基本信息
普诺·白玛丹增 男 博导 中国科学院昆明植物研究所
电子邮件: punopematenzin@mail.kib.ac.cn
通信地址: 云南省昆明市盘龙区蓝黑路132号
邮政编码: 650201
电子邮件: punopematenzin@mail.kib.ac.cn
通信地址: 云南省昆明市盘龙区蓝黑路132号
邮政编码: 650201
招生信息
招生专业
100701-药物化学
招生方向
天然产物化学,药物化学
教育背景
2004-09--2007-07 中科院昆明植物研究所 博士学位2001-09--2004-07 云南大学 硕士学位1997-09--2001-07 云南大学 学士学位
工作经历
工作简历
2014-01~现在, 中国科学院昆明植物研究所, 研究员2007-07~2013-12,中科院昆明植物研究所, 副研究员
专利与奖励
奖励信息
(1) 五味子化学研究, 特等奖, 省级, 2014(2) 香茶菜属植物二萜及其抗癌活性研究, 一等奖, 省级, 2013(3) 中国科学院卢嘉锡青年人才奖, , 院级, 2011(4) 第九届云南省科协优秀科技论文, 一等奖, 省级, 2010(5) 第八届云南省科协优秀科技论文, 二等奖, 省级, 2007
专利成果
[1] 普诺·白玛丹增, 郑永唐, 孙汉董, 周元飞, 颜秉超, 龙昕雁, 杨谦, 罗荣华. 毛萼内酯素B衍生物及其药物组合物与抗新冠肺炎的应用. CN114890971A, 2022-08-12.[2] 普诺·白玛丹增, 孙汉董, 周元飞, 颜秉超, 杨谦, 杜雪, 胡坤. 毛萼内酯素B衍生物与其在制备抗肿瘤药物中的应用. CN114805269A, 2022-07-29.[3] 普诺·白玛丹增, 孙汉董, 周元飞, 颜秉超, 杨谦, 杜雪, 胡坤. 毛萼内酯素A和毛萼内酯素B及其制备方法. CN114805270A, 2022-07-29.[4] 普诺·白玛丹增, 颜秉超, 周敏, 杜雪, 孙汉董. 一种帚状异酯素、其制备方法和应用,以及药物组合物. CN: CN112876366A, 2021-06-01.[5] 普诺·白玛丹增, 颜秉超, 周敏, 杜雪, 李昂, 孙汉董. 一种含四元环的杂二萜类化合物、其制备方法和应用,以及药物组合物. CN112812015A, 2021-05-18.[6] 陈策实, 普诺·白玛丹增, 孙汉董, 黄茂波, 周元飞. 3,4断裂的环阿尔廷型三萜类化合物在制备自噬抑制剂及抗肿瘤药物中的应用. CN: CN111481534A, 2020-08-04.
