General
Dr. & Prof. Peibiao Zhang(章培标)
 
Changchun Institute of Applied Chemistry
Chinese Academy of Sciences

Address: 5625 Renmin Street, Changchun, China
Postcode: 130022

Email: zhangpb@ciac.ac.cn
Tel: +86-431-85262058, +86-431-85262390
Fax: +86-431-85262058

CIAC website: http://yjsb.ciac.jl.cn/daoshi_read.php?brow=407&lb=

Research Areas

Materials for regenerative medicine,including:
Biopolymer;
Biocomposites;
Tissue/organ scaffolds;
Electric biological signals;
Stem cell and tissue engineering

Education

2003.6 Ph. D. Jilin University.
1999.6 M.Med Norman Bethune Medical University (Jilin University).
1993.6 Norman Bethune Medical University(Jilin University).

Honors & Distinctions

2007   First Prize of Jilin Provincial science and Technology Progress Award, China
2011   First Prize of Jilin Provincial science and Technology Progress Award, China
Apr., 2010- present, Gest Professor, RIKEN, Japan.

Publications

   
Papers
1. Haitao Cui , Yadong Liu, Mingxiao Deng, Xuan Pang, Peibiao Zhang, Xianhong Wang, Xuesi Chen, and Yen Wei. Synthesis of Biodegradable and Electroactive Tetraaniline Grafted Poly(ester amide) Copolymers for Bone Tissue Engineering. Biomacromolecules, 2012, 13 (9), pp 2881–2889
2. Xiaodong Wu, Xiaofeng Song, Dongsong Li, Jianguo Liu , Peibiao Zhang*, Xuesi Chen. Preparation of Mesoporous Nano-Hydroxyapatite Using a Surfactant Template Method for Protein Delivery. Journal of Bionic Engineering 2012; 9(2): 224–233
3. Yadong Liu; Jun Hu; Xiuli Zhuang; Peibiao Zhang; Yen Wei; Xianhong Wang; Xuesi Chen. Synthesis and characterization of novel biodegradable and electroactive hydrogel based on aniline oligomer and gelatin. Macromol Biosci 2012, 12(2): 241-250
4. Peibiao Zhang, Haitao Wu, Han Wu, Zhongwen Lu?, Chao Deng, Zhongkui Hong, Xiabin Jing, Xuesi Chen. RGD-conjugated copolymer incorporated into composite of poly(lactide-co-glycotide) and poly(l-lactide)-grafted nanohydroxyapatite for bone tissue engineering. Biomacromolecules 2011, 12 (7): 2667–2680
5. Yang Xu, Duo Zhang, Zong-liang Wang, Zhan-tuan Gao, Pei-biao Zhang* and Xue-si Chen. Preparation of Porous Nanocomposite Scaffolds with Honeycomb Monolith Structure by One Phase Solution Freeze-Drying Method. Chinese Journal of Polymer Science 2011; 29(2):215-224
6. Yadong Liu; Jun Hu; Xiuli Zhuang; Peibiao Zhang; Xuesi Chen; Yen Wei; Xianhong Wang. Preparation and Characterization of Biodegradable and Electroactive Polymer Blend Materials Based on mPEG/Tetraaniline and PLLA. MACROMOLECULAR BIOSCIENCE 2011; 11( 6): 806-813
7. Yang Xu, Duo Zhang**,Zong-liang Wang, Zhan-tuan Gao, Pei-biao Zhang* and Xue-si Chen. Preparation of Porous Nanocomposite Scaffolds with Honeycomb Monolith Structure by One Phase Solution Freeze-Drying Method. Chinese Journal of Polymer Science Vol. 29, No. 2, (2011), 1−10
8. Peibiao Zhang, Zhongkui Hong, Ting Yu, Xuesi Chen, Xiabin Jing. In vivo mineralization and osteogenesis of nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with poly(l-lactide). Biomaterials, 2009,30: 58–70
9. Yang Cui, Yi Liu, Yi Cui, Xiabin Jing, Peibiao Zhang*, Xuesi Chen.The Nano-Composite Scaffold of Poly (lactide-co-glycolide) and Hydroxyapatite Surface-Grafted with L-lactic Acid Oligomer for Bone Repair. Acta Biomaterialia, 2009, 5:2680-2692
10. Lu Tiancheng; Sun Jing; Chen Xuexi; Zhang Peibiao; Jing Xiabin. Folate-conjugated micelles and their folate-receptor-mediated endocytosis. Macromolecular bioscience 2009; 9(11):1059-68.
11. Junchao Wei, Aixue Liu, Lei Chen, Peibiao Zhang, Xuesi Chen, Xiabin Jing. The Surface Modification of Hydroxyapatite Nanoparticles by the Ring Opening Polymerization of gamma-Benzyl-L-glutamate N-carboxyanhydride. Macromol Biosci. 2009;9(7):631-8.
