General
NINGHUA TAN, Ph.D., Prof.
EDUCATION AND VISITING SCHOLAR / PROFESS
B.S.： Pharmacy, Guiyang Medical College, Guiyang, P. R. China. July, 1984
M.S. ： Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China. July, 1990
Ph.D.： Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China. July, 1993
Visiting Scholar： Pharmacology, BAYER AG, Wuppertal, Germany, January, 1996
Visiting Scholar ： Pharmacology, BAYER AG, West Haven, USA, February, 1996
Visiting Scholar： Pharmacology, National Cancer Institute, Friedrick, USA, April-September, 1998
Visiting Professor： Medicinal Chemistry, the University of Queensland, Brisbane, Australia, October-November, 2006
Visiting Professor： Medicinal Chemistry, University of Wisconsin, Madison, USA, December, 2008-February, 2009
M.S. ： Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China. July, 1990
Ph.D.： Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China. July, 1993
Visiting Scholar： Pharmacology, BAYER AG, Wuppertal, Germany, January, 1996
Visiting Scholar ： Pharmacology, BAYER AG, West Haven, USA, February, 1996
Visiting Scholar： Pharmacology, National Cancer Institute, Friedrick, USA, April-September, 1998
Visiting Professor： Medicinal Chemistry, the University of Queensland, Brisbane, Australia, October-November, 2006
Visiting Professor： Medicinal Chemistry, University of Wisconsin, Madison, USA, December, 2008-February, 2009
POST-DOCTORAL FELLOWSHIPS
1993-1995 Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
SELECTED PUBLICATIONS (2006-2010)
1.Grace G. L. Yue, Jun-Ting Fan, Julia K. M. Lee, Bin Kuang, Guang-Zhi Zeng, Tina W. F. Ho, Kwok-Pui Fung, Ping-Chung Leung, Ning-Hua Tan*, Clara B. S. Lau*. Cyclopeptide RA-V inhibits angiogenesis by downregulating extracellular signal-regulated kinase 1/2 phosphorylation in HUVEC and HMEC-1 endothelial cells. British Journal of Pharmacology, 2011, in press
2.Yishan Chen, Xulin Pan, He Yan, Ninghua Tan*. Multiple hydrogen-bonding interactions between macrocyclic triurea and F-, Cl-, Br-, I- and NO3-: A theoretical investigation. Physical Chemistry Chemical Physics, 2011, 13, 7384-7395
3. Jun-Ting Fan, Jia Su, Yan-Min Peng, Yan Li, Jia Li, Yu-Bo Zhou, Guang-Zhi Zeng, He Yan, Ning-Hua Tan*. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kB activation. Bioorganic & Medicinal Chemistry, 2010, 18: 8226-8234
4. Jun-Ting Fan, Yi-Shan Chen, Wen-Yan Xu, Liangcheng Du, Guang-Zhi Zeng, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Rubiyunnanin A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters, 2010, 51(52): 6810-6813
5. Jun Tang, Conan K. Wang, Xulin Pan, He Yan, Guangzhi Zeng, Wenyan Xu, Wenjun He, Norelle L. Daly, David J. Craik, Ninghua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 2010, 31: 1434-1440
6. Jun Tang, Conan K. Wang, Xulin Pan, He Yan, Guangzhi Zeng, Wenyan Xu, Wenjun He, Norelle L. Daly, David J. Craik*, Ninghua Tan*. Isolation and characterization of bioactive cyclotides from Viola labridorica. Helvetica Chimica Acta, 2010, 93(11): 2287-2295