出版信息
发表论文
[1] Xiao-Zheng Su, Lin-Fei Zhang, Kun Hu, Yang An, Qiao-Peng Zhang, Jian-Wei Tang, Bing- Chao Yan, Xing-Ren Li, Jie Cai, Xiao-Nian Li, Han-Dong Sun, Shi-You Jiang, Pema-Tenzin Puno. Discovery of Natural Potent HMG-CoA Reductase Degraders for Lowering Cholesterol. Angewandte Chemie International Edition[J]. 2024, 63(6): e202313859-, [2] Leilei Gou, Grace GarLee Yue, Julia KinMing Lee, Pema Tenzin Puno, Clara BikSan Lau. Natural product Eriocalyxin B suppressed triple negative breast cancer metastasis both in vitro and in vivo. BIOCHEMICAL PHARMACOLOGY[J]. 2023, 210: http://dx.doi.org/10.1016/j.bcp.2023.115491.[3] Li, MingXiang, Yan, BingChao, Zhou, Min, Li XingRen, Li, XiaoNian, He, ShiJun, Sun, Handong, Puno, PemaTenzin. Cyclobutane-containing meroditerpenoids, (+)-isoscopariusins B and C: structure elucidation and biomimetic synthesis. Organic Letters[J]. 2023, 25(17): 2981-2985., https://pubs.acs.org/doi/10.1021/acs.orglett.3c00742.[4] Qian Tan, Kun Hu, XiaoNian Li, XingZhi Yang, HanDong Sun, PemaTenzin Puno. Cytotoxic C-20 non-oxygenated ent-kaurane diterpenoids from Isodon wardii. BIOORGANIC CHEMISTRY[J]. 2023, 135: 106512-, http://dx.doi.org/10.1016/j.bioorg.2023.106512.[5] Rong Chen, Li-Jing Guo, Xue-Dan Li, Xing-Ren Li, Kun Hu, Jian-Wei Tang, Zhen-Nan Ye, Bing-ChaoYan, Pema-Tenzin Puno. Phomopsischalins A-C, polycyclic-fused cytochalasins from the endophytic fungus Phomopsis sp. shj2 and their abilities to induce lysosomal function. Organic Chemistry Frontiers[J]. 2023, 10(9): 2218-2225, https://pubs.rsc.org/en/content/articlelanding/2023/QO/D3QO00252G.[6] QiQi Zhang, Kun Hu, HanDong Sun, PemaTenzin Puno. Four new lanostane triterpenoids featuring extended π‑conjugated systems from the stems of Kadsura coccinea. 应用天然产物(英文)[J]. 2023, 13(1): 1-8, http://lib.cqvip.com/Qikan/Article/Detail?id=7109500419.[7] Tao-Bin He, Bing-Chao Yan, Yuan-Fei Zhou, Yue-Qian Sang, Xiao-Nian Li, Han-Dong Sun, Chu Wang, XiaoSong Xue, Pema-Tenzin Puno. Discovery and bioinspired total syntheses of unprecedented sesquiterpenoid dimers unveiled bifurcating 4 + 2 cycloaddition and target differentiation of enantiomers. CHEMICAL SCIENCE[J]. 2023, 15(4): 1260-1270, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10806648/.[8] Jia-Meng Dai, Bing-Chao Yan, Ling-Mei Kong, Kun Hu, Xing-Ren Li, Xiao-Nian Li, Han-Dong Sun, Yan Li, Pema-Tenzin Puno. Isoxerophilins A and B, two diterpene heterodimers from Isodon xerophilus: structural elucidation and semisynthesis of isoxerophilin analogues. Organic Chemistry Frontiers[J]. 2023, 11(1): 37-46, [9] XingRen Li, Kun Hu, BingChao Yan, XiaoNian Li, HanDong Sun, Yang Liu, PemaTenzin Puno. Scopariusicides D–M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused γ/δ-lactone core from Isodon scoparius. BIOORGANIC CHEMISTRY[J]. 