基本信息
孟颂东 男 博导 微生物研究所
电子邮件: mengsd@im.ac.cn
联系电话: 10-64807350
手机号码:
通信地址: 北京北辰西路1号中科院微生物所
邮政编码: 100101

研究领域

乙肝病毒免疫,肿瘤免疫,疫苗与免疫制剂

招生信息

硕博连读

招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
病毒免疫学
肿瘤免疫学

教育背景

   
学历
中科院沈阳应用生态所 --19980701 研究生毕业
学位
-- 博士
出国学习工作
2002-2007, UT Southwestern Medical Center at Dallas, USA

专利与奖励

   
专利成果
[1] 孟颂东, 郑华国. 热休克蛋白gp96在治疗类风湿性关节炎中的应用. CN: CN106039287B, 2019-12-31.

[2] 孟颂东, 侯军委, 刘炜炜, 邓蒙蒙, 陈立钊. 一种gp96蛋白和PD1抗体的偶联物的制备方法及其应用. CN: CN105194668B, 2019-03-26.

[3] 孟颂东, 管泽良, 丁筠, 鞠莹. 重组TRA1蛋白在治疗肝衰竭的应用. CN: CN108578680A, 2018-09-28.

[4] 孟颂东, 方敏, 彭善鑫, 王静, 李长菲. 微RNA mmu-mir-487b-5p及类似物的应用和表达该微RNA载体的应用. CN: CN108374011A, 2018-08-07.

[5] 方敏, 孟颂东, 王静, 彭善鑫, 魏松涛. 微RNA hsa-mir-593-5p及其类似物的应用和表达该微RNA载体的应用. CN: CN108359725A, 2018-08-03.

[6] 方敏, 孟颂东, 王静, 彭善鑫, 魏松涛. 微RNA hsa-mir-127-3p及其类似物,以及表达该微RNA载体的应用. CN: CN108342388A, 2018-07-31.

[7] 孟颂东, 方敏, 彭善鑫, 王静, 李长菲. 微RNA hsa-mir-1-3p及其类似物的应用,和表达该微RNA载体的应用. CN: CN108113995A, 2018-06-05.

[8] 孟颂东, 方敏, 彭善鑫, 王静, 李长菲. 微RNA hsa-mir-486-5p及其类似物的应用和表达该微RNA载体的应用. CN: CN108079007A, 2018-05-29.

[9] 孟颂东, 侯军委, 桂明明, 赵报, 陈立钊. 一种人热休克蛋白gp96的scFv抗体及其制备方法与应用. 中国: CN104356233B, 2017-09-29.

[10] 孟颂东, 陈密, 郑华国. 热休克蛋白gp96在预防和治疗1型糖尿病中的应用. 中国: CN105749251A, 2016-07-13.

[11] 孟颂东, 赵报, 刘炜炜, 邓蒙蒙, 陈立钊. 一种人热休克蛋白gp96的制备方法及其应用. 中国: CN104372025A, 2015-02-25.

[12] 孟颂东, 初骁宇, 陈立钊. 一种重组融合蛋白TAT-p53及其编码基因与应用. 中国: CN104356240A, 2015-02-18.

[13] 孟颂东, 桂明明, 赵报. 人热休克蛋白gp96在制备筛查肝病的产品中的应用. 中国: CN104330570A, 2015-02-04.

[14] 孟颂东, 李鑫, 李长菲, 陈立钊, 胡坤, 武尔杰, 赵报, 鞠莹. gp96蛋白的抗体在制备癌细胞抑制剂中的应用. 中国: CN103372209A, 2013-10-30.

[15] 田波, 潘煦文, 孟颂东. 阻断HIV-1膜融合的小环型DNA重组载体及其应用. 中国: CN103290049A, 2013-09-11.

[16] 孟颂东, 郝军莉, 李长菲, 胡俊. 一种RNA及载体在制备预防和/或治疗肝癌产品中的应用. 中国: CN103088061A, 2013-05-08.

[17] 孟颂东, 陈立钊, 胡坤, 李杨, 李鑫, 闫晓丽. 一组gp96蛋白的多肽片段及其应用. 中国: CN102827257A, 2012-12-19.

[18] 孟颂东, 胡坤, 陈立钊, 王彦中, 李星辉, 赵报. 组织干细胞提取物及其制备方法和应用. 中国: CN102727525A, 2012-10-17.

[19] 孟颂东, 李星辉, 刘振, 闫晓丽, 王赛锋, 李扬, 邱立鹏, 陈立钊, 胡坤. 一种促进gp96蛋白的免疫活性的方法及其应用. 中国: CN102462841A, 2012-05-23.

[20] 孟颂东, 王赛锋, 李扬, 李星辉, 刘振, 邱立鹏, 闫晓丽, 陈立钊, 胡坤. 乙肝治疗性疫苗. 中国: CN102462840A, 2012-05-23.