12. Jun Hu, Lihong Huang, Xiuli Zhuang, Peibiao Zhang, Le Lang, Xuesi Chen, Yen Wei, Xiabin Jing. Electroactive Aniline Pentamer Cross-Linking Chitosan for Stimulation Growth of Electrically Sensitive Cells. Biomacromolecules, 2008; 9(10):2637-44.
13. Tiancheng Lu, Xuesi Chen, Q uan Shi, Yu Wang, Peibiao Zhang, Xiabin Jing. The immobilization of proteins on biodegradable fibers via biotin–streptavidin bridges. Acta Biomaterialia, 2008;4(6):1770-7.
14. Lihong Huang, Xiuli Zhuang, Jun Hu, Le Lang, Peibiao Zhang, Yu Wang, Xuesi Chen*, YenWei*, and Xiabin Jing. Synthesis of Biodegradable and Electroactive Multiblock Polylactide and Aniline Pentamer Copolymer for Tissue Engineering Applications. Biomacromolecules, 2008, 9(3): 850-858.
15. Haijun Yu, Xuesi Chen , Tiancheng Lu, Jing Sun, Huayu Tian, Jun Hu, Yu Wang, Peibiao Zhang , Xiabin Jing. Poly(l-lysine)-Graft-Chitosan Copolymers: Synthesis, Characterization, and Gene Transfection Effect. Biomacromolecules, 2007, 8(5): 1425-1435.
16. Zhongkui Hong, Peibiao Zhang, Aixue Liu, Li Chen, Xuesi Chen, Xiabin Jing. Composites of poly(lactide-co-glycolide) and the surface modified carbonated hydroxyapatite nanoparticles . Journal of Biomedical Materials Research Part A, 2007, 81(3) : 515-522
17. Lihong Huang, Jun Hu, Le Lang, Xin Wang, Peibiao Zhang, Xiabin Jing, Xianhong Wang, Xuesi Chen, Peter I. Lelkes, Alan G. MacDiarmid, et al. Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer. Biomaterials, 2007, 28(10):1741-1751.
18. Haijun Yu, Xiaoyi Xu, Xuesi Chen, Tiancheng Lu, Peibiao Zhang, Xiabin Jing. Preparation and antibacterial effects of PVA-PVP hydrogels containing silver nanoparticles. Journal of Applied Polymer Science,2007, 103(1): 125-133
19. Huayu Tian, Xuesi Chen, Hao Lin, Chao Deng, Peibiao Zhang, Yen Wei, Xiabin Jing. Micellization and Reversible pH-Sensitive Phase Transfer of the Hyperbranched Multiarm PEI-PBLG Copolymer. Chemistry - A European Journal, 2006, 12(16): 4305-4312
20. YuanLin, Luling Wang, Peibiao Zhang, Xin Wang, Xuesi Chen, Xiabin Jing, Zhaohui Su. Surface modification of poly(L-lacticacid) to improve its cytocompatibility via assembly of polyelectrolytes and gelatin. Acta Biomaterialia, 2006, 2(2):155-164
21. Chao Deng, Huayu Tian, Peibiao Zhang, Jing Sun, Xuesi Chen, and Xiabin Jing. Synthesis and Characterization of RGD Peptide Grafted Poly(ethylene glycol)-b-Poly(L-lactide)-b-Poly(L-glutamic acid) Triblock Copolymer. Biomacromolecules, 2006, 7(2): 590-596

Research Interests

1. Biodegradable nanocomposites for bone tissue enngineering.
  Hydroxyapatite (HA) is the prospective one of inorganic biomaterials for bone regeneration, but the brittleness and fatigue failure in the body limit their clinical applications only for unloading bearing repair and substitute. The nanocomposite of PLGA and HAP showed some attractive properties, including good biocompatibility, improved mechanical properties and protein adsorption capacity, and adequate biodegradability at a controlled rate commensurate with remodeling. To solve the interface compatibility between the nanoparticles and the polymer matrix, the nano-HA particles surface-grafted with poly(L-lactide) (PLLA) (g-HAP) were synthesized and the nano-composites of g-HAP/PLLA (or g-HAP/PLGA) showed a wide potential application for bone fixation materials due to their improved interface compatibility, mechanical properties and good biocompatibility. The various 3-D scaffolds of fiber and porous foams of g-HAP/PLGA were fabricated with electrospinning, melted spinning, porogen leaching and gas foam, respectively. The possible applications of the composites for bone replacement material and tissue engineering scaffold have also been examined. 

