基本信息
孟幻  男  博导  国家纳米科学中心
电子邮件: mengh@nanoctr.cn
通信地址: 北京市海淀区中关村北一条11号
邮政编码:

研究领域

纳米药学、智能纳米药物递送、纳米生物效应和纳米安全性等。

招生信息

招生专业
0703J1-纳米科学与技术
100702-药剂学
招生方向
纳米药学,智能纳米药物递送,纳米生物效应和纳米安全性等

教育背景

2007-07--2008-06   Howard University   交换生
2003-09--2008-06   中国科学院研究生院   博士
1999-09--2003-06   北京大学   药学学士

工作经历

   
工作简历
2021-03~现在, 国家纳米科学中心, 研究员
2020-07~2021-02,University of California, Los Angeles, Associate Professor
2013-07~2020-06,University of California, Los Angeles, Assistant Professor
2010-07~2013-06,University of California, Los Angeles, Assistant Researcher
2008-07~2010-06,University of California, Los Angeles, 博士后
社会兼职
2022-01-01-今,《Biomedical Microdevices》(Nature出版社), 副主编
2021-08-01-今,《Nano Today》(Elsevier出版社), 咨询编辑
2021-06-01-今,中国抗癌协会纳米肿瘤学专业委员会, 委员
2018-07-01-今,中国毒理学会 纳米毒理专业委员会, 委员

专利与奖励

   
奖励信息
(1) Precision Nanomedicine Rising Talents, 一等奖, 其他, 2021

出版信息

   
发表论文
[1] Xie, Xiaodong, Jiang, Jinhong, Liu, Xiangsheng, Cao, Yuhong, Li, Jiulong, Xia, Tian, Meng, Huan. Interleukin-10 plasmid delivery by polymeric nanocarrier shows efficient and safe tissue repair in acute muscle damage models in mice. NANO TODAY[J]. 2022, 46: http://dx.doi.org/10.1016/j.nantod.2022.101544.

[2] Wang, Wenbin, Sun, Hui, Gong, Yan, Liu, Xiangsheng, Liu, Xiao, Wang, Mengru, Li, Silu, Li, Jiulong, Zhu, Lin, Meng, Huan. Ratiometric co-delivery of hydroxychloroquine and calculated low-dose paclitaxel efficiently suppresses tumor growth in hepatocellular carcinoma mouse models in vivo. NANO TODAY[J]. 2022, 44: http://dx.doi.org/10.1016/j.nantod.2022.101446.

[3] Li, Jiulong, Gao, Xingfa, Wang, Yuguang, Xia, Tian, Zhao, Yuliang, Meng, Huan. Precision design of engineered nanomaterials to guide immune systems for disease treatment. MATTERnull. 2022, 5(4): 1162-1191, http://dx.doi.org/10.1016/j.matt.2022.03.005.

[4] li, Bozhao, Zhang, Xiuping, Wu, Zhouliang, Chu, Tianjiao, Yang, Zhenlin, Xu, Shuai, Wu, Suying, Qie, Yunkai, Lu, Zefang, Qi, Feilong, Hu, Minggen, Zhao, Guodong, Wei, Jingyan, Zhao, Yuliang, Nie, Guangjun, Meng, Huan, Liu, Rong, Li, Suping. Reducing Postoperative Recurrence of Early-Stage Hepatocellular Carcinoma by a Wound-Targeted Nanodrug. Advanced Science[J]. 2022, 9(20): e2200477-, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000791693300001.

[5] Wang, Liying, Liu, Zimo, Zhou, Quan, Gu, Sufang, Liu, Xiangsheng, Huang, Jianxiang, Jiang, Haiping, Wang, Huifang, Cao, Liping, Sun, Jihong, Shen, Youqing, Meng, Huan, Liu, Xiangrui. Prodrug nanoparticles rationally integrating stroma modification and chemotherapy to treat metastatic pancreatic cancer. BIOMATERIALS[J]. 2021, 278: http://dx.doi.org/10.1016/j.biomaterials.2021.121176.

[6] Liu, Xiangsheng, Xie, Xiaodong, Jiang, Jinhong, Lin, Matthew, Zheng, Emily, Qiu, Waveley, Yeung, Iwin, Zhu, Motao, Li, Qinglin, Xia, Tian, Meng, Huan. Use of Nanoformulation to Target Macrophages for Disease Treatment. ADVANCED FUNCTIONAL MATERIALSnull. 2021, 31(38): http://dx.doi.org/10.1002/adfm.202104487.

[7] Liwei You, Zhenhan Feng, Yuliang Zhao, Huan Meng, Motao Zhu. The Role of Autophagy at Nano/Bio Interface - Underlying Mechanisms and Therapeutic Potential in Cancer. Precision Nanomedicine (2021)[J]. 2021, https://doaj.org/article/63dca529fc324818a21b6ab493f82e82.