[21] 田波, 孟颂东, 高福. 乙肝病毒抗原多肽与热休克蛋白的复合物及其应用. CN: CN1316431A, 2001-10-10.

出版信息

   
发表论文
[1] Yuxiu Xu, Erlong Liu, Xialin Xie, Jiuru Wang, Huaguo Zheng, Ying Ju, Lizhao Chen, Changfei Li, Xuyu Zhou, Zihai Li, Xin Li, Songdong Meng. Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases. iScience[J]. 2021, 24(12): 103445-, [2] Rongguo Wei, Biyan Zhou, Shaohua Li, Debin Zhong, Boan Li, Jianqiu Qin, Liping Zhao, Lixian Qin, Jun Hu, Jiuru Wang, Shixiong Yang, Jingming Zhao, Songdong Meng. Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19. Microbiology Spectrum[J]. 2021, 9(3): [3] 钱丽媛, 李长菲, 罗云敬, 孟颂东. 热休克蛋白gp96在恶性肿瘤中的研究进展. 生物化学与生物物理进展. 2021, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKHTPvOGrUOOqX1coEOzL8AGAokBD74iH8iQv5UZZqMC-DtgEwKMBv3uqlEBffYMCxXUrbB1XJHrq&uniplatform=NZKPT.
[4] 钱丽媛, 李长菲, 罗云敬, 孟颂东. 甲胎蛋白在肝癌的诊断和治疗中研究进展. 生物工程学报. 2021, https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKHTPvOGrUOOqX1coEOzL8AGueLURPhXaqlgMy7ivz10AXRpMwNyc51cbD0jpM76r7DowbNVLik09&uniplatform=NZKPT.
[5] Han Zhang, Huaguo Zheng, Peng Guo, Liuyi Hu, Zihao Wang, Jiuru Wang, Ying Ju, Songdong Meng. Correction for Zhang et al., "Broadly Protective CD8 + T Cell Immunity to Highly Conserved Epitopes Elicited by Heat Shock Protein gp96-Adjuvanted Influenza Monovalent Split Vaccine". Journal of Virology. 2021, 95(24): [6] 郭鹏, 张含, 李长菲, 孟颂东. Toll样受体通路调节Tregs功能的研究进展. 生物工程学报[J]. 2020, 36(9): 1701-1712, http://lib.cqvip.com/Qikan/Article/Detail?id=7103159064.
[7] 叶金统, 孟颂东, 朱晓东. 双特异抗体的研究进展. 生物工程学报[J]. 2020, 36(1): 33-43, http://lib.cqvip.com/Qikan/Article/Detail?id=7100862743.
[8] Guan, Zeliang, Ding, Yun, Liu, Yongai, Zhang, Yu, Zhao, Jingmin, Li, Changfei, Li, Zihai, Meng, Songdong. Extracellular gp96 is a crucial mediator for driving immune hyperactivation and liver damage. SCIENTIFIC REPORTS[J]. 2020, 10(1): http://dx.doi.org/10.1038/s41598-020-69517-7.
[9] 孟颂东. 海纳百川,励志前行-纪念田波院士. 微生物学报. 2020, 60(4): 628-, http://lib.cqvip.com/Qikan/Article/Detail?id=7101656172.
[10] Liu, LanLan, Hou, Junwei, Xu, Yuxiu, Qin, Lijuan, Liu, Weiwei, Zhang, Han, Li, Yang, Chen, Mi, Deng, Mengmeng, Zhao, Bao, Hu, Jun, Zheng, Huaguo, Li, Changfei, Meng, Songdong. PD-L1 upregulation by IFN-alpha/gamma-mediated Stat1 suppresses anti-HBV T cell response. PLOS ONE[J]. 2020, 15(7): https://www.webofscience.com/wos/woscc/full-record/WOS:000550068700002.
[11] Songdong Meng. PD-L1upregulation by IFN-a/r-mediated stat1 suppresses anti-HBV T cell response. PLOS ONE. 2020, [12] Qian, Liyuan, Fan, Hongxia, Ju, Ying, Chen, Lizhao, Li, Xin, Ye, Xin, Luo, Yunjing, Li, Changfei, Meng, Songdong. A peptide-based inhibitor of gp96 suppresses HBsAg expression and HBV replication by upregulation of p53. JOURNAL OF GENERAL VIROLOGY[J]. 2019, 100(8): 1241-1252, [13] Huaguo Zheng, Lanlan Liu, Han Zhang, Fangming Kan, Shuo Wang, Yang Li, Huaqin Tian, Songdong Meng. Dendritic cells pulsed with placental gp96 promote tumor-reactive immune responses.. PLoS ONE[J]. 2019, 14(1): https://doaj.org/article/91650ce685c14c8d8a7ab2b561813ec9.
[14] Li, Xin, Xu, Yuxiu, Ding, Yun, Li, Changfei, Zhao, Hong, Wang, Jiandong, Meng, Songdong. Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer. MOLECULAR CANCER[J]. 2018, 17(1): https://doaj.org/article/9aa543fe90d444089d458217795d3d49.
