基本信息
管敏  女  博导  中国科学院深圳先进技术研究院
电子邮件: min.guan@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码: 518055

研究领域

骨与骨关节疾病;代谢性疾病;药物研发;干细胞与组织再生;代谢调控;表观及转录调控

招生信息

   
招生专业
071010-生物化学与分子生物学
071009-细胞生物学
招生方向
代谢调控,骨与骨关节疾病,代谢性疾病,药物研发,
干细胞与组织再生,细胞与基因治疗

教育背景

2006-09--2009-07   中国科学院广州生物与健康研究院   博士
2001-09--2004-07   暨南大学   硕士
1997-09--2001-07   华南师范大学   学士
学历
博士 生物技术与医药专业

工作经历

研究员 (PI)     2018/01 – 至今   中科院深圳先进技术研究院医药所

副研究员 (PI)   2013/01 – 2017/12   中科院深圳先进技术研究院医药所

博士后研究员   2011/12 – 2012/12 美国约翰霍普金斯大学医学院                              

博士后研究员   2009/11 – 2011/11 美国加州大学戴维斯医学院                               



工作简历
2018-01~2021-12,中国科学院深圳先进技术研究院, 研究员
2013-01~2017-12,中科院深圳先进技术研究院, 副研究员
2011-12~2012-12,美国约翰霍普金斯大学医学院, 博士后
2009-11~2011-11,美国加州大学戴维斯医学院, 博士后

教授课程

干细胞与再生医学
材料生物学
生物专业高级英语
人文系列讲座
生命科学高级英语

专利与奖励

   
奖励信息
(1) 深圳市自然科学奖, 二等奖, 省级, 2022
(2) 广东省高层次人才特殊支持计划科技创新青年拔尖人才, 特等奖, 省级, 2018
(3) 中科院青年促进会会员, 研究所(学校), 2015
(4) 留学人员科技活动项目择优资助, 部委级, 2015
(5) 深圳市海外高层次孔雀计划B类人才, 二等奖, 市地级, 2014
(6) 美国加州大学戴维斯医学院优秀博士后奖, 特等奖, 研究所(学校), 2011
(7) 美国骨矿协会 ASBMR-Lilly/Pfizer青年研究员奖, 特等奖, 其他, 2011
(8) 国际骨矿协会 Alice L. Jee Memorial青年研究员奖, 特等奖, 其他, 2011

