裴端卿 男 汉族 博导 广州生物医药与健康研究院
Mobile phone:
Address: 广州市萝岗区开源大道190号
Postcode: 510530

Research Areas

Stem Cell


1985-1991 University of Pennsylvania, Philadelphia, Ph.D. Thesis: “Liver gene expression and hepatitis B virus: The characterization of the liver enriched transcriptional factor CCAAT/enhancer binding protein C/EBP”. Advisor: Chiaho Shih, Ph.D. 

1991.6 - 1995. 3 Postdoctoral Research Fellow, Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI   Mentor: Stephen J. Weiss, M.D.


1995.4- 1996.8    Research Investigator, Departm​ent of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical Center, Ann Arbor, MI.

1996.9- 2002.6    Assistant Professor, Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455

1997.9-2004.9     Member, Cancer Metastasis/Cell Biology program, University of Minnesota Comprehensive Cancer Center, MN 55455

2002.6-2004.7    Associate Professor with Tenure, Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455

2002.1-2004.6    Professor and Director, Institute of Pharmacology, Tsinghua University, Beijing, China. 

2003.8-2006.7    Visiting Professor, Shanghai Institute of Organic Chemistry, Shanghai, China. 

2004.2-2007.1    Honorary Professor, Department of Pharmacology, University of Hong Kong, Hong Kong, China. 

2004.7-2008.6   Professor and Deputy Director General, GIBH, Chinese Academy of Sciences, Guangzhou, China 

2008.6-             Professor and Director General, GIBH, Chinese Academy of Sciences, Guangzhou, China 

Honors & Distinctions

1981-1982    Best Student Award, Central China University of Agriculture, Wuhan, China
1985            Fellowship: China-United States Biochemistry and Molecular Biology Examination and Application Program (CUSBEA program)
1994            Research Award, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI.
1997            Feltl family Award, Arthritis Foundation-MN chapter.
2000            Ziegler Family Research Award, Arthritis Foundation. Career Investigator Award, American Lung Association. 
2002           Honorary Professor, University of Hong Kong
2006           Chair, Matrix Metalloproteinases in Cancer, IUPHAR 2006.
2006           Co-Chair, 9th Annual Chinese-American Frontiers of Science Symposium of the Chinese Academy of Sciences and the National  Academy of Sciences of USA, Irvine, California.
2007           Co-Chair, #313 Xiangshan meeting on “stem cell biology and cloning”, Xiangshan, Beijing; Nov, 2007.
2009           Program chair, 2009 IUBMB congress, Shanghai, China; Aug 2-7.
2010           Co-chair, Cold Spring Harbor meeting-Asia, Molecular switches for stem cells and development, Sept 21-25, 2010.
2010           The First Prize in the Medal of Science and Technology in Guangdong Province, 2010
2011           Session Chair, ISSCR Annual Meeting,Toronto,  June15-18 ,2011
2014           Committee Member, 2014 ISSCR Annual Meeting, Vancouver, June 18-21
2014           The Second Prize in the National Natural Science Award,2014
2015           Co-Chair, Gordon Research Conference: Nuclear Architecture in cell fate and disease, HongKong, June 7-12, 2015
2015           The First Prize in the Medal of Science and Technology in Guangdong Province, 2015


1.         Pei, D., C. Shih.  1990.  Transcriptional repression and activation by cellular DNA-binding protein C/EBP.  J. Virol. 64: 1517-1522.

2.         Pei, D., C. Shih. 1991.  An attenuator is sandwiched by two transactivation domains in the transcriptional factor C/EBP.  Mol. Cell. Biol. 11: 1480-1487.

3.         Pei, D., Majmudar, G., Weiss, S.J. 1994. Hydrolytic inactivation of a breast carcinoma cell-derived serpin by human stromelysin-3.  J Biol. Chem; 269: 25849-25855.

4.         Pei, D., Weiss, S.J. 1995. Furin-dependent Intracellular Activation of the Human Stromelysin-3 Zymogen.  Nature.  375: 244-247.

5.         Pei, D., Weiss, S.J., 1996. Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity. J. Biol. Chem. 271 (15): 9135-9140.

6.         Pei, D., Yi, J. 1998. A High Level Mammalian Expression System Based on the Madin-Darby canine kidney (MDCK) cell line.  Prot. Exp.& Puri. 13: 277-281.

7.         Lei, J., Jiang, A., and Pei, D. 1998. Identification and Characterization of a New Splicing Variant of Vascular Endothelial Growth Factor: VEGF183.  Biochim. Biophys. Acta 1443 (3): 400-406.

