苗露 女 中国科学院大连化学物理研究所
电子邮件： miaolu@dicp.ac.cn
通信地址： 辽宁省大连市中山路457号
邮政编码： 116023
2009和2014年先后获得吉林大学化学学院学士与博士学位，2014年到中国科学院大连化学物理研究所工作至今，2018年晋升为大连化学物理研究所副研究员。承担国家及省市科学基金4项，在cell Chem. Biol.、Angew、ACS sens.、 ACS nano等国际期刊发表论文40余篇，申请专利21项，其中授权专利6项。
研究领域
主要研究方向：
基因工程法对蛋白定点荧光标记与活细胞成像，用于微生物蛋白的活性和功能机制研究，包括病毒/细菌的感染机制、药物筛选，通过调节蛋白的组装调控功能蛋白活性等。
1. 细胞内蛋白质的标记：致力于开发新的蛋白标记策略。
2. 通过活细胞荧光成像研究蛋白的功能机制
3. 通过调节蛋白组装在体内/体外调控蛋白质活性
招生信息
招收硕士研究生1名
招生专业
070302-分析化学
教育背景
2009-09--2014-06 吉林大学化学学院 博士研究生
2005-09--2009-06 吉林大学化学学院 学士
2005-09--2009-06 吉林大学化学学院 学士
专利与奖励
专利成果
（ 1 ） 用于标记SNAP-tag的蛋白标签荧光探针, 专利授权, 2021, 第 3 作者, 专利号: CN109400609B
（ 2 ） 阻断COVID-19棘突状蛋白与人血管紧张素转化酶2结合的小分子抑制剂及其用途, 发明专利, 2021, 第 2 作者, 专利号: CN112457281A
（ 3 ） 用于SNAP蛋白标记的小分子荧光探针及其合成方法与应用, 专利授权, 2020, 第 4 作者, 专利号: CN108069966B
（ 4 ） 一种用于细胞内蛋白标记的荧光探针及其合成方法和应用, 专利授权, 2020, 第 2 作者, 专利号: CN108069967B
（ 5 ） 一种鉴别临床多种多重耐药细菌的荧光检测法, 发明专利, 2020, 第 3 作者, 专利号: CN110724727A
（ 6 ） 一种对膜电荷响应的比率荧光探针及其在细菌检测的应用, 发明专利, 2019, 第 2 作者, 专利号: CN110511186A
（ 7 ） 一种检测血液中谷胱甘肽的荧光探针及其合成方法与应用, 专利授权, 2019, 第 2 作者, 专利号: CN106866689B
（ 8 ） 一种用于蛋白标记及检测的荧光探针及其合成方法与应用, 专利授权, 2019, 第 3 作者, 专利号: CN106867515B
（ 2 ） 阻断COVID-19棘突状蛋白与人血管紧张素转化酶2结合的小分子抑制剂及其用途, 发明专利, 2021, 第 2 作者, 专利号: CN112457281A
（ 3 ） 用于SNAP蛋白标记的小分子荧光探针及其合成方法与应用, 专利授权, 2020, 第 4 作者, 专利号: CN108069966B
（ 4 ） 一种用于细胞内蛋白标记的荧光探针及其合成方法和应用, 专利授权, 2020, 第 2 作者, 专利号: CN108069967B
（ 5 ） 一种鉴别临床多种多重耐药细菌的荧光检测法, 发明专利, 2020, 第 3 作者, 专利号: CN110724727A
（ 6 ） 一种对膜电荷响应的比率荧光探针及其在细菌检测的应用, 发明专利, 2019, 第 2 作者, 专利号: CN110511186A
（ 7 ） 一种检测血液中谷胱甘肽的荧光探针及其合成方法与应用, 专利授权, 2019, 第 2 作者, 专利号: CN106866689B
（ 8 ） 一种用于蛋白标记及检测的荧光探针及其合成方法与应用, 专利授权, 2019, 第 3 作者, 专利号: CN106867515B
出版信息
发表论文
[1] Chem. Biomed. Imaging. 2024, 通讯作者
[2] Sensor. Actuat. B-Chem.. 2024, 通讯作者
[3] Lu Miao, Chunyu Yan, Yingzhu Chen, Wei Zhou, Xuelian Zhou, Qinglong Qiao, Zhaochao Xu. SIM imaging resolves endocytosis of SARS-CoV-2 spike RBD in living cells. CELL CHEMICAL BIOLOGY. 2023, 第 1 作者30(3): 248-260.e4, http://dx.doi.org/10.1016/j.chembiol.2023.02.001.
