基本信息
马晓丰  男  硕导  生命科学学院
电子邮件: maxiaofeng@ucas.ac.cn
通信地址: 北京市玉泉路19号甲
邮政编码: 100049

研究领域

天然产物化学:天然来源的脂肪酸合酶抑制剂的结构及生物功能研究
酶学:脂肪酸合酶抑制剂的作用机理研究

招生信息

   
招生专业
071010-生物化学与分子生物学
071001-植物学
071009-细胞生物学
招生方向
天然来源的脂肪酸合酶抑制剂
天然活性成分的结构与功能
脂肪酸合酶抑制剂对脂肪细胞的抑制作用

教育背景

2000-09--2003-07   沈阳药科大学   博士
1997-09--2000-07   辽宁中医学院   硕士
1993-09--1997-07   沈阳药科大学   学士
学历
沈阳药科大学 -- 研究生
学位
沈阳药科大学 -- 博士

工作经历

2001-2003年,北京大学药学院从事博士论文工作。
2003-2005年,中国科学院研究生院生物系酶学实验室,博士后工作。
2005-2007年,中国科学院研究生院生物系,教学及科研工作。
2007年6月-现在,中国科学院研究生院生命科学学院,教学及科研工作。
工作简历
2015-02~2016-02,National Institutes of Health, 访问学者
2006-06~2011-06,中国科学院研究生院, 副教授
2005-06~2006-06,中国科学院研究生院, 讲师
2003-09~2005-05,中国科学院研究生院, 博士后

教授课程

蛋白质组学
天然产物新药开发
药物分析
生物化学实验原理与技术
天然药物研究方法学导论
酶动力学及抑制剂
植物化学
植物化学讨论课
文献阅读课
生物医学与新药开发
天然产物与新药开发

专利与奖励

2008年获得李时珍医药创新奖1等奖 “威灵仙等5种常用中药化学成分和质量标准示范性研究”(排名第4)中华中医药学会。
2010年获得北京市科学技术3等奖“脂肪酸合酶的作用机制及植物来源的抑制剂”(排名第2)北京市科学技术委员会。
2010年获得中国科学院卢嘉锡青年人才奖。中国科学院王宽诚教育基金会。
中国科学院研究生院优良课程(2005-2006学年; 2006-2007学年)
中国科学院研究生院生命科学学院优秀课程(2009-2010学年)
中国科学院研究生院优秀个人(2006年度,2010年度)
奖励信息
(1) 中国科学院青年创新促进会年度优秀会员, 一等奖, 部委级, 2013
(2) 教育部科学技术进步奖, 二等奖, 部委级, 2012
(3) 中国科学院青年创新促进会, , 院级, 2011
(4) 卢嘉锡青年人才奖, 一等奖, 院级, 2010
(5) 李时珍医药创新奖, 一等奖, 部委级, 2008
(6) 北京市科学技术奖, 三等奖, 省级, 2008
专利成果
[1] 马晓丰, 舒庆艳, 赵颖涛, 赵利新, 邢旭, 郭星, 王纯妍. 一种基于模拟移动床分离神经酸的方法. CN: CN113173847A, 2021-07-27.
[2] 马晓丰, 樊慧锦, 赵颖涛, 赵利新, 邢旭, 郭星, 王纯妍. 具有脂肪酸合酶抑制活性的苹果皮提取物及其应用. CN: CN112870265A, 2021-06-01.
[3] 王小艳, 马晓丰, 蒋冰, 吕欢欢, 王洪伦. 白藜芦醇低聚体在制备药物中的用途. 中国: CN105147660A, 2015-12-16.
[4] 王小艳, 马晓丰, 袁木荣, 王洪伦, 田维熙, 李平, 索有瑞, 尤进茂. 一种脂肪酸合酶抑制剂及其应用. 中国: CN102847156A, 2013-01-02.
[5] 马晓丰, 王小艳, 王洪伦, 田维熙, 索有瑞, 王祎. 一种沙棘提取物及其制备方法与在抑制脂肪酸合酶活性中的应用. 中国: CN102755359A, 2012-10-31.