8.         Pei, D. 1999.  Identification and characterization of the fifth member of the membrane-type matrix metalloproteinase MT5-MMP. J. Biol. Chem. 274: 8925-8932.

9.         Pei, D. 1999. CA-MMP: a matrix metalloproteinase with a novel cysteine-array, but without the classic cysteine switch. FEBS Lett. 457: 262-270.

10.      Wang, X., Lei, L., Yi, J. and Pei, D. 1999. Expression, Purification and Charaterization of Recombinant Mouse MT5-MMP Protein Products.  FEBS Lett. 462: 261-266.

11.      Pei, D. 1999. MMP25/MT6-MMP/Leukolysin: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage, Cell Res. 9: 291-303.

12.      Pei, D., Kang, T., and Qi, H. 2000. CA-MMP/MMP-23 is a Type II Transmembrane Matrix Metalloproteinase Regulated by a Single Cleavage for Both Secretion and Activation. J. Biol. Chem. 275: 33988-33997.

13.      Kang, T., Yi, J., Yang, W., Wang, X., Jiang, A., and Pei, D. 2000. Functional characterization of MT3-MMP in transfected MDCK cells: progelatinase A activation and tubulogenesis in 3-D collagen lattice. FASEB J. 14:2559-2568.

14.      Damjanovski, S., Amano, T., Li, Q., Pei, D., and Shi, Y.-B. 2001.  Overexpression of Matrix Metalloproteinases Leads to Lethality in Transgenic Xenopus Laevis: Implications for Tissue-Dependent Functions of Matrix Metalloproteinases during Late Embryonic development.  Dev. Dynamics 221: 37-47.

15.      Iida, J., Pei, D., Kang, T., Simpson, M.A., Herlyn, M., Furcht, L. T., and McCarthy, J. B. 2001. Melanoma Chondroitin Sulfate Proteoglycan Regulates Matrix Metalloproteinase -Dependent Human Melanoma Invasion into Type I Collagen.  J. Biol. Chem. 276: 18786-18794.

16.      Kang, T., Yi, J., Guo, A., Wang, X., Overall, C.M., Jiang, W., Elde, R., Borregaard, N., and Pei, D. 2001.  Subcellular Distribution, Cytokine- and Chemokine- Regulated Secretion of Leukolysin / MT6-MMP /MMP-25 in Neutrophils. J. Biol. Chem. 276: 21960-21968. 

17.      Wang, X., Pei, D. 2001.  Shedding of MT5-MMP by a Furin-Type Convertase: A Potential Mechanism of Down-Regulation.  J. Biol. Chem. 276: 35953-60.

18.      Jiang, A., Lehti, K., Wang, X., Weiss, S.J., Keski-Oja, J., and Pei, D. 2001.  Regulation of Membrane-Type Matrix Metalloproteinase 1 Activity by Dynamin-Mediated Endocytosis.  Proc. Natl. Acad. Sci. 98: 13693-8. 

19.      Pei, D. 2001. Matrix Metalloproteinases: An Introduction. Chinese J. of Biochem. & Mol. Biol. 17:1-6.

20.      Kang, T., Nagase, H., and Pei, D. 2002. Transactivation of ProMT3-MMP by Proprotein-Convertase Furin in Trans-Golgi Network.  Cancer Res. 62: 675-681.

21.      Lehti,K.., Lohi, J., Juntunen, M. M., Pei, D., Keski-Oja, J. 2002.  Oligomerization through hemopexin and cytoplasmic domains regulate the activity and turnover of membrane-type-1 matrix metalloproteinase (MT1-MMP). J. Biol. Chem. 277:8440-8448.

22.      Wilson, MJ, RG Sellars, C Wiehr, O Melamud, Pei, D and DM Peehl.  2002. Expression of matrix metalloprotease-2 and ­9 and their inhibitors, tissue inhibitors of metalloprotease-1 and ­2, in primary cultures of human prostatic stromal and epithelial cells.  J. Cell. Physiol. 191: 208-216.

23.      Pan, GJ, Chang ZY, Scholer HR, Pei D. 2002. Stem cell pluripotency and transcription factor Oct4. Cell Res  12:321-9.

24.      Doherty, T.M., Asotra, K., Pei, D., Uzui, H., Wilkin, D.J., Shah, P.K., Rajavashisth, T.B. 2002. Therapeutic developments in matrix metalloproteinase inhibition. Expert Opinion on Therapeutic Patents. 12: 665-707.