[4] Yan, Chunyu, Miao, Lu, Zhang, Yan, Zhou, Xuelian, Wang, Guangying, Li, Yueqing, Qiao, Qinglong, Xu, Zhaochao. Dye disaggregation light-up aptamer for super-resolution RNA imaging. SENSORS AND ACTUATORS B-CHEMICAL[J]. 2023, 第 2 作者 通讯作者 386: http://dx.doi.org/10.1016/j.snb.2023.133731.
[5] Miao, Lu, Zhou, Wei, Yan, Chunyu, Zhang, Yuebin, Qiao, Qinglong, Zhou, Xuelian, Chen, Yingzhu, Wang, Guangying, Guo, Zhendong, Liu, Jun, Piao, Hailong, Pan, Xia, Yan, Mengxue, Zhao, Weijie, Li, Guohui, Li, Yueqing, Xu, Zhaochao. Rapid screening of SARS-CoV-2 inhibitors via ratiometric fluorescence of RBD-ACE2 complexes in living cells by competitive binding. ACTA PHARMACEUTICA SINICA B. 2022, 第 1 作者12(9): 3739-3742, http://lib.cqvip.com/Qikan/Article/Detail?id=7108634572.
[6] Qiao, Qinglong, Liu, Wenjuan, Zhang, Yinchan, Chen, Jie, Wang, Guangying, Tao, Yi, Miao, Lu, Jiang, Wenchao, An, Kai, Xu, Zhaochao. In Situ Real-Time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self-Assemblies by Super-Resolution Imaging. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 第 7 作者61(34): http://dx.doi.org/10.1002/anie.202208678.
[7] Bao, Fang, Liu, Jiayue, Chen, Haiyang, Miao, Lu, Xu, Zhaochao, Zhang, Guixin. Diagnosis Biomarkers of Cholangiocarcinoma in Human Bile: An Evidence-Based Study. CANCERS. 2022, 第 4 作者14(16): http://dx.doi.org/10.3390/cancers14163921.
[8] Liu, Weiwei, Miao, Lu, Li, Xiaolian, Xu, Zhaochao. Development of fluorescent probes targeting the cell wall of pathogenic bacteria. COORDINATION CHEMISTRY REVIEWS. 2021, 第 2 作者429: http://dx.doi.org/10.1016/j.ccr.2020.213646.
[9] Liu, Wenjuan, Qiao, Qinglong, Zheng, Jiazhu, Chen, Jie, Zhou, Wei, Xu, Ning, Li, Jin, Miao, Lu, Xu, Zhaochao. An assembly-regulated SNAP-tag fluorogenic probe for long-term super-resolution imaging of mitochondrial dynamics. BIOSENSORS & BIOELECTRONICS[J]. 2021, 第 8 作者176: http://dx.doi.org/10.1016/j.bios.2020.112886.
[10] Lu Miao. A Cell Membrane Fluorogenic Probe for Gram-Positive Bacteria Imaging and Real-Time Tracking of Bacterial Viability. ACS Appl. Bio Mater. 2021, 第 1 作者 通讯作者
[11] Deng, Fei, Qiao, Qinglong, Li, Jin, Yin, Wenting, Miao, Lu, Liu, Xiaogang, Xu, Zhaochao. Multiple Factors Regulate the Spirocyclization Equilibrium of Si-Rhodamines. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2020, 第 5 作者124(34): 7467-7474, https://www.webofscience.com/wos/woscc/full-record/WOS:000566758700013.
