基本信息
穆宇  男  博导  中国科学院脑科学与智能技术卓越创新中心
电子邮件: my@ion.ac.cn
通信地址: 岳阳路320号新生命科学楼a841
邮政编码: 200031

研究领域

以复杂系统科学的视角,在全脑尺度上解析细胞分辨率的结构、功能、分子等多维信息,揭示脑区间和细胞间的互作规律,这是阐释脑工作原理的重要策略。本研究组以斑马鱼为模式动物,研发了多种全脑尺度的研究新技术,开展了对视觉-运动系统的系列研究,在Cell、Nature Neuroscience、Neuron、eLife等发表论文,研究成果处于国际领先水平。具体而言,设计和搭建可在全脑尺度观察的光学显微镜,开发可进行活体成像的荧光探针,同时在虚拟现实中建立行为范式,针对物体识别、行为抉择开展实验和全脑模型的研究。

进一步融合复杂系统科学兼顾局部和整体的思路,发挥全脑尺度研究的特点,以视觉-运动转导为核心:在结构上,利用全脑神经联接图谱的信息,解析分析脑网络的底层架构规律;在功能上,剖析抉择和识别中视觉-运动转导的全脑动力学过程及其信息处理机制;在智能上,阐释基于全脑神经联接结构和动力学所涌现的视觉-运动转导的灵活性和鲁棒性的神经机理。从而,将在全脑尺度上揭示视觉-运动转导的基本原理,助推脑科学从局部到整体研究范式的转变。



招生信息

   
招生专业
071006-神经生物学
071008-发育生物学
0710Z2-计算生物学
招生方向
全脑成像,物体识别,行为抉择,感觉-运动传导,斑马鱼

教育背景

2006-09--2013-07   中国科学院大学   博士
2002-09--2006-06   南京大学   学士

工作经历

2020.6 - 至今 中国科学院脑科学与智能技术卓越创新中心

工作简历
2017-08~2020-05,Janelia Research Campus, HHMI, 研究专员
2013-08~2017-08,Janelia Research Campus, HHMI, 博士后

专利与奖励

奖励信息
(1) 国家自然科学基金优秀青年科学基金项目(海外), , 国家级, 2021
(2) 2020年度上海市科学技术奖(自然科学奖一等奖), 一等奖, 部委级, 2020
专利成果
( 1 ) 光学脑机接口系统和方法, 发明专利, 2024, 第 5 作者, 专利号: ZL 2023 1 0131178.9