25.      Kang, T., Zhao, Y.G., Pei, D., Sucic, F. J., Sang, Q-X. A. 2002. Intracellular Activation of Human Adamalysin 19/Disintegrin and Metalloproteinase 19 by Furin Occurs via one of the two Consecutive Recognition Sites. J. Biol. Chem. 277: 25583-91.

26.      Jiang, A., Pei, D. 2003. Distinct Roles of Catalytic and Pexin-like Domains in MT-MMP Mediated proMMP-2 Activation and Collagenolysis.  J. Biol. Chem. 278: 38765-38771.

27.      Nie, J., Pei, D. 2003. Direct Activation of proMMP-2 by Leukolysin / MT6-MMP at the Asn109-Tyr bond.  Cancer Res. 63:6758-6762.

28.      Pan, G., Pei, D. 2003.  Identification of Two Distinct Transactivation Domains in the Pluripotency Sustaining Factor Nanog.  Cell Res., 13:499-502.

29.      Zucker, S., Pei, D., Cao, J., Lopez-Otin. 2003.  Membrane-type Matrix Metalloproteinases (MT1-MMP).  Current Topics in Developmental Biology. 54: 1-74.

30.      Cui, P., Qin, B., Pan, G., Liu, N., and Pei, D. 2004, Nuclear Localization of the Phosphatidylserine Receptor Protein Via Multiple Nuclear Localization Signals.  Exp. Cell Res., 293: 154-163.

31.      Iida, J., Whilhelmson, K. L., Price, M A., Wilson, C. M., Pei, D., Furcht, L T. , and McCarthy, J.B. 2004. Memrane-type-1-matrix metalloproteinase (MT1-MMP) promotes human melanoma invasion and growth. J. Inv. Derm. 122: 167-176.

32.      Wilson, M.J., Jiang, A., Wiehr, C., Wang, X., Sinha, A.A., Pei. D. 2004, Limited Processing of Pro-Matrix Metalloprotease-2 (Gelatinase A) Overexpressed by Transfection in PC-3 Human Prostate Tumor Cells: Association With Restricted Cell Surface Localization of Membrane-Type Matrix Metalloproteinase-1. J. Andrology, 25: 274-285.

33.      Wang, X., Ma, D., Keski-Oja, J., and Pei, D. 2004. Co-recycling of MT1-MMP and MT3-MMP Through the trans-Golgi Network: Identification of DKV582 as a Recycling Signal. J. Biol. Chem., 279:9331-6.

34.      Zhao, H., Bernardo, M. M., Osenkowski, P., Pei, D., Nagase, H., Kashiwagi, M., Soloway, P. D., DeClerck, Y. A., Fridman, R. 2004. Differential Inhibition of MT3-MMP And MT1-MMP By TIMP-2 and TIMP-3 Regulates Pro-MMP-2 Activation. J. Biol. Chem.  279: 8592-8601.

35.      Wang, P., Tortorella, M., England, K., Malfait, A.M., Thomas, G., Arner, E., Pei, D. 2004. Proprotein Convertase Furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi Network. J. Biol. Chem.  279: 15434-15440.

36.      Wang, P., Wang, X., and Pei, D. 2004. Mint-3 regulates the retrieval of internalized MT5-MMP to plasma membrane by binding to its carboxyl end motif EWV. J. Biol. Chem. 279: 20461-20470.

37.      Nie, J., Pei, D. 2004. Rapid Inactivation of Alpha-1-Proteinase Inhibitor by Neutrophil Specific Leukolysin / Membrane-Type Matrix Metalloproteinase 6. Exp.Cell Res. 296: 145-150.

38.      Cha, T., Guo, A., Jun, Y., Pei, D., and Zhu, X. Y. 2004. Immobilization of oriented protein molecules on poly(ethylene glycol)-coated Si(111) (p NA). Proteomics, 4:1965-76. 

39.      Ma, D., Xie, WQ., Zou, B., Lei, Q., and Pei, D. An efficient and tunable route to AG7088, a rhinovirus protease inhibitor.  Tetrahedron Letters 45: 8103-5.

40.      Pan, G., Qin, B., Liu, N., Scholer, H.R., Pei, D. 2004. Identification of a nuclear localization signal in Oct4 and generation of a dominant negative mutant by its ablation. J. Biol. Chem. 279: 37013–37020.

41.      Wang, P., Nie, J., and Pei, D. 2004. The hemopexin domain of MT1-MMP is not required for its activation of proMMP2 on cell surface, but essential for MT1-MMP mediated invasion in 3-D type I collagen. J. Biol. Chem. 279: 51148 - 51155.