[15] Zhao, Jingmin, Zhang, Yu, Meng, Songdong. Disease Progress-Associated Evolution of Hepatitis B Virus Core Protein Driven By CD8(+) T-Cell Responses. HEPATOLOGYnull. 2018, 68: 150A-151A, https://www.webofscience.com/wos/woscc/full-record/WOS:000446020500243.
[16] Zhang, Yu, Wu, Yan, Deng, Mengmeng, Xu, Dongping, Li, Xiaodong, Xu, Zhihui, Hu, Jun, Zhang, Han, Liu, Kefang, Zhao, Yingze, Gao, Feng, Bi, Shengli, Gao, George F, Zhao, Jingmin, Liu, William J, Meng, Songdong. CD8(+) T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress. JOURNAL OF VIROLOGY[J]. 2018, 92(17): https://www.webofscience.com/wos/woscc/full-record/WOS:000443012300043.
[17] Songdong Meng. CD8+ T-Cell Responses-Associated Evolution of Hepatitis B Virus Core Protein in Disease Progress. J Virol. 2018, [18] Peng, Shanxin, Wang, Jing, Wei, Songtao, Li, Changfei, Zhou, Kai, Hu, Jun, Ye, Xin, Yan, Jinghua, Liu, Wenjun, Gao, George F, Fang, Min, Meng, Songdong. Endogenous Cellular MicroRNAs Mediate Antiviral Defense against Influenza A Virus. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2018, 10: 361-375, http://dx.doi.org/10.1016/j.omtn.2017.12.016.
[19] Zhang, Yu, Xu, Dongping, Meng, Songdong, Lu, Fengmin, Zhao, JingMin. Hepatitis B core-related antigen (HBcrAg) correlated with HBV serum viral markers and intrahepatic indicators in treatment-naive patients with acute and chronic HBV. HEPATOLOGYnull. 2017, 66: 785A-786A, https://www.webofscience.com/wos/woscc/full-record/WOS:000412089801610.
[20] Li, Xin, Wu, Bo, Chen, Lizhao, Ju, Ying, Li, Changfei, Meng, Songdong. Urokinase-type plasminogen activator receptor inhibits apoptosis in triple-negative breast cancer through miR-17/20a suppression of death receptors 4 and 5. ONCOTARGET[J]. 2017, 8(51): 88645-88657, https://www.webofscience.com/wos/woscc/full-record/WOS:000413585600036.
[21] Liu, William J, Lan, Jiaming, Liu, Kefang, Deng, Yao, Yao, Yanfeng, Wu, Shaolian, Chen, Hong, Bao, Lingling, Zhang, Haifeng, Zhao, Min, Wang, Qihui, Han, Lingxia, Chai, Yan, Qi, Jianxun, Zhao, Jincun, Meng, Songdong, Qin, Chuan, Gao, George F, Tan, Wenjie. Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus-Derived CD8(+) T Cell Epitopes and Host MHC. JOURNAL OF IMMUNOLOGY[J]. 2017, 198(2): 873-882, https://www.webofscience.com/wos/woscc/full-record/WOS:000392405000036.
[22] Shuo Wang, Hongxia Fan, Yang Li, Huaguo Zheng, Xin Li, Changfei Li, Lizhao Chen, Ying Ju, Songdong Meng. CD133 epitope vaccine with gp96 as adjuvant elicits an antitumor T cell response against leukemia. Chinese Journal of Biotechnology[J]. 2017, 33(6): 1006-1017, [23] Hong, Feng, Rachidi, Saleh Mohammad, Lundgren, Debbie, Han, David, Huang, Xiu, Zhao, Hongyu, Kimura, Yayoi, Hirano, Hisashi, Ohara, Osamu, Udono, Heichiiro, Meng, Songdong, Liu, Bei, Li, Zihai. Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90. PLOS ONE[J]. 2017, 12(1): https://doaj.org/article/8cc921265d2a4ee3a4d1c683cb44d165.
[24] Chu, Xiaoyu, Wu, Bo, Fan, Hongxia, Hou, Junwei, Hao, Junli, Hu, Jun, Wang, Baozhong, Liu, Guangze, Li, Changfei, Meng, Songdong. PTD-fused p53 as a potential antiviral agent directly suppresses HBV transcription and expression. ANTIVIRAL RESEARCH[J]. 2016, 127: 41-49, http://www.corc.org.cn/handle/1471x/2157548.