2022, 127: 105973-, http://dx.doi.org/10.1016/j.bioorg.2022.105973.[10] Li, XingRen, Chen, Li, Hu, Kun, Yan, BingChao, Du, Xue, Li, XiaoNian, Sun, HanDong, He, ShiJun, Puno, PemaTenzin. Discovery and biological evaluation of dispirocyclic and polycyclic ent-clerodane dimers from Isodon scoparius as novel inhibitors of Toll-like receptor signaling. ORGANIC CHEMISTRY FRONTIERS[J]. 2022, 9(15): 4023-4033, http://dx.doi.org/10.1039/d2qo00723a.[11] Liu, Yang, Li, Xingren, Wu, Xiuyin, Luo, Xingyan, Yan, Bingchao, Mo, Chunfen, Guo, Huijie, Yang, Shuxia, Wang, Yantang, Lai, Yi, Puno, Pematenzin, Li, Limei. Sis-25, a meroditerpenoid derivative with a cyclobutane scaffold, inhibits activated T cell proliferation by targeting GSK3 beta in vitro and in vivo. EUROPEAN JOURNAL OF PHARMACOLOGY[J]. 2022, 929: http://dx.doi.org/10.1016/j.ejphar.2022.175151.[12] Wang, Bin, Jiang, HuaYi, Yang, Jin, Li, Jun, Yan, BingChao, Chen, Xi, Hu, Kun, Li, XingRen, Sun, HanDong, Deng, Jun, Puno, PemaTenzin. Isolation and Bioinspired Total Synthesis of Rugosiformisin A, A Skeleton-Rearranged Abietane-Type Diterpenoid from Isodon rugosiformis. ORGANIC LETTERS[J]. 2022, 24(44): 8104-8108, http://dx.doi.org/10.1021/acs.orglett.2c02834.[13] Qiu, CaiLing, Ye, ZhenNan, Yan, BingChao, Hu, Kun, Yang, Jin, Yang, XingZhi, Li, HongMei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Structurally diverse diterpenoids from Isodon oresbius and their bioactivity. BIOORGANIC CHEMISTRY[J]. 2022, 124: 105811-, http://dx.doi.org/10.1016/j.bioorg.2022.105811.[14] Bing-Chao Yan, Wei-Guang Wang, Ling-Mei Kong, Jian-Wei Tang, Xue Du, Yan Li, Pema-Tenzin Puno. Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities. JOURNAL OF FUNGI[J]. 2022, 8(5): 543-, https://doaj.org/article/8550758b2ec84aea8873d04ed09fce07.[15] Yuan-Fei Zhou, Yan, Bing-Chao, Qian Yang, Xin-Yan Long, Dan-Qi Zhang, Rong-Hua Luo, Han-Yu Wang, Han-Dong Sun, Xiao-Song Xue, Yong-Tang Zheng, Pema-Tenzin Puno. Harnessing natural products by a pharmacophore-oriented semisynthesis approach for the discovery of potential anti-SARS-CoV-2 agents. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(28): e202201684-e202201684, https://onlinelibrary.wiley.com/doi/10.1002/anie.202201684.[16] ShuiMei Zhang, Kun Hu, XiaoNian Li, HanDong Sun, PemaTenzin Puno. Lignans and sesquiterpenoids from the stems of Schisandra bicolor var. tuberculate. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2022, 12(1): 1-9, [17] Xia, JiangNan, Hu, Kun, Su, XiaoZheng, Tang, JianWei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Discovery of ent-kaurane diterpenoids, characteristic metabolites of Isodon species, from an endophytic fungal strain Geopyxis sp. XY93 inhabiting Isodon parvifolia. FITOTERAPIA[J]. 2022, 158: http://dx.doi.org/10.1016/j.fitote.2022.105160.