42.      Pan. G., Pei. D. 2005. The Stem Cell Pluripotency Factor Nanog Activates Transcription With Two Unusually Potent Subdomains at its C-terminus. J. Biol. Chem. 280:1401-1407. 

43.      Pei, D. 2005. Matrix Metalloproteases Target Protease-activated Receptors During Tumor Progression.  Cancer Cell, 7: 207-8.

44.      Qin, B., Chen, X., Zhu, J., and Pei, D.  2005.  Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy.  Cell Res., 15(3):212-7.

45.      Liu, B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang J, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadinanos J, Lopez-Otin C, Tse HF, Hutchinson C, Chen J, Cao Y, Cheah KSE, Tryggvason K, Zhou Z. 2005. Genomic instability in laminopathy-based premature aging. Nat. Med. 11, 780 - 785.

46.      Yang, H., Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen K.Y., Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M & Rao Z. 2005. Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biology. 3(10): e324.

47.      Xie, W., Zou, B., Pei, D., and Ma, D. 2005. Total Synthesis of Cyclic Tetrapeptide FR235222, a Potent Immunosuppressant that Inhibits Mammalian Histone Deacetylases. Org. Lett.; 7: 2775 – 2777.

48.      Shi, W., Wang,H., Pan, G., Geng, Y., Guo Y., and Pei, D. 2006.  Regulation of the pluripotency marker Rex-1 by Nanog and Sox 2.  J. Biol. Chem. 2006,281: 33 23319-23325.

49.      Pan, G., Li, J., Zhou, Y., Zheng, H., and Pei, D. 2006. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.  FASEB J. 2006, 20:10 1730-2.

50.      Pei, D. 2006. Metalloproteinases as Therapeutical Targets for Cancer Therapy. IDrugs 9(9):598-9.

51.      Qin B, He M, Chen X, Pei D.  2006. Sorting nexin 10 induces giant vacuoles in mammalian cells. J Biol Chem. 281: 36891 – 36896.

52.      Minond, D., Lauer-Fields, JL., Cudic, M., Overall, CM., Pei, D., Brew, K., Visse, R., Nagase, H., and Fields, GB. 2006. The Roles of Substrate Thermal Stability and P2 and P1' Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity. J. Biol. Chem. 281: 38302 – 38313.

53.      Nie, J., Pei, J., Blumenthal, M., and Pei, D. 2007. Complete restoration of cell surface activity of transmembrane-truncated MT1-MMP by a GPI anchor: Implications for MT1-MMP mediated proMMP2 activation and collagenolysis in 3D.  J. Biol. Chem. 282: 6438-43.

54.      Qi, H., and Pei, D. 2007. The majic of four: induction of pluripotent stem cells from somatic cells by Oct4, Sox2, Myc and Klf4. Cell Res  17: 578-580.

55.      Li, J., Pan, G., Cui, K., Liu, Y., Xu, S., and Pei, D. 2007. A Dominant-negative Form of Mouse SOX2 Induces Trophectoderm Differentiation and Progressive Polyploidy in Mouse Embryonic Stem Cells. J. Biol. Chem. 282: 19481 – 19492.

56.      Qin, D., Li, W., Zhang, J., and Pei D. 2007. Direct generation of ES-like cells from unmodified mouse embryonic fibroblasts by Oct4/Sox2/Myc/Klf4. Cell Res. 17: 959-62.

57.      Wang, Z., Ma, T., Chi, X., and Pei, D. 2008. Aromatic residues in the C-terminal domain 2 is required for nanog to mediate lif-independent self renewal of mouse embryonic stem cells. J. Biol. Chem.,283: 4480-4489.

58.      Deng Y, Wang Y, Holtz B, Li J, Traaseth N, Veglia G, Stottrup BJ, Elde R, Pei D, Guo A, Zhu XY. 2008.  Fluidic and air-stable supported lipid bilayer and cell-mimicking microarrays. J Am Chem Soc. 130: 6267-71.

59.      Qin,D., Gan, Y., Shao, K., Wang, H., Li, W., Wang, T., He, W.,  Xu, J., Zhang, Yu., Kou, Z., Zeng, L., Sheng, G., Esteban, M. A., Gao, S., and Pei, D. 2008. Mouse Meningiocytes Express Sox2 and Yield High Efficiency of Chimeras after Nuclear Reprogramming with Exogenous Factors. J. Biol. Chem., 283: 33730 – 33735.

