基本信息
普诺·白玛丹增  男  博导  中国科学院昆明植物研究所
电子邮件: punopematenzin@mail.kib.ac.cn
通信地址: 云南省昆明市盘龙区蓝黑路132号
邮政编码: 650201

招生信息

   
招生专业
100701-药物化学
招生方向
天然产物化学,药物化学

教育背景

2004-09--2007-07   中科院昆明植物研究所   博士学位
2001-09--2004-07   云南大学   硕士学位
1997-09--2001-07   云南大学   学士学位

工作经历

   
工作简历
2014-01~现在, 中国科学院昆明植物研究所, 研究员
2007-07~2013-12,中科院昆明植物研究所, 副研究员
社会兼职
2020-11-01-2025-10-31,云南省植物学会, 第十三届理事会常务理事、副理事长
2020-01-01-2024-12-31,药用植物应用研究国家重点实验室(香港中文大学), 第三届学术委员会委员
2019-12-18-今,《应用天然产物(英)》(Natural Products&Bioprospecting), 第三届编辑委员会编辑委员
2018-04-26-2023-04-25,长白山生物资源与功能分子教育部重点实验室(延边大学), 第三届学术委员会学术委员
2018-01-01-2019-12-31,《中国科学:化学》和 Science China Chemistry, 第三届青年工作委员会委员
2018-01-01-2019-12-31,《波谱学杂志》, 第一届青年编委
2014-01-01-2017-12-31,云南省中医药学会第八届中药(民族药)专业委员会委员,
2013-01-01-2018-12-31,中国植物学会植物化学与资源学专业委员会委员,

专利与奖励

   
奖励信息
(1) 五味子化学研究, 特等奖, 省级, 2014
(2) 香茶菜属植物二萜及其抗癌活性研究, 一等奖, 省级, 2013
(3) 中国科学院卢嘉锡青年人才奖, , 院级, 2011
(4) 第九届云南省科协优秀科技论文, 一等奖, 省级, 2010
(5) 第八届云南省科协优秀科技论文, 二等奖, 省级, 2007
专利成果
[1] 普诺·白玛丹增, 颜秉超, 周敏, 杜雪, 孙汉董. 一种帚状异酯素、其制备方法和应用,以及药物组合物. CN: CN112876366A, 2021-06-01.
[2] 普诺·白玛丹增, 颜秉超, 周敏, 杜雪, 李昂, 孙汉董. 一种含四元环的杂二萜类化合物、其制备方法和应用,以及药物组合物. CN112812015A, 2021-05-18.
[3] 陈策实, 普诺·白玛丹增, 孙汉董, 黄茂波, 周元飞. 3,4断裂的环阿尔廷型三萜类化合物在制备自噬抑制剂及抗肿瘤药物中的应用. CN: CN111481534A, 2020-08-04.

