1. 新型荧光染料的开发及构效关系研究

2. 复杂体系(活细胞、材料等）动态超分辨荧光成像

3. 高灵敏度荧光探针设计

   

070302-分析化学

活细胞内超分辨荧光成像，荧光染料与探针开发

2012-09--2018-04   大连理工大学   博士
2008-09--2012-06   大连理工大学   学士

   

2025-10~现在, 中国科学与大连化学物理研究所, 研究员
2020-07~2025-04,中国科学院大连化学物理研究所, 副研究员
2018-07~2020-06,中国科学院大连化学物理研究所, 助理研究员

2025-06-13-2029-06-13,辽宁省生命科学学会, 青年委员
2025-01-01-2028-12-31,Chin. Chem. Lett. , 青年编委
2024-12-01-2028-12-01,大连市精细化工会, 会员

   

（1） Bright and Versatile Azetidinecarboxamide-Based Fluorophore-Ligand Conjugates for High-Resolution Cell Imaging, Angew. Chem. Int. Ed., 2025, 第 2 作者  通讯作者
（2） Two-Color Single-Molecule Blinking Ratiometricity: A Functional Super-Resolution Imaging Approach for Resolving Lysosomal pH and Dynamics, Angew. Chem. Int. Ed., 2025, 第 1 作者  通讯作者
（3） Whole-cell Lysosome SMLM Imaging as Indicators for Functional Diagnostics with a Low-Phototoxic Spontaneously Blinking Probe, Angew. Chem. Int. Ed., 2025, 第 1 作者  通讯作者
（4） Tail-Assisted Excited-State Intramolecular Proton Transfer (ta-ESIPT) Fluorophores: A Universal Ratiometric Platform for Hydration-Sensitive Biomolecular Imaging and Sensing, J. Am. Chem. Soc., 2025, 第 1 作者
（5） Precision Molecular Engineering of Compact Near-Infrared Fluorophores, J. Am. Chem. Soc., 2025, 第 2 作者
（6） Spontaneously Blinkogenic Probe for Wash-Free Single-Molecule Localization-Based Super-Resolution Imaging in Living Cells, Angew. Chem. Int. Ed., 2025, 第 1 作者
（7） Bacterial Membrane-induced Disassembly of Fluorescein Aggregates Enables Selective Imaging and Killing of Gram-positive Bacteria, Sensor. Actuat. B-Chem., 2024, 
（8） The Remarkable Effect of Amino Hydrogen on Membrane Permeability and Organelle Staining of 1,8-Naphthalimide Dyes, Chin. Chem. Lett., 2024, 
（9） Superimposed” Spectral Characteristics of Fluorophores Arising from Cross-Conjugation Hybridization, Chin. Chem. Lett., 2024, 第 2 作者
（10） Solvatochromic Buffering Fluorescent Probe Resolves the Lipid Transport and Morphological Changes during Lipid Droplet Fusion by Super-Resolution Imaging, Anal. Chem., 2024, 
（11） White Light Generation by Regulating Hydrogen Bond-Sensitive ESPT of Naphthalimide Dyes, Chin. Chem. Lett., 2024, 第 2 作者
（12） Trifluoroethylamine-Substituted Solvatochromic Fluorophores Exhibit Polarity-Insensitive High Brightness, Chem. Commun., 2024, 
（13） RNA Buffering Fluorogenic Probe for Nucleolar Morphology Stable Imaging and Nucleolar Stress-Generating Agents Screening, Adv. Sci., 2024, 
（14） Stable Super-Resolution Imaging of Cell Membrane Nanoscale Subcompartment Dynamics with a Buffering Cyanine Dye, Anal. Chem., 2024, 
（15） Protein Proximity Ligation Probe with Wide Sensing Range Resolving Dynamics of Subcellular pH by Super-Resolution Imaging, Sensor. Actuat. B-Chem., 2024, 
（16） Monitoring Amyloid Aggregation via Twisted Intramolecular Charge Transfer (TICT)-Based Fluorescent Sensor Array, Chem. Sci., 2023, 第 6 作者
（17） Aniline as a TICT rotor to derive methine fluorogens for biomolecules:A curcuminoid-BF2 compound for lighting up HSA/BSA, Aniline as a TICT rotor to derive methine fluorogens for biomolecules: A curcuminoid-BF2 compound for lighting up HSA/BSA, CHINESE CHEMICAL LETTERS, 2023, 第 9 作者  通讯作者
（18） Dye disaggregation light-up aptamer for super-resolution RNA imaging, SENSORS AND ACTUATORS B-CHEMICAL, 2023, 第 7 作者  通讯作者