[18] Huang, Maobo, Zhou, Yuanfei, Duan, Dongzhu, Yang, Chuanyu, Zhou, Zhongmei, Li, Fubing, Kong, Yanjie, Hsieh, YiChing, Zhang, Ruihan, Ding, Wenping, Xiao, Weilie, Puno, PemaTenzin, Chen, Ceshi. Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib. CANCER LETTERS[J]. 2021, 504: 125-136, http://dx.doi.org/10.1016/j.canlet.2021.02.009.[19] Gou, Leilei, Yue, Grace GarLee, Puno, Pema Tenzin, Lau, Clara BikSan. A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects?. PHARMACOLOGICAL RESEARCHnull. 2021, 164: http://dx.doi.org/10.1016/j.phrs.2020.105321.[20] Zhou, YuanFei, Hu, Kun, Wang, Fang, Tang, JianWei, Zhang, Liang, Sun, HanDong, Cai, XiangHai, Puno, PemaTenzin. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.. JOURNAL OF NATURAL PRODUCTS[J]. 2021, 84(4): 1244-1253, http://dx.doi.org/10.1021/acs.jnatprod.0c01305.[21] Zu, WenYu, Tang, JianWei, Hu, Kun, Zhou, YuanFei, Gou, LeiLei, Su, XiaoZheng, Lei, Xinxiang, Sun, HanDong, Puno, PemaTenzin. Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(1): 475-483, https://www.webofscience.com/wos/woscc/full-record/WOS:000606840200037.[22] Wang, Bin, Hu, Kun, Li, XiaoNian, Sun, HanDong, Qin, HongBo, Puno, PemaTenzin. Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China. BIOORGANIC CHEMISTRY[J]. 2021, 110: http://dx.doi.org/10.1016/j.bioorg.2021.104785.[23] Chen, SuPing, Hu, Kun, Li, XingRen, Zhang, Liang, Sun, HanDong, Puno, PemaTenzin. Scopariusicide C, a novel cyclobutene-containing meroditerpenoid from artificially cultivated Isodon scoparius. TETRAHEDRON LETTERS[J]. 2021, 73: http://dx.doi.org/10.1016/j.tetlet.2021.153133.[24] Ma, RenFen, Hu, Kun, Ding, WenPing, Wang, Bin, He, TaoBin, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Schipropins A-J, structurally diverse triterpenoids from Schisandra propinqua. PHYTOCHEMISTRY[J]. 2021, 182: https://www.webofscience.com/wos/woscc/full-record/WOS:000609228000001.[25] Li, XingRen, Yan, BingChao, Hu, Kun, He, Shijun, Sun, HanDong, Zuo, Jianping, Puno, PemaTenzin. Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis. ORGANIC LETTERS[J]. 2021, 23(15): 5647-5651, http://dx.doi.org/10.1021/acs.orglett.1c01724.[26] Wu, Hai, Ding, Yiming, Hu, Kun, Long, Xianwen, Qu, Chunlei, Puno, PemaTenzin, Deng, Jun. Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(29): 15963-15971, http://dx.doi.org/10.1002/anie.202102831.[27] Yan, BingChao, Zhou, Min, Li, Jian, Li, XiaoNian, He, ShiJun, Zuo, JianPing, Sun, HanDong, Li, Ang, Puno, PemaTenzin. (-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(23): 12859-12867, http://dx.doi.org/10.1002/anie.202100288.[28] HaoYi Li, BingChao Yan, LiXin Wei, HanDong Sun, PemaTenzin Puno. Tangutidines A-C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum.. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2021, 11(4): 459-464, http://lib.cqvip.com/Qikan/Article/Detail?id=7105833937.