主要致力于药用植物中可用于治疗老年痴呆症和抗耐药菌疾病的杂合分子的系统挖掘-结构类群、构效关系、结构修饰、作用机制、成药性评价等相关研究，以期获得活性更加优异、低毒高效、先导化合物，提供创新药物或候选药物明星分子。

有志于‘老药 (中草药资源) 新用’研究的天然药物化学硕士研究生。

105500-药学
100701-药物化学

天然药物化学
药用植物资源学
药效物质

2012-09--2015-07   中国科学院大学   博士研究生

研究生

理学博士

2020.10-至今  中国科学院青年创新促进会昆明分会秘书长

2019.1-至今  中国科学院昆明植物研究所   副研究员、硕士研究生导师

2022-04~现在, 中国科学院昆明植物研究所, 植化室第二党支部宣传委员兼纪检委员
2020-10~2022-03,中国科学院昆明植物研究所, 植化室第二党支部副书记
2019-01~现在, 中国科学院昆明植物研究所, 副研究员
2015-07~2018-12,中国科学院昆明植物研究所, 助理研究员

2022-01-01-今,云南中医药大学硕士生导师,

   

（ 1 ） 一种具有抗病毒活性的大叶桉酮及其制备方法和用途, 发明专利, 2021, 第 5 作者, 专利号: CN112159318A

（ 2 ） 一种间苯三酚杂萜类化合物及其制备方法和应用，以及药物组合物, 发明专利, 2020, 第 2 作者, 专利号: CN112028761A

（ 3 ） 甲酰间苯三酚杂萜类化合物和其药物组合物与其制备方法及应用, 发明专利, 2018, 第 2 作者, 专利号: CN107602524A

（ 4 ） C 27 螺甾烷型甾体皂苷化合物与其药物组合物和其应用, 发明专利, 2017, 第 4 作者, 专利号: CN106967147A

   