7. He Yan, Xulin Pan, Ninghua Tan*, Junting Fan, Guangzhi Zeng, Hongjin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44: 3425-3432 8. Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T., Hajdu, J., Bohlin, L., Claeson, P., Goransson, U., Rosengren, K. J., Tang, J., Tan, N. H., Craik, D. J. Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 2009, 284(16): 10672-10683
9. Jiang Xiong, Ning-Hua Tan*, Chang-Jiu Ji, Yang Lu, Ning-Bo Gong. Vilmoraconitine A, a novel skeleton C19-diterpenoid alkaloid from Aconitum vilmorinianum. Tetrahedron Letters, 2008, 49: 4851-4853
10. Xu WenYan, Tang Jun, Ji ChangJiu, He WenJun, Tan NingHua*. Application of a TLC chemical method to detection of cyclotides in plants. Chinese Science Bulletin, 2008, 53(11): 1671-1674
11. Yu-Mei Zhang, Ning-Hua Tan*, Yang Lu, Ying Chang, Rui-Rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon. Organic Letters, 2007, 9(22): 4579-4581
12. Ning-Hua Tan*, Jun Zhou. Plant cyclopeptides. Chemical Reviews, 2006, 106(3): 840-895
13. Xu-lin Pan, Ning-hua Tan*, Guang-zhi Zeng, Huo-qiang Huang, He Yan. 3D QSAR studies on ketoamides of human cathepsin K inhibitors based on two different alignment methods. European Journal of Medicinal Chemistry, 2010, 45: 667-681
14. Jun Tang, Conan K. Wang, Xu-lin Pan, He Yan, Guang-zhi Zeng, Wen-yan Xu, Wen-jun He, Norelle L. Daly, David J. Craik, Ning-hua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 2010, 31: 1434-1440
15. Conan K. Wang, Shu-Hong Hu, Jennifer L. Martin, Tove Sjogren, Janos Hajdu, Lars Bohlin, Per Claeson, Ulf Goransson, K. Johan Rosengren, Jun Tang, Ning-hua Tan, David J. Craik. Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as drug scaffold. Journal of Biological Chemistry, 2009, 284: 10672-10683
16. He Yan, Xu-lin Pan, Ning-hua Tan*, Jun-ting Fan, Guang-zhi Zeng, Hong-jin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44: 3425-3432
17. Jiang Xiong, Ning-hua Tan*, Chang-jiu Ji, Yang Lu, Ning-bo Gong. Vilmoraconitine A, a novel skeleton C19-diterpenoid alkaloid from Aconitum vilmorinianum. Tetrahedron Letters, 2008, 49: 4851-4853
18. Yu-mei Zhang, Ning-hua Tan*, Yang Lu, Ying Chang, Rui-rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon. Organic Letters, 2007, 9(22): 4579-4581
19. Ning-hua Tan*, Jun Zhou. Plant cyclopeptides. Chemical Reviews, 2006, 106(3): 840-895
2.Yishan Chen, Xulin Pan, He Yan, Ninghua Tan*. Multiple hydrogen-bonding interactions between macrocyclic triurea and F-, Cl-, Br-, I- and NO3-: A theoretical investigation. Physical Chemistry Chemical Physics, 2011, 13, 7384-7395
3. Jun-Ting Fan, Jia Su, Yan-Min Peng, Yan Li, Jia Li, Yu-Bo Zhou, Guang-Zhi Zeng, He Yan, Ning-Hua Tan*. Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kB activation. Bioorganic & Medicinal Chemistry, 2010, 18: 8226-8234
4. Jun-Ting Fan, Yi-Shan Chen, Wen-Yan Xu, Liangcheng Du, Guang-Zhi Zeng, Yu-Mei Zhang, Jia Su, Yan Li, Ning-Hua Tan*. Rubiyunnanin A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters, 2010, 51(52): 6810-6813
5. Jun Tang, Conan K. Wang, Xulin Pan, He Yan, Guangzhi Zeng, Wenyan Xu, Wenjun He, Norelle L. Daly, David J. Craik, Ninghua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 2010, 31: 1434-1440