出版信息

   
发表论文
[1] Huijin Fan, Wenyuan Huang, Yong Guo, Xiaofeng Ma, Jianhong Yang. Alpha-Linolenic Acid Suppresses Proliferation and Invasion in Osteosarcoma Cells via Inhibiting Fatty Acid Synthase. Molecules[J]. 2022, [2] Wenyuan Huang, Xing Guo, Chunyan Wang, Zhengan Liu, Xiaofeng Ma, Qingyan Shu. α-Linolenic acid induces apoptosis, inhibits the invasion and metastasis, and arrests cell cycle in human breast cancer cells by inhibiting fatty acid synthase. Journal of Functional Foods[J]. 2022, 92: 105041-, [3] Yan Liang, Fan Kong, Xiaofeng Ma, Qingyan Shu. Inhibitory Effect of Acer truncatum Bunge Seed Coat Extract on Fatty Acid Synthase, Differentiation and Lipid Accumulation in 3T3-L1 Adipocytes. Molecules[J]. 2022, 27(4): [4] Huang WenYuan, Wang HongJun, Alzhan, Amantay, Tian WeiXi, Ma XiaoFeng. Traditional Chinese Medicines With Anti-inflammatory Functions and Their Inhibitory Effects on Fatty Acid Synthase. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICSnull. 2020, 47(8): 809-817, https://www.webofscience.com/wos/woscc/full-record/WOS:000565297900013.
[5] Wang, Xiaoyan, Jiang, Bing, Lv, Huanhuan, Liang, Yan, Ma, Xiaofeng. Vitisin B as a novel fatty acid synthase inhibitor induces human breast cancer cells apoptosis. AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH[J]. 2019, 11(8): 5096-5104, https://www.webofscience.com/wos/woscc/full-record/WOS:000483963700040.
[6] Huang, Wenyuan, Liang, Yan, Ma, Xiaofeng. Alpha-mangostin induces endoplasmic reticulum stress and autophagy which count against fatty acid synthase inhibition mediated apoptosis in human breast cancer cells. CANCER CELL INTERNATIONAL[J]. 2019, 19(1): https://doaj.org/article/be795ceedfea45afa5ad6c76804dad9a.
[7] Jiang, Hezhong, Yuan, Juanjuan, Ma, Qingyun, Ma, Xiaofeng, Zhao, Youxing. Phenolic Compounds from Mangifera indica. CHEMISTRY OF NATURAL COMPOUNDS[J]. 2019, 55(1): 147-150, https://www.webofscience.com/wos/woscc/full-record/WOS:000461554200039.
[8] Wei, Guoqing, Chen, Hui, Nie, Fangyuan, Ma, Xiaofeng, Jiang, Hezhong. 1, 3, 6-Trihydroxy-7-Methyl-9, 10-Anthracenedione Isolated from genus Lindera with Anti-Cancer Activity. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY[J]. 2017, 17(11): 1604-1607, https://www.webofscience.com/wos/woscc/full-record/WOS:000416534200017.
[9] Nie, Fangyuan, Liang, Yan, Jiang, Bing, Li, Xiabing, Xun, Hang, He, Wei, Lau, Hay Tong, Ma, Xiaofeng. Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells. TUMOR BIOLOGY[J]. 2016, 37(2): 2137-2143, https://www.webofscience.com/wos/woscc/full-record/WOS:000374593300080.
[10] Fan, Huijin, Liang, Yan, Jiang, Bing, Li, Xiabing, Xun, Hang, Sun, Jia, He, Wei, Lau, Hay Tong, Ma, Xiaofeng. Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells. ONCOLOGY REPORTS[J]. 2016, 35(5): 2651-2656, https://www.webofscience.com/wos/woscc/full-record/WOS:000374077700018.
[11] Wei Cui, Yan Liang, Weixi Tian, Mingjuan Ji, Xiaofeng Ma. Regulating effect of β-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid synthesis. BBA - Molecular and Cell Biology of Lipids. 2016, 1861(3): 149-155, http://dx.doi.org/10.1016/j.bbalip.2015.12.002.
[12] Jiang, Bing, Liang, Yan, Sun, Xuebing, Liu, Xiaoxin, Tian, Weixi, Ma, Xiaofeng. Potent Inhibitory Effect of Chinese Dietary Spices on Fatty Acid Synthase. PLANT FOODS FOR HUMAN NUTRITION[J]. 2015, 70(3): 257-262, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201903250012369LS.