[25] Li, Changfei, Deng, Mengmeng, Hu, Jun, Li, Xin, Chen, Lizhao, Ju, Ying, Hao, Junli, Meng, Songdong. Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levels. ONCOTARGET[J]. 2016, 7(13): 17021-17034, https://www.webofscience.com/wos/woscc/full-record/WOS:000375692900130.
[26] Liu, Weiwei, Chen, Mi, Li, Xinghui, Zhao, Bao, Hou, Junwei, Zheng, Huaguo, Qiu, Lipeng, Li, Zihai, Meng, Songdong. Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response. PLOS ONE[J]. 2016, 11(5): https://doaj.org/article/be9161dd584a4f07b8319e533580e3ff.
[27] Songdong Meng. Heat shock protein gp96 enhances T cell responses and protective potential to Bacillus Calmette-Guérin vaccine. Scand J Immunol.. 2016, [28] 盛春海, 孙璐, 初骁宇, 李长菲, 孟颂东. 热休克蛋白gp96 3′UTR作为ceRNA通过miR-642a调控DOHH的表达*. 生物化学与生物物理进展[J]. 2016, 第10期(10): 990-996, http://www.corc.org.cn/handle/1471x/2091911.
[29] Deng, Mengmeng, Hou, Junwei, Hu, Jun, Wang, Shuo, Chen, Mi, Chen, Lizhao, Ju, Ying, Li, Changfei, Meng, Songdong. Hepatitis B virus mRNAs functionally sequester let-7a and enhance hepatocellular carcinoma. CANCER LETTERS[J]. 2016, 383(1): 62-72, http://dx.doi.org/10.1016/j.canlet.2016.09.028.
[30] Sheng ChunHai, Sun Lu, Chu XiaoYu, Li ChangFei, Meng SongDong. Heat Shock Protein gp96 3 ' UTR Functions as A ceRNA in Promoting DOHH Expression via miR-642a. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2016, 43(10): 990-996, http://www.corc.org.cn/handle/1471x/2159225.
[31] Songdong Meng. A C/EBPα-miR-122 inflammatory feedback circuit enhances hepatocellular carcinoma development.. Oncotarget. 2016, [32] 孟颂东. 热休克蛋白:肿瘤治疗的新希望. 知识就是力量. 2016, 8-9, http://lib.cqvip.com/Qikan/Article/Detail?id=667989916.
[33] Li, Xin, Wang, Baozhong, Liu, Weiwei, Gui, Mingming, Peng, Zheng, Meng, Songdong. Blockage of Conformational Changes of Heat Shock Protein gp96 on Cell Membrane by a alpha-Helix Peptide Inhibits HER2 Dimerization and Signaling in Breast Cancer. PLOS ONE[J]. 2015, 10(4): http://www.corc.org.cn/handle/1471x/2201420.
[34] Junwei Hou, Mengmeng Deng, Xin Li, Weiwei Liu, Xiaoyu Chu, Jing Wang, Feng Chen, Songdong Meng. Chaperone gp96 mediates ER-α36 cell membrane expression. Oncotarget. 2015, 6(31): 31857-31867, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741645/.
[35] Xin Li, Baozhong Wang, Weiwei Liu, Mingming Gui, Zheng Peng, Songdong Meng. Blockage of conformational changes of heat shock protein gp96 on cell membrane by a α-helix peptide inhibits HER2 dimerization and signaling in breast cancer.. PLoS ONE[J]. 2015, 10(4): [36] Wu, Bo, Chu, Xiaoyu, Feng, Cong, Hou, Junwei, Fan, Hongxia, Liu, Ningning, Li, Changfei, Kong, Xianping, Ye, Xin, Meng, Songdong. Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. CANCER LETTERS[J]. 2015, 359(2): 325-334, http://www.corc.org.cn/handle/1471x/2156254.
[37] Li, Xin, Sun, Lu, Hou, Junwei, Gui, Mingming, Ying, Jianming, Zhao, Hong, Lv, Ning, Meng, Songdong. Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer. INTERNATIONAL JOURNAL OF CANCER[J]. 2015, 137(3): 512-524, https://www.webofscience.com/wos/woscc/full-record/WOS:000354639200003.
[38] Hu, Jun, Xu, Yaxing, Li, Changfei, Hao, Junli, Peng, Shanxin, Chu, Xiaoyu, Zhang, Dake, Xu, Dongping, Meng, Songdong. A cross-talk between Hepatitis B virus and host mRNAs confers viral adaptation to liver. SCIENTIFIC REPORTS[J]. 2015, 5: https://www.webofscience.com/wos/woscc/full-record/WOS:000358035500001.