出版信息

   
发表论文
[1] CaiLing Qiu, ZhenNan Ye, BingChao Yan, Kun Hu, Jin Yang, XingZhi Yang, HongMei Li, XiaoNian Li, HanDong Sun, PemaTenzin Puno. Structurally diverse diterpenoids from Isodon oresbius and their bioactivity. Bioorganic Chemistry. 2022, 124: [2] Yuan-Fei Zhou, Yan, Bing-Chao, Qian Yang, Xin-Yan Long, Dan-Qi Zhang, Rong-Hua Luo, Han-Yu Wang, Han-Dong Sun, Xiao-Song Xue, Yong-Tang Zheng, Pema-Tenzin Puno. Harnessing natural products by a pharmacophore-oriented semisynthesis approach for the discovery of potential anti-SARS-CoV-2 agents. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, [3] Xia, JiangNan, Hu, Kun, Su, XiaoZheng, Tang, JianWei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Discovery of ent-kaurane diterpenoids, characteristic metabolites of Isodon species, from an endophytic fungal strain Geopyxis sp. XY93 inhabiting Isodon parvifolia. FITOTERAPIA[J]. 2022, 158: [4] Huang, Maobo, Zhou, Yuanfei, Duan, Dongzhu, Yang, Chuanyu, Zhou, Zhongmei, Li, Fubing, Kong, Yanjie, Hsieh, YiChing, Zhang, Ruihan, Ding, Wenping, Xiao, Weilie, Puno, PemaTenzin, Chen, Ceshi. Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib. CANCER LETTERS[J]. 2021, 504: 125-136, http://dx.doi.org/10.1016/j.canlet.2021.02.009.
[5] Gou, Leilei, Yue, Grace GarLee, Puno, Pema Tenzin, Lau, Clara BikSan. A review on the relationship of mast cells and macrophages in breast cancer - Can herbs or natural products facilitate their anti-tumor effects?. PHARMACOLOGICAL RESEARCHnull. 2021, 164: http://dx.doi.org/10.1016/j.phrs.2020.105321.
[6] Zhou, YuanFei, Hu, Kun, Wang, Fang, Tang, JianWei, Zhang, Liang, Sun, HanDong, Cai, XiangHai, Puno, PemaTenzin. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp.. JOURNAL OF NATURAL PRODUCTS[J]. 2021, 84(4): 1244-1253, http://dx.doi.org/10.1021/acs.jnatprod.0c01305.
[7] Zu, WenYu, Tang, JianWei, Hu, Kun, Zhou, YuanFei, Gou, LeiLei, Su, XiaoZheng, Lei, Xinxiang, Sun, HanDong, Puno, PemaTenzin. Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1. JOURNAL OF ORGANIC CHEMISTRY[J]. 2021, 86(1): 475-483, https://www.webofscience.com/wos/woscc/full-record/WOS:000606840200037.
[8] Wang, Bin, Hu, Kun, Li, XiaoNian, Sun, HanDong, Qin, HongBo, Puno, PemaTenzin. Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China. BIOORGANIC CHEMISTRY[J]. 2021, 110: http://dx.doi.org/10.1016/j.bioorg.2021.104785.
[9] Chen, SuPing, Hu, Kun, Li, XingRen, Zhang, Liang, Sun, HanDong, Puno, PemaTenzin. Scopariusicide C, a novel cyclobutene-containing meroditerpenoid from artificially cultivated Isodon scoparius. TETRAHEDRON LETTERS[J]. 2021, 73: http://dx.doi.org/10.1016/j.tetlet.2021.153133.
[10] Ma, RenFen, Hu, Kun, Ding, WenPing, Wang, Bin, He, TaoBin, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Schipropins A-J, structurally diverse triterpenoids from Schisandra propinqua. PHYTOCHEMISTRY[J]. 2021, 182: https://www.webofscience.com/wos/woscc/full-record/WOS:000609228000001.
[11] Li, XingRen, Yan, BingChao, Hu, Kun, He, Shijun, Sun, HanDong, Zuo, Jianping, Puno, PemaTenzin. Spiro ent-Clerodane Dimers: Discovery and Green Approaches for a Scalable Biomimetic Synthesis. ORGANIC LETTERS[J]. 2021, 23(15): 5647-5651, http://dx.doi.org/10.1021/acs.orglett.1c01724.
[12] Yan, BingChao, Zhou, Min, Li, Jian, Li, XiaoNian, He, ShiJun, Zuo, JianPing, Sun, HanDong, Li, Ang, Puno, PemaTenzin. (-)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(23): 12859-12867, http://dx.doi.org/10.1002/anie.202100288.
[13] Wu, Hai, Ding, Yiming, Hu, Kun, Long, Xianwen, Qu, Chunlei, Puno, PemaTenzin, Deng, Jun. Bioinspired Network Analysis Enabled Divergent Syntheses and Structure Revision of Pentacyclic Cytochalasans. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(29): 15963-15971, http://dx.doi.org/10.1002/anie.202102831.