[12] Miao, Lu, Liu, Weiwei, Qiao, Qinglong, Li, Xiaolian, Xu, Zhaochao. Fluorescent antibiotics for real-time tracking of pathogenic bacteria. JOURNAL OF PHARMACEUTICAL ANALYSIS[J]. 2020, 第 1 作者10(5): 444-451, http://lib.cqvip.com/Qikan/Article/Detail?id=7103211108.
[13] Xu, Zeling, Li, Ming, Li, Yanran, Cao, Huiluo, Miao, Lu, Xu, Zhaochao, Higuchi, Yusuke, Yamasaki, Seiji, Nishino, Kunihiko, Woo, Patrick C Y, Xiang, Hua, Yan, Aixin. Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa. CELLREPORTS[J]. 2019, 第 5 作者29(6): 1707-+, http://dx.doi.org/10.1016/j.celrep.2019.10.006.
[14] Long, Shuangshuang, Qiao, Qinglong, Deng, Fei, Miao, Lu, Yoon, Juyoung, Xu, Zhaochao. Self-assembling nanoprobes that display two-dimensional fluorescent signals for identification of surfactants and bacteria. CHEMICALCOMMUNICATIONS[J]. 2019, 第 4 作者 通讯作者 55(7): 969-972, http://cas-ir.dicp.ac.cn/handle/321008/166070.
[15] Deng, Fei, Liu, Limin, Qiao, Qinglong, Huang, Chunfang, Miao, Lu, Xu, Zhaochao. A general strategy to develop cell membrane fluorescent probes with location- and target-specific fluorogenicities: a case of a Zn2+ probe with cellular selectivity. CHEMICAL COMMUNICATIONS[J]. 2019, 第 5 作者55(100): 15045-15048,
[16] Qi, Qingkai, Chi, Weijie, Li, Yuanyuan, Qiao, Qinglong, Chen, Jie, Miao, Lu, Zhang, Yi, Li, Jin, Ji, Wei, Xu, Tao, Liu, Xiaogang, Yoon, Juyoung, Xu, Zhaochao. A H-bond strategy to develop acid-resistant photoswitchable rhodamine spirolactams for super-resolution single-molecule localization microscopy. CHEMICAL SCIENCE[J]. 2019, 第 6 作者10(18): 4914-4922, http://cas-ir.dicp.ac.cn/handle/321008/171927.
[17] 乔庆龙, 周伟, 陈婕, 刘文娟, 苗露, 尹文婷, 徐兆超. SNAP-tag蛋白标签技术与荧光分析法在蛋白原位分析中的联合应用. 色谱[J]. 2019, 第 5 作者37(8): 872-877, http://lib.cqvip.com/Qikan/Article/Detail?id=7002627640.
[18] Long, Shuangshuang, Qiao, Qinglong, Miao, Lu, Xu, Zhaochao. A self-assembly/disassembly two-photo ratiometric fluorogenic probe for bacteria imaging. CHINESE CHEMICAL LETTERS[J]. 2019, 第 3 作者30(3): 573-576, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849593.
[19] Long, Shuangshuang, Miao, Lu, Li, Ruihua, Deng, Fei, Qaao, Qinglong, Liu, Xiaogang, Yan, Aixin, Xu, Zhaochao. Rapid Identification of Bacteria by Membrane-Responsive Aggregation of a Pyrene Derivative. ACS SENSORS[J]. 2019, 第 2 作者4(2): 281-285, http://www.corc.org.cn/handle/1471x/2372684.
[20] Shuangshuang Long, Weijie Chi, Lu Miao, Qing long Qiao, Xiaogang Liu, Zhaochao Xu. Strong π-π stacking interactions led to the mis-assignment of dimer emissions to the monomers of 1-acetylpyrene. 中国化学快报:英文版[J]. 2019, 第 3 作者30(3): 601-604, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849599.
