基本信息
赵勤实 男 博导 中国科学院昆明植物研究所
电子邮件： qinshizhao@mail.kib.ac.cn
通信地址： 昆明市蓝黑路132号
邮政编码： 650201
电子邮件： qinshizhao@mail.kib.ac.cn
通信地址： 昆明市蓝黑路132号
邮政编码： 650201
研究领域
天然药物化学，创新药与药现代化
招生信息
招生专业
100701-药物化学
招生方向
天然药物化学
教育背景
1992-09--1995-10 中国科学院昆明植物研究所 理学博士1989-09--1992-07 云南大学化学系 理学硕士1981-09--1985-07 云南师范大学 学士
学历
中科院昆明植物研究所 -- 研究生
学位
中科院昆明植物研究所 -- 博士
出国学习工作
1999年至2000年3月，日本静冈县立大学客座研究
工作经历
工作简历
2010-07~2015-07,中国科学院昆明植物研究所, 公共技术服务中心主任2006-11~现在, 中国科学院昆明植物研究所, 国家重点实验室副主任2006-01~2006-03,日本静冈县立大学药学部生化教室, 访问学者2002-04~2013-06,中国科学院昆明植物研究所, 研究员2000-04~2002-03,中国科学院昆明植物研究所, 副研究员1999-01~2000-03,日本静冈县立大学药学部药品制造教室, 客座研究1998-04~1999-01,中国科学院昆明植物研究所, 副研究员1995-12~1998-03,军事医学科学院毒物药物研究所, 博士后1985-07~1989-08,大理师范专科学校, 助教
社会兼职
2013-01-01-2018-12-30,中国植物学会植物资源与植物化学专业委员会, 委员
2010-11-01-2014-12-31,中国花卉协会蕨类植物协会, 理事
2010-08-01-2013-08-31,广西植物功能物质研究与利用重点实验室学术委员会, 主任
2008-01-01-2013-12-31,中国植物学会植物资源与植物化学专业委员会, 委员
2010-11-01-2014-12-31,中国花卉协会蕨类植物协会, 理事
2010-08-01-2013-08-31,广西植物功能物质研究与利用重点实验室学术委员会, 主任
2008-01-01-2013-12-31,中国植物学会植物资源与植物化学专业委员会, 委员
教授课程
天然药物化学
专利与奖励
1. 5/7/6型紫杉烷二萜化合物，其药物组合物和其合成方法和用途，授权号 CN 101260040 B
2. 5/7/6型13(15)位环氧紫杉烷二萜化合物，其药物组合物和其合成方法和用途，公开号 CN 101255146 A
2. 5/7/6型13(15)位环氧紫杉烷二萜化合物，其药物组合物和其合成方法和用途，公开号 CN 101255146 A
奖励信息
（1） 十种鼠尾草属植物萜类化学成分与生物活性, 二等奖, 省级, 2020（2） 朱李月华优秀教师奖, 一等奖, 院级, 2014（3） 云南省政府特殊津贴, 一等奖, 省级, 2013（4） 云南省自然科学奖, 二等奖, 省级, 2003
专利成果
（ 1 ） 5/7/6型紫杉烷二萜化合物，其药物组合物和其合成方法和用途, 发明, 2011, 第 1 作者, 专利号: CN 101260040 B（ 2 ） 5/7/6型13(15)位环氧紫杉烷二萜化合物，其药物组合物和其用途, 发明, 2008, 第 1 作者, 专利号: CN 101255146 A（ 3 ） 贝壳杉烷型二萜衍生物及其药物组合物和其在医药中的用途, 发明, 2014, 第 1 作者, 专利号: CN102603519B（ 4 ） 景洪哥纳香甲素衍生物及其在制药中的应用, 发明, 2015, 第 1 作者, 专利号: ZL201310034985.5（ 5 ） 石松生物碱类化合物，其药物组合物及其制备方法和用途, 发明, 2017, 第 1 作者, 专利号: ZL201610800773.7（ 6 ） 呋喃半日花烷二萜衍生物及其药物组合物和其在制药中的应用, 发明, 2019, 第 1 作者, 专利号: ZL201610997814.6（ 7 ） 8-epi-hypophyllin E 及其衍生物和其药物组合物与其在制药中的应用, 发明, 2019, 第 1 作者, 专利号: ZL201710019196.2
出版信息
发表论文
[1] Chem. Biodiversity. 2024, 通讯作者 [2] Chem. Biodiversity. 2024, 通讯作者 [3] Chem. Biodiversity. 2024, 通讯作者 [4] Phytochemistry. 2024, 通讯作者 [5] Molecules. 2024, 通讯作者 [6] Journal of the American Chemical Society. 2024, 通讯作者 [7] CCS Chemistry. 2024, 通讯作者 [8] Bioorganic Chemistry. 2024, 通讯作者 [9] Organic Chemistry Frontiers. 2024, 通讯作者 [10] Organic Letters. 2023, 通讯作者 [11] Zhuohui Zhao, ZhenTao Deng, Suling Huang, Mengmeng Ning, Ying Feng, Yu Shen, QinShi Zhao, Ying Leng. Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice. NUTRIENTS[J]. 2022, 第 7 作者 通讯作者 14: https://doaj.org/article/fe19282fbde547c9931e16a90de0d1c2.[12] Wang, LiuYan, Li, WenYan, Zhou, HaoFeng, Zhao, XueYu, Li, XiaoNian, Wu, XingDe, Zhao, QinShi. Spiroligustolides A and B: Two pairs of enantiomeric spiro-orthoester-containing phthalide dimers as Ca(v)3.1 calcium channel inhibitors from Ligusticum Chuanxiong Hort. BIOORGANIC CHEMISTRY[J]. 