( 2 ) 检测色氨酸的新型探针,其制备方法及应用, 发明专利, 2023, 第 3 作者, 专利号: 202210229003 .7

出版信息

发表论文
[1] Chun-Feng Shang,, Yu-Fan Wang, Mei-Ting Zhao, Qiu-Xiang Fan, Shan Zhao, Yu Qian, Sheng-Jin Xu,, Yu, Mu, Hao, Jie, Du, Jiu-Lin. Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics. Nature Neuroscience[J]. 2024, 第 4 作者  通讯作者  27: 1014-1018, 
[2] Yuming Chai, Kexin Qi, Yubin Wu, Daguang Li, Guodong Tan, Yuqi Guo, Jun Chu, Yu Mu, Chen Shen, Quan Wen. All-optical interrogation of brain-wide activity in freely swimming larval zebrafish. ISCIENCE[J]. 2024, 第 8 作者27(1): 108385, https://doaj.org/article/d7e31c2034f9477fbc1b7d343b9d603e.
[3] Gu, W., Chen, JH., Zhang Y., Wang Z., Li, J., Wang S., Zhang H., Jiang A., Zhong Z., Zhang, J., Xi, C., Hou, T., Gill, D., Li, D., Mu, Y.*, Wang, S.*, Tang, A. *, Wang, Y. *. Highly Dynamic and Sensitive NEMOer Calcium Indicators for Imaging ER Calcium Signals in Excitable Cells. bioRxiv[J]. 2024, 
[4] Kui Wang, Tianlun Chen, Xinxin Zhang, Jianbin Cao, Pencheng Wang, Mingcang Wang,, Du, Jiu-Lin, Yu, Mu, Rongkun Tao. Unveiling Tryptophan Dynamics and Functions Across Model Organisms via Quantitative Imaging. bioRxiv[J]. 2024, 第 3 作者  通讯作者  
[5] Chun-Feng Shang, Yu-Fan Wang, Mei-Ting Zhao, Qiu-Xiang Fan, Shan Zhao, Yu Qian, Sheng-Jin Xu, Yu Mu, Jie Hao, Jiu-Lin Du. Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics. Nature Neuroscience[J]. 2024, 27: https://www.nature.com/articles/s41593-024-01595-6.
[6] Aditya Nanda, Graham W Johnson, Yu Mu, Misha B Ahrens, Catie Chang, Dario J Englot, Michael Breakspear, Mikail Rubinov. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena. CELL REPORTS. 2023, 第 3 作者42(4): 112254-112254, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10518034/.
[7] Tze Hui Koh, William E Bishop, Takashi Kawashima, Brian B Jeon, Ranjani Srinivasan, Yu Mu, Ziqiang Wei, Sandra J Kuhlman, Misha B Ahrens, Steven M Chase, Byron M Yu. Dimensionality reduction of calcium-imaged neuronal population activity. NATURE COMPUTATIONAL SCIENCE. 2023, 第 6 作者3(1): 71-85, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10358781/.
[8] Rongkun Tao, Kui Wang, Tianlun Chen, Xinxin Zhang, Jianbin Cao, Wenquan Zhao, Jiulin Du, Yu Mu. A genetically encoded ratiometric indicator for tryptophan. CELL DISCOVERY[J]. 2023, 第 8 作者  通讯作者  9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618466/.
[9] Li, Danyang, Mu, Yu. Neuromodulatory system in network science Comment on "Structure and function in artificial, zebrafish and human neural networks" by Peng Ji et al.. PHYSICS OF LIFE REVIEWS. 2023, 第 2 作者  通讯作者  46: 155-157, http://dx.doi.org/10.1016/j.plrev.2023.06.009.
[10] Ji, Peng, Ye, Jiachen, Mu, Yu, Lin, Wei, Tian, Yang, Hens, Chittaranjan, Perc, Matjaz, Tang, Yang, Sun, Jie, Kurths, Jurgen. Signal propagation in complex networks. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS. 2023, 第 3 作者1017: 1-96, http://dx.doi.org/10.1016/j.physrep.2023.03.005.
[11] Jiao, Zhenfei, Zhou, Zhou, Chen, Zhongyun, Xie, Jinze, Mu, Yu, DU, Jiulin, Fu, Ling. Simultaneous multi-plane imaging light-sheet fluorescence microscopy for simultaneously acquiring neuronal activity at varying depths. OPTICA[J]. 2023, 第 5 作者10(2): 239-247, http://dx.doi.org/10.1364/OPTICA.472674.
[12] Wang, Sijia, Wang, Zhirong, Mu, Yu. Locus Coeruleus in Non-Mammalian Vertebrates. BRAIN SCIENCES[J]. 2022, 第 3 作者  通讯作者  12(2): http://dx.doi.org/10.3390/brainsci12020134.
[13] Ye, Hong, Xu, Xin, Wang, Jixiang, Wang, Jing, He, Yi, Mu, Yu, Shi, Guohua. Polarization effects on fluorescence emission of zebrafish neurons using light-sheet microscopy. BIOMEDICAL OPTICS EXPRESS[J]. 2022, 第 6 作者13(12): 6733-6744, 
[14] 王晓鸥, 赵诗彤, 纪鹏, 穆宇. 基于斑马鱼功能成像的全脑计算. 人工智能. 2022, 第 4 作者93-102, http://lib.cqvip.com/Qikan/Article/Detail?id=7109108419.
[15] Zhao, Shan, Qian, Yu, Mu, Yu. Tracking single cells in zebrafish brain. JOURNAL OF NEUROSCIENCE METHODS[J]. 2021, 第 3 作者  通讯作者  353: http://dx.doi.org/10.1016/j.jneumeth.2021.109086.
[16] Mu, Yu, Narayan, Sujatha, Mensh, Brett D, Ahrens, Misha B. Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish. CURRENT OPINION IN NEUROBIOLOGY[J]. 2020, 第 1 作者  通讯作者  64: 151-160, http://dx.doi.org/10.1016/j.conb.2020.08.013.
[17] Mu, Yu, Bennett, Davis, V, Rubinov, Mikail, Narayan, Sujatha, Yang, ChaoTsung, Tanimoto, Masashi, Mensh, Brett D, Looger, Loren L, Ahrens, Misha B. Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior. CELL[J]. 2019, 第 1 作者  通讯作者  178(1): 27-+, http://dx.doi.org/10.1016/j.cell.2019.05.050.
