jing, Zhao, Jinxin, Zhang, Xinru, Yu, Heidi H, Velkov, Tony, Li, Jian. Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY[J]. 2020, 第 1 作者 通讯作者 310(3): 151412-151412, http://dx.doi.org/10.1016/j.ijmm.2020.151412.
[33] Hussein, Maytham, Hu, Xiaohan, Paulin, Olivia K A, Crawford, Simon, Zhou, Qi Tony, Baker, Mark, SchneiderFutschik, Elena K, Zhu, Yan, Li, Jian, Velkov, Tony. Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL[J]. 2020, 第 8 作者18: 2247-2258, https://doaj.org/article/4860056b8b054c22ac7edcdc1048a934.
[34] Chen, Zhen, Zhao, Pei, Li, Fuyi, MarquezLago, Tatiana T, Leier, Andre, Revote, Jerico, Zhu, Yan, Powell, David R, Akutsu, Tatsuya, Webb, Geoffrey, I, Chou, KuoChen, Smith, A Ian, Daly, Roger J, Li, Jian, Song, Jiangning. iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data. BRIEFINGS IN BIOINFORMATICS[J]. 2020, 第 7 作者21(3): 1047-1057, http://dx.doi.org/10.1093/bib/bbz041.
[35] Zhao, Jinxin, Zhu, Yan, Han, Jiru, Lin, YuWei, Aichem, Michael, Wang, Jiping, Chen, Ke, Velkov, Tony, Schreiber, Falk, Li, Jian. Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-Resistant Acinetobacter baumannii in a Murine Bloodstream Infection Model. MICROORGANISMS[J]. 2020, 第 2 作者 通讯作者 8(11): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000593244900001.
[36] Huang, Jiayuan, Li, Chen, Song, Jiangning, Velkov, Tony, Wang, Lushan, Zhu, Yan, Li, Jian. Regulating polymyxin resistance in Gram-negative bacteria: roles of two-component systems PhoPQ and PmrAB. FUTURE MICROBIOLOGY. 2020, 第 6 作者 通讯作者 15(6): 445-459, http://dx.doi.org/10.2217/fmb-2019-0322.
[37] Yan Zhu, Jing Lu, MeiLing Han, Xukai Jiang, Mohammad A K Azad, Nitin A Patil, YuWei Lin, Jinxin Zhao, Yang Hu, Heidi H Yu, Ke Chen, John D Boyce, Rhys A Dunstan, Trevor Lithgow, Christopher K Barlow, Weifeng Li, Elena K SchneiderFutschik, Jiping Wang, Bin Gong, Bjorn Sommer, Darren J Creek, Jing Fu, Lushan Wang, Falk Schreiber, Tony Velkov, Jian Li. Acinetobacter baumannii : Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance (Adv. Sci. 15. ADVANCED SCIENCE. 2020, 第 1 作者7(15): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404140/.
[38] Nusaibah Abdul Rahim, SoonEe Cheah, Matthew D Johnson, Yan Zhu, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Phillip J Bergen, Tony Velkov, Jian Li. Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. 2020, 第 4 作者56(2): http://dx.doi.org/10.1016/j.ijantimicag.2020.106061.
[39] Lu, Jing, Zhu, Yan, Williams, Sarah, Watts, Michelle, Tonta, Mary A, Coleman, Harold A, Parkington, Helena C, Claudianos, Charles. Autism-associated miR-873 regulates ARID1B, SHANK3 and NRXN2 involved in neurodevelopment. TRANSLATIONAL PSYCHIATRY[J]. 2020, 第 2 作者10(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7708977/.
[40] Xueliang Hua, Chen Li, Jason M Pogue, Varun S Sharma, Ilias Karaiskos, Keith S Kaye, Brian T Tsuji, Phillip J Bergen, Yan Zhu, Jiangning Song, Jian Li. Correction: ColistinDose, a Mobile App for Determining Intravenous Dosage Regimens of Colistimethate in Critically Ill Adult Patients: Clinician-Centered Design and Development Study. JMIR MHEALTH AND UHEALTH. 2020, 第 9 作者8(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7775816/.
[41] Hussein, Maytham, SchneiderFutschik, Elena K, Paulin, Olivia K A, Allobawi, Rafah, Crawford, Simon, Zhou, Qi Tony, Hanif, Adil, Baker, Mark, Zhu, Yan, Li, Jian, Velkov, Tony. Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline. ACS INFECTIOUS DISEASES[J]. 2020, 第 9 作者6(6): 1436-1450, http://dx.doi.org/10.1021/acsinfecdis.0c00108.
[42] Li, Mengyao, Aye, Su Mon, Ahmed, Maizbha Uddin, Han, MeiLing, Li, Chen, Song, Jiangning, Boyce, John D, Powell, David R, Azad, Mohammad A K, Velkov, Tony, Zhu, Yan, Li, Jian. Pan-transcriptomic analysis identified common differentially expressed genes of Acinetobacter baumannii in response to polymyxin treatments. MOLECULAR OMICS[J]. 2020, 第 11 作者 通讯作者 16(4): 327-338, http://dx.doi.org/10.1039/d0mo00015a.