2022, 第 7 作者 通讯作者 123: http://dx.doi.org/10.1016/j.bioorg.2022.105749.[13] Deng, ZhenTao, Wu, XingDe, Yuan, ZaiFeng, Yu, NaiRong, Ou, YuFei, Zhao, QinShi. Total synthesis of huperserratines A and B. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 6 作者 通讯作者 9(14): 3664-3668, http://dx.doi.org/10.1039/d2qo00608a.[14] Meng Li, Xianlan She, Yufei Ou, Jiangxin Liu, Zaifeng Yuan, Qinshi Zhao. Design, synthesis and biological evaluation of a new class of Hsp90 inhibitors vibsanin C derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2022, 第 6 作者244: http://dx.doi.org/10.1016/j.ejmech.2022.114844.[15] Wu, XingDe, Ding, LinFen, Li, WenYan, Cheng, Bin, Lei, Tie, Zhou, HaoFeng, Zhao, QinShi. Hypoestins A-D: highly modified fusicoccane diterpenoids with promising Ca(v)3.1 calcium channel inhibitory activity from Hypoestes purpurea. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 第 7 作者 通讯作者 9(11): 3075-3083, http://dx.doi.org/10.1039/D2QO00265E.[16] Wu, XingDe, Huang, Suling, Shi, Yu, Shen, Yu, Tu, WenChao, Leng, Ying, Zhao, QinShi. Design, synthesis and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 第 7 作者 通讯作者 232: http://dx.doi.org/10.1016/j.ejmech.2022.114171.[17] Nie, Wei, Ding, LinFen, Lei, Tie, Pan, ZhengHong, Song, LiuDong, Wu, XingDe, Zhao, QinShi. Illilanceolide A, a unique seco-prezizaane sesquiterpenoid with 5/5/6 tricyclic scaffold from the fruits of Illicium lanceolatum A. C. Smith. TETRAHEDRON LETTERS[J]. 2021, 第 7 作者 通讯作者 70: http://dx.doi.org/10.1016/j.tetlet.2021.153022.[18] Liu, Jiangxin, Wu, XingDe, Li, Wenyan, Yuan, Zaifeng, Yang, Kun, Zhao, QinShi. Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism. BIOORGANIC CHEMISTRY[J]. 2021, 第 6 作者 通讯作者 112: http://dx.doi.org/10.1016/j.bioorg.2021.104963.[19] Jiang, TingTing, Ding, LinFen, Nie, Wei, Wang, LiuYan, Lei, Tie, Wu, XingDe, Zhao, QinShi. Tetranorlanostane and Lanostane Triterpenoids with Cytotoxic Activity from the Epidermis of Poria cocos. CHEMISTRY & BIODIVERSITY[J]. 2021, 第 7 作者 通讯作者 18(5): http://dx.doi.org/10.1002/cbdv.202100196.[20] Wang, DeSheng, Nie, Wei, Jiang, TingTing, Ding, LinFen, Song, LiuDong, Wu, XingDe, Zhao, QinShi. Caesalpanins A-C, Three Dimeric Cassane Diterpenoids from the Seeds of Caesalpinia sappan L.. CHEMISTRY & BIODIVERSITY[J]. 2020, 第 7 作者 通讯作者 17(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000527328800001.[21] Fan, Min, Luo, Dan, Peng, LiYan, Wu, XingDe, Ji, Xu, Zhao, QinShi. Rearranged neoclerodane diterpenoids from the aerial parts of Salvia hispanica L.. FITOTERAPIA[J]. 2020, 第 6 作者 通讯作者 146: http://dx.doi.org/10.1016/j.fitote.2020.104672.[22] Liu, Siwen, Huang, Suling, Wu, Xingde, Feng, Ying, Shen, Yu, Zhao, Qinshi, Leng, Ying. Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway. MOLECULAR METABOLISM[J]. 2020, 第 11 作者41: http://dx.doi.org/10.1016/j.molmet.2020.101045.[23] Ding, LinFen, Peng, LiYan, Zhou, HaoFeng, Song, LiuDong, Wu, XingDe, Zhao, QinShi. Artemilavanolides A and B, two sesquiterpenoids with a 6-oxabicyclo 3.2.1octane scaffold from Artemisia lavandulaefolia. TETRAHEDRON LETTERS[J]. 2020, 第 6 作者 通讯作者 61(21): http://dx.doi.org/10.1016/j.tetlet.2020.151872.[24] Hua, Xiaohui, Huang, Maowen, Deng, Xu, Xu, Jiheng, Luo, Yisi, Xie, Qipeng, Xu, Jiawei, Tian, Zhongxian, Li, Jingxia, Zhu, Junlan, Huang, Chao, Zhao, Qinshi, Huang, Haishan, Huang, Chuanshu. The inhibitory effect of compound ChlA-F on human bladder cancer cell invasion can be attributed to its blockage of SOX2 protein. CELL DEATH AND DIFFERENTIATION[J]. 2020, 第 12 作者 通讯作者 27(2): 632-645, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205984/.[25] Zhang, ZhiJun, Zhu, QinFeng, Wu, XingDe, Zhao, QinShi. Phlegmadines B and C, two Lycopodium alkaloids with 6/5/5/5/7 pentacyclic skeleton from Phlegmariurus phlegmaria. TETRAHEDRON LETTERS[J]. 2020, 第 4 作者 通讯作者 61(2): http://dx.doi.org/10.1016/j.tetlet.2019.151381.[26] Wu, XingDe, Li, XiaoNian, Peng, LiYan, Zhao, QinShi. Huperserratines A and B, Two Macrocyclic Lycopodium Alkaloids with an Unusual Skeleton from Huperzia serrata. JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 第 4 作者 通讯作者 85(10): 6803-6807, https://www.webofscience.com/wos/woscc/full-record/WOS:000535303300052.[27] Tu, WenChao, Qi, YanYan, Ding, LinFen, Yang, Hui, Liu, JiangXin, Peng, LiYan, Song, LiuDong, Gong, Xun, Wu, XingDe, Zhao, QinShi. Diterpenoids and sesquiterpenoids from the stem bark of Metasequoia glyptostroboides. PHYTOCHEMISTRY[J]. 2019, 第 10 作者 通讯作者 161: 86-96, http://dx.doi.org/10.1016/j.phytochem.2019.02.008.[28] Zhang, ZhiJun, Wang, Chen, Wu, XingDe, Huang, Yan, Zhou, WenXia, Zhao, QinShi. Phlegmadine A: A Lycopodium Alkaloid with a Unique Cyclobutane Ring from Phlegmariurus phlegmaria. JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 第 6 作者 通讯作者 84(17): 11301-11305, [29] Ding, LinFen, Liu, JiangXin, Xie, ZhangQiao, Wang, DeShen, Nie, Wei, Song, LiuDong, Wu, XingDe, Zhao, QinShi. Magnograndins J-M, elemane sesquiterpenoids from the leaves of Magnolia grandiflora and their inhibitory effects on nitric oxide production. PHYTOCHEMISTRY LETTERS[J]. 2019, 第 8 作者 通讯作者 31: 121-124, http://dx.doi.org/10.1016/j.phytol.2019.03.021.[30] QinFengZhu, LiDongShao, XingDeWu, JiangXinLiu, QinShiZhao. Isolation, Structural Assignment of Isoselagintamarlin A fromSelaginella tamariscinaand Its Biomimetic Synthesis. Natural Products and Bioprospecting[J]. 2019, 第 5 作者 通讯作者 9(1): 69-74, http://npb.kib.ac.cn/EN/10.1007/s13659-018-0195-5.