出版信息

   
发表论文
[1] Tongling Huang, Zhaocheng Lu, Zihui Wang, Lixin Cheng, Lu Gao, Jun Gao, Ning Zhang, ChangAn Geng, Xiaoli Zhao, Huaiyu Wang, ChiWai Wong, Kelvin W K Yeung, Haobo Pan, William Weijia Lu, Min Guan. Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow. NATURE COMMUNICATIONS[J]. 2024, 第 15 作者  通讯作者  15: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11069533/.
[2] Cui, Can, Wu, ShengLi, Chen, JiJun, Gongpan, Pianchou, Guan, Min, Geng, ChangAn. Sesquiterpenoids from Alpinia oxyphylla with GLP-1 Stimulative Effects through Ca 2+ /CaMKII and PKA Pathways and Multiple-Enzyme Inhibition. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2023, 第 5 作者71(43): 16148-16159, http://dx.doi.org/10.1021/acs.jafc.3c06093.
[3] Yang, Liang, Shen, Junfeng, Liu, Chunhua, Kuang, Zhonghua, Tang, Yong, Qian, Zhengjiang, Guan, Min, Yang, Yongfeng, Zhan, Yang, Li, Nan, Li, Xiang. Nicotine rebalances NAD(+) homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity. NATURE COMMUNICATIONS[J]. 2023, 第 7 作者14(1): http://dx.doi.org/10.1038/s41467-023-36543-8.
[4] 李利, 高军, 王紫辉, 张敏仪, 吴尚英, 姚冬生, 管敏. 穿心莲内酯拮抗雌激素相关受体α活性影响小肠脂质分泌的作用机制. 中国细胞生物学学报[J]. 2023, 第 7 作者  通讯作者  45(7): 1047-1057, http://lib.cqvip.com/Qikan/Article/Detail?id=7110531072.
[5] Wu, ShengLi, Zhang, ChenChen, Chen, JiJun, Zhang, XueMei, Guan, Min, Geng, ChangAn. Oligostilbenes from the seeds of Paeonia lactiflora as potent GLP-1 secretagogues targeting TGR5 receptor. FITOTERAPIA[J]. 2022, 第 5 作者163: http://dx.doi.org/10.1016/j.fitote.2022.105336.
[6] Yanyan Zheng, Ang Gao, Jiaxiang Bai, Qing Liao, Yuzheng Wu, Wei Zhang, Min Guan, Liping Tong, Dechun Geng, Xin Zhao, Paul K Chu, Huaiyu Wang. A programmed surface on polyetheretherketone for sequentially dictating osteoimmunomodulation and bone regeneration to achieve ameliorative osseointegration under osteoporotic conditions. Bioactive Materials[J]. 2022, 第 7 作者14: 364-376, 
[7] Zang, Tongtong, Chen, Han, Shen, Shutong, Xu, Fei, Wang, Rui, Yin, Jia, Chen, Xiehui, Guan, Min, Shen, Li, Pan, Haobo, Ge, Junbo. Highly Purified Eicosapentaenoic Acid Alleviates the Inflammatory Response and Oxidative Stress in Macrophages during Atherosclerosis via the miR-1a-3p/sFRP1/Wnt/PCP-JNK Pathway. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY[J]. 2022, 第 8 作者2022: http://dx.doi.org/10.1155/2022/9451058.
[8] Lingxia Xie, Guomin Wang, Yuzheng Wu, Qing Liao, Shi Mo, Xiaoxue Ren, Liping Tong, Wei Zhang, Min Guan, Haobo Pan, Paul KChu, Huaiyu Wang. Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially. The Innovation[J]. 2021, 第 9 作者2(3): 100148-134, https://doaj.org/article/5692019fb4594fc1acca4b5794c3f335.
[9] Li, Yanqun, Yue, Jianhui, Liu, Yuan, Wu, Jun, Guan, Min, Chen, Di, Pan, Haobo, Zhao, Xiaoli, Lu, William W. Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division. ACTA BIOMATERIALIA[J]. 2021, 第 5 作者119: 432-443, http://dx.doi.org/10.1016/j.actbio.2020.10.030.
[10] yuzheng wu, qing liao, wu lie, Yongxiang Luo, Wei Zhang, min guan, haobo pan, liping tong, paul k chu, Huaiyu Wang. ZnL 2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter. ACS Nano.[J]. 2021, 第 6 作者
[11] 钟丽红, 卢兆成, 黄童龄, 杨萌, 段锐, 管敏. ERR拮抗剂Compound 29抑制破骨细胞改善肥胖引起的骨丢失. 生物骨科材料与临床研究[J]. 2021, 第 6 作者  通讯作者  18(3): 24-29, http://lib.cqvip.com/Qikan/Article/Detail?id=7104854201.
[12] 黄童龄, 钟丽红, 卢兆成, 管敏. 快讯:骨组织细胞的代谢与分化调控. 集成技术[J]. 2021, 第 4 作者  通讯作者  10(3): 103-104, http://lib.cqvip.com/Qikan/Article/Detail?id=7104819899.
[13] Huang, Tongling, Fu, Xuekun, Wang, Na, Yang, Meng, Zhang, Minyi, Wang, Binxu, Chen, Tianke, Majaz, Sidra, Wang, Huaiyu, Wong, ChiWai, Liu, Jinsong, Guan, Min. Andrographolide prevents bone loss via targeting estrogen-related receptor-alpha-regulated metabolic adaption of osteoclastogenesis. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2021, 第 12 作者  通讯作者  178(21): 4352-4367, http://dx.doi.org/10.1111/bph.15614.
