基本信息
潘国辉  男  博导  中国科学院微生物研究所
电子邮件: panguohui@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究领域

微生物天然药物基因组发掘,生物合成机制解析,合成生物学。

招生信息

   
招生专业
100705-微生物与生化药学
071010-生物化学与分子生物学
招生方向
微生物天然药物发现、生物合成与合成生物学

教育背景

2008-09--2014-01   中国科学院大学   博士
2004-09--2008-07   中国矿业大学(北京)   学士
学历
研究生

学位
博士

工作经历

   
工作简历
2022-01~现在, 中国科学院微生物研究所, 研究员
2019-08~2022-01,中国科学院微生物研究所, 项目研究员
2014-02~2019-08,美国斯克里普斯研究所, 博士后
社会兼职
2022-09-01-今,Frontiers in Microbiology, Review editor
2021-10-01-今,微生物学通报, 编委
2021-04-01-今,Chinese Journal of Natural Medicines, 青年编委
2016-05-16-今,Frontiers in Bioengineering and Biotechnology, Review Editor

教授课程

天然产物药物的生物合成及生物催化

专利与奖励

   
专利成果
( 1 ) JadG蛋白在催化角蒽环芳香聚酮氧化开环和氨基酸插入反应中的应用, 发明专利, 2013, 第 3 作者, 专利号: CN103233047A