[31] Fan, Min, Luo, Dan, Peng, LiYan, Li, XiaoNian, Wu, XingDe, Ji, Xu, Zhao, QinShi. Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects. PHYTOCHEMISTRY[J]. 2019, 第 7 作者 通讯作者 166: 112065, http://dx.doi.org/10.1016/j.phytochem.2019.112065.[32] Xie, ZhangQiao, Ding, LinFen, Wang, DeSheng, Nie, Wei, Liu, JiangXin, Qin, Jing, Song, LiuDong, Wu, XingDe, Zhao, QinShi. Sesquiterpenes from the Leaves of Magnolia delavayi Franch. and Their Cytotoxic Activities. CHEMISTRY & BIODIVERSITY[J]. 2019, 第 9 作者 通讯作者 16(5): http://dx.doi.org/10.1002/cbdv.201900013.[33] ZhiJunZhang, QinFengZhu, JiaSu, XingDeWu, QinShiZhao. Lycoplanines B-D, ThreeLycopodiumAlkaloids fromLycopodium complanatum. Natural Products and Bioprospecting[J]. 2018, 第 5 作者 通讯作者 8(3): 177-182, http://npb.kib.ac.cn/EN/10.1007/s13659-018-0161-2.[34] ZhiJun Zhang, YanYan Qi, XingDe Wu, Jia Su, QinShi Zhao. Erratum to "Lycogladines A-H, fawcettimine-type Lycopodium alkaloids from Lycopodium complanatum var. glaucum Ching" Tetrahedron 74 (2018) 1692–1697. TETRAHEDRON. 2018, 第 5 作者74(31): 4288-4288, http://dx.doi.org/10.1016/j.tet.2018.05.074.[35] Li, LaiWei, Qi, YanYan, Liu, ShiXi, Wu, XingDe, Zhao, QinShi. Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav.. FITOTERAPIA[J]. 2018, 第 5 作者 通讯作者 127: 367-374, http://ir.kib.ac.cn/handle/151853/64734.[36] Qi, YanYan, Su, Jia, Zhang, ZhiJun, Li, LaiWei, Fan, Min, Zhu, Yu, Wu, XingDe, Zhao, QinShi. Two New Anti-Proliferative C-18-Norditerpenes from the Roots of Podocarpus macrophyllus. CHEMISTRY & BIODIVERSITY[J]. 2018, 第 8 作者 通讯作者 15(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000430664800015.[37] Fan, Min, Chen, XueJiao, Wu, XingDe, Shao, LiDong, Ji, Xu, Zhao, QinShi. Salvifarinin A, a neo-clerodane diterpenoid with a 6/5/7 tricyclic skeleton from Salvia farinacea. TETRAHEDRON LETTERS[J]. 2018, 第 6 作者 通讯作者 59(32): 3065-3068, http://dx.doi.org/10.1016/j.tetlet.2018.06.015.[38] Wu, Xing-De, Zhao, Qin-Shi, Cheng, Bin, Ding, Lin-Fen, Yan, Tong, Xie, Zhang-Qiao, Zhang, Zhi-jun, Song, Liu-Dong. Hypofolins A - L, ent-Labdane Diterpenoids from the Roots of Hypoestes phyllostachya "Pink Splash'. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2018, 第 2 作者59: 384-390, http://ir.kib.ac.cn/handle/151853/63369.[39] Zhu, QinFeng, Qi, YanYan, Zhang, ZhiJun, Fan, Min, Bi, Ran, Su, Jia, Wu, XingDe, Shao, LiDong, Zhao, QinShi. Vibsane-Type Diterpenoids from Viburnum odoratissimum and Their Cytotoxic and HSP90 Inhibitory Activities. CHEMISTRY & BIODIVERSITY[J]. 2018, 第 9 作者 通讯作者 15(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000434072600010.[40] Zhu, Yu, Shao, LiDong, Deng, ZhenTao, Bao, Ying, Shi, Xin, Zhao, QnShi. PIDA/I-2-Mediated alpha- and beta-C(sp(3))-H Bond Dual Functionalization of Tertiary Amines. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 83(17): 10166-10174, https://www.webofscience.com/wos/woscc/full-record/WOS:000444364600050.[41] Shi, Xin, Bao, Ying, Deng, ZhenTao, Zhu, Yu, Shao, LiDong, Zhang, HongBin, Zhao, QinShi. A Practical Total Synthesis of (+/-)-Cermizine D and a Formal Synthesis of (+/-)-Cermizine C. JOURNAL OF CHEMICAL RESEARCH[J]. 2018, 第 7 作者 通讯作者 42(5): 274-279, http://dx.doi.org/10.3184/174751918X15271572210923.[42] Hua, Xiaohui, Xu, Jiheng, Deng, Xu, Xu, Jiawei, Li, Jingxia, Zhu, David Q, Zhu, Junlan, Jin, Honglei, Tian, Zhongxian, Huang, Haishan, Zhao, Qinshi, Huang, Chuanshu. New compound ChlA-F induces autophagy-dependent anti-cancer effect via upregulating Sestrin-2 in human bladder cancer. CANCER LETTERS[J]. 2018, 第 11 作者 通讯作者 436: 38-51, http://dx.doi.org/10.1016/j.canlet.2018.08.013.[43] Fan, Min, Zhu, Yu, Zhang, ZhiJun, Du, RuNan, Zhu, QinFeng, Wu, XingDe, Zhao, QinShi. Salvihispin A and its glycoside, two neo-clerodane diterpenoids with neurotrophic activities from Salvia hispanica L.. TETRAHEDRON LETTERS[J]. 2018, 第 7 作者 通讯作者 59(2): 143-146, http://dx.doi.org/10.1016/j.tetlet.2017.12.010.[44] Ding, LinFen, Su, Jia, Pan, ZhengHong, Zhang, ZhiJun, Li, XiaoNian, Song, LiuDong, Wu, XingDe, Zhao, QinShi. Cytotoxic sesquiterpenoids from the leaves of Magnolia grandiflora. PHYTOCHEMISTRY[J]. 2018, 第 8 作者 通讯作者 155: 182-190, http://dx.doi.org/10.1016/j.phytochem.2018.08.006.[45] Li-Dong Shao, Ying Bao, Yu Shen, Jia Su, Ying Leng, Qin-Shi Zhao. Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2017, 第 6 作者135: 324-338, http://dx.doi.org/10.1016/j.ejmech.2017.04.059.[46] Li, HongMei, Chen, XueJiao, Luo, Dan, Fan, Min, Zhang, ZhiJun, Peng, LiYan, Wu, XingDe, Li, RongTao, Ji, Xu, Zhao, QinShi. Protostane-Type Triterpenoids from Alisma orientale. CHEMISTRY & BIODIVERSITY[J]. 2017, 第 10 作者 通讯作者 14(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000418421800021.[47] Fan, Min, Bao, Ying, Zhang, ZhiJun, Zhang, HongBin, Zhao, QinShi. New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia. FITOTERAPIA[J]. 2017, 第 5 作者 通讯作者 123: 44-50, http://dx.doi.org/10.1016/j.fitote.2017.09.013.[48] Shao, LiDong, Su, Jia, Ye, Baixin, Liu, JiangXin, Zuo, ZhiLi, Li, Yan, Wang, YueYing, Xia, Chengfeng, Zhao, QinShi. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 第 9 作者 通讯作者 60(21): 9053-9066, https://www.webofscience.com/wos/woscc/full-record/WOS:000415140600028.[49] YuChen Liu, ZhiJun Zhang, Jia Su, LiYan Peng, LuTai Pan, XingDe Wu, QinShi Zhao. Lycodine-Type Lycopodium Alkaloids from the Whole Plants of Huperzia serrata. NAT. PROD. BIOPROSPECT.[J]. 2017, 第 7 作者7: 405–411, http://ir.kib.ac.cn/handle/151853/64655.