[14] Hao-Yi Li, Bing-Chao Yan, Li-Xin Wei, Han-Dong Sun, Pema-Tenzin Puno. Tangutidines A–C, Three Amphoteric Diterpene Alkaloids from Aconitum tanguticum. Natural Products and Bioprospecting. 2021, 11(4): 459-464, http://dx.doi.org/10.1007/s13659-021-00310-3.
[15] Huang, Lihong, Fu, Qiang, Dai, JiaMeng, Yan, BingChao, Wang, Dawei, Puno, PemaTenzin, Yue, Jianbo. High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities. CELL BIOLOGY AND TOXICOLOGY[J]. 2021, 37(5): 695-713, http://dx.doi.org/10.1007/s10565-021-09580-6.
[16] Tang, Jianwei, Hu, Kun, Su, Xiaozheng, Li, Xiaonian, Yan, Bingchao, Sun, Handong, Puno, Pematenzin. Phomopsisins A-C: Three new cytochalasans from the plant endophytic fungus Phomopsis sp. sh917. TETRAHEDRON[J]. 2020, 76(39): http://dx.doi.org/10.1016/j.tet.2020.131475.
[17] Su, XiaoZheng, Zhu, YiYing, Tang, JianWei, Hu, Kun, Li, XiaoNian, Sun, HanDong, Li, Yan, Puno, PemaTenzin. Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30. SCIENCE CHINA-CHEMISTRY[J]. 2020, 63(9): 1208-1213, http://lib.cqvip.com/Qikan/Article/Detail?id=7102701151.
[18] Yang, Peng, Li, Jian, Sun, Li, Yao, Ming, Zhang, Xiang, Xiao, WeiLie, Wang, JianHua, Tian, Ping, Sun, HanDong, Puno, PemaTenzin, Li, Ang. Elucidation of the Structure of Pseudorubriflordilactone B by Chemical Synthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(32): 13701-13708, https://www.webofscience.com/wos/woscc/full-record/WOS:000562942200012.
[19] Dai, JiaMeng, Hu, Kun, Yan, BingChao, Li, XingRen, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus. JOURNAL OF NATURAL PRODUCTS[J]. 2020, 83(12): 3717-3725, https://www.webofscience.com/wos/woscc/full-record/WOS:000603402900026.
[20] Jiang, XueChun, Yan, BingChao, Li, XingRen, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. 4,5-Seco-18-nor-ent-clerodanoids and their derivatives: Structure elucidation, synthesis and resistant reversal activities against fluconazole-resistance Candida albicans. TETRAHEDRON[J]. 2020, 76(14): http://dx.doi.org/10.1016/j.tet.2020.131043.
[21] He, TaoBin, Yan, BingChao, Hu, Kun, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi. BIOORGANIC CHEMISTRY[J]. 2020, 105: http://dx.doi.org/10.1016/j.bioorg.2020.104353.
[22] Zhang, QinYu, Yan, BingChao, Hu, Kun, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Isorugosiformins A-F, six ent-kaurane diterpenoids from Isodon rugosiformis. FITOTERAPIA[J]. 2020, 142: http://dx.doi.org/10.1016/j.fitote.2020.104529.
[23] Chen, Lin, Fan, DongMei, Tang, JianWei, An, Tao, Li, Xue, Kong, LingMei, Puno, PemaTenzin, Li, Yan. Discovery of isopenicin A, a meroterpenoid as a novel inhibitor of tubulin polymerization. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 525(2): 303-307, http://dx.doi.org/10.1016/j.bbrc.2020.02.026.
[24] 胡坤, 孙汉董, 普诺白玛丹增. 量子化学计算核磁共振参数在天然产物结构鉴定中的应用. 波谱学杂志. 2019, 36(3): 359-376, http://lib.cqvip.com/Qikan/Article/Detail?id=7100033748.
[25] Tang, JianWei, Kong, LingMei, Zu, WenYu, Hu, Kun, Li, XiaoNian, Yan, BingChao, Wang, WeiGuang, Sun, HanDong, Li, Yan, Puno, PemaTenzin. Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18. ORGANIC LETTERS[J]. 2019, 21(3): 771-775, http://ir.kib.ac.cn/handle/151853/64235.
[26] Xu, HouChao, Hu, Kun, Shi, XiaoHuo, Tang, JianWei, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D from Kadsura coccinea. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(10): 1619-1626, [27] Chen, Ling, Yang, Qian, Hu, Kun, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Isoforrethins A-D, four ent-abietane diterpenoids from Isodon forrestii var. forrestii. FITOTERAPIA[J]. 2019, 134: 158-164, http://dx.doi.org/10.1016/j.fitote.2019.02.026.
[28] Hu, Jing, Li, Xingren, Tian, Weifeng, Lu, Yanting, Xu, Yuhui, Wang, Fang, Qin, Wanying, Ma, Xiuli, Puno, PemaTenzin, Xiong, Wenyong. Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS. MOLECULES[J]. 2019, 24(1): http://ir.kib.ac.cn/handle/151853/64459.