[13] Zhang, Qiulong, Luan, Guangxiang, Ma, Tao, Hu, Na, Suo, Yourui, Wang, Xiaoyan, Ma, Xiaofeng, Ding, Chenxu. Application of chromatography technology in the separation of active alkaloids from Hypecoum leptocarpum and their inhibitory effect on fatty acid synthase. JOURNAL OF SEPARATION SCIENCE[J]. 2015, 38(23): 4063-4070, http://www.irgrid.ac.cn/handle/1471x/1138748.
[14] Nie, Fangyuan, Liang, Yan, Xun, Hang, Sun, Jia, He, Fei, Ma, Xiaofeng. Inhibitory effects of tannic acid in the early stage of 3T3-L1 preadipocytes differentiation by down-regulating PPAR gamma expression. FOOD & FUNCTION[J]. 2015, 6(3): 894-901, https://www.webofscience.com/wos/woscc/full-record/WOS:000351367900025.
[15] Ma, Xiaofeng, Ito, Yoichiro. New analytical spiral tube assembly for separation of proteins by counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2015, 1405: 193-196, http://dx.doi.org/10.1016/j.chroma.2015.05.051.
[16] Fan, Huijin, Tian, Weixi, Ma, Xiaofeng. Curcumin induces apoptosis of HepG2 cells via inhibiting fatty acid synthase. TARGETED ONCOLOGY[J]. 2014, 9(3): 279-286, https://www.webofscience.com/wos/woscc/full-record/WOS:000341832300010.
[17] Li, Ping, Tian, Weixi, Ma, Xiaofeng. Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells. MOLECULAR CANCER[J]. 2014, 13(1): 138-138, http://www.corc.org.cn/handle/1471x/2374325.
[18] Ma Xiaofeng. Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan medicinal plant Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells. 2014, [19] Wang, Yi, Nie, Fangyuan, Ouyang, Jian, Wang, Xiaoyan, Ma, Xiaofeng. Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells. TUMOR BIOLOGY[J]. 2014, 35(10): 9563-9569, http://www.irgrid.ac.cn/handle/1471x/914303.
[20] Xiaofeng Ma, Weixi Tian, Yan Liang. Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase. 2013, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201706297482397ZK.
[21] Fan, Huijin, Wu, Dan, Tian, Weixi, Ma, Xiaofeng. Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS[J]. 2013, 1831(7): 1260-1266, http://dx.doi.org/10.1016/j.bbalip.2013.04.003.
[22] Wu, Dan, Ma, Xiaofeng, Tian, Weixi. Pomegranate husk extract, punicalagin and ellagic acid inhibit fatty acid synthase and adipogenesis of 3T3-L1 adipocyte. JOURNAL OF FUNCTIONAL FOODS[J]. 2013, 5(2): 633-641, http://dx.doi.org/10.1016/j.jff.2013.01.005.
[23] 马晓丰, 刘杨, 张三国, 陈传楚, 田维熙. 中药寒热相关药性和抑制脂肪酸合酶能力关系的探索. 中国科学院研究生院学报[J]. 2012, 29(5): 699-706, http://lib.cqvip.com/Qikan/Article/Detail?id=43165217.
[24] 权小芳, 马晓丰. 氧杂蒽酮对脂肪酸合酶的抑制作用及构效分析. 中国科学院研究生院学报[J]. 2012, 29(6): 841-846, [25] Ma Xiaofeng. A new furostanol glycoside with fatty acid synthase inhibitory activity from Ophiopogon japonicas. 2012, [26] Wang, Yi, Tian, WeiXi, Ma, XiaoFeng. Inhibitory Effects of Onion (Allium cepa L.) Extract on Proliferation of Cancer Cells and Adipocytes via Inhibiting Fatty Acid Synthase. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION[J]. 2012, 13(11): 5573-5579, [27] 樊慧锦, 田维熙, 马晓丰. 熊果酸抑制脂肪酸合酶及诱导HepG2细胞凋亡机制研究. 北京师范大学学报:自然科学版[J]. 2012, 48(3): 266-269, http://lib.cqvip.com/Qikan/Article/Detail?id=42433970.
[28] Quan, Xiaofang, Wang, Yi, Ma, Xiaofeng, Liang, Yan, Tian, Weixi, Ma, Qingyun, Jiang, Hezhong, Zhao, Youxing. alpha-Mangostin Induces Apoptosis and Suppresses Differentiation of 3T3-L1 Cells via Inhibiting Fatty Acid Synthase. PLOS ONE[J]. 2012, 7(3): http://dx.doi.org/10.1371/journal.pone.0033376.