60.      Zhang,X., Zhang,J., Wang,T., Esteban,M.A., and Pei, D. 2008. ESRRB activates Oct4 transcription and sustains self renewal and pluripotency in embryonic stem cells. J. Biol. Chem. 283: 35825-33

61.      Pei, D. 2009.  Regulation of pluripotency and reprogramming by transcription factors. J. Biol. Chem.(minireview).  284: 3365-69.

62.      Pei, D. 2008. 2008: year of the rat for stem cell research. Cell Res. 19:149-51. 

63.      Zhang J, Zhang X, Guo Y, Xu L, Pei D. 2009. Sorting nexin 33 induces mammalian cell micronucleated phenotype and actin polymerization by interacting with wiskott-aldrich syndrome protein. J Biol Chem.  Jun 1.

64.      Esteban MA, Xu J, Yang J, Peng M, Qin D, Li W, Jiang Z, Chen J, Deng K, Zhong M, Cai J, Lai L, Pei D. 2009 Generation of induced pluripotent stem cell lines from Tibetan miniature pig. J Biol Chem. 284(26):17634-40.

65.      Ma T, Wang Z, Guo Y, Pei D. 2009. The C-terminal Pentapeptide of Nanog Tryptophan Repeat Domain Interacts with Nac1 and Regulates Stem Cell Proliferation but Not Pluripotency. J Biol Chem. 284(24):16071-81.

66.      Wang X, Wilson MJ, Slaton JW, Sinha AA, Ewing SL, Pei D. 2009. Increased aggressiveness of human prostate PC-3 tumor cells expressing cell surface localized membrane type-1 matrix metalloproteinase (MT1-MMP). J Androl. 30(3):259-74.

67.      Zhou J, Duan L, Chen H, Ren X, Zhang Z, Zhou F, Liu J, Pei D, Ding K.2009. Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.  Bioorg Med Chem Lett. 2009 Sep 1;19(17):5091-4.

68.      Zhang J, Zhang X, Guo Y, Xu L, Pei D. 2009.  Sorting nexin 33 induces Mammalian cell micronucleated phenotype and actin polymerization by interacting with wiskott-Aldrich syndrome protein.  J Biol Chem 284(32):21659-69.

69.      Zarzeczny, A., Scott, C., Hyun, I., Bennett, J., Chandler, J., Chargé,S.,  Heine, H., Isasi, R., Kato, K., Lovell-Badge, R., McNagny, K., Pei, D., Rossant, J., Surani, A., Taylor, P.L., Ogbogu,U., and T. Caulfield. 2009. iPS Cells: Mapping the Policy Issues.  Cell 139: 1032-37.

70.      Esteban, M. A., Wang, T., Qin, B., Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., Chen, K., Li, Y., Liu, X., Xu, J., Zhang, S., Li, F., He, W., Labuda, K., Song,Y., Peterbauer, A., Wolbank, S., Redl, H., Zhong, M., Cai, D., Zeng, L., and D. Pei. 2010. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell, 6:71-9.

71.      Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA, Pei D. 2010. Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem. 285(15):11227-34.

72.      Chen J, Liu J, Han Q, Qin D, Xu J, Chen Y, Yang J, Song H, Yang D, Peng M, He W, Li R, Wang H, Gan Y, Ding K, Zeng L, Lai L, Esteban MA, Pei D. 2010. Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem. 2010 Jul 1.

73.      Li R, Liang J, Ni S, Zhou T, Qing X, Li H, He W, Chen J, Li F, Zhuang Q, Qin B, Xu J, Li W, Yang J, Gan Y, Qin D, Feng S, Song H, Yang D, Zhang B, Zeng L, Lai L, Esteban MA, Pei D. 2010. A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts. Cell Stem Cell. 7:51-63.

74.      Lian Q, Chow Y, Esteban MA, Pei D, Tse HF. 2010. Future perspective of induced pluripotent stem cells for diagnosis, drug screening and treatment of human diseases. Thromb Haemost. 104(1):39-44.

75.      Ning F, Guo Y, Tang J, Zhou J, Zhang H, Lu W, Gao Y, Wang L, Pei D, Duan Y, Jin Y. 2010. Differentiation of mouse embryonic stem cells into dental epithelial-like cells induced by ameloblasts serum-free conditioned medium. Biochem Biophys Res Commun. 394(2):342-7.

76.      Cai Q, Li Z, Wei J, Fu L, Ha C, Pei D, Ding K. 2010.  Synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reactions.  Org Lett. 12:1500-3.