（19） Modulation of dynamic aggregation in fluorogenic SNAP‐tag probes for long‐term super‐resolution imaging, AGGREGATE, 2023, 第 1 作者
（20） Cellular membrane imaging of the dynamic binding-dissociation of rhodamine-benzenesulfonamide bioconjugate with carbonic anhydrase IX for inhibitor screening, SENSORS AND ACTUATORS B-CHEMICAL, 2023, 第 2 作者  通讯作者
（21） Spontaneously Blinking Rhodamine Dyes for Single-Molecule Localization Microscopy, Angew. Chem. Int. Ed., 2023, 第 3 作者
（22） In Situ Real-Time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self-Assemblies by Super-Resolution Imaging, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 第 1 作者
（23） An Acid-Regulated Self-Blinking Fluorescent Probe for Resolving Whole-Cell Lysosomes with Long-Term Nanoscopy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 第 1 作者
（24） Enhancing Brightness and Photostability of Organic Small Molecular Fluorescent Dyes Through Inhibiting Twisted Intramolecular Charge Transfer (TICT), ACTA CHIMICA SINICA, 2022, 第 2 作者  通讯作者
（25） Systematic study of synthesizing various heteroatom-substituted rhodamines from diaryl ether analogues, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2020, 第 5 作者  通讯作者
（26） Quantitative Design of Bright Fluorophores and AIEgens by the Accurate Prediction of Twisted Intramolecular Charge Transfer (TICT), ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 2 作者
（27） Descriptor Delta G(C-O)Enables the Quantitative Design of Spontaneously Blinking Rhodamines for Live-Cell Super-Resolution Imaging, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 2 作者
（28） Long-term super-resolution imaging of mitochondrial dynamics, Long-term super-resolution imaging of mitochondrial dynamics, CHINESE CHEMICAL LETTERS, 2020, 第 4 作者  通讯作者
（29） A Photoexcitation-Induced Twisted Intramolecular Charge Shuttle, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 2 作者
（30） A general strategy to develop cell membrane fluorescent probes with location- and target-specific fluorogenicities: a case of a Zn2+ probe with cellular selectivity, CHEMICAL COMMUNICATIONS, 2019, 第 3 作者  通讯作者
（31） Combined application of SNAP-tag and fluorescence technique in in-situ protein analysis, CHINESE JOURNAL OF CHROMATOGRAPHY, 2019, 第 1 作者
（32） Strong π-π stacking interactions led to the mis-assignment of dimer emissions to the monomers of 1-acetylpyrene, CHINESECHEMICALLETTERS, 2019, 第 4 作者  通讯作者
（33） A wash-free SNAP-tag fluorogenic probe based on the additive effects of quencher release and environmental sensitivity, CHEMICAL COMMUNICATIONS, 2017, 第 2 作者
（34） A naphthalimide-derived fluorogenic probe for SNAP-tag with a fast record labeling rate, DYES AND PIGMENTS, 2017, 第 1 作者
（35） Aziridinyl fluorophores demonstrate bright fluorescence and superior photostability by effectively inhibiting twisted intramolecular charge transfer, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 2 作者
（36） A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells, RSC ADVANCES, 2014, 第 1 作者
（37） Constructing D-π-A-π dye to obtain red-emission fluorescent probe for structured illumination microscopy imaging of lipid droplet dynamics, GREEN CHEMICAL ENGINEERING, 第 5 作者

（1） Imaging Tools for Chemical Biology, RSC, 2024-11, 第 3 作者
（2） 荧光染料及其生物医学应用, 化学工业出版社, 2022-03, 第 其他 作者