[29] Yang, Qian, Hu, Kun, Yan, BingChao, Liu, Miao, Li, XiaoNian, Sun, HanDong, Puno, PemaTenzin. Maoeriocalysins A-D, four novel ent-kaurane diterpenoids from Isodon eriocalyx and their structure determination utilizing quantum chemical calculation in conjunction with quantitative interproton distance analysis. ORGANIC CHEMISTRY FRONTIERS[J]. 2019, 6(1): 45-53, http://ir.kib.ac.cn/handle/151853/64294.
[30] Gou, LeiLei, Hu, Kun, Yang, Qian, Li, XiaoNian, Sun, HanDong, Xiang, ChunLei, Puno, PemaTenzin. Structurally diverse diterpenoids from Isodon ternifolius collected from three regions. TETRAHEDRON[J]. 2019, 75(19): 2797-2806, http://ir.kib.ac.cn/handle/151853/66908.
[31] Wang, JingNan, Che, Yun, Yuan, ZuYang, Lu, ZhiLiang, Li, Yuan, Zhang, ZhiRong, Li, Ning, Li, RenDa, Wan, Jun, Sun, HanDong, Sun, Nan, Puno, PemaTenzin, He, Jie. Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2019, 365: 71-83, http://dx.doi.org/10.1016/j.taap.2019.01.005.
[32] Tang, JianWei, Xu, HouChao, Wang, WeiGuang, Hu, Kun, Zhou, YuanFei, Chen, Rong, Li, XiaoNian, Du, Xue, Sun, HanDong, Puno, PemaTenzin. (+)- and (-)-Alternarilactone A: Enantiomers with a Diepoxy-Cage-like Scaffold from an Endophytic Alternaria sp.. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(4): 735-740, http://ir.kib.ac.cn/handle/151853/66914.
[33] Sajesh, Babu, V, On, Ngoc H, Omar, Refaat, Alrushaid, Samaa, Kopec, Brian M, Wang, WeiGuang, Sun, HanDong, Lillico, Ryan, Lakowski, Ted M, Siahaan, Teruna J, Davies, Neal M, Puno, PemaTenzin, Vanan, Magimairajan Issai, Miller, Donald W. Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors. PHARMACEUTICS[J]. 2019, 11(9): https://doaj.org/article/25cc141381be4297a117030ee6ead52b.
[34] Hu Kun, Li XingRen, Tang JianWei, Li XiaoNian, Puno, PemaTenzin. Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2019, 17(12): 970-981, http://lib.cqvip.com/Qikan/Article/Detail?id=7100772593.
[35] Zhu, Huifang, Wang, Bin, Kong, Lingmei, An, Tao, Li, Gentao, Zhou, Hongyu, Gong, Liang, Zhao, Zhangxun, Gong, Yaxiao, Sun, Handong, Puno, Pematenzin, Li, Yan. Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin. CELL CHEMICAL BIOLOGY[J]. 2019, 26(8): 1122-+, http://dx.doi.org/10.1016/j.chembiol.2019.04.003.
[36] Li, XingRen, Fu, Qiang, Zhou, Min, Hu, Kun, Du, Xue, Li, XiaoNian, Sun, HanDong, Yue, JianBo, Zhang, HongBin, Puno, PemaTenzin. Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2019, 21(10): 977-984, [37] 孙汉董. 香茶菜属植物二萜和五味子降三萜合成进展. 有机化学. 2018, [38] Shi, YiMing, Hu, Kun, Pescitelli, Gennaro, Liu, Miao, Li, XiaoNian, Du, Xue, Xiao, WeiLie, Sun, HanDong, Puno, PemaTenzin. Schinortriterpenoids with Identical Configuration but Distinct ECD Spectra Generated by Nondegenerate Exciton Coupling. ORGANIC LETTERS[J]. 2018, 20(6): 1500-1504, https://www.webofscience.com/wos/woscc/full-record/WOS:000428003600006.
[39] Wang, JingNan, Zhang, ZhiRong, Che, Yun, Yuan, ZuYang, Lu, ZhiLiang, Li, Yuan, Li, Ning, Wan, Jun, Sun, HanDong, Sun, Nan, Puno, PemaTenzin, He, Jie. Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer. CANCER BIOLOGY & THERAPY[J]. 2018, 19(7): 609-621, https://www.webofscience.com/wos/woscc/full-record/WOS:000433932300009.
[40] Wang, Jingnan, Zhang, Zhirong, Che, Yun, Yuan, Zuyang, Lu, Zhiliang, Li, Yuan, Wan, Jun, Sun, Handong, Chen, Zhaoli, Pu, Jianxin, He, Jie. Rabdocoestin B exhibits antitumor activity by inducing G2/M phase arrest and apoptosis in esophageal squamous cell carcinoma. CANCER CHEMOTHERAPY AND PHARMACOLOGY[J]. 2018, 81(3): 469-481, https://www.webofscience.com/wos/woscc/full-record/WOS:000426060100005.
[41] Hu, ZhengXi, Liu, Miao, Wang, WeiGuang, Li, XiaoNian, Hu, Kun, Li, XingRen, Du, Xue, Zhang, YongHui, Puno, PemaTenzin, Sun, HanDong. 7 alpha,20-Epoxy-ent-kaurane Diterpenoids from the Aerial Parts of Isodon pharicus. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(1): 106-116, https://www.webofscience.com/wos/woscc/full-record/WOS:000423778900016.