77.      Nie J, Pei D. 2010.Expression and purification of membrane-type MMPs. Methods Mol Biol.  622:99-110.

78.      Esteban MA, Peng M, Deli Z, Cai J, Yang J, Xu J, Lai L, Pei D. 2010. Porcine induced pluripotent stem cells may bridge the gap between mouse and human iPS.  IUBMB Life.; 62(4):277-82.

79.      Pei D. 2010. The mighty mice prove pluripotency for iPSCs. J Mol Cell Biol. 2:171-2.

80.      Liu P, Yang J, Pei J, Pei D, Wilson MJ. Regulation of MT1-MMP activity by β-catenin in MDCK non-cancer and HT1080 cancer cells. J Cell Physiol. 2010 Nov;225(3):810-21.

81.      Xu J, Li H, Wang B, Xu Y, Yang J, Zhang X, Harten SK, Shukla D, Maxwell PH, Pei D, Esteban MA. VHL inactivation induces HEF1 and Aurora kinase A. J Am Soc Nephrol. 2010 Dec;21(12):2041-6.

82.      Yang J, Cai J, Zhang Y, Wang X, Li W, Xu J, Li F, Guo X, Deng K, Zhong M, Chen Y, Lai L, Pei D, Esteban MA.Induced pluripotent stem cells can be used to model the genomic imprinting disorder Prader-Willi syndrome. J Biol Chem. 2010 Dec 17;285(51):40303-11.

83.      Zhang J, Zhou J, Ren X, Diao Y, Li H, Jiang H, Ding K, Pei D.A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton. Invest New Drugs. 2010 Nov 16.

84.      Chen J, Liu J, Yang J, Chen Y, Chen J, Ni S, Song H, Zeng L, Ding K, Pei D.BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res. 2011 Jan;21(1):205-12.

85.      Wang Y, Chen J, Hu JL, Wei XX, Qin D, Gao J, Zhang L, Jiang J, Li JS, Liu J, Lai KY, Kuang X, Zhang J, Pei D, Xu GL.Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO Rep. 2011 Apr;12(4):373-8.

86.      Chen J, Liu J, Chen Y, Yang J, Chen J, Liu H, Zhao X, Mo K, Song H, Guo L, Chu S, Wang D, Ding K, Pei D. Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Res. 2011 Jun;21(6):884-94.

87.      Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D.MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem. 2011 May 13;286(19):17359-64.

88.      Ho JC, Zhou T, Lai WH, Huang Y, Chan YC, Li X, Wong NL, Li Y, Au KW, Guo D, Xu J, Siu CW, Pei D, Tse HF, Esteban MA.Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C. Aging (Albany NY). 2011 Apr;3(4):380-90.

89.      Yang D, Yang H, Li W, Zhao B, Ouyang Z, Liu Z, Zhao Y, Fan N, Song J, Tian J, Li F, Zhang J, Chang L, Pei D, Chen YE, Lai L.Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res. 2011 Jun;21(6):979-82.

90.      Zhang S, Chen S, Li W, Guo X, Zhao P, Xu J, Chen Y, Pan Q, Liu X, Zychlinski D, Lu H, Tortorella MD, Schambach A, Wang Y, Pei D, Esteban MA. Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin.Hum Mol Genet. 2011 Aug 15;20(16):3176-87.

91.      Zhou T, Benda C, Duzinger S, Huang Y, Li X, Li Y, Guo X, Cao G, Chen S, Hao L, Chan YC, Ng KM, Ho JC, Wieser M, Wu J, Redl H, Tse HF, Grillari J, Grillari-Voglauer R, Pei D, Esteban MA. Generation of induced pluripotent stem cells from urine. J Am Soc Nephrol. 2011 Jul;22(7):1221-8.

92.      Wang Q, Xu X, Li J, Liu J, Gu H, Zhang R, Chen J, Kuang Y, Fei J, Jiang C, Wang P, Pei D, Ding S, Xie X.  Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res. 2011 Oct;21(10):1424-35.

93.      Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, Qin B, Zeng L, Esteban MA, Pan G, Pei D. The histone demethylases jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell. 2011 Dec 2;9(6):575-87.

94.      Chen J, Han Q, Pei D. EMT and MET as paradigms for cell fate switching. J Mol Cell Biol. 2011 Dec 2.

95.      Li W, Wang X, Fan W, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D, Esteban MA. Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Hum Mol Genet. 2012 Jan 1;21(1):32-45.