6. Jun Tang, Conan K. Wang, Xulin Pan, He Yan, Guangzhi Zeng, Wenyan Xu, Wenjun He, Norelle L. Daly, David J. Craik*, Ninghua Tan*. Isolation and characterization of bioactive cyclotides from Viola labridorica. Helvetica Chimica Acta, 2010, 93(11): 2287-2295
7. He Yan, Xulin Pan, Ninghua Tan*, Junting Fan, Guangzhi Zeng, Hongjin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44: 3425-3432 8. Wang, C. K., Hu, S. H., Martin, J. L., Sjogren, T., Hajdu, J., Bohlin, L., Claeson, P., Goransson, U., Rosengren, K. J., Tang, J., Tan, N. H., Craik, D. J. Combined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold. Journal of Biological Chemistry, 2009, 284(16): 10672-10683
9. Jiang Xiong, Ning-Hua Tan*, Chang-Jiu Ji, Yang Lu, Ning-Bo Gong. Vilmoraconitine A, a novel skeleton C19-diterpenoid alkaloid from Aconitum vilmorinianum. Tetrahedron Letters, 2008, 49: 4851-4853
10. Xu WenYan, Tang Jun, Ji ChangJiu, He WenJun, Tan NingHua*. Application of a TLC chemical method to detection of cyclotides in plants. Chinese Science Bulletin, 2008, 53(11): 1671-1674
11. Yu-Mei Zhang, Ning-Hua Tan*, Yang Lu, Ying Chang, Rui-Rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon. Organic Letters, 2007, 9(22): 4579-4581
12. Ning-Hua Tan*, Jun Zhou. Plant cyclopeptides. Chemical Reviews, 2006, 106(3): 840-895
13. Xu-lin Pan, Ning-hua Tan*, Guang-zhi Zeng, Huo-qiang Huang, He Yan. 3D QSAR studies on ketoamides of human cathepsin K inhibitors based on two different alignment methods. European Journal of Medicinal Chemistry, 2010, 45: 667-681
14. Jun Tang, Conan K. Wang, Xu-lin Pan, He Yan, Guang-zhi Zeng, Wen-yan Xu, Wen-jun He, Norelle L. Daly, David J. Craik, Ning-hua Tan*. Isolation and characterization of cytotoxic cyclotides from Viola tricolor. Peptides, 2010, 31: 1434-1440
15. Conan K. Wang, Shu-Hong Hu, Jennifer L. Martin, Tove Sjogren, Janos Hajdu, Lars Bohlin, Per Claeson, Ulf Goransson, K. Johan Rosengren, Jun Tang, Ning-hua Tan, David J. Craik. Combined x-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as drug scaffold. Journal of Biological Chemistry, 2009, 284: 10672-10683
16. He Yan, Xu-lin Pan, Ning-hua Tan*, Jun-ting Fan, Guang-zhi Zeng, Hong-jin Han. 2D- and 3D-QSAR studies on 54 anti-tumor Rubiaceae-type cyclopeptides. European Journal of Medicinal Chemistry, 2009, 44: 3425-3432
17. Jiang Xiong, Ning-hua Tan*, Chang-jiu Ji, Yang Lu, Ning-bo Gong. Vilmoraconitine A, a novel skeleton C19-diterpenoid alkaloid from Aconitum vilmorinianum. Tetrahedron Letters, 2008, 49: 4851-4853
18. Yu-mei Zhang, Ning-hua Tan*, Yang Lu, Ying Chang, Rui-rui Jia. Chamobtusin A, a novel skeleton diterpenoid alkaloid from Chamaecyparis obtusa cv. tetragon. Organic Letters, 2007, 9(22): 4579-4581
19. Ning-hua Tan*, Jun Zhou. Plant cyclopeptides. Chemical Reviews, 2006, 106(3): 840-895
Address
Deputy Director of State Key Laboratory of Phytochemistry and Plant Resources in West China,
Professor of Kunming Institute of Botany, Chinese Academy of Sciences,
No. 132, Lanhei Road, Heilongtan, Kunming 650204, Yunnan, P. R. China
E-mail: nhtan@mail.kib.ac.cn; Tel./Fax: 86-871-5223800
Professor of Kunming Institute of Botany, Chinese Academy of Sciences,
No. 132, Lanhei Road, Heilongtan, Kunming 650204, Yunnan, P. R. China
E-mail: nhtan@mail.kib.ac.cn; Tel./Fax: 86-871-5223800