[29] Huang, Lihong, Fu, Qiang, Dai, JiaMeng, Yan, BingChao, Wang, Dawei, Puno, PemaTenzin, Yue, Jianbo. High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities. CELL BIOLOGY AND TOXICOLOGY[J]. 2021, 37(5): 695-713, http://dx.doi.org/10.1007/s10565-021-09580-6.[30] Zhang, QinYu, Yan, BingChao, Hu, Kun, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Isorugosiformins A-F, six ent-kaurane diterpenoids from Isodon rugosiformis. FITOTERAPIA[J]. 2020, 142: http://dx.doi.org/10.1016/j.fitote.2020.104529.[31] Chen, Lin, Fan, DongMei, Tang, JianWei, An, Tao, Li, Xue, Kong, LingMei, Puno, PemaTenzin, Li, Yan. Discovery of isopenicin A, a meroterpenoid as a novel inhibitor of tubulin polymerization. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 525(2): 303-307, http://dx.doi.org/10.1016/j.bbrc.2020.02.026.[32] Tang, Jianwei, Hu, Kun, Su, Xiaozheng, Li, Xiaonian, Yan, Bingchao, Sun, Handong, Puno, Pematenzin. Phomopsisins A-C: Three new cytochalasans from the plant endophytic fungus Phomopsis sp. sh917. TETRAHEDRON[J]. 2020, 76(39): 131475-, http://dx.doi.org/10.1016/j.tet.2020.131475.[33] Su, XiaoZheng, Zhu, YiYing, Tang, JianWei, Hu, Kun, Li, XiaoNian, Sun, HanDong, Li, Yan, Puno, PemaTenzin. Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30. SCIENCE CHINA-CHEMISTRY[J]. 2020, 63(9): 1208-1213, http://lib.cqvip.com/Qikan/Article/Detail?id=7102701151.[34] Yang, Peng, Li, Jian, Sun, Li, Yao, Ming, Zhang, Xiang, Xiao, WeiLie, Wang, JianHua, Tian, Ping, Sun, HanDong, Puno, PemaTenzin, Li, Ang. Elucidation of the Structure of Pseudorubriflordilactone B by Chemical Synthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(32): 13701-13708, https://www.webofscience.com/wos/woscc/full-record/WOS:000562942200012.[35] JiaMeng Dai, Kun Hu, BingChao Yan, XingRen Li, XiaoNian Li, HanDong Sun, PemaTenzin Puno. ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(12): 3717-3725, https://www.webofscience.com/wos/woscc/full-record/WOS:000603402900026.[36] Xue-Chun Jiang, Bing-Chao Yan, Xing-Ren Li, Xiao-Nian Li, Han-Dong Sun, Pema-Tenzin Puno. 4,5-Seco-18-nor-ent-clerodanoids and their derivatives: Structure elucidation, synthesis and resistant reversal activities against fluconazole-resistance Candida albicans. TETRAHEDRON[J]. 2020, 76(14): 131043-, http://dx.doi.org/10.1016/j.tet.2020.131043.[37] He, TaoBin, Yan, BingChao, Hu, Kun, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi. BIOORGANIC CHEMISTRY[J]. 2020, 105: http://dx.doi.org/10.1016/j.bioorg.2020.104353.[38] 胡坤, 孙汉董, 普诺白玛丹增. 量子化学计算核磁共振参数在天然产物结构鉴定中的应用. 波谱学杂志[J]. 2019, 36(3): 359-376, http://lib.cqvip.com/Qikan/Article/Detail?id=7100033748.[39] Tang, JianWei, Kong, LingMei, Zu, WenYu, Hu, Kun, Li, XiaoNian, Yan, BingChao, Wang, WeiGuang, Sun, HanDong, Li, Yan, Puno, PemaTenzin. Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18. ORGANIC LETTERS[J]. 2019, 21(3): 771-775, http://ir.kib.ac.cn/handle/151853/64235.[40] Xu, HouChao, Hu, Kun, Shi, XiaoHuo, Tang, JianWei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D from Kadsura coccinea. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(10): 1619-1626, [41] Chen,Ling, Yang,Qian, Hu,Kun, Li,XiaoNian, Sun,HanDong, Puno,PemaTenzin. Isoforrethins A-D, four ent-abietane diterpenoids from Isodon forrestii var. forrestii. FITOTERAPIA[J]. 2019, 134: 158-164, http://dx.doi.org/10.1016/j.fitote.2019.02.026.[42] Hu, Jing, Li, Xingren, Tian, Weifeng, Lu, Yanting, Xu, Yuhui, Wang, Fang, Qin, Wanying, Ma, Xiuli, Puno, PemaTenzin, Xiong, Wenyong. Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS. MOLECULES[J]. 2019, 24(1): http://ir.kib.ac.cn/handle/151853/64459.[43] Yang, Qian, Hu, Kun, Yan, BingChao, Liu, Miao, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Maoeriocalysins A-D, four novel ent-kaurane diterpenoids from Isodon eriocalyx and their structure determination utilizing quantum chemical calculation in conjunction with quantitative interproton distance analysis. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(1): 45-53, http://ir.kib.ac.cn/handle/151853/64294.[44] Gou, LeiLei, Hu, Kun, Yang, Qian, Li, XiaoNian, Sun, HanDong, Xiang, ChunLei, Puno, PemaTenzin. Structurally diverse diterpenoids from Isodon ternifolius collected from three regions. TETRAHEDRON[J]. 2019, 75(19): 2797-2806, http://ir.kib.ac.cn/handle/151853/66908.[45] Wang, JingNan, Che, Yun, Yuan, ZuYang, Lu, ZhiLiang, Li, Yuan, Zhang, ZhiRong, Li, Ning, Li, RenDa, Wan, Jun, Sun, HanDong, Sun, Nan, Puno, PemaTenzin, He, Jie. Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2019, 365: 71-83, http://dx.doi.org/10.1016/j.taap.2019.01.005.[46] Tang, JianWei, Xu, HouChao, Wang, WeiGuang, Hu, Kun, Zhou, YuanFei, Chen, Rong, Li, XiaoNian, Du, Xue, Sun, HanDong, Puno, PemaTenzin. (+)- and (-)-Alternarilactone A: Enantiomers with a Diepoxy-Cage-like Scaffold from an Endophytic Alternaria sp.. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(4): 735-740, http://ir.kib.ac.cn/handle/151853/66914.[47] Sajesh, Babu, V, On, Ngoc H, Omar, Refaat, Alrushaid, Samaa, Kopec, Brian M, Wang, WeiGuang, Sun, HanDong, Lillico, Ryan, Lakowski, Ted M, Siahaan, Teruna J, Davies, Neal M, Puno, PemaTenzin, Vanan, Magimairajan Issai, Miller, Donald W. Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors. PHARMACEUTICS[J]. 2019, 11(9): https://doaj.org/article/25cc141381be4297a117030ee6ead52b.[48] Hu Kun, Li XingRen, Tang JianWei, Li XiaoNian, Puno, PemaTenzin. Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2019, 17(12): 970-981, http://lib.cqvip.com/Qikan/Article/Detail?id=7100772593.