96.      Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D. A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Res. 2012 Feb;22(2):333-45

97.      Chen J, Pei D. Reprogramming in suspension. Nat Methods. 2012 Apr 27;9(5):449-51

98.      Esteban MA, Pei D. Vitamin C improves the quality of somatic cell reprogramming. Nat Genet. 2012 Mar 28;44(4):366-7.

99.      Pan G, Wang T, Yao H, Pei D. Somatic cell reprogramming for regenerative medicine: SCNT vs. iPS cells. Bioessays. 2012 Jun;34(6):472-6.

100.  Xu L, Yin W, Xia J, Peng M, Li S, Lin S, Pei D, Shu X. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Hepatology. 2012 Jun;55(6):1985-93.

101.  Yuan W, Sipp D, Wang ZZ, Deng H, Pei D, Zhou Q, Cheng T. Stem cell science on the rise in China. Cell Stem Cell. 2012 Jan 6;10(1):12-5. Review.

102.  Chang S, Zhang L, Xu S, Luo J, Lu X, Zhang Z, Xu T, Liu Y, Tu Z, Xu Y, Ren X, Geng M, Ding J, Pei D, Ding K. Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant. J Med Chem. 2012 Mar 22;55(6):2711-23.

103.  Esteban MA, Bao X, Zhuang Q, Zhou T, Qin B, Pei D. The mesenchymal-to-epithelial transition in somatic cell reprogramming. Curr Opin Genet Dev. 2012 Oct;22(5):423-8.

104.  Pan G., Pei, D., Order from Chaos: Single Cell Reprogramming in Two Phases. Cell Stem Cell. 2012. Oct. 5; 11:445-7.

105.  Benda C, Zhou T, Wang X, Tian W, Grillari J, Tse HF, Grillari-Voglauer R, Pei D, Esteban MA.Urine as a Source of Stem Cells. Adv Biochem Eng Biotechnol. 2012 Oct

106.  Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, Wang Y, Zhang Y, Zhuang Q, Li Y, Bao X, Tse HF, Grillari J, Grillari-Voglauer R, Pei D, Esteban MA. Generation of human induced pluripotent stem cells from urine samples. Nat Protoc. 2012 Dec;7(12):2080-9

107.  Chen J., Liu H., Liu J.,  Qi J., Wei B., Yang J, Liang H., Chen Y, Chen J, Wu Y, Guo L,  Zhu J, Peng T., Zhang Y., Chen S, Li X, Li D, Wang,T, Pei, D. H3K9 Methylation is a barrier during somatic cell reprogramming into iPSCs.  Nature Genetics, 2013. 45: 34-42.

108.  Wang L., Wang L., Huang W, Su H., Xue Y., Su Z., Liao B., Wang H., Bao X., Qin D., He J., Wu W., So K.F., Pan G. , Pei D., Generation of integration-free neural progenitor cells from cells in human urine. Nature Methods, 2013. 10:84-89

109.  Zhuang Q, Qing X, Ying Y, Wu H, Benda C, Lin J, Huang Z, Liu L, Xu Y, Bao X, Qin B, Pei D, Esteban MA. Class IIa Histone Deacetylases and MEF2 proteins Regulate the Mesenchymal-to-Epithelial Transition of Somatic Cell Reprogramming. J Biol Chem. 2013 Mar 6. [Epub ahead of print]

110.  Su H, Wang L, Huang W, Qin D, Cai J, Yao X, Feng C, Li Z, Wang Y, So KF, Pan G, Wu W, Pei D.Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. Stem Cell Res. 2013 Jan 13;10(3):338-348

111.  Bao X, Zhu X, Liao B, Benda C, Zhuang Q, Pei D, Qin B, Esteban MA.MicroRNAs in somatic cell reprogramming. Curr Opin Cell Biol. 2013 Apr;25(2):208-14.

112. Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013 Jan;23(1):162-6.

113. Su H, Wang L, Huang W, Qin D, Cai J, Yao X, Feng C, Li Z, Wang Y, So KF, Pan G, Wu W, Pei D. Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells. Stem Cell Res. 2013 Jan 13;10(3):338-348.

114. Liu, X. P., H. Sun, J. Qi, L. L. Wang, S. W. He, J. Liu, C. Q. Feng, C. L. Chen, W. Li, Y. Q. Guo, D. J. Qin, G. J. Pan, J. K. Chen, D. Q. Pei, and H. Zheng., Sequential introduction of reprogramming factors reveals a time-sensitive requirement of individual factor and a sequential EMT-MET mechanism for optimal reprogramming. Nature Cell Biology 2013: 15, 829–838

115. Liu, P. F., S. B. Chen, X. Li, L. Qin, K. Huang, L. H. Wang, W. H. Huang, S. B. Li, B. Jia, M. Zhong, G. J. Pan, J. L. Cai, and D. Q. Pei. "Low Immunogenicity of Neural Progenitor Cells Differentiated from Induced Pluripotent Stem Cells Derived from Less Immunogenic Somatic Cells." Plos One 8, no. 7 (2013).