[1] Yu, Mu-Yuan, Liu, Si-Na, Luo, E-E, Jin, Qiong, Liu, Hui, Liu, Hai-Yang, Luo, Xiao-Dong, Qin, Xu-Jie. Phloroglucinols with hAChE and α-glucosidase inhibitory activities from the leaves of tropic Rhodomyrtus tomentosa. Phytochemistry[J]. 2022, 203: 113394-, http://dx.doi.org/10.1016/j.phytochem.2022.113394.
[2] Jin Qiong, Zhao, Yun-Li, Liu, Ya-Ping, Zhang, Ruo-Song, Zhu, Pei-Feng, Zhao, Lan-Qin, Qin, Xu-Jie, Luo, Xiao-Dong. Anti-inflammatory and analgesic monoterpenoid indole alkaloids of Kopsia officinalis. Journal of Ethnopharmacology[J]. 2022, 285: 114848-114848, [3] Yu, Mu-Yuan, Liu, Si-Na, Liu, Hui, Meng, Qing-Hong, Qin, Xu-Jie, Liu, Hai-Yang. Acylphloroglucinol trimers from Callistemon salignus seeds: Isolation, configurational assignment, hAChE inhibitory effects, and molecular docking studies. Bioorganic Chemistry[J]. 2021, 117: 105404-105404, [4] Qin, Xu-Jie, Liu, Hui, Li, Pan-Pan, Ni, Wei, He, Li, Khan, Afsar, Hao, Xiao-Jiang, Liu, Hai-Yang. Polymethylated acylphloroglucinols from Rhodomyrtus tomentosa exert acetylcholinesterase inhibitory effects. Bioorganic Chemistry[J]. 2021, 107: 104519-104519, [5] Li, Dan, Yan, Huan, Wang, Jie, Yu, Qian, Ni, Wei, An, LinKun, Qin, Xu-Jie, Liu, Hai-Yang. Spirostanol and sesquiterpenoid glycosides from the rhizomes of Trillium tschonoskii. Steroids[J]. 2020, 155: 108569-108569, [6] Qin, Xu-Jie, Zhang, Lan-Jun, Zhang, Yu, Ni, Wei, Yang, Xing-Zhi, Yu, Qian, Yan, Huan, An, Lin-Kun, Liu, Hai-Yang. Polyphyllosides A-F, six new spirostanol saponins from the stems and leaves of Paris polyphylla var. chinensis. Bioorganic Chemistry[J]. 2020, 99: 103788-103788, [7] Liu Hui, He, Xiao-Zhi, Feng, Mi-Yan, Zeng, Yuan, Rauwolf, Tyler J., Shao, Li-Dong, Ni, Wei, Yan, Hui, Jr. Porco, John A, Hao, Xiao-Jiang, Qin, Xu-Jie, Liu, Hai-Yang. Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta. Bioorganic Chemistry[J]. 2020, 103: 104127-104127, [8] Li, Dan, Liu, Hui, Ni, Wei, Xiao, Wei-Lie, He, Li, Guo, Zhen-Yu, Qin, Xu-Jie, Liu, Hai-Yang. Molecular networking-based strategy for the discovery of polyacetylated 18-norspirostanol saponins from Trillium tschonoskii maxim. Phytochemistry[J]. 2019, 168: 112125-112125, [9] Qin, Xu-Jie, Rauwolf, Tyler J, Li, Pan-Pan, Liu, Hui, McNeely, James, Hua, Yan, Liu, Hai-Yang, Porco, John A, Jr.. Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate. Angewandte Chemie International Edition[J]. 2019, 58(13): 4291-4296, [10] Qin, Xu-Jie, Feng, Mi-Yan, Liu, Hui, Ni, Wei, Rauwolf, Tyler, Porco, John A, Jr., Yan, Huan, He, Li, Liu, Hai-Yang. Eucalyptusdimers A-C, Dimeric Phloroglucinol Phellandrene Meroterpenoids from Eucalyptus robusta. Organic Letters[J]. 2018, 20(16): 5066-5070, [11] Qin, Xu-Jie, Jin, Ling-Yu, Yu, Qian, Liu, Hui, Khan, Afsar, Yan, Huan, Hao, Xiao-Jiang, An, Lin-Kun, Liu, Hai-Yang. Eucalypglobulusals A-J, Formyl-Phloroglucinol-Terpene Meroterpenoids from Eucalyptus globulus Fruits. Journal of Natural Products[J]. 2018, 81(12): 2638-2646, [12] Qin, Xu-Jie, Wei Ni, Chen, Chang-Xiang, Liu, Hai-Yang. Untiring Researches for Alternative Resources of Rhizoma Paridis. Natural Products and Bioprospecting[J]. 2018, 8(4): 265-278, [13] Qin, Xu-Jie, Ni, Wei, Chen, Chang-Xiang, Liu, Hai-Yang. Seeing the light: Shifting from wild rhizomes to extraction of active ingredients from above-ground parts of Paris polyphylla var. yunnanensis. Journal of Ethnopharmacology[J]. 2018, 224: 134-139, [14] Qin, Xu-Jie, Si, Yong-Ai, Chen, Yu, Liu, Hui, Ni, Wei, Yan, Huan, Shu, Tong, Ji, Yun-Heng, Liu, Hai-Yang. Cytotoxic steroidal saponins from Trillium kamtschaticum. Bioorganic & Medicinal Chemistry Letters[J]. 2017, 27(11): 2267-2273, http://dx.doi.org/10.1016/j.bmcl.2017.04.057.
[15] Qin, Xu-Jie, Yu, Qian, Yan, Huan, Khan, Afsar, Feng, Mi-Yan, Li, Pan-Pan, Hao, Xiao-Jiang, An, Lin-Kun, Liu, Hai-Yang. Meroterpenoids with Antitumor Activities from Guava (Psidium guajava). Journal of Agricultural and Food Chemistry[J]. 2017, 65(24): 4993-4999, http://ir.kib.ac.cn/handle/151853/54451.
[16] Qin, Xu-Jie, Liu, Hui, Yu, Qian, Yan, Huan, Tang, Jin-Feng, An, Lin-Kun, Khan, Afsar, Chen, Qi-Run, Hao, Xiao-Jiang, Liu, Hai-Yang. Acylphloroglucinol derivatives from the twigs and leaves of Callistemon salignus. Tetrahedron[J]. 2017, 73(14): 1803-1811, http://dx.doi.org/10.1016/j.tet.2017.01.052.
[17] Qin Xu-Jie, Lunga, Paul-Keilah, Zhao Yun-Li, Liu Ya-Ping, Luo Xiao-Dong. Chemical constituents of Solanum coagulans and their antimicrobial activities. Chinese Journal of Natural Medicines[J]. 2016, 14(4): 308-312, http://dx.doi.org/10.1016/S1875-5364(16)30033-4.
[18] Qin, Xu-Jie, Yu, Mu-Yuan, Ni, Wei, Yan, Huan, Chen, Chang-Xiang, Cheng, Yung-Chi, He, Li, Liu, Hai-Yang. Steroidal saponins from stems and leaves of Paris polyphylla var. yunnanensis. Phytochemistry[J]. 2016, 121: 20-29, http://dx.doi.org/10.1016/j.phytochem.2015.10.008.
[19] Qin, Xu-Jie, Zhao, Yun-Li, Lunga, Paul-Keilah, Yang, Xing-Wei, Song, Chang-Wei, Cheng, Gui-Guang, Liu, Lu, Chen, Ying-Ying, Liu, Ya-Ping, Luo, Xiao-Dong. Indole alkaloids with antibacterial activity from aqueous fraction of Alstonia scholaris. Tetrahedron[J]. 2015, 71(25): 4372-4378, http://dx.doi.org/10.1016/j.tet.2015.04.046.
[20] Xu-Jie Qin, Yun-Li Zhao, Chang-Wei Song, Bei Wang, Ying-Ying Chen, Lu Liu, Qiong Li, Dan Li, Ya-Ping Liu, Xiao-Dong Luo. Monoterpenoid Indole Alkaloids from Inadequately Dried Leaves of Alstonia scholaris. Natural Products and Bioprospecting[J]. 2015, 5(4): 185-193, http://ir.kib.ac.cn/handle/151853/33811.
[21] Qin, Xu-Jie, Lunga, Paul-Keilah, Zhao, Yun-Li, Li, Jiang-Ling, Yang, Xing-Wei, Liu, Ya-Ping, Luo, Xiao-Dong. Antibacterial prenylbenzoic acid derivatives from Anodendron formicinum. Fitoterapia[J]. 2014, 92: 238-243, http://www.irgrid.ac.cn/handle/1471x/832455.
[22] Qin, Xu-Jie, Chen, Chang-Xiang, Ni, Wei, Yan, Huan, Liu, Hai-Yang. C22 steroidal lactone glycosides from stems and leaves of Paris polyphylla var. yunnanensis. Fitoterapia[J]. 2013, 84: 248-251, http://www.irgrid.ac.cn/handle/1471x/660296.

