Hong Pan, Man, Docoral Supervisor, PhD/Associate Professor


Address:1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, P.R. China.

Postcode: 518055

Research Areas

Cell immunotherapy;  Nanomedicine; Click Chemistry; Virus infection and tracking.


2015/09 - 2018/12, University of Chinese Academy of Sciences, Biochemistry and Molecular Biology, PhD

2008/09 - 2011/07, Sun Yat-sen University, School of Life Science, Biotechnology, Master

2004/09 - 2008/07, Hunan University of Science and Technology, Biological Engineering, Bachelor


Work Experience

2011.06 - Present, Research Assistant / Assistant Professor / Associate Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences



(1)   Hong Pan, Mingbin Zheng, Aiqing Ma, Lanlan Liu, Lintao Cai*, Cell/bacteria-based bioactive materials for cancer immune modulation and precision therapy, Adv. Mater., 2021, 25, 2100241

(2)   Ze Chen, Hong Pan*, Yingmei Luo, Ting Yin, Baozhen Zhang, Jianhong Liao, Mengmeng Wang, Xiaofan Tang, Guojun Huang, Guanjun Deng, Mingbin Zheng,* Lintao Cai*, Nanoengineered CAR-T Biohybrids for Solid Tumor Immunotherapy with Microenvironment Photothermal-Remodeling StrategySmall, 2021, 17, 2007494 (*: Corresponding authors) 

(3)   Hong Pan, WenJun Li, Ze Chen, Yingmei Luo, Wei He, Mengmeng Wang, Xiaofan Tang , Huamei He, Lanlan Liu, Mingbin Zheng, Xin Jiang, Ting Yin, Ruijing Liang, Yifan Ma* and Lintao Cai*, Click CAR-T Cell Engineering for Robustly Boosting Cell Immunotherapy in Blood and Subcutaneous Xenograft Tumor, Bioactive Materials, 2021, 6, 951-962 

(4)   Hong Pan, Ping Li, Guifei Li, Wenjun Li, Huamei He, Ze Chen, Fangfang Wang, Lanlan Liu, Yifeng Gong, Yifan Ma*, Lintao Cai*, Yan Jin*, Glycometabolic Bioorthogonal Chemistry-Guided Viral Transduction for Robust Human T Cell EngineeringAdv. Funct. Mater., 2019, 29, 1807528

(5)   Yutong Han #Hong Pan #, Wenjun Li, Ze Chen, Aiqing Ma, Ruijing Liang, Ting Ying, Fuming Chen, Yifan Ma, Yan Jin, Mingbin Zheng*, Baohong Li*, Lintao Cai*, T Cell Membrane Mimicking Nanoparticles with Bioorthogonal Targeting and Immune Recognition for Enhanced Photothermal Therapy. Adv. Sci., 2019, 6, 1900251. (#: Co-first authors) 

(6)   Wenjun Li #Hong Pan#, Huamei He, Xiaoqing Meng, Qian Ren, Ping Gong, Xing Jiang, Zhengguo Liang, Lanlan Liu, Ximing Shao, Yifan Ma*, Lintao Cai*, Bioorthogonal T Cell Targeting Strategy for Robustly Enhancing Cytotoxicity against Tumor Cells, Small, 2019, 15, 1804383. (#: Co-first authors)

(7)   Fangfang Wang, Hong Pan*, Xiangjie Yao, Huamei He, Lanlan Liu, Yingmei Luo, Haimei Zhou, Mingbin Zheng, Renli Zhang, Yifan Ma*, Lintao Cai*, Bioorthogonal  metabolic labeling utilizing protein biosynthesis for dynamic visualization of non-enveloped enterovirus 71 infection, ACS Appl. Mater. Interfaces, 2020, 12, 3363-3370. (*: Corresponding authors) 

(8)   Hong Pan, Xiangjie Yao, Weihua Chen, Fangfang Wang, Huamei He, Lanlan Liu, Yaqing He, Jinquan Chen, Puzi Jiang, Renli Zhang*, Yifan Ma*, Lintao Cai*, Dissecting complicated viral spreading of enterovirus 71 using in situ bioorthogonal fluorescent labeling., Biomaterials, 2018, 181, 199-209. 

(9)   Hong Pan, Wenjun Li, Xiangjie Yao, Yayun Wu, Lanlan Liu, Huamei He, Renli Zhang, Yifan Ma*, Lintao Cai*In situ bioorthogonal metabolic labeling for fluorescence imaging of virus infection in vivo., Small, 2017, 13, 201604036. 

(10) Hong Pan, Pengfei Zhang, Duyang Gao, Yijuan Zhang, Ping Li, Lanlan Liu, Ce Wang, Hanzhong Wang, Yifan Ma*, Lintao Cai*, Noninvasive visualization of respiratory viral infection using bioorthogonal conjugated near-infrared-emitting quantum dots, ACS Nano, 2014, 86:5468-5477.