[39] Hou, Junwei, Deng, Mengmeng, Li, Xin, Liu, Weiwei, Chu, Xiaoyu, Wang, Jing, Chen, Feng, Meng, Songdong. Chaperone gp96 mediates ER-alpha 36 cell membrane expression. ONCOTARGET[J]. 2015, 6(31): 31857-31867, https://www.webofscience.com/wos/woscc/full-record/WOS:000363185200118.
[40] Hou, Junwei, Li, Xin, Li, Changfei, Sun, Lu, Zhao, Yulai, Zhao, Jingmin, Meng, Songdong. Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR. MOLECULAR ONCOLOGY[J]. 2015, 9(7): 1312-1323, http://dx.doi.org/10.1016/j.molonc.2015.03.004.
[41] Li, Changfei, Hu, Jun, Hao, Junli, Zhao, Bao, Wu, Bo, Sun, Lu, Peng, Shanxin, Gao, George F, Meng, Songdong. Competitive virus and host RNAs: the interplay of a hidden virus and host interaction. PROTEIN & CELLnull. 2014, 5(5): 348-356, https://www.webofscience.com/wos/woscc/full-record/WOS:000334936000005.
[42] Ju, Ying, Fan, Hongxia, Liu, Jun, Hu, Jun, Li, Xinghui, Li, Changfei, Chen, Lizhao, Gao, Qiang, Gao, George F, Meng, Songdong. Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine. VACCINE[J]. 2014, 32(23): 2703-2711, http://dx.doi.org/10.1016/j.vaccine.2014.03.045.
[43] Sun, Lu, Zhang, Yu, Zhao, Bao, Deng, Mengmeng, Liu, Jun, Li, Xin, Hou, Junwei, Gui, Mingming, Zhang, Shuijun, Li, Xiaodong, Gao, George F, Meng, Songdong. A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes. PROTEIN & CELL[J]. 2014, 5(4): 317-327, https://www.webofscience.com/wos/woscc/full-record/WOS:000334428400008.
[44] Peng Zheng, Li ChangFei, Hao JunLi, Meng SongDong. Mechanisms and Therapeutic Strategies of Chronic Infection and Inflammation-Associated Hepatocellular Carcinoma. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 41(1): 17-23, https://www.webofscience.com/wos/woscc/full-record/WOS:000330203100004.
[45] 冯聪, 吴博, 范红霞, 李长菲, 孟颂东. NF-κB激活gp96转录从而促进肝细胞生长、细胞周期进展和细胞转化. 微生物学报[J]. 2014, 第10期(10): 1212-1220, http://www.corc.org.cn/handle/1471x/2106087.
[46] Peng Zheng, Li ChangFei, Hao JunLi, Meng SongDong. Mechanisms and Therapeutic Strategies of Chronic Infection and Inflammation-Associated Hepatocellular Carcinoma. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2014, 41(1): 17-23, https://www.webofscience.com/wos/woscc/full-record/WOS:000330203100004.
[47] Zhao, Bao, Li, Xin, Wang, Beinan, Gao, Bin, Meng, Songdong. Prophylactic cancer vaccine, from concept to reality?. CHINESE SCIENCE BULLETINnull. 2014, 59(10): 944-949, https://www.webofscience.com/wos/woscc/full-record/WOS:000333023100003.
[48] 桂明明, 武慧英, 孙璐, 徐亚星, 赵报, 李鑫, 李长菲, 王希东, 孟颂东. 毕赤酵母表达gp96-scFv抗体及生物活性测定. 生物工程学报[J]. 2014, 30(4): 595-604, [49] Zhao, Bao, Wang, Yanzhong, Wu, Bo, Liu, Shan, Wu, Erjie, Fan, HongXia, Gui, MingMing, Chen, Lizhao, Li, Changfei, Ju, Ying, Zhang, Wei, Meng, Songdong. Placenta-derived gp96 as a multivalent prophylactic cancer vaccine. SCIENTIFIC REPORTS[J]. 2013, 3: https://www.webofscience.com/wos/woscc/full-record/WOS:000319960300001.
[50] Wang, Saifeng, Zhang, Xiaojun, Ju, Ying, Zhao, Bao, Yan, Xiaoli, Hu, Jun, Shi, Lei, Yang, Lebing, Ma, Zhibo, Chen, Lizhao, Liu, Yali, Duan, Zhongping, Chen, Xinyue, Meng, Songdong. MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B. JOURNAL OF IMMUNOLOGY[J]. 2013, 191(1): 293-301, https://www.webofscience.com/wos/woscc/full-record/WOS:000320765000034.