[50] Zhang, ZhiJun, Nian, Yin, Zhu, QinFeng, Li, XiaoNian, Su, Jia, Wu, XingDe, Yang, Jian, Zhao, QinShi. Lycoplanine A, a C16N Lycopodium Alkaloid with a 6/9/5 Tricyclic Skeleton from Lycopodium complanatum. ORGANIC LETTERS[J]. 2017, 第 8 作者 通讯作者 19(17): 4668-4671, http://159.226.149.26:8080/handle/152453/12033.[51] Zhu, QinFeng, Bao, Ying, Zhang, ZhiJun, Su, Jia, Shao, LiDong, Zhao, QinShi. A biomimetic semisynthesis enables structural elucidation of selaginellin U: a tautomeric cyclic alkynylphenol from Selaginella tamariscina. ROYAL SOCIETY OPEN SCIENCE[J]. 2017, 第 6 作者 通讯作者 4(7): https://doaj.org/article/0c707267ba3b4ab18e9732b76f72999b.[52] Shi, Xin, Deng, ZhenTao, Zhu, Yu, Bao, Ying, Shao, LiDong, Zhao, QinShi. Total Synthesis of (+/-)-Cermizine B. JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 第 6 作者 通讯作者 82(20): 11110-11116, http://dx.doi.org/10.1021/acs.joc.7b02073.[53] Gao, Xiu, He, Juan, Wu, XingDe, Peng, LiYan, Shao, LiDong, Li, Yan, Cheng, Xiao, Zhao, QinShi. Sauruchinenols A and B, unprecedented monocyclic diterpenes with new carbon skeleton from the aerial parts of Saururus chinensis. FITOTERAPIA[J]. 2017, 第 8 作者 通讯作者 116: 116-120, http://www.irgrid.ac.cn/handle/1471x/1180592.[54] Li, HongMei, Fan, Min, Xue, Yong, Peng, LiYan, Wu, XingDe, Liu, Dan, Li, RongTao, Zhao, QinShi. Guaiane-Type Sesquiterpenoids from Alismatis Rhizoma and Their Anti-inflammatory Activity. 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JOURNALOFAGRICULTURALANDFOODCHEMISTRY[J]. 2010, 第 9 作者58(23): 12157-12161, http://www.irgrid.ac.cn/handle/1471x/767334.[107] Pan, ZhengHong, He, Juan, Li, Yan, Zhao, Yu, Wu, XingDe, Wang, Kou, Peng, LiYan, Xu, Gang, Zhao, QinShi. Castanolide and epi-castanolide, two novel diterpenoids with a unique seco-norabietane skeleton from Salvia castanea Diels f. pubescens Stib.. TETRAHEDRON LETTERS[J]. 2010, 第 9 作者 通讯作者 51(38): 5083-5085, http://dx.doi.org/10.1016/j.tetlet.2010.07.107.[108] Chen, XuanQin, Li, Yan, Cheng, Xiao, Wang, Kou, He, Juan, Pan, ZhengHong, Li, MingMing, Peng, LiYan, Xu, Gang, Zhao, QinShi. Polycyclic Polyprenylated Acylphloroglucinols and Chromone O-Glucosides from Hypericum henryi subsp uraloides. CHEMISTRY & BIODIVERSITY[J]. 2010, 第 10 作者7(1): 196-204, http://www.irgrid.ac.cn/handle/1471x/377278.[109] Pan, ZhengHong, Wang, YuanYuan, Li, MingMing, Xu, Gang, Peng, LiYan, He, Juan, Zhao, Yu, Li, Yan, Zhao, QinShi. Terpenoids from Salvia trijuga. JOURNAL OF NATURAL PRODUCTS[J]. 2010, 第 9 作者 通讯作者 73(6): 1146-1150, https://www.webofscience.com/wos/woscc/full-record/WOS:000279070300022.[110] He, Juan, Chen, XuanQin, Li, MingMing, Zhao, Yu, Xu, Gang, Cheng, Xiao, Peng, LiYan, Xie, MinJin, Zheng, YongTang, Wang, YiPing, Zhao, QinShi. Lycojapodine A, a Novel Alkaloid from Lycopodium japonicum. ORGANIC LETTERS[J]. 