基本信息

曲静  女  博导  中国科学院动物研究所
电子邮件: qujing@ioz.ac.cn
通信地址: 北京市朝阳区大屯路甲3号
邮政编码: 100101

研究领域

综合利用人类干细胞和灵长类动物模型,结合新一代组学技术及其他生物学手段,关注人类衰老及相关疾病发生发展过程中,组织特异的生理或病理变化,以及致使这种改变的遗传与环境因素的互作,发现机体或器官退行的标志物,筛选调控器官失稳和促进原位再生的关键基因或候选小分子药物,揭示干细胞衰老的关键调控通路,发展干预人类干细胞衰老乃至器官衰老的有效手段。

教育背景与工作经历

1998.9-2002.7     兰州大学,生物学学士
2002.9-2007.7     中国科学院生物物理研究所,理学博士
2007.11-2010.5   美国Sanford-Burnham医学研究所,博士后
2010.5 -2012.10  美国Salk生物研究所,Research Associate
2013.1-2014.10   中科院生物物理研究所研究员
2014.10-至今       中科院动物研究所研究员,干细胞与衰老研究组组长


荣誉奖励

2021-02  2020中国科学十大进展
2021-01  2020中国生命科学十大进展
2020-11  中国科学院杰出科技成就奖(三位突出贡献者之一)
2020-11  中国科学院大学朱李月华优秀教师奖
2020-10  中国细胞生物学学会干细胞分会青年研究员奖
2018-12  2018中国生命科学十大进展
2017-11  北京市科学技术二等奖
2016-11  首都十大疾病科技攻关创新型科技进展奖

代表性论著

  1. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC#, Qu J#, Tang F#, Liu GH#. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180 (3), 585-600.e19. Cover story. (#Corresponding author)

  2. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC#, Zhang W#, Qu J#, Liu GH#. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020.180(5),984-1001.e22 (#Corresponding author)

  3. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W#, Qu J#, Liu GH#. (2020) Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021,31(2):187-205. (#Corresponding author)

  4. Li J, Zheng Y, Yan P, Song M, Wang S, Sun L, Liu Z, Ma S, Chan P, Zhou Q, Belmonte JC, Zhang W#, Liu GH#, Tang F#, Qu J#. A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging. National Science Review. 2021, 8(2): nwaa127 DOI: 10.1093/nsr/nwaa127 (#Corresponding author)

  5. Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH#, Tang F#, Qu J#. A Single-Cell Transcriptomic landscape of Primate Arterial Aging. Nature Communications. 2020.11(1):2202 (#Corresponding author)

  6. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Wang S#, Zhang W#, Liu GH#, Qu J#. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Research. 2020. 19;48(11):6001-6018. (#Corresponding author)

  7. Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH#, Zhang W#, Song M#, Qu J#. FOXO3-Engineered Human Mesenchymal Progenitor Cells Efficiently Promote Cardiac Repair after Myocardial Infarction. Protein Cell. 2021, 12(2): 145-151 (#Corresponding author)

  8. Wang S#, Zheng Y, Li Q, He X, Ren R, Zhang W, Song M, Hu H, Liu F, Sun G, Sun S, Liu Z, Yu Y, Chan P, Zhao GG, Zhou Q, Liu GH#, Tang F# Qu J#. Deciphering primate retinal aging at single-cell resolution. Protein Cell. 2020. DOI: 10.1007/s13238-020-00791-x. (#Corresponding author)

  9. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Zhang W#, Song M#, Liu GH#, Qu J#. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020. 11(7):483-504 (#Corresponding author)

  10. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W#, Sun Q#, Qu J#, Liu GH#. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870(#Corresponding author)

  11. Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Belmonte JCI, Xiao C, Qu J#, Wang H#, Liu GH#, Su W#. A human circulating immune cell landscape in aging and COVID-19. Protein Cell. 2020. DOI: 10.1007/s13238-020-00762-2(#Corresponding author)

  12. He X, Memczak S, Qu J#, Belmonte JC#, Liu GH#. Single-cell “OMICS” in aging: a young growing field. Nature Metabolism. 2020. 2: 293–302 (#Corresponding author)

  13. Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M#, Zhang W#, Liu GH#, Qu J#. Low-dose quercetin positively regulates mouse healthspan. Protein Cell. 2019. 10 (10), 770-775 (#Corresponding author)

  14. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W#, Song M#, Liu GH#, Qu J#. Telomere-Dependent and Telomere-Independent Roles of RAP1 in Regulating Human Stem Cell Homeostasis. Protein Cell. 2019. 10 (9), 649-667 (#Corresponding author)

  15. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J#, Tang F#, Liu GH#.  FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell. 2019. 24(3), 447-461 (cover story) (#Corresponding author)

  16. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Belmonte J, Chan P, Qu J#, Liu GH#. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nature Communications. 2019.10(1):3329. (#Corresponding author)

  17. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J#, Tang F#, Liu GH#. Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology. 2019. 17(4):e3000201 (#Corresponding author)

  18. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J#, Tang F#, Liu GH#.Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports. 2019. 26(13):3643-3656. (#Corresponding author)

  19. Zhang W, Song M, Qu J# Liu GH#. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786. (#Corresponding author)

  20. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T#, Qu J#, Liu GH#.Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research. 2017. 27(4):483-504 (#Corresponding author)