[42] Hu, ZhengXi, Xu, HouChao, Hu, Kun, Liu, Miao, Li, XiaoNian, Li, XingRen, Du, Xue, Zhang, YongHui, Puno, PemaTenzin, Sun, HanDong. Structurally diverse diterpenoids from Isodon pharicus. ORGANIC CHEMISTRY FRONTIERS[J]. 2018, 5(15): 2379-2389, https://www.webofscience.com/wos/woscc/full-record/WOS:000439946500016.
[43] Puno, Pema-Tenzin, Zhang Hong-Bin, Jiang Hua-Yi, Li Xiao-Nian, Sun Han-Dong. Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius. FITOTERAPIA[J]. 2018, 127: 74-80, http://ir.kib.ac.cn/handle/151853/63359.
[44] Ding, WenPing, Hu, Kun, Liu, Miao, Li, XingRen, Chen, Rong, Li, XiaoNian, Du, Xue, Puno, PemaTenzin, Sun, HanDong. Five new schinortriterpenoids from Schisandra propinqua var. propinqua. FITOTERAPIA[J]. 2018, 127: 193-200, http://dx.doi.org/10.1016/j.fitote.2018.02.019.
[45] Miao Liu, ZhengXi Hu, YuanQing Luo, Min Zhou, WeiGuang Wang, XiaoNian Li, Xue Du, JianXin Pu, HanDong Sun. Two New Compounds from Schisandra propinqua var. propinqua. Nat. Prod. Bioprospect.[J]. 2017, 7: :257–262-, http://ir.kib.ac.cn/handle/151853/54990.
[46] Zhou, Xunian, Yue, Grace GarLee, Chan, Andrew ManLok, Tsui, Stephen KwokWing, Fung, KwokPui, Sun, Handong, Pu, Jianxin, Lau, Clara BikSan. Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer. BIOCHEMICAL PHARMACOLOGY[J]. 2017, 142: 58-70, http://dx.doi.org/10.1016/j.bcp.2017.06.133.
[47] Jiang HuaYi, Wang WeiGuang, Tang JianWei, Liu Miao, Li XingRen, Hu Kun, Du Xue, Li XiaoNian, Zhang HongBin, Pu JianXin, Sun HanDong. Structurally Diverse Diterpenoids from Isodon scoparius and Their Bioactivity. Journal of Natural Products[J]. 2017, [48] Liu, Miao, Wang, WeiGuang, Sun, HanDong, Pu, JianXin. Diterpenoids from Isodon species: an update. NATURAL PRODUCT REPORTSnull. 2017, 34(9): 1090-1140, https://www.webofscience.com/wos/woscc/full-record/WOS:000409009000004.
[49] Hu ZhengXi, Li XiaoNian, Shi YiMing, Wang WeiGuang, Du Xue, Li Yan, Zhang YongHui, Pu JianXin, Sun HanDong. Lanostane-type triterpenoids from Kadsura coccinea. Tetrahedron[J]. 2017, [50] Jin Yang, WeiGuang Wang, HaiYan Wu, Miao Liu, HuaYi Jiang, Xue Dua, Yan Li, JianXin Pu, HanDong Sun. Ent-Kaurane Diterpenoids from Isodon phyllostachys. Tetrahedron Letters[J]. 2017, 58: 349–351-, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000257531400017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[51] Wan, Jun, Jiang, HuaYi, Tang, JianWei, Li, XingRen, Du, Xue, Li, Yan, Sun, HanDong, Pu, JianXin. Ent-Abietanoids Isolated from Isodon serra. MOLECULES[J]. 2017, 22(2): http://ir.kib.ac.cn/handle/151853/50994.
[52] Zhou, YuanFei, Shi, HaiXia, Hu, Kun, Tang, JianWei, Li, XingRen, Du, Xue, Sun, HanDong, Wang, LiSong, Pu, JianXin. Gypmacrophin A, a Rare Pentacyclic Sesterterpenoid, Together with Three Depsides, Functioned as New Chemical Evidence for Gypsoplaca macrophylla (Zahlbr.) Timdal Identification. MOLECULES[J]. 2017, 22(10): https://doaj.org/article/2b9acc11753a46e2b533ddcd10838a22.
[53] Sun, Xiaoyan, Wang, Weiguang, Chen, Jiao, Cai, Xueting, Yang, Jie, Yang, Yang, Yan, Huaijiang, Cheng, Xiaolan, Ye, Juan, Lu, Wuguang, Hu, Chunping, Sun, Handong, Pu, Jianxin, Cao, Peng. The Natural Diterpenoid Isoforretin A Inhibits Thioredoxin-1 and Triggers Potent ROS-Mediated Antitumor Effects. CANCER RESEARCH[J]. 2017, 77(4): 926-936, http://www.irgrid.ac.cn/handle/1471x/1175749.
[54] Tang JianWei, Wang WeiGuang, Li Ao, Yan BingChao, Chen Rong, Li XiaoNian, Du Xue, Sun HanDong, Pu JianXin. Polyketides from the endophytic fungus Phomopsis sp. sh917 by using the one strain/many compounds strategy. Tetrahedron[J]. 2017, [55] Zhang, YuanYuan, Jiang, HuaYi, Liu, Miao, Hu, Kun, Wang, WeiGuang, Du, Xue, Li, XiaoNian, Pu, JianXin, Sun, HanDong. Bioactive ent-kaurane diterpenoids from Isodon rubescens. PHYTOCHEMISTRY[J]. 2017, 143: 199-207, http://dx.doi.org/10.1016/j.phytochem.2017.08.009.