[8] Feng, Zhenhan, Meng, Huan. Efficient nano-enabled therapy for gastrointestinal cancer using silicasome delivery technology. SCIENCE CHINA-CHEMISTRY[J]. 2021, 64(11): 1946-1957, http://dx.doi.org/10.1007/s11426-021-1126-x.

[9] Allen, Sean D, Liu, Xiangsheng, Jiang, Jinhong, Liao, YuPei, Chang, Chong Hyun, Nel, Andre E, Meng, Huan. Immune checkpoint inhibition in syngeneic mouse cancer models by a silicasome nanocarrier delivering a GSK3 inhibitor. BIOMATERIALS[J]. 2021, 269: 120635-120635, http://dx.doi.org/10.1016/j.biomaterials.2020.120635.

[10] Liu, Xiangsheng, Jiang, Jinhong, Liao, YuPei, Tang, Ivanna, Zheng, Emily, Qiu, Waveley, Lin, Matthew, Wang, Xiang, Ji, Ying, Mei, KuoChing, Liu, Qi, Chang, Chong Hyun, Wainberg, Zev A, Nel, Andre E, Meng, Huan. Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1. ADVANCED SCIENCE[J]. 2021, 8(6): https://doaj.org/article/c08726d25ff14c68a302bfa813b306c1.

[11] Liu, Xiangsheng, Jiang, Jinhong, Chang, Chong Hyun, Liao, YuPei, Lodico, Jared J, Tang, Ivanna, Zheng, Emily, Qiu, Waveley, Lin, Matthew, Wang, Xiang, Ji, Ying, Mei, KuoChing, Nel, Andre E, Meng, Huan. Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy. SMALL[J]. 2021, 17(14): e2005993-e2005993, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8035264/.

[12] Wang, Yiting, Shi, Hubing, Meng, Huan, Xu, Jie. Editorial: Targeting the PD-1/PD-L1 Cancer Immune Evasion Axis: Challenges and Emerging Strategies. FRONTIERS IN PHARMACOLOGY[J]. 2020, 11: https://doaj.org/article/46b3212c8e2747e48e25f5a54e18d853.

[13] Mei, KuoChing, Liao, YuPei, Jiang, Jinhong, Chiang, Michelle, Khazaieli, Mercedeh, Liu, Xiangsheng, Wang, Xiang, Liu, Qi, Chang, Chong Hyun, Zhang, Xiao, Li, Juan, Ji, Ying, Melano, Brenda, Telesca, Donatello, Xia, Tian, Meng, Huan, Nel, Andre E. Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-immunotherapy in Multiple Solid Tumors. ACS NANO[J]. 2020, 14(10): 13343-13366, https://www.webofscience.com/wos/woscc/full-record/WOS:000586793400085.

[14] Ying Ji, Xiangsheng Liu, Juan Li, Xiaodong Xie, Max Huang, Jinhong Jiang, YuPei Liao, Timothy Donahue, Huan Meng. Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment. NATURE COMMUNICATIONS[J]. 2020, 11(1): https://doaj.org/article/31c76ea7b3164187a605c51cb968ea7b.

[15] Nie, Huifang, Xie, Xiaodong, Zhang, Doudou, Zhou, Yu, Li, Bifei, Li, Fengqiao, Li, Feiyang, Cheng, Yunlong, Mei, Hao, Meng, Huan, Jia, Lee. Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer. NANOSCALE[J]. 2020, 12(2): 877-887, http://dx.doi.org/10.1039/c9nr09011h.

[16] Xiangsheng Liu, Ivanna Tang, Zev A Wainberg, Huan Meng. Safety Considerations of Cancer Nanomedicine – A key step towards translation. Small (Weinheim an der Bergstrasse, Germany). 2020, 16(36): e2000673-e2000673, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486239/.

[17] Liu, Xiangsheng, Jiang, Jinhong, Meng, Huan. Transcytosis - An effective targeting strategy that is complementary to "EPR effect" for pancreatic cancer nano drug delivery. THERANOSTICSnull. 2019, 9(26): 8018-8025, http://dx.doi.org/10.7150/thno.38587.

[18] Ji, Ying, Liu, Xiangsheng, Huang, Max, Jiang, Jinhong, Liao, YuPei, Liu, Qi, Chang, Chong Hyun, Liao, Han, Lu, Jianqin, Wang, Xiang, Spencer, Melissa J, Meng, Huan. Development of self-assembled multi-arm polyrotaxanes nanocarriers for systemic plasmid delivery in vivo. BIOMATERIALS[J]. 2019, 192: 416-428, http://dx.doi.org/10.1016/j.biomaterials.2018.11.027.