116. Cai, J., Y. Zhang, P. Liu, S. Chen, X. Wu, Y. Sun, A. Li, K. Huang, R. Luo, L. Wang, Y. Liu, T. Zhou, S. Wei, G. Pan, and D. Pei. "Generation of Tooth-Like Structures from Integration-Free Human Urine Induced Pluripotent Stem Cells." Cell Regen (Lond) 2, no. 1 (2013): 6.

117. Chen, J. K., L. Guo, L. Zhang, H. Y. Wu, J. Q. Yang, H. Liu, X. S. Wang, X. Hu, T. P. Gu, Z. W. Zhou, J. Liu, J. D. Liu, H. L. Wu, S. Q. Mao, K. L. Mo, Y. Y. Li, K. Y. Lai, J. Qi, H. J. Yao, G. J. Pan, G. L. Xu, and D. Q. Pei. "Vitamin C Modulates Tet1 Function During Somatic Cell Reprogramming." Nature Genetics 45, no. 12 (2013): 1504-U140.

118. Chen, Y. L., L. Guo, J. K. Chen, X. J. Zhao, W. C. Zhou, C. Zhang, J. C. Wang, L. Jin, D. Q. Pei, and F. Zhang. "Genome-Wide Cnv Analysis in Mouse Induced Pluripotent Stem Cells Reveals Dosage Effect of Pluripotent Factors on Genome Integrity." Bmc Genomics 15,  (2014).

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120. Huang, K., P. F. Liu, X. Li, S. B. Chen, L. H. Wang, L. Qin, Z. H. Su, W. H. Huang, J. L. Liu, B. Jia, J. Liu, J. L. Cai, D. Q. Pei, and G. J. Pan. "Neural Progenitor Cells from Human Induced Pluripotent Stem Cells Generated Less Autogenous Immune Response." Science China-Life Sciences 57, no. 2 (2014): 162-170.

121. Zheng, H., A. P. Hutchins, G. J. Pan, Y. X. Li, D. Q. Pei, and G. Pei. "Where Cell Fate Conversions Meet Chinese Philosophy." Cell Research 24, no. 10 (2014): 1162-1163.

122. Yasong Wu, Yuan Li, Hui Zhang, Yinghua Huang, Ping Zhao, Yujia Tang, Xiaohui Qiu, Yue Ying, Wen Li, Su Ni, Meng Zhang, Longqi Liu, Yan Xu, Qiang Zhuang, Zhiwei Luo, Christina Benda, Hong Song, Baohua Liu, Liangxue Lai, Xingguo Liu, Hung-Fat Tse, Xichen Bao, Wai-Yee Chan, Miguel A. Esteban, Baoming Qin & Duanqing Pei;Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming Nature Cell Biology Volume:17,Pages:715–725 Year published:(2015) DOI:doi:10.1038/ncb3172

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姚冬  硕士研究生  071010-生物化学与分子生物学  

韩庆凯  硕士研究生  071009-细胞生物学  

黄晨  硕士研究生  071010-生物化学与分子生物学  

李华鹏  博士研究生  071009-细胞生物学  

秦宝明  博士研究生  071009-细胞生物学  

张进  博士研究生  071009-细胞生物学  

梁佳良  硕士研究生  071009-细胞生物学  

李荣辉  硕士研究生  071009-细胞生物学  

张澎涛  博士研究生  070303-有机化学  

李文华  博士研究生  070303-有机化学  


张雷雷  博士研究生  071009-细胞生物学  

谢海军  博士研究生  071010-生物化学与分子生物学  

张仕强  博士研究生  071009-细胞生物学  

殷文广  博士研究生  071009-细胞生物学  

倪甦  博士研究生  071009-细胞生物学  

陈捷凯  博士研究生  071010-生物化学与分子生物学  

赵平  硕士研究生  071010-生物化学与分子生物学  

吴亚松  硕士研究生  071010-生物化学与分子生物学  

郭琳  硕士研究生  071010-生物化学与分子生物学  

王丽辉  博士研究生  071010-生物化学与分子生物学  

刘晶  博士研究生  071010-生物化学与分子生物学  

陈可实  博士研究生  071010-生物化学与分子生物学