[21] Qiao Qinglong, Zhou Wei, Chen Jie, Liu Wenjuan, Miao Lu, Yin Wenting, Xu Zhaochao. Combined application of SNAP-tag and fluorescence technique in in-situ protein analysis. CHINESE JOURNAL OF CHROMATOGRAPHY[J]. 2019, 第 5 作者37(8): 872-877,
[22] Long, Shuangshuang, Chi, Weijie, Miao, Lu, Qiao, Qinglong, Liu, Xiaogang, Xu, Zhaochao. Strong pi-pi stacking interactions led to the mis-assignment of dimer emissions to the monomers of 1-acetylpyrene. CHINESE CHEMICAL LETTERS[J]. 2019, 第 3 作者30(3): 601-604, http://www.corc.org.cn/handle/1471x/2372646.
[23] Shuangshuang Long, Qinglong Qiao, Lu Miao, Zhaochao Xu. A self-assembly/disassembly two-photo ratiometric fluorogenic probe for bacteria imaging. 中国化学快报:英文版[J]. 2019, 第 3 作者30(3): 573-576, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849593.
[24] Shuangshuang Long, Weijie Chi, Lu Miao, Qinglong Qiao, Xiaogang Liu, Zhaochao Xu. Strong π-π stacking interactions led to the mis-assignment of dimer emissions to the monomers of 1-acetylpyrene. CHINESECHEMICALLETTERS[J]. 2019, 第 3 作者30(3): 601-604, http://lib.cqvip.com/Qikan/Article/Detail?id=7001849599.
[25] Meiling Wang, Dongfang Yue, Qinglong Qiao, Lu Miao, Haidong Zhao, Zhaochao Xu. Aptamer based fluorescent probe for serum HER2-ECD detection: The clinical utility in breast cancer. 中国化学快报：英文版[J]. 2018, 第 4 作者29(5): 703-706, http://lib.cqvip.com/Qikan/Article/Detail?id=675219424.
[26] Wang, Meiling, Yue, Dongfang, Qiao, Qinglong, Miao, Lu, Zhao, Haidong, Xu, Zhaochao. Aptamer based fluorescent probe for serum HER2-ECD detection: The clinical utility in breast cancer. CHINESE CHEMICAL LETTERS[J]. 2018, 第 4 作者 通讯作者 29(5): 703-706, http://lib.cqvip.com/Qikan/Article/Detail?id=675219424.
[27] Leng, Shuang, Qiao, QingLong, Gao, Yue, Miao, Lu, Deng, WuGuo, Xu, ZhaoChao. SNAP-tag fluorogenic probes for wash free protein labeling. CHINESE CHEMICAL LETTERS[J]. 2017, 第 4 作者 通讯作者 28(10): 1911-1915, http://lib.cqvip.com/Qikan/Article/Detail?id=673829518.
[28] Leng, Shuang, Qiao, Qinglong, Miao, Lu, Deng, Wuguo, Cui, Jingnan, Xu, Zhaochao. A wash-free SNAP-tag fluorogenic probe based on the additive effects of quencher release and environmental sensitivity. CHEMICAL COMMUNICATIONS[J]. 2017, 第 3 作者 通讯作者 53(48): 6448-6451, https://www.webofscience.com/wos/woscc/full-record/WOS:000403211300015.
[29] Qiao, Qinglong, Liu, Wenjuan, Chen, Jie, Zhou, Wei, Yin, Wenting, Miao, Lu, Cui, Jingnan, Xu, Zhaochao. A naphthalimide-derived fluorogenic probe for SNAP-tag with a fast record labeling rate. DYES AND PIGMENTS[J]. 2017, 第 6 作者 通讯作者 147: 327-333, http://dx.doi.org/10.1016/j.dyepig.2017.08.032.