[14] Yang, Meng, Geng, ChangAn, Liu, Xinguang, Guan, Min. Lipid Disorders in NAFLD and Chronic Kidney Disease. BIOMEDICINES[J]. 2021, 第 4 作者  通讯作者  9(10): http://dx.doi.org/10.3390/biomedicines9101405.
[15] Yang, Meng, Ma, Feng, Guan, Min. Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease. METABOLITES. 2021, 第 3 作者  通讯作者  11(5): https://doaj.org/article/2405cb6d59214b268202339ae4e8a7d4.
[16] Yang, Meng, Liu, Qingli, Huang, Tongling, Tan, Wenjuan, Qu, Linbing, Chen, Tianke, Pan, Haobo, Chen, Ling, Liu, Jinsong, Wong, ChiWai, Lu, William W, Guan, Min. Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development. THERANOSTICS[J]. 2020, 第 12 作者  通讯作者  10(24): 10874-10891, https://www.webofscience.com/wos/woscc/full-record/WOS:000573667200003.
[17] Du, Jing, Yuan, Chao, Wang, Weijie, Yu, Zitong, Hao, Rui, Zhang, Yi, Guan, Min, Li, Nan, Yang, Hui. Aptasensor-enabled quantitative analysis of nanosized extracellular vesicles by flow cytometry. ANALYST[J]. 2020, 第 7 作者145(23): 7551-7558, https://www.webofscience.com/wos/woscc/full-record/WOS:000592315100034.
[18] Sun, Mengge, Hu, Liqiu, Wang, Shang, Huang, Tongling, Zhang, Minyi, Yang, Meng, Zhen, Wanxin, Yang, Dazhi, Lu, William, Guan, Min, Peng, Songlin. Circulating MicroRNA-19b Identified From Osteoporotic Vertebral Compression Fracture Patients Increases Bone Formation. JOURNAL OF BONE AND MINERAL RESEARCH[J]. 2020, 第 10 作者  通讯作者  35(2): 306-316, http://dx.doi.org/10.1002/jbmr.3892.
[19] Zhang, Minyi, Yang, Meng, Wang, Na, Liu, Qingli, Wang, Binxu, Huang, Tongling, Tong, Yan, Ming, Yanlin, Wong, ChiWai, Liu, Jinsong, Yao, Dongsheng, Guan, Min. Andrographolide modulates HNF4 alpha activity imparting on hepatic metabolism. MOLECULAR AND CELLULAR ENDOCRINOLOGY[J]. 2020, 第 12 作者  通讯作者  513: https://www.webofscience.com/wos/woscc/full-record/WOS:000548713200006.
[20] Yang, Meng, Zhang, Minyi, Liu, Qingli, Xu, Tingting, Huang, Tongling, Yao, Dongsheng, Wong, ChiWai, Liu, Jinsong, Guan, Min. 18 beta-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism. PHARMACOLOGICAL RESEARCH[J]. 2020, 第 9 作者  通讯作者  157: https://www.webofscience.com/wos/woscc/full-record/WOS:000538778100001.
[21] Huang, Tongling, Yan, Guoyong, Guan, Min. Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 第 3 作者  通讯作者  21(4): https://doaj.org/article/6e9e309e7cf44eaf9d6b669c72571bb8.
[22] Gao, Ang, Liao, Qing, Xie, Lingxia, Wang, Guomin, Zhang, Wei, Wu, Yuzheng, Li, Penghui, Guan, Min, Pan, Haobo, Tong, Liping, Chu, Paul K, Wang, Huaiyu. Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration. Biomaterials[J]. 2020, 第 8 作者230: http://dx.doi.org/10.1016/j.biomaterials.2019.119642.
[23] Tong, Liping, Liao, Qing, Zhao, Yuetao, Huang, Hao, Gao, Ang, Zhang, Wei, Gao, Xiaoyong, Wei, Wei, Guan, Min, Chu, Paul K, Wang, Huaiyu. Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant. Biomaterials[J]. 2019, 第 9 作者193: 1-11, http://ir.ipe.ac.cn/handle/122111/27870.
[24] Chen, Longhui, Wu, Min, Zhang, Shengnan, Tan, Wenjuan, Guan, Min, Feng, Liqiang, Chen, Chen, Tao, Jun, Chen, Ling, Qu, Linbing. Estrogen-related receptor gamma regulates hepatic triglyceride metabolism through phospholipase A2 G12B. FASEB JOURNAL[J]. 2019, 第 5 作者33(7): 7942-7952, https://www.webofscience.com/wos/woscc/full-record/WOS:000476234700012.
[25] Fu, Xuekun, Li, Yunyan, Huang, Tongling, Yu, Zhiwu, Ma, Kun, Yang, Meng, Liu, Qingli, Pan, Haobo, Wang, Huaiyu, Wang, Junfeng, Guan, Min. Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate Containing Bone Apatite Formation. ADVANCED SCIENCE[J]. 2018, 第 11 作者  通讯作者  5(4): http://ir.siat.ac.cn:8080/handle/172644/14714.
[26] Li, Pingchao, Feng, Fengling, Pan, Enxiang, Fan, Xiaozhen, Yang, Qing, Guan, Min, Chen, Ling, Sun, Caijun. Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection. VIROLOGY[J]. 2018, 第 6 作者519: 86-98, http://ir.siat.ac.cn:8080/handle/172644/14715.