(11) Hong Pan, Yijuan Zhang, Zichao Luo, Ping Li, Lanlan Liu, Ce Wang, Hanzhong Wang, Hongchang Li, Yifan Ma*, Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-kappaB and p38 MAPK signaling pathways.Am. J. Physiol. Lung Cell Mol. Physiol., 2014, 3062:L183-L195.  AJP Featured Article

(12) Yijuan Zhang #, Ping Li #Hong Pan #, Lanlan Liu, Manyi Ji, Nan Sheng, Ce Wang, Lintao Cai, Yifan Ma*, Retinal-conjugated pH-sensitive micelles induce tumor senescence for boosting breast cancer chemotherapy., Biomaterials, 2016, 83:219-232. (#: Co-first authors) 

(13) Yijuan Zhang #Hong Pan, Pengfei Zhang, Ningning Gao, Yi Lin, Zichao Luo, Ping Li, Ce Wang, Lanlan Liu, Daiwen Pang, Lintao Cai, Yifan Ma*, Functionalized quantum dots induce proinflammatory responses in vitro: the role of terminal functional group-associated endocytic pathways.Nanoscale, 2013, 513:5919-5929. 

(14)  Hong Pan, Lanlan Liu, Lintao Cai*, Polypeptide Cationic Micelles Mediated Co-delivery of Docetaxel and siRNA for Synergistic Tumor Therapy. Biomaterial Engineering. Gene Delivery (Book)Chapter 18-1, Springer Nature, 2021.


​1. Lintao Cai, Hong Pan, Yifan Ma, Wenjun Li, Yingmei Luo, Fangfang Wang, Preparation and Application of Human-targeted CAR T cells, 2019-05-29, China, ZL201910456437.9

2. Lintao Cai, Hong Pan, Yifan Ma, Pengfei Zhang, Wenjun Li, A Fluorescent labeling method for organisms with cell membrane structure, 2013-12-31, China, CN201310754554.6

3. Lintao Cai, Hong Pan, Mingbin Zheng, Yutong Han, Wenjun Li, Ze Chen, Yingmei Luo, Preparation and Application of Bionic Membrane Biomimetic Nanoparticles with orthogonal targeting, 2019-05-15, China, CN201910400977.5

4. Lintao Cai, Yifan Ma, Hong Pan, Ping Li, Yan Jin, Wenjun Li, A Novel synergistic agent for viral transfection and its Application in Viral transfection based on click chemistry, WIPO 2020-04-17, PCT/CN2017/0938

5. Lintao Cai, Fangfang Wang, Hong Pan, Yifan Ma, Huamei He, Metabolic Modification and in situ Biologic Orthogonal Labeling of Non-enveloped virus and its application, 2019-03-21, China, CN201910217713

6. Lintao Cai, Wenjun Li, Hong Pan, Yifan Ma, Ping Gong, Methods and Applications of Promoting biological interaction, 2018-11-29, China, ZL201811450846

7. Lintao Cai, Wenjun Li, Xiaoqing Meng, Hong Pan, Ping Gong, Monosaccharide analogs and their molecular probes and their applications, 2019-09-22, China, ZL201811446431.5

8. Lintao Cai, Hong Liu, Zhengyin Pan, Pengfei Zhang, Wenjun Li, Hong Pan, Yifan Ma, Method and Application of in situ Cell labeling, 2016-6-29, China, ZL201410154914.3

9. Lintao Cai, Huamei He, Lanlan Liu, Ruijing Liang, Haimei Zhou, Hong Pan, A Novel method to Overcome drug resistance of tumor, 2021-08-17, China, ZL201911190133.9

10. Lintao Cai, Huamei He, Lanlan Liu, Ruijing Liang, Haimei Zhou, Hong Pan, A Novel method to Improve tumor hypoxia, WIPO, 2017-11-17, PCT/CN2020/129541

Research Interests

Research interests include nanomedicine, tumor immunity, Cell immunotherapy, and virus infection etc.


1. ChinaNanomedicine 2018. The 3rd International Conference on Nanomedicine, October 15 -17, 2018, Shanghai, China;

2. The 32nd Annual Conference of the Chinese Chemical Society, April 19-22, 2021, Zhuhai, China



胡雨微  硕士研究生  085600-材料与化工  

亢天放  硕士研究生  085600-材料与化工  

Honors & Distinctions

He has presided over a number of scientific research projects such as the National Natural Science Foundation of China81971749,81601552, Guangdong Provincial Natural Science Foundation, the Shenzhen Science and Technology ProgramJCYJ20210324101807020,JCYJ20170818163739458,JCYJ20170306160217433and the Excellent Youth Innovation Fund of SIAT(Y5G004). Moreover, he has also won the second prize of Guangdong Province Science and Technology Award in 2016, and the first class prize of the Shenzhen Natural Science Award for 2020.