The initiation of Meiosis and Recombination

 The Decision of Spermatogonial Stem Cell Fate

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Shanghai Second Medical University, Shanghai, China  B.S., Oral Medicine, 1984-1990

Shanghai Second Medical University, Shanghai, China  M.S., Oral Medicine, 1991-1994

 Shanghai Second Medical University, Shanghai, China Ph.D., Human Anatomy (Reproductive Biology),1997- 2000

 University of Pennsylvania, Philadelphia, PA Postdoctoral, ,Reproductive Biology, 2001-2003

 Northwestern University, Chicago, IL Postdoctoral, ,Reproductive Biology, 2004

   

2013- present,ShanghaiInstitute of Biochemistry and Cell Biology, Principle Investigator

2009-2013,Washington State University, Assistant/Associate professor

2005-2009,Northwestern University, Assistant professor

1994-2000,Shanghai Second Medical University,Lecturer

1990-1991,Anhui chaohu sikang hospital, Physician

 

 

​Shanghai Second Medical University:

Teaching Assistant, Human Histology and Embryology (1991-1995)

                 Instructor, Human Histology and Embryology (1996-2000)

                                  Graduate Cell Biology (1998-2000)

                                  Advanced Topics in Reproductive Biology (1998-2000)

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（1） The histone methyltransferase Setd2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, corresponding author

（2） Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis, Cell Research, 2017, corresponding author

（3） Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes, Development, 2016, corresponding author

（4） Similarity of epigenetic reprogramming in primordial germ cells between human and mouse, National Science Review, 2015, corresponding author

（ 1 ） Mettl3敲除的精子发生障碍动物模型及其构建方法, 发明, 2017, 第 1 作者, 专利号: 201710734939.4
（ 2 ） Mettl14敲除的精子发生障碍动物模型及其构建方法, 发明, 2017, 第 1 作者, 专利号: 201710735644.9
（ 3 ） 精子细胞表面标志物的筛选与应用, 发明, 2018, 第 1 作者, 专利号: 201810488954.X

The initiation of Meiosis and Recombination

The Decision of Spermatogonial Stem Cell Fate

​

现指导学生

陈瑶  博士研究生  071009-细胞生物学  

林震  博士研究生  071009-细胞生物学  

谢南南  硕士研究生  071009-细胞生物学  

王秋  博士研究生  0710J3-生物信息学  

 Shanghai Thousand Talent,2013