2. Intelligent conducting copolymer for bimedical application.
  Electrically conductive polymers have been discovered and explored for increasing applications in many areas of applied chemistry and physics for many years. More recently, there is a growing interest in electrically conductive polymers for various biomedical applications, including medicine delivery, biosensor and tissue engineering. Conductive polymers exhibit quite good effectiveness in improving many cell functions, such as cell attachment, proliferation, migration, and differentiation through electrical stimulation. Meanwhile, electrical stimulation has been widely and effectively applied to the therapy of bone nonunion in clinic. The combination of conducting polymer and electrical stimulation is expected to develop a new technique for repairing large bone defects. However, toxicity and undegradability of conductive polymers are critical limitation in application of bone tissue engineering. A novel biodegradable conducting polymer, PLA-b-AP-b-PLA (PAP) triblock copolymer of PLA and aniline pentamer (AP) with electroactivity and biodegradability, was synthesized in our group. Meanwhile, the nanocomposite of the triblock copolymer and hydroxyapatite was prepared and investigated for the application in bone repair.

Conferences

(1) 分会报告:高分子纳米复合人工骨材料的仿生制备与医学应用,北京:第一届中国国际复合材料科技大会(CCCM-1),2013-09,章培标*,王宇,王宗良,崔立国,唐宇锋,陈学思
(2) 分会报告:骨组织工程支架材料及制品的开发与医学应用,西安:2013第六届全国组织工程与再生医学大会,2013-04,章培标*,王宇,王宗良,崔立国,唐宇锋,陈学思
(3) 口头报告:可吸收医用高分子材料与组织工程,医学组织工程高峰论坛,2012-11,章培标
(4) Oral presentation: Biodegradable synthetic nanocomposites for bone regeneration,Kyungpook National University: Recent Trend of Nanobiotechnology for Tissue Engineering,2012-09,Peibiao Zhang
(5) Oral presentation: Biodegradable synthetic nanocomposite for bone regeneration,Daegu, Korea: 15 International Biotechnology Symposium and Exhibition 2012 (IBS 2012) ,2012-09,Peibiao Zhang
(6) Oral presentation: Insight into tissue engineering: an effort on biomimic design and fabrication of synthetic polymer scaffolds for guiding tissue regeneration,Tianjing: China and Finland Workshop on Biomanufacturing and Evaluation Techniques (CFWBET-2011 ),2011-04,Peibiao Zhang, Han Wu, Zhongwen Lv, Zongliang Wang and Xuesi Chen
(7) 口头报告:智能型可生物降解电活性高分子纳米复合材料,成都:全国生物材料大会(CCBM 2010),2010-04,章培标1*,于婷1,2,刘娅2,邬海涛1,2,焦自学1,危岩3,陈学思
(8) Oral presentation: Intelligent biodegradable nanocomposite of hydroxyapatite and conducting copolymer for biomedical application,San franscisco : The 239th ACS National Meeting and Exposition,2010-03,Peibiao Zhang1**, Ting Yu1,2, Ya Liu2, Zhixue Jiao1,Zheng Xiang1, Xiabin Jing1, Yen Wei3, Xuesi Chen


Students

现指导学生

王宗良  博士研究生  070305-高分子化学与物理  

李晓媛  博士研究生  070305-高分子化学与物理  

闫欢欢  硕士研究生  085216-化学工程  

李林龙  博士研究生  081704-应用化学  

Experience

   
Work Experience
Dec. 2012 - present : Professor, Changchun Institute of Applied Chemistry, Chinese Academy of Science
Apr., 2010-Oct., 2010, Visiting researcher, RIKEN, Japan.
Feb. 2006 - Nov. 2012: Associate Professor, Changchun Institute of Applied Chemistry, Chinese Academy of Science. 
Sep. 2003-Dec.2005: Postdoc, Changchun Institute of Applied Chemistry, Chinese Academy of Science.

Funding

1.The National High Technology Research and Development Program of China(863 Program): No.2007AA03Z320
2.The National Natural Science Foundation of China : Grant No.50673090,50973109,51273195

Professional Activities

Societies
Committee of Biological Composite Materials, Chinese Society for Composite Materials

Editorials
Editorial Board of Chinese Journal of Injury Repair and Wound Healing