[27] Huang, Tongling, Liu, Renzhong, Fu, Xuekun, Yao, Dongsheng, Yang, Meng, Liu, Qingli, Lu, William W, Wu, Chuanyue, Guan, Min. Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells. STEM CELLS[J]. 2017, 第 9 作者  通讯作者  35(2): 411-424, https://www.webofscience.com/wos/woscc/full-record/WOS:000393573300013.
[28] Zhao, Yuetao, Tong, Liping, Li, Yong, Pan, Haobo, Zhang, Wei, Guan, Min, Li, Weihao, Chen, Yixin, Li, Qing, Li, Zhongjun, Wang, Huaiyu, Yu, XueFeng, Chu, Paul K. Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 第 6 作者8(9): 5813-5820, https://www.webofscience.com/wos/woscc/full-record/WOS:000371945700011.
[29] Liu, Qingli, Yang, Meng, Fu, Xuekun, Liu, Renzhong, Sun, Caijun, Pan, Haobo, Wong, ChiWai, Guan, Min. Activation of farnesoid X receptor promotes triglycerides lowering by suppressing phospholipase A2 G12B expression. MOLECULAR AND CELLULAR ENDOCRINOLOGY[J]. 2016, 第 8 作者  通讯作者  436(C): 93-101, http://dx.doi.org/10.1016/j.mce.2016.07.027.
[30] Chen, Y, Wang, T, Guan, M, Zhao, W, Leung, FKL, Pan, H, Cao, X, Guo, X E, Lu, W W. Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis. OSTEOARTHRITIS AND CARTILAGE[J]. 2015, 23(12): 2174-2183, http://dx.doi.org/10.1016/j.joca.2015.07.012.
[31] Chen, Yan, Guan, Min, Leung, Frankie, Cao, Xu, Pan, Xiaohua, Lu, William. Elevated Mean Arterial Pressure Is Associated With Higher Rate of Subchondral Bone Turnover in Patients With Knee Osteoarthritis.. JOURNAL OF BONE AND MINERAL RESEARCH. 2014, 第 2 作者29: S269-S270, https://www.webofscience.com/wos/woscc/full-record/WOS:000356598701507.
[32] Yao, Wei, Guan, Min, Jia, Junjing, Dai, Weiwei, Lay, YuAn E, Amugongo, Sarah, Liu, Ruiwu, Olivos, David, Saunders, Mary, Lam, Kit S, Nolta, Jan, Olvera, Diana, Ritchie, Robert O, Lane, Nancy E. Reversing Bone Loss by Directing Mesenchymal Stem Cells to Bone. STEM CELLS[J]. 2013, 第 2 作者31(9): 2003-2014, https://www.webofscience.com/wos/woscc/full-record/WOS:000325255700025.
[33] Zhong, Zhendong, ZylstraDiegel, Cassandra R, Schumacher, Cassie A, Baker, Jacob J, Carpenter, April C, Rao, Sujata, Yao, Wei, Guan, Min, Helms, Jill A, Lane, Nancy E, Lang, Richard A, Williams, Bart O. Wntless functions in mature osteoblasts to regulate bone mass. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 第 8 作者109(33): E2197-E2204, https://www.webofscience.com/wos/woscc/full-record/WOS:000307807000005.
[34] Guan, Min, Yao, Wei, Liu, Ruiwu, Lam, Kit S, Nolta, Jan, Jia, Junjing, Panganiban, Brian, Meng, Liping, Zhou, Ping, Shahnazari, Mohammad, Ritchie, Robert O, Lane, Nancy E. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. NATURE MEDICINE[J]. 2012, 第 1 作者18(3): 456-U159, https://www.webofscience.com/wos/woscc/full-record/WOS:000301264800050.
[35] Jia, Junjing, Yao, Wei, Guan, Min, Dai, Weiwei, Shahnazari, Mohammad, Kar, Rekha, Bonewald, Lynda, Jiang, Jean X, Lane, Nancy E. Glucocorticoid dose determines osteocyte cell fate. FASEB JOURNAL[J]. 2011, 第 3 作者25(10): 3366-3376, https://www.webofscience.com/wos/woscc/full-record/WOS:000295356400009.
[36] Guan, Min, Qu, Linbing, Tan, Wenjuan, Chen, Ling, Wong, ChiWai. Hepatocyte Nuclear Factor-4 Alpha Regulates Liver Triglyceride Metabolism in Part Through Secreted Phospholipase A(2) GXIIB. HEPATOLOGY[J]. 2011, 第 1 作者53(2): 458-466, http://ir.gibh.ac.cn/handle/344009/104.
[37] Yao, Wei, Dai, Weiwei, Shahnazari, Mohammad, Pham, Aaron, Chen, Zhiqiang, Chen, Haiyan, Guan, Min, Lane, Nancy E. Inhibition of the Progesterone Nuclear Receptor during the Bone Linear Growth Phase Increases Peak Bone Mass in Female Mice. PLOS ONE[J]. 2010, 第 7 作者5(7): https://doaj.org/article/be00cb330d9147798888044dafa9e095.

科研活动

   

指导学生

已指导学生

黄童龄  博士研究生  071010-生物化学与分子生物学  

钟丽红  硕士研究生  071010-生物化学与分子生物学  

杨萌  博士研究生  071010-生物化学与分子生物学  

现指导学生

高璐  博士研究生  071010-生物化学与分子生物学  

王紫辉  硕士研究生  086000-生物与医药  

袁卓蕾  硕士研究生  086000-生物与医药