[51] Li, Changfei, Wang, Yanzhong, Wang, Saifeng, Wu, Bo, Hao, Junli, Fan, Hongxia, Ju, Ying, Ding, Yuping, Chen, Lizhao, Chu, Xiaoyu, Liu, Wenjun, Ye, Xin, Meng, Songdong. Hepatitis B Virus mRNA-Mediated miR-122 Inhibition Upregulates PTTG1-Binding Protein, Which Promotes Hepatocellular Carcinoma Tumor Growth and Cell Invasion. JOURNAL OF VIROLOGY[J]. 2013, 87(4): 2193-2205, https://www.webofscience.com/wos/woscc/full-record/WOS:000314072000025.
[52] Zhang, Yu, Ren, Yulin, Wu, Yan, Zhao, Bao, Qiu, Lipeng, Li, Xiaodong, Xu, Dongping, Liu, Jun, Gao, George F, Meng, Songdong. The L60V Variation in Hepatitis B Virus Core Protein Elicits New Epitope-Specific Cytotoxic T Lymphocytes and Enhances Viral Replication. JOURNAL OF VIROLOGY[J]. 2013, 87(14): 8075-8084, https://www.webofscience.com/wos/woscc/full-record/WOS:000321017700027.
[53] Chen, Caiwei, Li, Jing, Bi, Yuhai, Yang, Limin, Meng, Shanshan, Zhou, Yuancheng, Jia, Xiaojuan, Meng, Songdong, Sun, Lei, Liu, Wenjun. Synthetic B- and T-cell epitope peptides of porcine reproductive and respiratory syndrome virus with Gp96 as adjuvant induced humoral and cell-mediated immunity. VACCINE[J]. 2013, 31(14): 1838-1847, http://dx.doi.org/10.1016/j.vaccine.2013.01.049.
[54] Hongxia Fan, Xiaoli Yan, Yu Zhang, Xiaojun Zhang, Yanzhou Gao, Yaxing Xu, Fusheng Wang, Songdong Meng. Increased expression of Gp96 by HBx-induced NF-κB activation feedback enhances hepatitis B virus production.. PLoS ONE[J]. 2013, 8(6): https://doaj.org/article/8a3024e160814ec48a83166b449c0e7c.
[55] Li, Xinghui, Liu, Zhen, Yan, Xiaoli, Zhang, Xiaojun, Li, Yang, Zhao, Bao, Wang, Shengdian, Zhou, Xuyu, Gao, George F, Meng, Songdong. Induction of Regulatory T Cells by High-Dose gp96 Suppresses Murine Liver Immune Hyperactivation. PLOS ONE[J]. 2013, 8(7): https://doaj.org/article/17ebb4e46790479abee023d23227ea27.
[56] Songdong Meng. HBV mRNAs-mediated miR-122 inhibition up-regulates PTTG1-binding protein which promotes HCC tumor growth and cell invasion.. Journal of Virology. 2013, [57] Zhao, Bao, Wang, Yanzhong, Zhang, Yu, Li, Yang, Zhang, Xiaojun, Xu, Yaxing, Chen, Lizhao, Li, Changfei, Ju, Ying, Meng, Songdong. TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses. VACCINE[J]. 2013, 31(3): 545-552, http://dx.doi.org/10.1016/j.vaccine.2012.11.011.
[58] Songdong Meng. The L60V variation in HBV core protein elicits new epitope-specific cytotoxic T lymphocytes and enhances viral replication. Journal of Virology. 2013, [59] Hao, Junli, Jin, Wensong, Li, Xinghui, Wang, Saifeng, Zhang, Xiaojun, Fan, Hongxia, Li, Changfei, Chen, Lizhao, Gao, Bin, Liu, Guangze, Meng, Songdong. Inhibition of Alpha Interferon (IFN-alpha)-Induced MicroRNA-122 Negatively Affects the Anti-Hepatitis B Virus Efficiency of IFN-alpha. JOURNAL OF VIROLOGY[J]. 2013, 87(1): 137-147, https://www.webofscience.com/wos/woscc/full-record/WOS:000312455500011.
[60] 徐亚星, 王彦中, 赵报, 张小俊, 范红霞, 李星辉, 孟颂东. 电转联合热休克蛋白佐剂疫苗引发抗HBV的免疫应答. 生物工程学报[J]. 2013, 29(12): 1765-1775, [61] Songdong Meng. IFN-α-induced miR-122 inhibition negatively affects the anti-HBV efficiency of IFN-α.. 2013, [62] 徐亚星, 王彦中, 赵报, 张小俊, 范红霞, 李星辉, 孟颂东. 电转联合热休克蛋白佐剂疫苗引发抗HBV的免疫应答(英文). 生物工程学报. 2013, 1765-1775, [[["https://nxgp.cnki.net/kcms/detail?v=3uoqIhG8C46NmWw7YpEsKI4TPwAUKfiQHF-GpnOO1Am0jlsDKtI1Lkz4xc-QV28rgHzEqx-q6BpiyAlkmhsxAgLKFoSaQEdr&uniplatform=NZKPT"]]].