[49] Zhu, Huifang, Wang, Bin, Kong, Lingmei, An, Tao, Li, Gentao, Zhou, Hongyu, Gong, Liang, Zhao, Zhangxun, Gong, Yaxiao, Sun, Handong, Puno, Pematenzin, Li, Yan. Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin. CELL CHEMICAL BIOLOGY[J]. 2019, 26(8): 1122-+, http://dx.doi.org/10.1016/j.chembiol.2019.04.003.[50] Li, XingRen, Fu, Qiang, Zhou, Min, Hu, Kun, Du, Xue, Li, XiaoNian, Sun, HanDong, Yue, JianBo, Zhang, HongBin, Puno, PemaTenzin. Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2019, 21(10): 977-984, [51] 孙汉董. 香茶菜属植物二萜和五味子降三萜合成进展. 有机化学. 2018, [52] Shi, YiMing, Hu, Kun, Pescitelli, Gennaro, Liu, Miao, Li, XiaoNian, Du, Xue, Xiao, WeiLie, Sun, HanDong, Puno, PemaTenzin. Schinortriterpenoids with Identical Configuration but Distinct ECD Spectra Generated by Nondegenerate Exciton Coupling. ORGANIC LETTERS[J]. 2018, 20(6): 1500-1504, https://www.webofscience.com/wos/woscc/full-record/WOS:000428003600006.[53] Wang, JingNan, Zhang, ZhiRong, Che, Yun, Yuan, ZuYang, Lu, ZhiLiang, Li, Yuan, Li, Ning, Wan, Jun, Sun, HanDong, Sun, Nan, Puno, PemaTenzin, He, Jie. Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer. CANCER BIOLOGY & THERAPY[J]. 2018, 19(7): 609-621, https://www.webofscience.com/wos/woscc/full-record/WOS:000433932300009.[54] Wang, Jingnan, Zhang, Zhirong, Che, Yun, Yuan, Zuyang, Lu, Zhiliang, Li, Yuan, Wan, Jun, Sun, Handong, Chen, Zhaoli, Pu, Jianxin, He, Jie. 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Henrischinins A-C: Three New Triterpenoids from Schisandra henryi. ORGANIC LETTERS[J]. 2011, 13(6): 1564-1567, http://www.irgrid.ac.cn/handle/1471x/392896.[112] Yang, JianHong, Zhang, HaiYan, Wen, Jin, Du, Xue, Chen, JianHua, Zhang, HaiBo, Xiao, WeiLie, Pu, JianXin, Tang, XiCan, Sun, HanDong. Dibenzocyclooctadiene Lignans with Antineurodegenerative Potential from Kadsura ananosma. JOURNAL OF NATURAL PRODUCTS[J]. 2011, 74(5): 1028-1035, http://www.irgrid.ac.cn/handle/1471x/392932.[113] JianHong Yang, HaiYan Zhang, Xue Du, Wei Wang, WeiLie Xiao, Jin Wen, JianXin Pu, XiCan Tang, HanDong Sun. New dibenzocyclooctadiene lignans from the Kadsura ananosma. TETRAHEDRON[J]. 2011, 67(25): 4498-4504, http://dx.doi.org/10.1016/j.tet.2011.04.105.[114] Yang, JianHong, Wen, Jin, Du, Xue, Li, XiaoNian, Wang, YuanYuan, Li, Yan, Xiao, WeiLie, Pu, JianXin, Sun, HanDong. Triterpenoids from the stems of Kadsura ananosma. TETRAHEDRON[J]. 2010, 66(46): 8880-8887, http://dx.doi.org/10.1016/j.tet.2010.09.059.
发表著作
(1) 二萜化学, Diterpene chemistry, 化学工业出版社, 2012-01, 第 5 作者
科研活动
科研项目