[30] Shuang Leng, Qing-Long Qiao, Yue Gao, Lu Miao, Wu-Guo Deng, Zhao-Chao Xu. SNAP-tag fluorogenic probes for wash free protein labeling. 中国化学快报：英文版[J]. 2017, 第 4 作者28(10): 1911-1915, http://lib.cqvip.com/Qikan/Article/Detail?id=673829518.
[31] Liu, Yang, Qiao, Qinglong, Zhao, Miao, Yin, Wenting, Miao, Lu, Wang, Liqiu, Xu, Zhaochao. Cd2+-triggered amide tautomerization produces a highly Cd2+-selective fluorescent sensor across a wide pH range. DYES AND PIGMENTS[J]. 2016, 第 5 作者133: 339-344, http://cas-ir.dicp.ac.cn/handle/321008/170050.
[32] Sun, Hongcheng, Zhang, Xiyu, Miao, Lu, Zhao, Linlu, Luo, Quan, Xu, Jiayun, Liu, Junqiu. Micelle-Induced Self-Assembling Protein Nanowires: Versatile Supramolecular Scaffolds for Designing the Light-Harvesting System. ACS NANO[J]. 2016, 第 3 作者10(1): 421-428, http://cas-ir.dicp.ac.cn/handle/321008/171326.
[33] Miao, Lu, Fan, Qiusheng, Zhao, Linlu, Qiao, Qinglong, Zhang, Xiyu, Hou, Chunxi, Xu, Jiayun, Luo, Quan, Liu, Junqiu. The construction of functional protein nanotubes by small molecule-induced self-assembly of cricoid proteins. CHEMICAL COMMUNICATIONS[J]. 2016, 第 1 作者52(21): 4092-4095, https://www.webofscience.com/wos/woscc/full-record/WOS:000372010600025.
[34] Feng, Wei, Qiao, QingLong, Leng, Shuang, Miao, Lu, Yin, WenTing, Wang, LiQiu, Xu, ZhaoChao. A 1,8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells. CHINESE CHEMICAL LETTERS[J]. 2016, 第 4 作者27(9): 1554-1558, http://dx.doi.org/10.1016/j.cclet.2016.06.016.
[35] Sun, Hongcheng, Miao, Lu, Li, Jiaxi, Fu, Shuang, An, Guo, Si, Chengye, Dong, Zeyuan, Luo, Quan, Yu, Shuangjiang, Xu, Jiayun, Liu, Junqiu. Self-Assembly of Cricoid Proteins Induced by "Soft Nanoparticles": An Approach To Design Multienzyme-Cooperative Antioxidative Systems. ACS NANO[J]. 2015, 第 2 作者9(5): 5461-5469, https://www.webofscience.com/wos/woscc/full-record/WOS:000355383000083.
[36] Miao, Lu, Han, Jishu, Zhang, Hao, Zhao, Linlu, Si, Chengye, Zhang, Xiyu, Hou, Chunxi, Luo, Quan, Xu, Jiayun, Liu, Junqiu. Quantum-Dot-Induced Self-Assembly of Cricoid Protein for Light Harvesting. ACS NANO[J]. 2014, 第 1 作者8(4): 3743-3751, https://www.webofscience.com/wos/woscc/full-record/WOS:000334990600069.
[37] Zhang, Chunqiu, Pan, Tiezheng, Salesse, Christian, Zhang, Dongmei, Miao, Lu, Wang, Liang, Gao, Yuzhou, Xu, Jiayun, Dong, Zeyuan, Luo, Quan, Liu, Junqiu. Reversible Ca2+ Switch of An Engineered Allosteric Antioxidant Selenoenzyme. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2014, 第 5 作者53(49): 13536-13539, https://www.webofscience.com/wos/woscc/full-record/WOS:000345590300041.
[38] Miao, Lu, Zhang, Xiyu, Si, Chengye, Gao, Yuzhou, Zhao, Linlu, Hou, Chunxi, Shoseyov, Oded, Luo, Quan, Liu, Junqiu. Construction of a highly stable artificial glutathione peroxidase on a protein nanoring. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2014, 第 1 作者12(2): 362-369, https://www.webofscience.com/wos/woscc/full-record/WOS:000329551700018.
