基本信息
潘国辉  男  博导  中国科学院微生物研究所
电子邮件: panguohui@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究领域

微生物天然药物基因组发掘,生物合成机制解析,合成生物学。

招生信息

   
招生专业
100705-微生物与生化药学
071010-生物化学与分子生物学
招生方向
微生物天然药物发现、生物合成与合成生物学

教育背景

2008-09--2014-01   中国科学院大学   博士
2004-09--2008-07   中国矿业大学(北京)   学士
学历
研究生

学位
博士

工作经历

   
工作简历
2022-01~现在, 中国科学院微生物研究所, 研究员
2019-08~2022-01,中国科学院微生物研究所, 项目研究员
2014-02~2019-08,美国斯克里普斯研究所, 博士后
社会兼职
2022-09-01-今,Frontiers in Microbiology, Review editor
2021-10-01-今,微生物学通报, 编委
2021-04-01-今,Chinese Journal of Natural Medicines, 青年编委
2016-05-16-今,Frontiers in Bioengineering and Biotechnology, Review Editor

教授课程

天然产物药物的生物合成及生物催化

专利与奖励

   
专利成果
( 1 ) JadG蛋白在催化角蒽环芳香聚酮氧化开环和氨基酸插入反应中的应用, 发明专利, 2013, 第 3 作者, 专利号: CN103233047A

出版信息

   
发表论文
(1) Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585, FRONTIERS IN MICROBIOLOGY, 2022, 第 6 作者
(2) (S)-3-aminopiperidine-2,6-dione is a biosynthetic intermediate of microbial blue-pigments indigoidine., mLife, 2022, 通讯作者
(3) Dynamic Control Strategy to Produce Riboflavin with Lignocellulose Hydrolysate in the Thermophile Geobacillus thermoglucosidasius, ACS SYNTHETIC BIOLOGY, 2022, 第 9 作者
(4) The Richness and Diversity of Catalases in Bacteria, FRONTIERS IN MICROBIOLOGY, 2021, 通讯作者
(5) 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2,3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物, Bioinformatics-directed discovery of dehydrated linear trimer and dimer of 2,3-dihydroxybenzoyl-L-serine from Streptomyces albofaciens JCM 4342, 微生物学通报, 2021, 第 7 作者
(6) Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase, NATURE COMMUNICATIONS, 2021, 第 4 作者
(7) 基于生物信息学分析从Streptomyces albofaciens JCM 4342中发现2,3-二羟基苯甲酸酯-L-丝氨酸脱水三聚体和二聚体天然产物(英文) 网络首发, 微生物学通报, 2021, 第 7 作者
(8) A Versatile Transcription-Translation in One Approach for Activation of Cryptic Biosynthetic Gene Clusters, ACS CHEMICAL BIOLOGY, 2020, 通讯作者
(9) Targeting Bacterial Genomes for Natural Product Discovery, TRENDS IN PHARMACOLOGICAL SCIENCES, 2020, 第 2 作者
(10) The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research, NATURAL PRODUCT REPORTS, 2019, 第 47 作者
(11) P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities, BIOCHEMISTRY, 2018, 第 3 作者
(12) Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 2 作者
(13) Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2017, 第 2 作者
(14) Discovery of the leinamycin family of natural products by mining actinobacterial genomes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 1 作者
(15) Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis, ACS CHEMICAL BIOLOGY, 2017, 第 1 作者
(16) New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp CB01883, JOURNAL OF ANTIBIOTICS, 2017, 第 2 作者
(17) Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 第 3 作者
(18) Overproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 第 4 作者
(19) Characterization of the Ketosynthase and Acyl CarrierProtein Domains at the LnmI Nonribosomal Peptide Synthetase–PolyketideSynthase Interface for Leinamycin Biosynthesis, ORGANIC LETTERS, 2016, 第 3 作者
(20) Minimum Information about a Biosynthetic Gene cluster, NATURE CHEMICAL BIOLOGY, 2015, 第 39 作者
(21) Kinamycin biosynthesis employs a conserved pair of oxidases for b-ring contraction, CHEMICAL COMMUNICATIONS, 2015, 第 5 作者
(22) Improvement of Wuyiencin Biosynthesis in Streptomyces wuyiensis CK-15 by Identification of a Key Regulator, WysR, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 第 4 作者
(23) Angucyclines as signals modulate the behaviors of Streptomyces coelicolor, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 6 作者
(24) 放线菌天然产物糖基化改造研究进展, Engineering the glycosylation pattern of natural products in actinobacteria, 微生物学通报, 2013, 第 2 作者
(25) JadR*-mediated feed-forward regulation of cofactor supply in jadomycin biosynthesis, MOLECULAR MICROBIOLOGY, 2013, 第 2 作者
(26) Identification of JadG as the B Ring Opening Oxygenase Catalyzing the Oxidative C-C Bond Cleavage Reaction in Jadomycin Biosynthesis, CHEMISTRY & BIOLOGY, 2012, 第 2 作者
(27) A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in iso-Migrastatin Biosynthesis, ANGEWANDTE CHEMIE (INTERNATIONAL ED. IN ENGLISH), 第 4 作者
发表著作
(1) “Hybrid Peptide-Polyketide Natural Product Biosynthesis” in Comprehensive Natural Products: Chemistry and Biology, Elsevier, 2019-11, 第 3 作者

科研活动

   
参与会议
(1)微生物组与次级代谢产物   第三届青年生命科学论坛   2021-06-06
(2)Leinamycin Family of Natural Products: Discovery and Biosynthesis   全国化学生物学会议   2019-11-20
(3)科学道德和学风建设的几点思考   2019年研究生导师科学道德和学风建设宣讲教育专题研讨班   2019-09-20
(4)Nature as the Ultimate Combinatorial Biosynthetic Chemist: Discovery of the Leinamycin Family of Natural Products   2018-01-21