[29] Jiang, HeZhong, Ma, QingYun, Fan, HuiJin, Liang, WenJuan, Huang, ShengZhuo, Dai, HaoFu, Wang, PengCheng, Ma, XiaoFeng, Zhao, YouXing. Fatty Acid Synthase Inhibitors Isolated from Punica granatum L.. JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY[J]. 2012, 23(5): 889-893, [30] Chen, Qiuping, Luo, Xiaowei, Ma, Xiaofeng, Jiang, Tianjia, Lu, Baiyi, Shen, Jianfu, Zhang, Ying. Fatty Acid Synthase Inhibitors Separated from Oiltea Camellia by High-Speed Counter-Current Chromatography. JOURNAL OF FOOD SCIENCE[J]. 2011, 76(5): C750-C754, https://www.webofscience.com/wos/woscc/full-record/WOS:000291231100038.
[31] Zhao, YouXing, Liang, WenJuan, Fan, HuiJin, Ma, QingYun, Tian, WeiXi, Dai, HaoFu, Jiang, HeZhong, Li, Ning, Ma, XiaoFeng. Fatty acid synthase inhibitors from the hulls of Nephelium lappaceum L.. CARBOHYDRATE RESEARCH[J]. 2011, 346(11): 1302-1306, http://dx.doi.org/10.1016/j.carres.2011.04.028.
[32] Weixi Tian, Xiaofeng Ma, Shuyan Zhang, Yinghui Sun, Binghui Li. Fatty acid synthase inhibitors from plants and their potential application in the prevention of metabolic syndrome. Clinical Oncology and Cancer Research,. 2011, 8(1): [33] Zeng, XiaoFei, Li, WeiWei, Fan, HuiJin, Wang, XiaoYan, Ji, Pan, Wang, ZeRong, Ma, Shuang, Li, LinLi, Ma, XiaoFeng, Yang, ShengYong. Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2011, 21(16): 4742-4744, http://dx.doi.org/10.1016/j.bmcl.2011.06.075.
[34] Liu, Yang, Tian, Weixi, Ma, Xiaofeng, Ding, Wenjun. Evaluation of inhibition of fatty acid synthase by ursolic acid: Positive cooperation mechanism. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2010, 392(3): 386-390, https://www.webofscience.com/wos/woscc/full-record/WOS:000275019800025.
[35] Sun, XueBing, Zhao, Jiong, Ma, XiaoFeng, Tian, WeiXi. Inhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY[J]. 2010, 25(2): 290-295, http://www.corc.org.cn/handle/1471x/2412764.
[36] []. Inhibitory effects on bacterial growth and B-ketoacyl-ACP reductase by different species of maple leaf extracts and tannic acid. 2010, [37] Duan, ChangLing, Ma, XiaoFeng, Jiang, Yong, Liu, JianXun, Tu, PengFei. Two new furostanol glycosides from the fibrous root of Ophiopogon japonicus (Thunb.) Ker-Gawl. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2010, 12(9): 745-751, [38] []. 草莓提取物对脂肪酸合酶和脂肪细胞的抑制作用. 2010, [39] Jiang, He Zhong, Quan, Xiao Fang, Tian, Wei Xi, Hu, Jiang Miao, Wang, Peng Cheng, Huang, Sheng Zhuo, Cheng, Zhong Quan, Liang, Wen Juan, Zhou, Jun, Ma, Xiao Feng, Zhao, You Xing. Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2010, 20(20): 6045-6047, http://dx.doi.org/10.1016/j.bmcl.2010.08.061.
[40] Bao, Li, Ma, Xiaofeng, Song, Xiaohong, Wang, Manyuan, Liu, Hongwei. Two New Resveratrol Tetramers Isolated from Cayratia japonica (THUNB.) GAGN. with Strong Inhibitory Activity on Fatty Acid Synthase and Antioxidant Activity. CHEMISTRY & BIODIVERSITY[J]. 2010, 7(12): 2931-2940, http://www.corc.org.cn/handle/1471x/2408841.
[41] []. 中药抑制脂肪酸合酶的能力与其中医药性的相关性研究. 2009, [42] 梁妍, 田维熙, 马晓丰. 首乌藤的化学成分. 沈阳药科大学学报[J]. 2009, 26(7): 536-538,546, http://lib.cqvip.com/Qikan/Article/Detail?id=30966266.
[43] Zhang, ShuYan, Ma, XiaoFeng, Zheng, ChaoGu, Wang, Yan, Cao, XueLi, Tian, WeiXi. Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY[J]. 2009, 24(3): 623-631, http://www.irgrid.ac.cn/handle/1471x/757883.
[44] Han, Xiao, Ma, Xiaofeng, Zhang, Tianyou, Zhang, Yabin, Liu, Qinghui, Ito, Yoichiro. Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2007, 1151(1-2): 180-182, http://www.corc.org.cn/handle/1471x/2381098.