2009, 第 11 作者 通讯作者 11(6): 1397-1400, http://ir.simm.ac.cn/handle/153631/1232.[111] Xu, Gang, Peng, LiYan, Hou, AiJun, Yang, Jing, Han, QuanBin, Xu, HongXi, Zhao, QinShi. Isolation, structural elucidation, and chemical transformation of interconvertible 8,12-hemiketal germacranolide sesquiterpenoids from Salvia castanea Diels f. tomentosa Stib.. TETRAHEDRON[J]. 2008, 第 7 作者 通讯作者 64(40): 9490-9494, http://dx.doi.org/10.1016/j.tet.2008.07.074.[112] Zhao, Yu, Guo, Na, Lou, LiGuang, Cong, YuWen, Peng, LiYan, Zhao, QinShi. Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2008, 第 6 作者 通讯作者 16(9): 4860-4871, http://dx.doi.org/10.1016/j.bmc.2008.03.041.[113] Li, Xiao Li, Yang, LiuMeng, Zhao, Yu, Wang, RuiRui, Xu, Gang, Zheng, YongTang, Tu, Lin, Peng, LiYan, Cheng, Xiao, Zhao, QinShi. Tetranorclerodanes and clerodane-type diterpene glycosides from Dicranopteris dichotoma. JOURNAL OF NATURAL PRODUCTS[J]. 2007, 第 11 作者70(2): 265-268, http://www.irgrid.ac.cn/handle/1471x/1151233.[114] Zhao, Yu, Niu, XueMei, Qian, LiPing, Liu, ZeYuan, Zhao, QinShi, Sun, HanDong. Synthesis and cytotoxicity of some new eriocalyxin B derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2007, 第 5 作者42(4): 494-502, http://dx.doi.org/10.1016/j.ejmech.2006.11.004.[115] Xu, Gang, Hou, AiJun, Zheng, YongTang, Zhao, Yu, Li, Xiao Li, Peng, LiYan, Zhao, QinShi. Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii maxim. ORGANIC LETTERS[J]. 2007, 第 7 作者 通讯作者 9(2): 291-293, http://159.226.149.42:8080:8088/handle/152453/4609.[116] Xu, Gang, Hou, AiJun, Wang, RuiRui, Liang, GuangYu, Zheng, YongTang, Liu, ZeYuan, Li, Xiao Li, Zhao, Yu, Huang, ShengXiong, Peng, LiYan, Zhao, QinShi. Przewalskin A: A new C-23 terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii maxim. ORGANIC LETTERS[J]. 2006, 第 11 作者8(20): 4453-4456, http://159.226.149.42:8080:8088/handle/152453/4555.[117] Xu, G, Peng, LY, Lu, L, Weng, ZY, Zhao, Y, Li, XL, Zhao, QS, Sun, HD. Two new abietane diterpenoids from Salvia yunnanensis. PLANTA MEDICA[J]. 2006, 72(1): 84-86, http://www.irgrid.ac.cn/handle/1471x/501475.[118] Zhao, Yu, Wang, FuSheng, Peng, LiYan, Li, XiaoLi, Xu, Gang, Luo, XiaoXin, Lu, Yang, Wu, Li, Zheng, QiTai, Zhao, QinShi. Taxoids from Taxus chinensis. JOURNAL OF NATURAL PRODUCTS[J]. 2006, 第 11 作者69(12): 1813-1815, https://www.webofscience.com/wos/woscc/full-record/WOS:000243086200030.[119] Li, XL, Cheng, X, Yang, LM, Wang, RR, Zheng, YT, Xiao, WL, Zhao, Y, Xu, G, Lu, Y, Chang, Y, Zheng, QT, Zhao, QS, Sun, HD. Dichotomains A and B: Two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma. ORGANIC LETTERS[J]. 2006, 8(9): 1937-1940, http://159.226.149.42:8080:8088/handle/152453/4559.