[56] Yun Chea, Jingnan Wang, Zuyang Yuan, Yuan Li, Zhiliang Lu, Zhirong Zhang, Jinyao Zhang, Jun Wan, Handong Sun, Zhaoli Chen, Jianxin Pu, Jie He. The Therapeutic Effects of Longikaurin A, a Natural ent-Kauranoid, in Esophageal Squamous Cell Carcinoma Depend on ROS Accumulation and JNK/p38 MAPK Activation. Toxicology Letters[J]. 2017, 280: 106–115-, http://dx.doi.org/10.1016/j.toxlet.2017.08.005.
[57] Hu, ZhengXi, Shi, YiMing, Wang, WeiGuang, Tang, JianWei, Zhou, Min, Du, Xue, Zhang, YongHui, Pu, JianXin, Sun, HanDong. Structural Characterization of Kadcoccinin A: A Sesquiterpenoid with a Tricyclo4.4.0.0(3,10)decane Scaffold from Kadsura coccinea. ORGANIC LETTERS[J]. 2016, 18(9): 2284-2287, http://www.irgrid.ac.cn/handle/1471x/1109566.
[58] Zhou, Xunian, Yue, Grace GarLee, Liu, Minghua, Zuo, Zhili, Lee, Julia KinMing, Li, Mingyue, Tsui, Stephen KwokWing, Fung, KwokPui, Sun, Handong, Pu, Jianxin, Lau, Clara BikSan. Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling. ONCOTARGET[J]. 2016, 7(50): 82820-82835, http://dx.doi.org/10.18632/oncotarget.12652.
[59] Yang, Jin, Wang, WeiGuang, Wu, HaiYan, Du, Xue, Li, XiaoNian, Li, Yan, Pu, JianXin, Sun, HanDong. Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys (vol 79, pg 132, 2016). JOURNAL OF NATURAL PRODUCTSnull. 2016, 79(7): 1897-1897, https://www.webofscience.com/wos/woscc/full-record/WOS:000380422400029.
[60] Shi, YiMing, Cai, SongLiang, Li, XiaoNian, Liu, Miao, Shang, ShanZhai, Du, Xue, Xiao, WeiLie, Pu, JianXin, Sun, HanDong. LC-UV-Guided Isolation and Structure Determination of Lancolide E: A Nortriterpenoid with a Tetracyclo5.4.0.0(2,4).0(3,7)undecane-Bridged System from a "Talented" Schisandra Plant. ORGANIC LETTERS[J]. 2016, 18(1): 100-103, http://www.irgrid.ac.cn/handle/1471x/1055493.
[61] Yan, BingChao, Wang, WeiGuang, Hu, DongBao, Sun, Xiang, Kong, LingMei, Li, XiaoNian, Du, Xue, Luo, ShiHong, Liu, Yan, Li, Yan, Sun, HanDong, Pu, JianXin. Phomopchalasins A and B, Two Cytochalasans with Polycyclic-Fused Skeletons from the Endophytic Fungus Phomopsis sp shj2. ORGANIC LETTERS[J]. 2016, 18(5): 1108-1111, http://ir.kib.ac.cn/handle/151853/26012.
[62] Wang, WeiGuang, Li, Ao, Yan, BingChao, Niu, ShuBin, Tang, JianWei, Li, XiaoNian, Du, Xue, Challis, Gregory L, Che, Yongsheng, Sung, HanDong, Pu, JianXin. LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp sh18. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(1): 149-155, http://ir.kib.ac.cn/handle/151853/25943.
[63] Yang, JianHong, Pu, JianXin, Wen, Jin, Li, XiaoNian, He, Fei, Su, Jia, Li, Yan, Sun, HanDong. Unusual cycloartane triterpenoids from Kadsura ananosma. PHYTOCHEMISTRY[J]. 2015, 109: 36-42, http://dx.doi.org/10.1016/j.phytochem.2014.10.014.
[64] Hu, ZhengXi, Shi, YiMing, Wang, WeiGuang, Li, XiaoNian, Du, Xue, Liu, Miao, Li, Yan, Xue, YongBo, Zhang, YongHui, Pu, JianXin, Sun, HanDong. Kadcoccinones A-F, New Biogenetically Related Lanostane-Type Triterpenoids with Diverse Skeletons from Kadsura coccinea. ORGANIC LETTERS[J]. 2015, 17(18): 4616-4619, http://www.irgrid.ac.cn/handle/1471x/1028963.
[65] Liu, Xu, Yang, Jing, Wang, WeiGuang, Li, Yan, Wu, JiZhou, Pu, JianXin, Sun, HanDong. Diterpene Alkaloids with an Aza-ent-kaurane Skeleton from Isodon rubescens. JOURNAL OF NATURAL PRODUCTS[J]. 2015, 78(2): 196-201, http://www.irgrid.ac.cn/handle/1471x/959057.
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[69] Zhou, Min, Li, XingRen, Tang, JianWei, Liu, Yang, Li, XiaoNian, Wu, Bin, Qin, HongBo, Du, Xue, Li, LiMei, Wang, WeiGuang, Pu, JianXin, Sun, HanDong. Scopariusicides, Novel Unsymmetrical Cyclobutanes: Structural Elucidation and Concise Synthesis by a Combination of Intermolecular 2+2 Cycloaddition and C-H Functionalization. ORGANIC LETTERS[J]. 2015, 17(24): 6062-6065, http://www.irgrid.ac.cn/handle/1471x/1029014.