科研活动

   
科研项目
( 1 ) 脂肪酸合酶抑制剂影响乳腺癌细胞发生发展的机理, 主持, 市地级, 2015-06--2017-12
( 2 ) 基于几种青藏高原特色植物资源功效性化学成分的天然脂肪酸合酶抑制剂的研制, 主持, 省级, 2015-07--2019-05
( 3 ) 来源于真菌的高活性脂肪酸合酶抑制剂, 主持, 市地级, 2017-01--2019-12
( 4 ) 牡丹提取物抗肿瘤及减肥活性研究, 主持, 市地级, 2019-06--2021-12
( 5 ) 细胞自噬及内质网应激在脂肪酸合酶抑制剂诱导乳腺癌细胞凋亡过程中的保护作用机制研究, 主持, 市地级, 2019-01--2021-12
( 6 ) 药食同源植物中的脂肪酸合酶抑制剂的研究, 主持, 院级, 2020-10--2023-12
( 7 ) 植物提取物中的脂肪酸合酶抑制剂的研究, 主持, 院级, 2021-06--2022-12
参与会议
(1)Fatty acid synthase inhibitors   中德科学院双边研讨会   2019-09-07
(2)以脂肪酸合酶为靶点的天然抗肿瘤药物研究    第十一届全国酶学学术讨论会   马晓丰   2013-05-16
(3)Pomegranate Husk Extracts and Its Constituents Inhibit Fatty Acid Synthase and Adipogenesis of 3T3L1 preadipocyte   上海国际生化大会   Dan Wu, Xiaofeng Ma, Weixi Tian   2009-08-02

指导学生

已指导学生

刘晓鑫  硕士研究生  071001-植物学  

权小芳  硕士研究生  071001-植物学  

樊慧锦  硕士研究生  071010-生物化学与分子生物学  

王祎  硕士研究生  071010-生物化学与分子生物学  

李平  硕士研究生  085238-生物工程  

聂方园  硕士研究生  071010-生物化学与分子生物学  

蒋冰  硕士研究生  071010-生物化学与分子生物学  

金昭君  硕士研究生  085238-生物工程  

黄文元  硕士研究生  085238-生物工程  

徐艳红  硕士研究生  085238-生物工程  

现指导学生

邢旭  硕士研究生  085238-生物工程  

郭星  硕士研究生  071010-生物化学与分子生物学  

王纯妍  硕士研究生  086000-生物与医药  

曾春萍  硕士研究生  071010-生物化学与分子生物学