   

（ 1 ） 桃金娘科植物间苯三酚及其生物活性研究, 负责人, 中国科学院计划, 2019-01--2022-12
（ 2 ） 具有乙酰胆碱酯酶抑制活性间苯三酚衍生物的发现及其作用机制研究, 负责人, 国家任务, 2020-01--2023-12
（ 3 ） 抗老年痴呆先导分子的发现、优化及其作用机制研究, 负责人, 地方任务, 2020-06--2023-05
（ 4 ） 云南省'万人计划'-青年拔尖人才, 负责人, 地方任务, 2021-01--2025-12
（ 5 ） 云南省-‘中青年学术和技术带头人后备人才’, 负责人, 地方任务, 2021-01--2025-12
（ 6 ） 延龄草属植物止血药效物质基础及其作用机制研究, 负责人, 国家任务, 2017-01--2019-12
（ 7 ） 天然hAChE抑制剂类先导物的深入挖掘及其作用机制, 负责人, 地方任务, 2022-06--2025-05

（1）植物特征性、活性成分及其潜在科学问题   2020年度植物化学与西部植物资源持续利用国家重点实验室青年论坛与研究生学术年会   2021-01-14

现指导学生

刘思娜  硕士研究生  105500-药学  

罗娥娥  硕士研究生  105500-药学  

雷淑镁  硕士研究生  105500-药学