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[81] Dong, Ke, Pu, JianXin, Du, Xue, Li, XiaoNian, Sun, HanDong. Two new guaianolide-type sesquiterpenoids from Kadsura interior. CHINESE CHEMICAL LETTERS[J]. 2013, 24(2): 111-113, http://dx.doi.org/10.1016/j.cclet.2013.01.024.
[82] Jiang, HuaYi, Wang, WeiGuang, Zhou, Min, Wu, HaiYan, Zhan, Rui, Li, XiaoNian, Du, Xue, Li, Yan, Pu, JianXin, Sun, HanDong. Enmein-type 6,7-seco-ent-Kauranoids from Isodon sculponeatus. JOURNAL OF NATURAL PRODUCTS[J]. 2013, 76(11): 2113-2119, http://dx.doi.org/10.1021/np400669t.
[83] Zhou, Min, Zhang, HaiBo, Wang, WeiGuang, Gong, NingBo, Zhan, Rui, Li, XiaoNian, Du, Xue, Li, LiMei, Li, Yan, Lu, Yang, Pu, JianXin, Sun, HanDong. Scopariusic Acid, a New Meroditerpenoid with a Unique Cyclobutane Ring Isolated from Isodon scoparius. ORGANIC LETTERS[J]. 2013, 15(17): 4446-4449, http://www.irgrid.ac.cn/handle/1471x/784377.
[84] Zhan, Rui, Li, XiaoNian, Du, Xue, Wang, WeiGuang, Dong, Ke, Su, Jia, Li, Yan, Pu, JianXin, Sun, HanDong. ent-Atisane and ent-kaurane diterpenoids from Isodon rosthornii. FITOTERAPIA[J]. 2013, 88: 76-81, https://www.webofscience.com/wos/woscc/full-record/WOS:000321599600010.
[85] Zhou, Min, Geng, HuiChun, Zhang, HaiBo, Dong, Ke, Wang, WeiGuang, Du, Xue, Li, XiaoNian, He, Fei, Qin, HongBo, Li, Yan, Pu, JianXin, Sun, HanDong. Scopariusins, A New Class of ent-Halimane Diterpenoids Isolated from Isodon scoparius, and Biomimetic Synthesis of Scopariusin A and Isoscoparin N. ORGANIC LETTERS[J]. 2013, 15(2): 314-317, http://www.irgrid.ac.cn/handle/1471x/596082.
[86] Wang, WeiGuang, Du, Xue, Li, XiaoNian, Wu, HaiYan, Liu, Xu, Shang, ShanZhai, Zhan, Rui, Liang, ChengGin, Kong, LingMei, Li, Yan, Pu, JianXin, Sun, HanDong. New Bicyclo3.1.0hexane Unit ent-Kaurane Diterpene and Its seco-Derivative from Isodon eriocalyx var. laxiflora. ORGANIC LETTERS[J]. 2012, 14(1): 302-305, http://www.irgrid.ac.cn/handle/1471x/448467.
[87] Wang, WeiGuang, Li, XiaoNian, Du, Xue, Dong, Ke, Zhao, Wei, Wu, HaiYan, Kong, LingMei, Li, Yan, Pu, JianXin, Sun, HanDong. Biogenetically related caged ent-kaurane diterpenoids from Isodon eriocalyx var. laxiflora. TETRAHEDRON LETTERS[J]. 2012, 53(22): 2777-2781, http://dx.doi.org/10.1016/j.tetlet.2012.03.112.
[88] Wang, WeiGuang, Li, XiaoNian, Du, Xue, Wu, HaiYan, Liu, Xu, Su, Jia, Li, Yan, Pu, JianXin, Sun, HanDong. Laxiflorolides A and B, Epimeric Bishomoditerpene Lactones from Isodon eriocalyx. JOURNAL OF NATURAL PRODUCTS[J]. 2012, 75(6): 1102-1107, http://www.irgrid.ac.cn/handle/1471x/832353.
[89] Gao, XueMei, Pu, JianXin, Zhao, Yong, Yang, LiBin, Sun, HanDong. Lignans from Kadsura angustifolia and Kadsura coccinea. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2012, 14(2): 129-134, https://www.webofscience.com/wos/woscc/full-record/WOS:000302030300007.
[90] Zhao, Yong, Pu, JianXin, Huang, ShengXiong, Ding, LiSheng, Li, LiMei, Li, Xian, Yang, LiBin, Xiao, WeiLie, Wu, YingLi, Chen, GuoQiang, Sun, HanDong. 19-Oxygenated ent-Kaurane Diterpenoids from Isodon pharicus. PLANTA MEDICA[J]. 2012, 78(1): 52-58, http://www.irgrid.ac.cn/handle/1471x/656424.
[91] Dong, Ke, Pu, JianXin, Du, Xue, Su, Jia, Li, XiaoNian, Yang, JianHong, Zhao, Wei, Li, Yan, Sun, HanDong. Kadpolysperins A-N, lanostane triterpene acids possessing rich structure types from Kadsura polysperma. TETRAHEDRON[J]. 2012, 68(24): 4820-4829, http://dx.doi.org/10.1016/j.tet.2012.03.116.
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[93] Zhao, Wei, Wang, WeiGuang, Li, XiaoNian, Du, Xue, Zhan, Rui, Zou, Juan, Li, Yan, Zhang, HaiBo, He, Fei, Pu, JianXin, Sun, HanDong. Neoadenoloside A, a highly functionalized diterpene C-glycoside, from Isodon adenolomus. CHEMICAL COMMUNICATIONS[J]. 2012, 48(62): 7723-7725, http://ir.kib.ac.cn/handle/151853/20405.
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发表著作
(1) 二萜化学, Diterpene chemistry, 化学工业出版社, 2012-01, 第 5 作者