[18] Fleishman Greg M, Zhang Miaomiao, Tustison Nicholas J, EspinosaMedina Isabel, Mu Yu, Khairy Khaled, Ahrens Misha, IEEE. DEFORMABLE REGISTRATION OF WHOLE BRAIN ZEBRAFISH MICROSCOPY USING AN IMPLEMENTATION OF THE FLASH ALGORITHM WITHIN ANTS. 2019 IEEE 16TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2019). 2019, 第 5 作者213-217, 
[19] Vladimirov, Nikita, Wang, Chen, Hockendorf, Burkhard, Pujala, Avinash, Tanimoto, Masashi, Mu, Yu, Yang, ChaoTsung, Wittenbach, Jason D, Freeman, Jeremy, Preibisch, Stephan, Koyama, Minoru, Keller, Philipp J, Ahrens, Misha B. Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function. NATURE METHODS[J]. 2018, 第 6 作者15(12): 1117-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000451826200039.
[20] Chen, Xiuye, Mu, Yu, Hu, Yu, Kuan, Aaron T, Nikitchenko, Maxim, Randlett, Owen, Chen, Alex B, Gavornik, Jeffery P, Sompolinsky, Haim, Engert, Florian, Ahrens, Misha B. Brain-wide Organization of Neuronal Activity and Convergent Sensorimotor Transformations in Larval Zebrafish. NEURON[J]. 2018, 第 2 作者100(4): 876-+, http://dx.doi.org/10.1016/j.neuron.2018.09.042.
[21] Friedrich, Johannes, Yang, Weijian, Soudry, Daniel, Mu, Yu, Ahrens, Misha B, Yuste, Rafael, Peterka, Darcy S, Paninski, Liam. Multi-scale approaches for high-speed imaging and analysis of large neural populations. PLOS COMPUTATIONAL BIOLOGY[J]. 2017, 第 4 作者13(8): http://dx.doi.org/10.1371/journal.pcbi.1005685.
[22] Pnevmatikakis, Eftychios A, Soudry, Daniel, Gao, Yuanjun, Machado, Timothy A, Merel, Josh, Pfau, David, Reardon, Thomas, Mu, Yu, Lacefield, Clay, Yang, Weijian, Ahrens, Misha, Bruno, Randy, Jessell, Thomas M, Peterka, Darcy S, Yuste, Rafael, Paninski, Liam. Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data. NEURON[J]. 2016, 第 8 作者89(2): 285-299, http://dx.doi.org/10.1016/j.neuron.2015.11.037.
[23] Dunn, Timothy W, Mu, Yu, Narayan, Sujatha, Randlett, Owen, Naumann, Eva A, Yang, ChaoTsung, Schier, Alexander F, Freeman, Jeremy, Engert, Florian, Ahrens, Misha B. Brain-wide mapping of neural activity controlling zebrafish exploratory locomotion. ELIFE[J]. 2016, 第 2 作者5: https://doaj.org/article/bc9d35b970cf4043a814fd28dce3abfb.
[24] Du Jiulin. Zebrafish swimming in neuroscience research: a visible mind in a transparent brain. Science in China. 2015, 
[25] Viadimirov, Nikita, Mu, Yu, Kawashima, Takashi, Bennett, Davis V, Yang, ChaoTsung, Looger, Loren L, Keller, Philipp J, Freeman, Jeremy, Ahrens, Misha B. Light-sheet functional imaging in fictively behaving zebrafish. NATURE METHODS. 2014, 第 2 作者11(9): 883-884, https://www.webofscience.com/wos/woscc/full-record/WOS:000341409700005.
[26] Du Jiulin. Progress in the application of zebrafish in neuroscience research. Annual Review of New Biology. 2014, 
[27] Freeman, Jeremy, Vladimirov, Nikita, Kawashima, Takashi, Mu, Yu, Sofroniew, Nicholas J, Bennett, Davis V, Rosen, Joshua, Yang, ChaoTsung, Looger, Loren L, Ahrens, Misha B. Mapping brain activity at scale with cluster computing. NATURE METHODS[J]. 2014, 第 4 作者11(9): 941-950, https://www.webofscience.com/wos/woscc/full-record/WOS:000341409700024.
[28] 穆宇, 李小泉. 用心看,用眼听,目遇之而为声. 生命科学[J]. 2012, 第 1 作者24(12): 1380-1383, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4779755&detailType=1.
[29] Mu, Yu, Li, Xiaoquan, Zhang, Bo, Du, Jiulin. Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism. NEURON[J]. 2012, 第 1 作者75(4): 688-699, http://dx.doi.org/10.1016/j.neuron.2012.05.035.
[30] Han, Yanchao, Mu, Yu, Li, Xiaoquan, Xu, Pengfei, Tong, Jingyuan, Liu, Zhaoting, Ma, Tingting, Zeng, Guodong, Yang, Shuyan, Du, Jiulin, Meng, Anming. Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. HUMAN MOLECULAR GENETICS[J]. 2011, 第 2 作者20(16): 3213-3226, http://www.irgrid.ac.cn/handle/1471x/502149.
[31] Feng, Yan, Yan, Tingting, Zheng, Jin, Ge, Xinjian, Mu, Yu, Zhang, Yi, Wu, Dongmei, Du, Jiulin, Zhai, Qiwei. Overexpression of Wld(S) or Nmnat2 in Mauthner Cells by Single-Cell Electroporation Delays Axon Degeneration in Live Zebrafish. JOURNAL OF NEUROSCIENCE RESEARCH[J]. 2010, 第 5 作者88(15): 3319-3327, http://www.irgrid.ac.cn/handle/1471x/502309.
[32] Yuming Chai, Kexin Qi, Yubin Wu, Daguang Li, Guodong Tan, Yuqi Guo, Jun Chu, Yu Mu, Chen Shen, Quan Wen. All-optical interrogation of brain-wide activity in freely swimming larval zebrafish. ISCIENCE. 第 8 作者http://dx.doi.org/10.1016/j.isci.2023.108385.
[33] Aditya Nanda, Graham W Johnson, Yu Mu, Misha B Ahrens, Catie Chang, Dario J Englot, Michael Breakspear, Mikail Rubinov. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena. CELL REPORTS. 第 3 作者http://dx.doi.org/10.1016/j.celrep.2023.112254.

指导学生

现指导学生

李丹阳  硕士研究生  071006-神经生物学  

王斯佳  硕士研究生  071006-神经生物学  

赵姗  硕士研究生  071006-神经生物学