[63] Fan, Hongxia, Yan, Xiaoli, Zhang, Yu, Zhang, Xiaojun, Gao, Yanzhou, Xu, Yaxing, Wang, Fusheng, Meng, Songdong. Increased Expression of Gp96 by HBx-Induced NF-kappa B Activation Feedback Enhances Hepatitis B Virus Production. PLOS ONE[J]. 2013, 8(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000320755400045.
[64] Songdong Meng. Loss of MiR-122 Expression in Patients with Hepatitis B Enhances Hepatitis B Virus Replication through Cyclin G1 Modulated P53 Activity.. 2012, [65] 徐亚星, 王赛锋, 张小俊, 孟颂东. 热激蛋白gp96免疫学功能及在主动免疫治疗肿瘤和传染病中的应用. 生物工程学报[J]. 2012, 28(3): 261-266, http://lib.cqvip.com/Qikan/Article/Detail?id=41242381.
[66] Wang, Yetao, Tong, Xiaomei, Omoregie, Ehimwenma Sheena, Liu, Wenjun, Meng, Songdong, Ye, Xin. Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid-inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination-dependent Manner. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 287(41): 34626-34634, http://dx.doi.org/10.1074/jbc.M112.390401.
[67] Wang, Saifeng, Qiu, Lipeng, Yan, Xiaoli, Jin, Wensong, Wang, Yanzhong, Chen, Lizhao, Wu, Erjie, Ye, Xin, Gao, George F, Wang, Fusheng, Chen, Yu, Duan, Zhongping, Meng, Songdong. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G1-modulated P53 activity. HEPATOLOGY[J]. 2012, 55(3): 730-741, https://www.webofscience.com/wos/woscc/full-record/WOS:000300699900010.
[68] Hu, Jun, Xu, Yaxing, Hao, Junli, Wang, Saifeng, Li, Changfei, Meng, Songdong. MiR-122 in hepatic function and liver diseases. PROTEIN & CELLnull. 2012, 3(5): 364-371, https://www.webofscience.com/wos/woscc/full-record/WOS:000310528300006.
[69] Yan, Xiaoli, Zhang, Xiaojun, Wang, Yanzhong, Li, Xinghui, Wang, Saifeng, Zhao, Bao, Li, Yang, Ju, Ying, Chen, Lizhao, Liu, Wenjun, Meng, Songdong. Regulatory T-cell depletion synergizes with gp96-mediated cellular responses and antitumor activity. CANCER IMMUNOLOGY IMMUNOTHERAPY[J]. 2011, 60(12): 1763-1774, https://www.webofscience.com/wos/woscc/full-record/WOS:000297342400010.
[70] Yan, Xiaoli, Zhang, Xiaojun, Wang, Yanzhong, Li, Xinghui, Wang, Saifeng, Zhao, Bao, Li, Yang, Ju, Ying, Chen, Lizhao, Liu, Wenjun, Meng, Songdong. Regulatory T-cell depletion synergizes with gp96-mediated cellular responses and antitumor activity. CANCER IMMUNOLOGY IMMUNOTHERAPY[J]. 2011, 60(12): 1763-1774, https://www.webofscience.com/wos/woscc/full-record/WOS:000297342400010.
[71] Zhang Yudan, Cao Sheng, Meng Songdong, Gao, George Fu. A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous protein and E. coli heterologously-expressed fragment. JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY[J]. 2011, 18(6): 1857-1864, http://lib.cqvip.com/Qikan/Article/Detail?id=40231943.
[72] Li, Yang, Song, Haolei, Li, Jin, Wang, Yanzhong, Yan, Xiaoli, Zhao, Bao, Zhang, Xiaojun, Wang, Saifeng, Chen, Lizhao, Qiu, Bingsheng, Meng, Songdong. Hansenula polymorpha expressed heat shock protein gp96 exerts potent T cell activation activity as an adjuvant. JOURNAL OF BIOTECHNOLOGY[J]. 2011, 151(4): 343-349, http://dx.doi.org/10.1016/j.jbiotec.2010.12.006.
[73] 陈才伟, 贾晓娟, 孟颂东, 刘文军. Gp96蛋白的免疫学及其临床应用研究进展. 生物工程学报[J]. 2011, 27(5): 704-711, http://lib.cqvip.com/Qikan/Article/Detail?id=37994744.