[39] Bai, Yushi, Luo, Quan, Zhang, Wei, Miao, Lu, Xu, Jiayun, Li, Hongbin, Liu, Junqiu. Highly Ordered Protein Nanorings Designed by Accurate Control of Glutathione S-Transferase Self-Assembly. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2013, 第 4 作者135(30): 10966-10969, https://www.webofscience.com/wos/woscc/full-record/WOS:000322752900022.
[2] Sensor. Actuat. B-Chem.. 2024, 通讯作者
[3] Lu Miao, Chunyu Yan, Yingzhu Chen, Wei Zhou, Xuelian Zhou, Qinglong Qiao, Zhaochao Xu. SIM imaging resolves endocytosis of SARS-CoV-2 spike RBD in living cells. CELL CHEMICAL BIOLOGY. 2023, 第 1 作者30(3): 248-260.e4, http://dx.doi.org/10.1016/j.chembiol.2023.02.001.
[4] Yan, Chunyu, Miao, Lu, Zhang, Yan, Zhou, Xuelian, Wang, Guangying, Li, Yueqing, Qiao, Qinglong, Xu, Zhaochao. Dye disaggregation light-up aptamer for super-resolution RNA imaging. SENSORS AND ACTUATORS B-CHEMICAL[J]. 2023, 第 2 作者 通讯作者 386: http://dx.doi.org/10.1016/j.snb.2023.133731.
[5] Miao, Lu, Zhou, Wei, Yan, Chunyu, Zhang, Yuebin, Qiao, Qinglong, Zhou, Xuelian, Chen, Yingzhu, Wang, Guangying, Guo, Zhendong, Liu, Jun, Piao, Hailong, Pan, Xia, Yan, Mengxue, Zhao, Weijie, Li, Guohui, Li, Yueqing, Xu, Zhaochao. Rapid screening of SARS-CoV-2 inhibitors via ratiometric fluorescence of RBD-ACE2 complexes in living cells by competitive binding. ACTA PHARMACEUTICA SINICA B. 2022, 第 1 作者12(9): 3739-3742, http://lib.cqvip.com/Qikan/Article/Detail?id=7108634572.
[6] Qiao, Qinglong, Liu, Wenjuan, Zhang, Yinchan, Chen, Jie, Wang, Guangying, Tao, Yi, Miao, Lu, Jiang, Wenchao, An, Kai, Xu, Zhaochao. In Situ Real-Time Nanoscale Resolution of Structural Evolution and Dynamics of Fluorescent Self-Assemblies by Super-Resolution Imaging. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 第 7 作者61(34): http://dx.doi.org/10.1002/anie.202208678.
[7] Bao, Fang, Liu, Jiayue, Chen, Haiyang, Miao, Lu, Xu, Zhaochao, Zhang, Guixin. Diagnosis Biomarkers of Cholangiocarcinoma in Human Bile: An Evidence-Based Study. CANCERS. 2022, 第 4 作者14(16): http://dx.doi.org/10.3390/cancers14163921.
[8] Liu, Weiwei, Miao, Lu, Li, Xiaolian, Xu, Zhaochao. Development of fluorescent probes targeting the cell wall of pathogenic bacteria. COORDINATION CHEMISTRY REVIEWS. 2021, 第 2 作者429: http://dx.doi.org/10.1016/j.ccr.2020.213646.
[9] Liu, Wenjuan, Qiao, Qinglong, Zheng, Jiazhu, Chen, Jie, Zhou, Wei, Xu, Ning, Li, Jin, Miao, Lu, Xu, Zhaochao. An assembly-regulated SNAP-tag fluorogenic probe for long-term super-resolution imaging of mitochondrial dynamics. BIOSENSORS & BIOELECTRONICS[J]. 2021, 第 8 作者176: http://dx.doi.org/10.1016/j.bios.2020.112886.