( 1 ) 西南地区南五味子属植物中新颖结构类型化合物及生物活性成分的研究, 主持, 国家级, 2010-01--2012-12( 2 ) 三种高原地区特有香茶菜, 主持, 省级, 2008-12--2011-12( 3 ) 两种药典中药用植物的生物活性成分研究, 主持, 市地级, 2010-01--2011-12( 4 ) 横断山区香茶菜属植物生物活性成分及其应用基础研究, 主持, 部委级, 2011-01--2013-12( 5 ) 香茶菜属植物中对映-贝壳杉烷二萜成分及其抗肿瘤成药性评价, 主持, 部委级, 2013-01--2015-12( 6 ) 具有免疫抑制活性的天然对映-贝壳杉烷二萜类化合物的研究, 主持, 国家级, 2012-01--2015-12( 7 ) 天然产物化学, 主持, 国家级, 2014-01--2016-12( 8 ) 云南三江并流区域香茶菜属植物二萜及其抗癌活性研究, 主持, 国家级, 2014-01--2017-12( 9 ) 帚状香茶菜中具有免疫抑制活性新颖杂二萜的发现、合成及作用机制研究, 主持, 国家级, 2017-01--2020-12( 10 ) 人工种植帚状香茶菜中具有免疫抑制活性新颖化合物的挖掘, 主持, 研究所(学校), 2017-11--2019-11( 11 ) 唇形科香茶菜属核心分枝的二萜化学及系统发育信号初探, 主持, 市地级, 2016-09--2018-08( 12 ) 特殊生境植物内生真菌中新颖活性天然产物的挖掘, 主持, 国家级, 2019-01--2022-12( 13 ) 第二次青藏高原综合科学考察研究——植物多样性可持续利用与评估(子专题:藏药资源的挖掘利用), 主持, 国家级, 2019-11--2024-10( 14 ) 新颖先导化合物的发现, 主持, 部委级, 2020-01--2022-12( 15 ) “五味子科和香茶菜属”植物及其内生菌中新颖先导化合物的深度挖掘, 主持, 省级, 2019-07--2022-06( 16 ) 香茶菜属植物中的化学成分及其生物活性研究, 主持, 部委级, 2015-01--2016-12( 17 ) 香茶菜属植物中对映-贝壳杉烷二萜成分及其抗肿瘤成药性评价, 主持, 部委级, 2015-01--2016-12( 18 ) 香茶菜属植物中的化学成分及其生物活性研究, 主持, 部委级, 2011-08--2014-12( 19 ) 西南地区南五味子属植物中新颖结构类型化合物及生物活性成分的研究, 主持, 省级, 2011-09--2014-09( 20 ) 横断山脉区域特有香茶菜属植物及其内生菌中新颖先导化合物的发现, 主持, 国家级, 2021-01--2024-12
参与会议
(1)重要类群植物及其内生菌中新颖先导化合物的发现 第十一届同德国际学术周—中医药研发与产业化论坛 2020-11-07(2)“一科一属”植物及其内生菌中新颖天然产物的研究 第十一届全国化学生物学学术会议 2019-11-18(3)Secondary Metabolites from “One family and One genus” Species and their Endophytic Fungi 第七届中泰双边天然产物化学与药物发现研讨会 2018-11-04(4)Exploration of the Secondary Metabolites and their Bioactivities from “One family and One genus” Species and their Endophytic Fungi 2018-08-31(5)“一科一属”植物及其内生菌次生代谢产物与生物功能的挖掘 中国化学会第31届学术年会 2018-05-05(6)香茶菜属植物及其内生菌次生代谢产物与生物功能的研究 中国化学会第十一届全国天然有机化学学术会议 2016-09-25(7)Secondary Metabolites and their Bioactivities from Isodon species and their endophytic fungi 2016-09-01(8)香茶菜属植物及其内生菌次生代谢产物与生物功能的研究 中国化学会第30届学术年会 2016-07-01(9)Diterpenoids from Isodon species Jian-Xin Pu 2015-11-09(10)Research Progress of Diterpenoids from Isodon species Jian-Xin Pu 2014-09-21(11)Research Progress of a New Type of potential anti-cancer drugs: ent-kaurane diterpenoids Jian-Xin Pu 2012-11-26(12)Studies on the Chemical Constituents and Bioactivity of Two Medicinal Plants Distributed in Qinling Mountain 秦岭药用植物资源开发与利用国际研讨会 Jian-Xin Pu, Li-Bin Yang, Juan Zou, and Han-Dong Sun 2011-05-27(13)Chemical constituents from Kadsura species and their Bioactivities 第二届东亚植物遗传资源及其成分多样性研讨会 Jian-Xin Pu and Han-Dong Sun 2010-10-27(14)Chemical constituents from Kadsura species and their Bioactivities Jian-Xin Pu and Han-Dong Sun 2010-08-23
指导学生
已指导学生
颜秉超 硕士研究生 078001-药物化学
唐健维 硕士研究生 078001-药物化学
万俊 硕士研究生 078001-药物化学
蒋学春 硕士研究生 105500-药学
周元飞 硕士研究生 078001-药物化学
陈玲 硕士研究生 078001-药物化学
唐健维 博士研究生 100701-药物化学
马仁芬 硕士研究生 105500-药学
刘淼 博士研究生 100701-药物化学
胡坤 博士研究生 100701-药物化学
李行任 博士研究生 100701-药物化学
颜秉超 博士研究生 100701-药物化学
蒋华夷 博士研究生 100701-药物化学
杨谦 博士研究生 100701-药物化学
张源渊 硕士研究生 105500-药学
罗远情 硕士研究生 078001-药物化学
徐厚朝 硕士研究生 078001-药物化学
粟孝政 硕士研究生 078001-药物化学
何桃斌 博士研究生 100701-药物化学
苟蕾蕾 硕士研究生 078001-药物化学
现指导学生
代家猛 博士研究生 100701-药物化学
王彬 博士研究生 100701-药物化学
周元飞 博士研究生 100701-药物化学
张智坚 硕士研究生 105500-药学
陈素萍 硕士研究生 078001-药物化学
邱彩玲 硕士研究生 078001-药物化学
苟蕾蕾 博士研究生 100701-药物化学
张水妹 硕士研究生 078001-药物化学
谭茜 硕士研究生 078001-药物化学
粟孝政 博士研究生 100701-药物化学