科研活动

   
科研项目
( 1 ) 西南地区南五味子属植物中新颖结构类型化合物及生物活性成分的研究, 主持, 国家级, 2010-01--2012-12
( 2 ) 三种高原地区特有香茶菜, 主持, 省级, 2008-12--2011-12
( 3 ) 两种药典中药用植物的生物活性成分研究, 主持, 市地级, 2010-01--2011-12
( 4 ) 横断山区香茶菜属植物生物活性成分及其应用基础研究, 主持, 部委级, 2011-01--2013-12
( 5 ) 香茶菜属植物中对映-贝壳杉烷二萜成分及其抗肿瘤成药性评价, 主持, 部委级, 2013-01--2015-12
( 6 ) 具有免疫抑制活性的天然对映-贝壳杉烷二萜类化合物的研究, 主持, 国家级, 2012-01--2015-12
( 7 ) 天然产物化学, 主持, 国家级, 2014-01--2016-12
( 8 ) 云南三江并流区域香茶菜属植物二萜及其抗癌活性研究, 主持, 国家级, 2014-01--2017-12
( 9 ) 帚状香茶菜中具有免疫抑制活性新颖杂二萜的发现、合成及作用机制研究, 主持, 国家级, 2017-01--2020-12
( 10 ) 人工种植帚状香茶菜中具有免疫抑制活性新颖化合物的挖掘, 主持, 研究所(学校), 2017-11--2019-11
( 11 ) 唇形科香茶菜属核心分枝的二萜化学及系统发育信号初探, 主持, 市地级, 2016-09--2018-08
( 12 ) 特殊生境植物内生真菌中新颖活性天然产物的挖掘, 主持, 国家级, 2019-01--2022-12
( 13 ) 第二次青藏高原综合科学考察研究——植物多样性可持续利用与评估(子专题:藏药资源的挖掘利用), 主持, 国家级, 2019-11--2024-10
( 14 ) 新颖先导化合物的发现, 主持, 部委级, 2020-01--2022-12
( 15 ) “五味子科和香茶菜属”植物及其内生菌中新颖先导化合物的深度挖掘, 主持, 省级, 2019-07--2022-06
( 16 ) 香茶菜属植物中的化学成分及其生物活性研究, 主持, 部委级, 2015-01--2016-12
( 17 ) 香茶菜属植物中对映-贝壳杉烷二萜成分及其抗肿瘤成药性评价, 主持, 部委级, 2015-01--2016-12
( 18 ) 香茶菜属植物中的化学成分及其生物活性研究, 主持, 部委级, 2011-08--2014-12
( 19 ) 西南地区南五味子属植物中新颖结构类型化合物及生物活性成分的研究, 主持, 省级, 2011-09--2014-09
( 20 ) 横断山脉区域特有香茶菜属植物及其内生菌中新颖先导化合物的发现, 主持, 国家级, 2021-01--2024-12
参与会议
(1)重要类群植物及其内生菌中新颖先导化合物的发现   第十一届同德国际学术周—中医药研发与产业化论坛   2020-11-07
(2)“一科一属”植物及其内生菌中新颖天然产物的研究   第十一届全国化学生物学学术会议   2019-11-18
(3)Secondary Metabolites from “One family and One genus” Species and their Endophytic Fungi   第七届中泰双边天然产物化学与药物发现研讨会   2018-11-04
(4)Exploration of the Secondary Metabolites and their Bioactivities from “One family and One genus” Species and their Endophytic Fungi   2018-08-31
(5)“一科一属”植物及其内生菌次生代谢产物与生物功能的挖掘   中国化学会第31届学术年会   2018-05-05
(6)香茶菜属植物及其内生菌次生代谢产物与生物功能的研究   中国化学会第十一届全国天然有机化学学术会议   2016-09-25
(7)Secondary Metabolites and their Bioactivities from Isodon species and their endophytic fungi   2016-09-01
(8)香茶菜属植物及其内生菌次生代谢产物与生物功能的研究   中国化学会第30届学术年会   2016-07-01
(9)Diterpenoids from Isodon species   Jian-Xin Pu   2015-11-09
(10)Research Progress of Diterpenoids from Isodon species   Jian-Xin Pu   2014-09-21
(11)Research Progress of a New Type of potential anti-cancer drugs: ent-kaurane diterpenoids   Jian-Xin Pu   2012-11-26
(12)Studies on the Chemical Constituents and Bioactivity of Two Medicinal Plants Distributed in Qinling Mountain   秦岭药用植物资源开发与利用国际研讨会   Jian-Xin Pu, Li-Bin Yang, Juan Zou, and Han-Dong Sun   2011-05-27
(13)Chemical constituents from Kadsura species and their Bioactivities    第二届东亚植物遗传资源及其成分多样性研讨会   Jian-Xin Pu and Han-Dong Sun   2010-10-27
(14)Chemical constituents from Kadsura species and their Bioactivities   Jian-Xin Pu and Han-Dong Sun   2010-08-23

指导学生

已指导学生

颜秉超  硕士研究生  078001-药物化学  

唐健维  硕士研究生  078001-药物化学  

万俊  硕士研究生  078001-药物化学  

蒋学春  硕士研究生  105500-药学  

周元飞  硕士研究生  078001-药物化学  

陈玲  硕士研究生  078001-药物化学  

唐健维  博士研究生  100701-药物化学  

马仁芬  硕士研究生  105500-药学  

刘淼  博士研究生  100701-药物化学  

胡坤  博士研究生  100701-药物化学  

李行任  博士研究生  100701-药物化学  

颜秉超  博士研究生  100701-药物化学  

蒋华夷  博士研究生  100701-药物化学  

杨谦  博士研究生  100701-药物化学  

张源渊  硕士研究生  105500-药学  

罗远情  硕士研究生  078001-药物化学  

徐厚朝  硕士研究生  078001-药物化学  

粟孝政  硕士研究生  078001-药物化学  

何桃斌  博士研究生  100701-药物化学  

苟蕾蕾  硕士研究生  078001-药物化学  

现指导学生

代家猛  博士研究生  100701-药物化学  

王彬  博士研究生  100701-药物化学  

周元飞  博士研究生  100701-药物化学  

张智坚  硕士研究生  105500-药学  

陈素萍  硕士研究生  078001-药物化学  

邱彩玲  硕士研究生  078001-药物化学  

苟蕾蕾  博士研究生  100701-药物化学  

张水妹  硕士研究生  078001-药物化学  

谭茜  硕士研究生  078001-药物化学  

粟孝政  博士研究生  100701-药物化学