微生物天然药物基因组发掘，生物合成机制解析，合成生物学。

   

100705-微生物与生化药学
071010-生物化学与分子生物学

微生物天然药物发现、生物合成与合成生物学

2008-09--2014-01   中国科学院大学   博士
2004-09--2008-07   中国矿业大学（北京）   学士

研究生

博士

   

2022-01~现在, 中国科学院微生物研究所, 研究员
2019-08~2022-01,中国科学院微生物研究所, 项目研究员
2014-02~2019-08,美国斯克里普斯研究所, 博士后

2022-09-01-今,Frontiers in Microbiology, Review editor
2021-10-01-今,微生物学通报, 编委
2021-04-01-今,Chinese Journal of Natural Medicines, 青年编委
2016-05-16-今,Frontiers in Bioengineering and Biotechnology, Review Editor

天然产物药物的生物合成及生物催化

   

（ 1 ） C8 位多糖基修饰的四环素类化合物及其生物合成方法与应用, 发明专利, 2026, 第 1 作者, 专利号: 2026103804430

（ 2 ） 用于生产去甲四环素的重组质粒、重组菌及其构建方法与应用, 发明专利, 2025, 第 1 作者, 专利号: 202511239623.9

（ 3 ） JadG蛋白在催化角蒽环芳香聚酮氧化开环和氨基酸插入反应中的应用, 发明专利, 2013, 第 3 作者, 专利号: CN103233047A

   

（1） Functional Conservation and Divergence of AlpJ-Family Oxygenases Catalyzing C-C Bond Cleavage in Atypical Angucycline Biosynthesis, ACS CHEMICAL BIOLOGY, 2025, 第 11 作者  通讯作者
（2） Discovery of Tricyclic Aromatic Polyketides Reveals Hidden Chain-Length Flexibility in Type II Polyketide Synthases, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 第 13 作者  通讯作者
（3） Uncovering the Molecular Landscape of Tetracycline Family Natural Products through Bacterial Genome Mining, Journal of the American Chemical Society, 2025, 第 18 作者  通讯作者
（4） 龟裂霉素新产生菌株的鉴定及其产量优化, Identification and yield improvement of a new rimocidin-producing strain, 微生物学通报, 2024, 第 8 作者
（5） 拟无枝酸菌属次级代谢潜能分析及代表菌株基因编辑体系建立, Secondary metabolic potential of Amycolatopsis and development of gene editing systems for representative strains, 微生物学通报, 2024, 第 7 作者
（6） 莫西霉素高产菌株的构建, Construction of high-producing strains of kirromycin, 微生物学通报, 2024, 第 7 作者
（7） A Simple and Effective Strategy for the Development of Robust Promoter-Centric Gene Expression Tools, ACS SYNTHETIC BIOLOGY, 2024, 第 6 作者  通讯作者
（8） 糖丝菌属次级代谢潜能分析及代表菌株基因编辑体系建立, Secondary metabolism potential of Saccharothrix and establishment of gene editing systems in representative strains, 微生物学通报, 2024, 第 4 作者
（9） 喷他霉素新生产菌的发现及产量提高, Discovery and production improvement of new pentamycin-producing bacteria, 微生物学通报, 2024, 第 10 作者
（10） Development of a xylose-inducible and glucose-insensitive expression system for Parageobacillus thermoglucosidasius, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2024, 第 6 作者
（11） An Isopentenol Utilization Pathway-Based "Deuterium-Scanning" Method for Mechanistic Investigations of Terpene Cyclases, ACS CATALYSIS, 2024, 第 9 作者
（12） Confirmation of the stereochemistry of spiroviolene, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2024, 第 8 作者
（13） Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis, Beilstein Journal of Organic Chemistry, 2024, 第 10 作者  通讯作者
（14） Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis, Biochemistry, 2024, 第 3 作者
（15） Tetracycline family natural products: discovery, biosynthesis and engineering, Chinese Journal of Natural Medicines, 2022, 第 4 作者  通讯作者
（16） Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585, FRONTIERS IN MICROBIOLOGY, 2022, 第 6 作者
（17） (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine., mLife, 2022, 第 7 作者  通讯作者
（18） Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius, ACS SYNTHETIC BIOLOGY, 2022, 第 9 作者
（19） The Richness and Diversity of Catalases in Bacteria, FRONTIERS IN MICROBIOLOGY, 2021, 第 8 作者  通讯作者
（20） 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物, Bioinformatics-directed discovery of dehydrated linear trimer and dimer of 2,3-dihydroxybenzoyl-L-serine from Streptomyces albofaciens JCM 4342, 微生物学通报, 2021, 第 7 作者
（21） Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase, NATURE COMMUNICATIONS, 2021, 第 4 作者
（22） 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2，3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物（英文）, Bioinformatics-directed discovery of dehydrated linear trimer and dimer of 2,3-dihydroxybenzoyl-L-serine from Streptomyces albofaciens JCM 4342, 微生物学通报, 2021, 第 7 作者
（23） A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters, ACS CHEMICAL BIOLOGY, 2020, 第 9 作者  通讯作者
（24） Targeting Bacterial Genomes for Natural Product Discovery, TRENDS IN PHARMACOLOGICAL SCIENCES, 2020, 第 2 作者
（25） The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research, NATURAL PRODUCT REPORTS, 2019, 第 47 作者
（26） P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities, BIOCHEMISTRY, 2018, 第 3 作者
（27） Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 2 作者
（28） Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2017, 第 2 作者
（29） Discovery of the leinamycin family of natural products by mining actinobacterial genomes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 1 作者
（30） Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis, ACS CHEMICAL BIOLOGY, 2017, 第 1 作者
（31） New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp CB01883, JOURNAL OF ANTIBIOTICS, 2017, 第 2 作者
（32） Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 第 3 作者
（33） Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 第 4 作者
（34） Characterization of the Ketosynthase and Acyl CarrierProtein Domains at the LnmI Nonribosomal Peptide Synthetase–PolyketideSynthase Interface for Leinamycin Biosynthesis, ORGANIC LETTERS, 2016, 第 3 作者
（35） Minimum Information about a Biosynthetic Gene cluster, NATURE CHEMICAL BIOLOGY, 2015, 第 39 作者
（36） Kinamycin biosynthesis employs a conserved pair of oxidases for b-ring contraction, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者
（37） Improvement of Wuyiencin Biosynthesis in Streptomyces wuyiensis CK-15 by Identification of a Key Regulator, WysR, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 第 4 作者
（38） Angucyclines as signals modulate the behaviors of Streptomyces coelicolor, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 6 作者
（39） 放线菌天然产物糖基化改造研究进展, Engineering the glycosylation pattern of natural products in actinobacteria, 微生物学通报, 2013, 第 2 作者
（40） JadR*-mediated feed-forward regulation of cofactor supply in jadomycin biosynthesis, MOLECULAR MICROBIOLOGY, 2013, 第 2 作者
（41） Identification of JadG as the B Ring Opening Oxygenase Catalyzing the Oxidative C-C Bond Cleavage Reaction in Jadomycin Biosynthesis, CHEMISTRY & BIOLOGY, 2012, 第 2 作者
（42） A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in iso-Migrastatin Biosynthesis, ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH), 第 4 作者

（1） 中国合成科学2035发展战略, 科学出版社, 2023-05, 第 其他 作者
（2） “Hybrid Peptide-Polyketide Natural Product Biosynthesis” in Comprehensive Natural Products: Chemistry and Biology, Elsevier, 2019-11, 第 3 作者