科研活动
科研项目
（ 1 ） 国家重点基础研究发展计划（973计划）"蛋白质配体与资源化合物库的建设", 主持, 国家级, 2011-01--2015-12（ 2 ） 国家自然科学基金-云南省联合基金“西南地区特有蕨类植物中先导化合物的发现与作用机制研究”, 主持, 国家级, 2010-01--2014-12（ 3 ） 国家重大科技专项“毛兰属等18种对照品备选原料的研究”, 主持, 国家级, 2010-01--2011-12（ 4 ） 国家自然科学基金“靶向NF-KB通路的迈克尔反应受体小分子探针发现与功能研究”, 主持, 国家级, 2009-01--2011-12（ 5 ） 西部之光，“迈克尔反应受体分子化学生物学研究”, 主持, 部委级, 2010-01--2011-12（ 6 ） 中国特有植物和微生物药用活性物质的基础研究, 参与, 国家级, 2009-07--2013-12（ 7 ） 抑制11β-羟化类固醇脱氢酶1天然产物活性成分结构优化与成药性研究, 主持, 国家级, 2016-01--2019-12（ 8 ） 治疗心血管疾病药物研究与开发, 主持, 省级, 2018-01--2020-12（ 9 ） 新型石松生物碱先导化合物发现与研究, 主持, 国家级, 2019-01--2023-12
参与会议
（1）Phytochemical Study on Plants Distributed in Southwest of China 第三届中泰天然产物与药物发现双边学术研讨会 赵勤实 2010-08-18（2）药用蕨类植物化学研究 赵勤实 2009-08-04
指导学生
已指导学生
赵昱 博士研究生 071001-植物学
张鹏涛 硕士研究生 100701-药物化学
李晓莉 博士研究生 071001-植物学
郭娜 硕士研究生 100701-药物化学
陈宣钦 博士研究生 071001-植物学
李明明 硕士研究生 100701-药物化学
潘争红 博士研究生 100701-药物化学
胡疆 博士研究生 100701-药物化学
王扣 博士研究生 100701-药物化学
何隽 博士研究生 100701-药物化学
夏志华 博士研究生 071001-植物学
吴兴德 博士研究生 100701-药物化学
程锦堂 硕士研究生 077901-药物化学
邓旭 博士研究生 100701-药物化学
张雪媛 硕士研究生 077901-药物化学
邵立东 博士研究生 100701-药物化学
董廖斌 博士研究生 100701-药物化学
刘菲 硕士研究生 077901-药物化学
范敏 硕士研究生 077901-药物化学
高秀 博士研究生 100701-药物化学
姜薇薇 博士研究生 100701-药物化学
徐君 博士研究生 100701-药物化学
石鑫 博士研究生 100701-药物化学
任健 博士研究生 100701-药物化学
刘宇晨 博士研究生 100701-药物化学
朱煜 硕士研究生 078001-药物化学
祁艳艳 硕士研究生 078001-药物化学
张治军 博士研究生 100701-药物化学
范敏 博士研究生 100701-药物化学
李来伟 博士研究生 100701-药物化学
朱勤凤 博士研究生 100701-药物化学
杨坤 硕士研究生 105500-药学
现指导学生
邓振涛 博士研究生 100701-药物化学
毕冉 博士研究生 100701-药物化学
周浩锋 博士研究生 100701-药物化学
蒋帅 博士研究生 100701-药物化学
王磊 硕士研究生 078001-药物化学
高贝贝 博士研究生 100701-药物化学
吴琪 博士研究生 100701-药物化学
郁乃容 博士研究生 100701-药物化学
欧玉飞 博士研究生 100701-药物化学
李瑶 硕士研究生 078001-药物化学
陈丽婷 硕士研究生 105500-药学