新陈代谢是所有生物学过程的核心，包括免疫细胞的分化、增殖和免疫功能的维持；代谢紊乱会导致免疫功能障碍和疾病进展。

(1)  黏膜免疫及肿瘤免疫代谢；

(2)   脂质稳态对免疫细胞功能和免疫重塑的影响；

(3)   肝脏脂质组装、分泌的分子机制。

2011-09--2015-06   中国科学院广州生物医药与健康研究院   博士研究生
2006-09--2010-06   中国科学技术大学   硕士研究生
2002-09--2006-06   合肥工业大学   学士

   

2021-03~现在, 中国科学院广州生物医药与健康研究院, 副研究员
2015-07~2021-02,中国科学院广州生物医药与健康研究院, 助理研究员
2010-07~2011-08,中国科学院广州生物医药与健康研究院, 研究实习员

   

（1） An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape, FRONTIERS IN IMMUNOLOGY, 2025, 第 12 作者  通讯作者
（2） PLA2G12A protects against diet-induced obesity and insulin resistance by enhancing energy expenditure and clearance of circulating triglycerides, FASEB JOURNAL, 2024, 第 10 作者  通讯作者
（3） Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 第 18 作者
（4） Secreted phospholipase PLA2G2E contributes to regulation of T cell immune response against influenza virus infection, JOURNAL OF VIROLOGY, 2024, 第 11 作者  通讯作者
（5） SARS-CoV-2 induces cardiomyocyte apoptosis and inflammation but can be ameliorated by ACE inhibitor Captopril, ANTIVIRAL RESEARCH, 2023, 第 15 作者  通讯作者
（6） Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients, JOURNAL OF IMMUNOLOGY, 2021, 第 17 作者  通讯作者
（7） A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice, JOURNAL OF VIROLOGY, 2021, 第 11 作者
（8） Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients, EMERGING MICROBES & INFECTIONS, 2021, 第 22 作者  通讯作者
（9） Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via Fc gamma Receptor-Dependent and -Independent Pathways, MBIO, 2021, 第 19 作者
（10） Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles, JOURNAL OF VIROLOGY, 2020, 第 4 作者
（11） Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development, THERANOSTICS, 2020, 第 5 作者
（12） Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response, EMERGING MICROBES & INFECTIONS, 2020, 第 5 作者
（13） Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients (vol 11, 582010, 2020), FRONTIERS IN IMMUNOLOGY, 2020, 第 11 作者
（14） Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus, ANTIVIRAL RESEARCH, 2019, 第 17 作者  通讯作者
（15） Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model, EMERGING MICROBES AND INFECTIONS, 2019, 第 3 作者
（16） Estrogen-related receptor gamma regulates hepatic triglyceride metabolism through phospholipase A2 G12B, FASEB JOURNAL, 2019, 第 10 作者  通讯作者
（17） An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques, EMERGING MICROBES & INFECTIONS, 2018, 第 12 作者
（18） Incorporation of ns1 and prm/m are important to confer effective protection of adenovirus-vectored zika virus vaccine carrying e protein, NPJ VACCINES, 2018, 第 2 作者
（19） AXL is not essential for Zika virus infection in the mouse brain, EMERGING MICROBES & INFECTIONS, 2017, 第 3 作者
（20） Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE., SCIENTIFIC REPORTS, 2017, 第 4 作者
（21） Group IIE Secretory Phospholipase A(2) Regulates Lipolysis in Adipocytes, OBESITY, 2015, 第 2 作者
（22） Hepatocyte Nuclear Factor 4 alpha and Downstream Secreted Phospholipase A(2) GXIIB Regulate Production of Infectious Hepatitis C Virus, JOURNAL OF VIROLOGY, 2014, 第 3 作者
（23） Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB, HEPATOLOGY, 2011, 第 2 作者
（24） 饥饿状态下HNF4α对MTP的表达调控, Starvation induced MTP expression in part through HNF4α, 中国科学技术大学学报, 2010, 第 1 作者

   

（ 1 ） 基于新型载体的鼻喷型流感疫苗研发, 参与, 地方任务, 2025-04--2028-03
（ 2 ） 冠状病毒诱导黏膜分泌型IgA的产生及其调控机制研究, 参与, 国家任务, 2025-01--2028-12