[43] Zhu, Yan, Lu, Jing, Han, MeiLing, Jiang, Xukai, Azad, Mohammad A K, Patil, Nitin A, Lin, YuWei, Zhao, Jinxin, Hu, Yang, Yu, Heidi H, Chen, Ke, Boyce, John D, Dunstan, Rhys A, Lithgow, Trevor, Barlow, Christopher K, Li, Weifeng, SchneiderFutschik, Elena K, Wang, Jiping, Gong, Bin, Sommer, Bjorn, Creek, Darren J, Fu, Jing, Wang, Lushan, Schreiber, Falk, Velkov, Tony, Li, Jian. Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance. ADVANCED SCIENCE[J]. 2020, 第 1 作者7(15): https://doaj.org/article/92a829d27e4a414f96c5fbfdbdf2014c.
[44] Aye, Su Mon, Galani, Irene, Han, MeiLing, Karaiskos, Ilias, Creek, Darren J, Zhu, Yan, Lin, YuWei, Velkov, Tony, Giamarellou, Helen, Li, Jian. Lipid A profiling and metabolomics analysis of paired polymyxin-susceptible and -resistant MDR Klebsiella pneumoniae clinical isolates from the same patients before and after colistin treatment. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY[J]. 2020, 第 6 作者75(10): 2852-2863, http://dx.doi.org/10.1093/jac/dkaa245.
[45] Han, MeiLing, Liu, Xiaofen, Velkov, Tony, Lin, YuWei, Zhu, Yan, Creek, Darren J, Barlow, Christopher K, Yu, Heidi H, Zhou, Zhihui, Zhang, Jing, Li, Jian. Comparative Metabolomics Reveals Key Pathways Associated With the Synergistic Killing of Colistin and Sulbactam Combination Against Multidrug-Resistant Acinetobacter baumannii. FRONTIERS IN PHARMACOLOGY[J]. 2019, 第 5 作者10: https://doaj.org/article/1e9fe2ea497f4ca2a282e14162850b4d.
[46] Lin, YuWei, Rahim, Nusaibah Abdul, Zhao, Jinxin, Han, MeiLing, Yu, Heidi H, Wickremasinghe, Hasini, Chen, Ke, Wang, Jiping, Paterson, David L, Zhu, Yan, Rao, Gauri G, Zhou, Qi Tony, Forrest, Alan, Velkov, Tony, Li, Jian. Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2019, 第 10 作者63(4):
[47] Zhu, Yan, Zhao, Jinxin, Maifiah, Mohd Hafidz Mahamad, Velkov, Tony, Schreiber, Falk, Li, Jian. Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling. MSYSTEMS[J]. 2019, 第 1 作者 通讯作者 4(1): http://dx.doi.org/10.1128/mSystems.00157-18.
[48] Zhua, Yan, Galani, Irene, Karaiskos, Ilias, Lu, Jing, Aye, Su Mon, Huang, Jiayuan, Yu, Heidi H, Velkov, Tony, Giamarellou, Helen, Li, Jian. Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment. JOURNAL OF INFECTION[J]. 2019, 79(4): 312-321, http://dx.doi.org/10.1016/j.jinf.2019.07.009.
[49] Lin, YuWei, Han, MeiLing, Zhao, Jinxin, Zhu, Yan, Rao, Gauri, Forrest, Alan, Song, Jiangning, Kaye, Keith S, Hertzog, Paul, Purcell, Anthony, Creek, Darren, Zhou, Qi Tony, Velkov, Tony, Li, Jian. Synergistic Combination of Polymyxin B and Enrofloxacin Induced Metabolic Perturbations in Extensive Drug-Resistant Pseudomonas aeruginosa. FRONTIERS IN PHARMACOLOGY[J]. 2019, 第 4 作者10: http://dx.doi.org/10.3389/fphar.2019.01146.
[50] Han, MeiLing, Zhu, Yan, Creek, Darren J, Lin, YuWei, Gutu, Alina D, Hertzog, Paul, Purcell, Tony, Shen, HsinHui, Moskowitz, Samuel M, Velkov, Tony, Li, Jian. Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa. MSYSTEMS[J]. 2019, 第 2 作者4(1): https://doaj.org/article/daa9c3166dc749088a18c8913fecaef7.
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科研活动
科研项目
（ 1 ） 谷氨酸棒杆菌氨基酸虚拟细胞工厂设计与测试, 负责人, 地方任务, 2022-11--2025-11
（ 2 ） 数字细胞创制新方法研究, 负责人, 国家任务, 2023-12--2028-11
（ 2 ） 数字细胞创制新方法研究, 负责人, 国家任务, 2023-12--2028-11
指导学生
现指导学生
张洪宇 博士研究生 071010-生物化学与分子生物学