出版信息

   
发表论文
[1] Yao Kong, Yuanning Liu, Kaibiao Wang, Tao Wang, Chen Wang, Ben Ai, Hongli Jia, Guohui Pan, Min Yin, Zhengren Xu. Confirmation of the stereochemistry of spiroviolene. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY[J]. 2024, 第 8 作者20(1): 852-858, https://doaj.org/article/5e54e6614cfc4d359cfdee7eba043145.
[2] Jinmin Gao, Liyuan Li, Shijie Shen, Guomin Ai, Bin Wang, Fang Guo, Tongjian Yang, Hui Han, Zhengren Xu, Guohui Pan, Keqiang Fan. Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis. Beilstein Journal of Organic Chemistry[J]. 2024, 第 10 作者  通讯作者  20: 1198-1206, https://www.beilstein-journals.org/bjoc/articles/20/102.
[3] Andrew D Steele, Hui Jiang, Guohui Pan, Si-Kyu Lim, Edward Kalkreuter, Jianhua Ju, Thomas Kwong, Scott Rajski, Ben Shen. Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis. Biochemistry[J]. 2024, 第 3 作者63(4): 563-575, https://pubs.acs.org/doi/10.1021/acs.biochem.3c00672.
[4] Haiyan Wang, Lijun Wang, Keqiang Fan, Guohui Pan. Tetracycline family natural products: discovery, biosynthesis and engineering. Chinese Journal of Natural Medicines[J]. 2022, 第 4 作者  通讯作者  20(10): 773-794, 
[5] Zhang, Chaobo, Zhao, Youbao, Li, Zilong, Wang, Weishan, Huang, Ying, Pan, Guohui, Fan, Keqiang. Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585. FRONTIERS IN MICROBIOLOGY[J]. 2022, 第 6 作者13: http://dx.doi.org/10.3389/fmicb.2022.1078293.
[6] 张志龙, 李鹏伟, 王敏, 张雁, 吴边, 陶勇, 潘国辉, 陈义华. (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine.. mLife[J]. 2022, 第 7 作者  通讯作者  
[7] Wang, Junyang, Li, Zilong, Wang, Weishan, Pang, Shen, Yao, Yongpeng, Yuan, Fang, Wang, Huizhuan, Xu, Zhen, Pan, Guohui, Liu, Zihe, Chen, Yihua, Fan, Keqiang. Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius. ACS SYNTHETIC BIOLOGY[J]. 2022, 第 9 作者11(6): 2163-2174, http://dx.doi.org/10.1021/acssynbio.2c00087.
[8] Yuan, Fang, Yin, Shouliang, Xu, Yang, Xiang, Lijun, Wang, Haiyan, Li, Zilong, Fan, Keqiang, Pan, Guohui. The Richness and Diversity of Catalases in Bacteria. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 8 作者  通讯作者  12: https://www.webofscience.com/wos/woscc/full-record/WOS:000635791400001.
[9] 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉. 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2,3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物. 微生物学通报[J]. 2021, 第 7 作者48(7): 2307-2317, http://lib.cqvip.com/Qikan/Article/Detail?id=7105380929.
[10] Meng, Song, Steele, Andrew D, Yan, Wei, Pan, Guohui, Kalkreuter, Edward, Liu, YuChen, Xu, Zhengren, Shen, Ben. Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase. NATURE COMMUNICATIONS[J]. 2021, 第 4 作者12(1): http://dx.doi.org/10.1038/s41467-021-25798-8.
[11] 王立军, 范可强, 王海燕, 胡会涛, 向丽军, 艾国民, 潘国辉. 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2,3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物(英文). 微生物学通报[J]. 2021, 第 7 作者48(7): 2307-2317, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21072307?st=article_issue.
[12] Zhang, Qian, Ren, JinWei, Wang, Weishan, Zhai, Jian, Yang, Jing, Liu, Ning, Huang, Ying, Chen, Yihua, Pan, Guohui, Fan, Keqiang. A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters. ACS CHEMICAL BIOLOGY[J]. 2020, 第 9 作者  通讯作者  15(9): 2551-2557, https://www.webofscience.com/wos/woscc/full-record/WOS:000574920900024.
[13] Kalkreuter, Edward, Pan, Guohui, Cepeda, Alexis J, Shen, Ben. Targeting Bacterial Genomes for Natural Product Discovery. TRENDS IN PHARMACOLOGICAL SCIENCES. 2020, 第 2 作者41(1): 13-26, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938545/.
[14] McAlpine, James B, Chen, ShaoNong, Kutateladze, Andrei, MacMillan, John B, Appendino, Giovanni, Barison, Andersson, Beniddir, Mehdi A, Biavatti, Maique W, Bluml, Stefan, Boufridi, Asmaa, Butler, Mark S, Capon, Robert J, Choi, Young H, Coppage, David, Crews, Phillip, Crimmins, Michael T, Csete, Marie, Dewapriya, Pradeep, Egan, Joseph M, Garson, Mary J, GentaJouve, Gregory, Gerwick, William H, Gross, Harald, Harper, Mary Kay, Hermanto, Precilia, Hook, James M, Hunter, Luke, Jeannerat, Damien, Ji, NaiYun, Johnson, Tyler A, Kingston, David G I, Koshino, Hiroyuki, Lee, HsiauWei, Lewin, Guy, Li, Jie, Linington, Roger G, Liu, Miaomiao, McPhail, Kerry L, Molinski, Tadeusz F, Moore, Bradley S, Nam, JooWon, Neupane, Ram P, Niemitz, Matthias, Nuzillard, JeanMarc, Oberlies, Nicholas H, Ocampos, Fernanda M M, Pan, Guohui, Quinn, Ronald J, Reddy, D Sai, Renault, JeanHugues, RiveraChavez, Jose, Robien, Wolfgang, Saunders, Carla M, Schmidt, Thomas J, Seger, Christoph, Shen, Ben, Steinbeck, Christoph, Stuppner, Hermann, Sturm, Sonja, TaglialatelaScafati, Orazio, Tantillo, Dean J, Verpoorte, Robert, Wang, BinGui, Williams, Craig M, Williams, Philip G, Wist, Julien, Yue, JianMin, Zhang, Chen, Xu, Zhengren, Simmler, Charlotte, Lankin, David C, Bisson, Jonathan, Pauli, Guido F. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. NATURAL PRODUCT REPORTS. 2019, 第 47 作者36(1): 35-107, https://explore.openaire.eu/search/publication?articleId=od______1400::6c8d23a84083002a3e15bf7dd2ff8a15.
[15] Kwong, Thomas, Ma, Ming, Pan, Guohui, Hindra, Yang, Dong, Yang, Chunying, Lohman, Jeremy R, Rudolf, Jeffrey D, Cleveland, John L, Shen, Ben. P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. BIOCHEMISTRY[J]. 2018, 第 3 作者57(33): 5005-5013, https://www.webofscience.com/wos/woscc/full-record/WOS:000448082300007.
[16] Xu, Zhengren, Pan, Guohui, Zhou, Hao, Shen, Ben. Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 第 2 作者140(49): 16957-16961, http://dx.doi.org/10.1021/jacs.8b11463.
[17] Li, Liyuan, Pan, Guohui, Zhu, Xifen, Fan, Keqiang, Gao, Wubin, Ai, Guomin, Ren, Jinwei, Shi, Mingxin, Olano, Carlos, Salas, Jose A, Yang, Keqian. Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2017, 第 2 作者101(13): 5291-5300, https://www.webofscience.com/wos/woscc/full-record/WOS:000404146300007.
[18] Pan, Guohui, Xu, Zhengren, Guo, Zhikai, Hindra, Ma, Ming, Yang, Dong, Zhou, Hao, Gansemans, Yannick, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Cheng, Jinhua, Van Nieuwerburgh, Filip, Suh, JooWon, Duan, Yanwen, Shen, Ben. Discovery of the leinamycin family of natural products by mining actinobacterial genomes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 1 作者114(52): E11131-E11140, https://www.webofscience.com/wos/woscc/full-record/WOS:000418722400009.
[19] Pan, Guohui, Gao, Xiaoqin, Fan, Keqiang, Liu, Junlin, Meng, Bing, Gao, Jinmin, Wang, Bin, Zhang, Chaobo, Han, Hui, Ai, Guomin, Chen, Yihua, Wu, Dong, Liu, ZhiJie, Yang, Keqian. Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis. ACS CHEMICAL BIOLOGY[J]. 2017, 第 1 作者12(1): 142-152, http://dx.doi.org/10.1021/acschembio.6b00621.
[20] Guo, Zhikai, Pan, Guohui, Xu, Zhengren, Yang, Dong, Hindra, Zhu, Xiangcheng, Huang, Yong, Zhao, LiXing, Jiang, Yi, Duan, Yanwen, Shen, Ben. New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp CB01883. JOURNAL OF ANTIBIOTICS[J]. 2017, 第 2 作者70(4): 414-422, https://www.webofscience.com/wos/woscc/full-record/WOS:000397547900011.
[21] Huang, Yong, Yang, Dong, Pan, Guohui, Tang, GongLi, Shen, Ben. Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 3 作者100(24): 10555-10562, http://dx.doi.org/10.1007/s00253-016-7864-2.
[22] Zhang, Bo, Yang, Dong, Yan, Yijun, Pan, Guohui, Xiang, Wensheng, Shen, Ben. Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 4 作者100(5): 2267-2277, https://www.webofscience.com/wos/woscc/full-record/WOS:000371243500021.
[23] Huang, Yong, Tang, GongLi, Pan, Guohui, Chang, ChinYuan, Shen, Ben. Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis. ORGANIC LETTERS[J]. 2016, 第 3 作者18(17): 4288-4291, https://www.webofscience.com/wos/woscc/full-record/WOS:000382711200036.
[24] Medema, Marnix H, Kottmann, Renzo, Yilmaz, Pelin, Cummings, Matthew, Biggins, John B, Blin, Kai, de Bruijn, Irene, Chooi, Yit Heng, Claesen, Jan, Coates, R Cameron, CruzMorales, Pablo, Duddela, Srikanth, Duesterhus, Stephanie, Edwards, Daniel J, Fewer, David P, Garg, Neha, Geiger, Christoph, GomezEscribano, Juan Pablo, Greule, Anja, Hadjithomas, Michalis, Haines, Anthony S, Helfrich, Eric J N, Hillwig, Matthew L, Ishida, Keishi, Jones, Adam C, Jones, Carla S, Jungmann, Katrin, Kegler, Carsten, Kim, Hyun Uk, Koetter, Peter, Krug, Daniel, Masschelein, Joleen, Melnik, Alexey V, Mantovani, Simone M, Monroe, Emily A, Moore, Marcus, Moss, Nathan, Nuetzmann, HansWilhelm, Pan, Guohui, Pati, Amrita, Petras, Daniel, Reen, F Jerry, Rosconi, Federico, Rui, Zhe, Tian, Zhenhua, Tobias, Nicholas J, Tsunematsu, Yuta, Wiemann, Philipp, Wyckoff, Elizabeth, Yan, Xiaohui, Yim, Grace, Yu, Fengan, Xie, Yunchang, Aigle, Bertrand, Apel, Alexander K, Balibar, Carl J, Balskus, Emily P, BaronaGomez, Francisco, Bechthold, Andreas, Bode, Helge