[19] Emami, Michael R, Young, Courtney S, Ji, Ying, Liu, Xiangsheng, Mokhonova, Ekaterina, Pyle, April D, Meng, Huan, Spencer, Melissa J. Polyrotaxane Nanocarriers Can Deliver CRISPR/Cas9 Plasmid to Dystrophic Muscle Cells to Successfully Edit the DMD Gene. ADVANCED THERAPEUTICS[J]. 2019, 2(7): 
[20] Liu, Xiangsheng, Jiang, Jinhong, Chan, Ryan, Ji, Ying, Lu, Jianqin, Liao, YuPei, Okene, Michael, Lin, Joshua, Lin, Paulina, Chang, Chong Hyun, Wang, Xiang, Tang, Ivanna, Zheng, Emily, Qiu, Waveley, Wainberg, Zev A, Nel, Andre E, Meng, Huan. Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer. ACS NANO[J]. 2019, 13(1): 38-53, 
[21] Meng Huan. Use of Nano Engineered Approaches to Overcome the Stromal Barrier in Pancreas Cancer. Adv. Drug Deliv. Rev. 2018, 
[22] Meng, Huan, Leong, Wei, Leong, Kam W, Chen, Chunying, Zhao, Yuliang. Walking the line: The fate of nanomaterials at biological barriers. BIOMATERIALS[J]. 2018, 174: 41-53, http://dx.doi.org/10.1016/j.biomaterials.2018.04.056.

[23] Meng Huan. Irinotecan Delivery by Lipid-Coated Mesoporous Silica Nanoparticles Show Improved Efficacy and Safety over Liposomes for Pancreatic Cancer. ACS Nano. 2016, 
[24] Meng, Huan, Wang, Meiying, Liu, Huiyu, Liu, Xiangsheng, Situ, Allen, Wu, Bobby, Ji, Zhaoxia, Chang, Chong Hyun, Nel, Andre E. Use of a Lipid-Coated Mesoporous Silica Nanoparticle Platform for Synergistic Gemcitabine and Paclitaxel Delivery to Human Pancreatic Cancer in Mice. ACS NANO[J]. 2015, 9(4): 3540-3557, 
[25] Meng Huan. Pellegrino T*. Plasmonic Copper Sulfide Nanocrystals Exhibiting Near-infrared Photothermal and Photodynamic Therapeutic Effects. ACS Nano. 2015, 
[26] Meng, Huan, Wei, Ran. Use of smart designed nanoparticles to impact cancer surgery. SCIENCE BULLETIN. 2015, 60(1): 142-143, http://dx.doi.org/10.1007/s11434-014-0701-z.

[27] Mai, Wilson X, Meng, Huan. Mesoporous silica nanoparticles: A multifunctional nano therapeutic system. INTEGRATIVE BIOLOGYnull. 2013, 5(1): 19-28, https://www.webofscience.com/wos/woscc/full-record/WOS:000312391300003.

[28] Meng, Huan, Mai, Wilson X, Zhang, Haiyuan, Xue, Min, Xia, Tian, Lin, Sijie, Wang, Xiang, Zhao, Yang, Ji, Zhaoxia, Zink, Jeffrey I, Nel, Andre E. Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo. ACS NANO[J]. 2013, 7(2): 994-1005, https://www.webofscience.com/wos/woscc/full-record/WOS:000315618700015.

[29] Meng, Huan, Zhao, Yang, Dong, Juyao, Xue, Min, Lin, YuShen, Ji, Zhaoxia, Mai, Wilson X, Zhang, Haiyuan, Chang, Chong Hyun, Brinker, C Jeffrey, Zink, Jeffrey I, Nel, Andre E. Two-Wave Nanotherapy To Target the Stroma and Optimize Gemcitabine Delivery To a Human Pancreatic Cancer Model in Mice. ACS NANO[J]. 2013, 7(11): 10048-10065, https://www.webofscience.com/wos/woscc/full-record/WOS:000327752200053.

[30] Xiangsheng Liu, Paulina Lin, Ian Perrett, Joshua Lin, YuPei Liao, Chong Hyun Chang, Jinhong Jiang, Nanping Wu, Timothy Donahue, Zev Wainberg, Andre E Nel, Huan Meng. Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer. The Journal of Clinical Investigation. 127(5): 2007-2018, https://www.webofscience.com/wos/woscc/full-record/WOS:000400381000036.

发表著作
(1) Nanotoxicology, American Scientific Publisher, 2007-03, 第 其他 作者
(2) Advanced Delivery and Therapeutic Applications of RNAi, John Wiley & Sons, Inc., 2013-04, 第 3 作者
(3) Cancer Nano Plan 2015, NCI/NIH, Bethesda, Maryland, USA, 2015-07, 第 其他 作者

科研活动

   
科研项目
( 1 ) 药用纳米生物工程研究, 主持, 部委级, 2021-03--2024-03