[74] Wang, Saifeng, Qiu, Lipeng, Liu, Guangze, Li, Yang, Zhang, Xiaojun, Jin, Wensong, Gao, George F, Kong, Xianping, Meng, Songdong. Heat shock protein gp96 enhances humoral and T cell responses, decreases Treg frequency and potentiates the anti-HBV activity in BALB/c and transgenic mice. VACCINE[J]. 2011, 29(37): 6342-6351, http://dx.doi.org/10.1016/j.vaccine.2011.05.008.
[75] 闫晓丽, 李长菲, 张小俊, 鞠莹, 赵报, 孟颂东. 体外大量制备新型gp96肿瘤疫苗及其诱导的特异性抗肿瘤免疫应答分析. 生物工程学报[J]. 2011, 27(11): 1598-1605, http://lib.cqvip.com/Qikan/Article/Detail?id=40031584.
[76] Cao, Sheng, Li, Yang, Li, Jin, Li, ChangFei, Zhang, Wei, Yang, ZengQi, Meng, SongDong. Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer. ONCOLOGY REPORTS[J]. 2010, 23(2): 423-428, https://www.webofscience.com/wos/woscc/full-record/WOS:000273873500016.
[77] Qiu, Lipeng, Fan, Hongxia, Jin, Wensong, Zhao, Bao, Wang, Yanzhong, Ju, Ying, Chen, Lizhao, Chen, Yu, Duan, Zhongping, Meng, Songdong. miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2010, 398(4): 771-777, http://124.16.144.217/handle/311023/2470.
[78] 金文松, 胡坤, 杨日高, 胡开辉, 孟颂东. 热休克蛋白-多肽复合物疫苗用于肿瘤治疗的研究进展. 肿瘤防治研究[J]. 2010, 963-966, http://lib.cqvip.com/Qikan/Article/Detail?id=35046383.
[79] 任玉林, 张宇, 邱立鹏, 张小俊, 陈煜, 王福生, 谢尧, 高斌, 段钟平, 孟颂东. 新型HLA-A2限制的B,C型HBV特异性CTL表位的筛选及鉴定. 科学通报[J]. 2010, 2915-2926, http://lib.cqvip.com/Qikan/Article/Detail?id=35969653.
[80] Songdong Meng. RNAi-mediated Downregulation of uPAR Synergizes with Targeting of HER2 Through ERK Pathway in Breast Cancer Cells.. International Journal of Cancer. 2010, [81] 李杨, 王赛锋, 孟颂东. 乙肝治疗性疫苗的研制与临床应用. 生物技术通报[J]. 2010, 33-37, http://lib.cqvip.com/Qikan/Article/Detail?id=33509970.
[82] 孟颂东. gp96新型乙肝治疗性疫苗. 中国科技成果. 2009, 10-10, http://lib.cqvip.com/Qikan/Article/Detail?id=32110809.
[83] 刘振, 崔玉东, 孟颂东. 联合使用低剂量环磷酰胺有效增强热休克蛋白gp96免疫佐剂功能. 生物技术通报[J]. 2009, 117-121, http://lib.cqvip.com/Qikan/Article/Detail?id=30577800.
[84] 李长菲, 操胜, 孟颂东. 肿瘤休眠机制与治疗靶点的发现. 癌症:英文版[J]. 2009, 555-558, http://lib.cqvip.com/Qikan/Article/Detail?id=30273433.
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[86] Liu, Zhen, Li, Xinghui, Qiu, Lipeng, Zhang, Xiaojun, Chen, Lizhao, Cao, Sheng, Wang, Fusheng, Meng, Songdong. Treg suppress CTL responses upon immunization with HSP gp96. EUROPEAN JOURNAL OF IMMUNOLOGY[J]. 2009, 39(11): 3110-3120, http://124.16.144.217/handle/311023/1241.
[87] 李燕, 孟颂东, 陈溥言, 高福, 田波. 马立克氏病毒感染的鸡肝脏肿瘤中热应激蛋白108含量的增高及其基因序列分析和表达的研究. 自然科学进展[J]. 2003, 13(7): 698-702, http://lib.cqvip.com/Qikan/Article/Detail?id=8077012.
[88] Meng Songdong, Wang Rong, Yang Huaiyi, Tian Bo, Huang Guocun. Cloning of Glutamate Dehydrogenase cDNA from Chlorella sorokinmna and Analysis of Transgenic Tobacco Plants. Acta Botanica Sinica[J]. 2002, 44(3): 318-324, [89] 黄国存, 孟颂东. 小球藻NADP—谷氨酸脱氢酶的cDNA克隆及转基因烟草分析. 植物学报:英文版. 2002, 44(3): 318-324, http://lib.cqvip.com/Qikan/Article/Detail?id=6129301.
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指导学生

已指导学生

任玉林  硕士研究生  071010-生物化学与分子生物学  

邱立鹏  博士研究生  071010-生物化学与分子生物学  

闫晓丽  硕士研究生  071005-微生物学  

王彦中  硕士研究生  071005-微生物学  

现指导学生

王赛锋  博士研究生  071010-生物化学与分子生物学  

郝军莉  硕士研究生  071005-微生物学  

范红霞  博士研究生  071005-微生物学  

李星辉  博士研究生  071005-微生物学  

胡俊  硕士研究生  071010-生物化学与分子生物学  

徐亚星  硕士研究生  430139-生物工程  

郜衍周  硕士研究生  071010-生物化学与分子生物学  

李鑫  博士研究生  071010-生物化学与分子生物学