B, Borriss, Rainer, Brady, Sean F, Brakhage, Axel A, Caffrey, Patrick, Cheng, YiQiang, Clardy, Jon, Cox, Russell J, De Mot, Rene, Donadio, Stefano, Donia, Mohamed S, van der Donk, Wilfred A, Dorrestein, Pieter C, Doyle, Sean, Driessen, Arnold J M, EhlingSchulz, Monika, Entian, KarlDieter, Fischbach, Michael A, Gerwick, Lena, Gerwick, William H, Gross, Harald, Gust, Bertolt, Hertweck, Christian, Hofte, Monica, Jensen, Susan E, Ju, Jianhua, Katz, Leonard, Kaysser, Leonard, Klassen, Jonathan L, Keller, Nancy P, Kormanec, Jan, Kuipers, Oscar P, Kuzuyama, Tomohisa, Kyrpides, Nikos C, Kwon, HyungJin, Lautru, Sylvie, Lavigne, Rob, Lee, Chia Y, Linquan, Bai, Liu, Xinyu, Liu, Wen, Luzhetskyy, Andriy, Mahmud, Taifo, Mast, Yvonne, Mendez, Carmen, MetsaKetela, Mikko, Micklefield, Jason, Mitchell, Douglas A, Moore, Bradley S, Moreira, Leonilde M, Mueller, Rolf, Neilan, Brett A, Nett, Markus, Nielsen, Jens, OGara, Fergal, Oikawa, Hideaki, Osbourn, Anne, Osburne, Marcia S, Ostash, Bohdan, Payne, Shelley M, Pernodet, JeanLuc, Petricek, Miroslav, Piel, Joern, Ploux, Olivier, Raaijmakers, Jos M, Salas, Jose A, Schmitt, Esther K, Scott, Barry, Seipke, Ryan F, Shen, Ben, Sherman, David H, Sivonen, Kaarina, Smanski, Michael J, Sosio, Margherita, Stegmann, Evi, Suessmuth, Roderich D, Tahlan, Kapil, Thomas, Christopher M, Tang, Yi, Truman, Andrew W, Viaud, Muriel, Walton, Jonathan D, Walsh, Christopher T, Weber, Tilmann, van Wezel, Gilles P, Wilkinson, Barrie, Willey, Joanne M, Wohlleben, Wolfgang, Wright, Gerard D, Ziemert, Nadine, Zhang, Changsheng, Zotchev, Sergey B, Breitling, Rainer, Takano, Eriko, Gloeckner, Frank Oliver. Minimum Information about a Biosynthetic Gene cluster. NATURE CHEMICAL BIOLOGY. 2015, 第 39 作者11(9): 625-631, 
[25] Wang, Bin, Ren, Jinwei, Li, Liyuan, Guo, Fang, Pan, Guohui, Ai, Guomin, Aigle, Bertrand, Fan, Keqiang, Yang, Keqian. Kinamycin biosynthesis employs a conserved pair of oxidases for B-ring contraction. CHEMICAL COMMUNICATIONS[J]. 2015, 第 5 作者51(42): 8845-8848, http://www.corc.org.cn/handle/1471x/2376547.
[26] Liu, Yanyan, Ryu, Hojin, Ge, Beibei, Pan, Guohui, Sun, Lei, Park, Kyungseok, Zhang, Kecheng. Improvement of Wuyiencin Biosynthesis in Streptomyces wuyiensis CK-15 by Identification of a Key Regulator, WysR. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 第 4 作者24(12): 1644-1653, http://dx.doi.org/10.4014/jmb.1405.05017.
[27] Wang, Weishan, Ji, Junjie, Li, Xiao, Wang, Juan, Li, Shanshan, Pan, Guohui, Fan, Keqiang, Yang, Keqian. Angucyclines as signals modulate the behaviors of Streptomyces coelicolor. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2014, 第 6 作者111(15): 5688-5693, http://dx.doi.org/10.1073/pnas.1324253111.
[28] 朱西粉, 潘国辉, 李莉媛, 罗琼, 杨克迁. 放线菌天然产物糖基化改造研究进展. 微生物学通报[J]. 2013, 第 2 作者40(10): 1765-1782, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb13101765?st=article_issue.
[29] Zhang, Yanyan, Pan, Guohui, Zou, Zhengzhong, Fan, Keqiang, Yang, Keqian, Tan, Huarong. JadR*-mediated feed-forward regulation of cofactor supply in jadomycin biosynthesis. MOLECULAR MICROBIOLOGY[J]. 2013, 第 2 作者90(4): 884-897, http://dx.doi.org/10.1111/mmi.12406.
[30] Fan, Keqiang, Pan, Guohui, Peng, Xiaojing, Zheng, Jianting, Gao, Wubin, Wang, Juan, Wang, Weishan, Li, Yue, Yang, Keqian. Identification of JadG as the B Ring Opening Oxygenase Catalyzing the Oxidative C-C Bond Cleavage Reaction in Jadomycin Biosynthesis. CHEMISTRY & BIOLOGY[J]. 2012, 第 2 作者19(11): 1381-1390, http://dx.doi.org/10.1016/j.chembiol.2012.09.009.
[31] Zhang Bo, Xu Zhengren, Teng Qihui, Pan Guohui, Ma Ming, Shen Ben. A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in iso-Migrastatin Biosynthesis. ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH)[J]. 第 4 作者56(25): 7247-7251, https://www.webofscience.com/wos/woscc/full-record/WOS:000402857800045.
发表著作
(1) “Hybrid Peptide-Polyketide Natural Product Biosynthesis” in Comprehensive Natural Products: Chemistry and Biology, Elsevier, 2019-11, 第 3 作者

科研活动

   
参与会议
(1)微生物组与次级代谢产物   第三届青年生命科学论坛   2021-06-06
(2)Leinamycin Family of Natural Products: Discovery and Biosynthesis   全国化学生物学会议   2019-11-20
(3)科学道德和学风建设的几点思考   2019年研究生导师科学道德和学风建设宣讲教育专题研讨班   2019-09-20
(4)Nature as the Ultimate Combinatorial Biosynthetic Chemist: Discovery of the Leinamycin Family of Natural Products   2018-01-21