[10] Lu Miao. A Cell Membrane Fluorogenic Probe for Gram-Positive Bacteria Imaging and Real-Time Tracking of Bacterial Viability. ACS Appl. Bio Mater. 2021, 第 1 作者 通讯作者
[11] Deng, Fei, Qiao, Qinglong, Li, Jin, Yin, Wenting, Miao, Lu, Liu, Xiaogang, Xu, Zhaochao. Multiple Factors Regulate the Spirocyclization Equilibrium of Si-Rhodamines. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2020, 第 5 作者124(34): 7467-7474, https://www.webofscience.com/wos/woscc/full-record/WOS:000566758700013.
[12] Miao, Lu, Liu, Weiwei, Qiao, Qinglong, Li, Xiaolian, Xu, Zhaochao. Fluorescent antibiotics for real-time tracking of pathogenic bacteria. JOURNAL OF PHARMACEUTICAL ANALYSIS[J]. 2020, 第 1 作者10(5): 444-451, http://lib.cqvip.com/Qikan/Article/Detail?id=7103211108.
[13] Xu, Zeling, Li, Ming, Li, Yanran, Cao, Huiluo, Miao, Lu, Xu, Zhaochao, Higuchi, Yusuke, Yamasaki, Seiji, Nishino, Kunihiko, Woo, Patrick C Y, Xiang, Hua, Yan, Aixin. Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa. CELLREPORTS[J]. 2019, 第 5 作者29(6): 1707-+, http://dx.doi.org/10.1016/j.celrep.2019.10.006.
[14] Long, Shuangshuang, Qiao, Qinglong, Deng, Fei, Miao, Lu, Yoon, Juyoung, Xu, Zhaochao. Self-assembling nanoprobes that display two-dimensional fluorescent signals for identification of surfactants and bacteria. CHEMICALCOMMUNICATIONS[J]. 2019, 第 4 作者 通讯作者 55(7): 969-972, http://cas-ir.dicp.ac.cn/handle/321008/166070.
[15] Deng, Fei, Liu, Limin, Qiao, Qinglong, Huang, Chunfang, Miao, Lu, Xu, Zhaochao. A general strategy to develop cell membrane fluorescent probes with location- and target-specific fluorogenicities: a case of a Zn2+ probe with cellular selectivity. CHEMICAL COMMUNICATIONS[J]. 2019, 第 5 作者55(100): 15045-15048,
[16] Qi, Qingkai, Chi, Weijie, Li, Yuanyuan, Qiao, Qinglong, Chen, Jie, Miao, Lu, Zhang, Yi, Li, Jin, Ji, Wei, Xu, Tao, Liu, Xiaogang, Yoon, Juyoung, Xu, Zhaochao. A H-bond strategy to develop acid-resistant photoswitchable rhodamine spirolactams for super-resolution single-molecule localization microscopy. CHEMICAL SCIENCE[J]. 2019, 第 6 作者10(18): 4914-4922, http://cas-ir.dicp.ac.cn/handle/321008/171927.
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科研活动
科研项目
（ 1 ） 以谷胱甘肽硫转移酶为受体构建专一识别谷胱甘肽的生物荧光探针及其生物应用, 负责人, 国家任务, 2016-01--2018-12
（ 2 ） 基于环状荧光染料适配体的活细胞蛋白非共价标记和超分辨成像, 负责人, 国家任务, 2024-01--2027-12
（ 3 ） 胆管癌光动力治疗智能光敏药物研发, 负责人, 研究所自主部署, 2024-01--2025-12
（ 2 ） 基于环状荧光染料适配体的活细胞蛋白非共价标记和超分辨成像, 负责人, 国家任务, 2024-01--2027-12
（ 3 ） 胆管癌光动力治疗智能光敏药物研发, 负责人, 研究所自主部署, 2024-01--2025-12