基本信息
马波  男  博导  中国科学院青岛生物能源与过程研究所
电子邮件: mabo@qibebt.ac.cn
通信地址: 山东青岛崂山区松岭路189号中科院青岛生物能源与过程研究所
邮政编码: 266101

研究领域

高通量单细胞技术

微生物组


招生信息

招收相关专业博士和硕士研究生

招生专业
071005-微生物学
081703-生物化工
070302-分析化学
招生方向
定量微生物学微流控新技术,高通量微生物筛选,便携式微生物快检
高通量工业微生物选育,发酵在线监测,单细胞技术
微流控技术, 拉曼细胞分选

教育背景

2003-09--2008-05   中科院大连化物所   博士
1998-09--2001-07   四川大学   硕士
1994-09--1998-07   西华师范大学   学士

工作经历

   
工作简历
2010-12~2012-07,Rice University, 博士后研究员
2009-06~2010-11,Texas A&M University, 博士后研究员
2008-06~2009-06,University of Carlifornia, Los angeles, 博士后研究员
2001-07~2003-07,西华师范大学, 讲师

教授课程

前沿论坛
功能基因组
单细胞功能基因组

出版信息

   
发表论文
[1] 刁志钿, 王喜先, 孙晴, 徐健, 马波. 单细胞拉曼光谱测试分选装备研制及应用进展. 合成生物学[J]. 2023, 第 5 作者4(5): 1020-1035, http://lib.cqvip.com/Qikan/Article/Detail?id=7110877250.
[2] Zhang, Jia, Ren, Lihui, Zhang, Lei, Gong, Yanhai, Xu, Teng, Wang, Xiaohang, Guo, Cheng, Zhai, Lei, Yu, Xuejian, Li, Ying, Zhu, Pengfei, Chen, Rongze, Jing, Xiaoyan, Jing, Gongchao, Zhou, Shiqi, Xu, Mingyue, Wang, Chen, Niu, Changkai, Ge, Yuanyuan, Ma, Bo, Shang, Gaishuang, Cui, Yunlong, Yao, Su, Xu, Jian. Single‐cell rapid identification, in situ viability and vitality profiling, and genome‐based source‐tracking for probiotics products. iMeta[J]. 2023, 第 20 作者
[3] 王喜先, 孙晴, 刁志钿, 徐健, 马波. 拉曼光谱技术在单细胞表型检测与分选中的应用进展. 合成生物学[J]. 2023, 第 5 作者4(1): 204-224, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7427977&detailType=1.
[4] Zhu, Meijia, Xu, Teng, Cheng, Yongqiang, Ma, Bo, Xu, Jian, Diao, Zhidian, Wu, Fei, Dai, Jing, Han, Xiao, Zhu, Pengfei, Pang, Chao, Li, Jing, Wang, Hongwei, Xu, Ranran, Li, Xiaotong. Integrated Microfluidic Chip for Rapid Antimicrobial Susceptibility Testing Directly from Positive Blood Cultures. ANALYTICAL CHEMISTRY[J]. 2023, 第 4 作者95(38): 14375-14383, http://dx.doi.org/10.1021/acs.analchem.3c02737.
[5] Wang, Xixian, Ren, Lihui, Diao, Zhidian, He, Yuehui, Zhang, Jiaping, Liu, Min, Li, Yuandong, Sun, Lijun, Chen, Rongze, Ji, Yuetong, Xu, Jian, Ma, Bo. Robust Spontaneous Raman Flow Cytometry for Single-Cell Metabolic Phenome Profiling via pDEP-DLD-RFC. ADVANCED SCIENCE[J]. 2023, 第 12 作者  通讯作者  10(16): http://dx.doi.org/10.1002/advs.202207497.
[6] Ge, Anle, Liu, Fengyi, Teng, Xindong, Cui, Chaojie, Wu, Fei, Liu, Wenjing, Liu, Yang, Chen, Xiaoguang, Xu, Jian, Ma, Bo. A Palm Germ-Radar (PaGeR) for rapid and simple COVID-19 detection by reverse transcription loop-mediated isothermal amplification (RT-LAMP). BIOSENSORS & BIOELECTRONICS[J]. 2022, 第 10 作者  通讯作者  200: 113925-113925, http://dx.doi.org/10.1016/j.bios.2021.113925.
[7] Li, Zhizai, Yang, Siwei, Ye, Caichao, Wang, Gang, Ma, Bo, Yao, Huanhuan, Wang, Qian, Peng, Guoqiang, Wang, Qiang, Zhang, HaoLi, Jin, Zhiwen. Ordered Element Distributed C3N Quantum Dots Manipulated Crystallization Kinetics for 2D CsPbI3 Solar Cells with Ultra-High Performance. SMALL[J]. 2022, 第 5 作者18(15): http://dx.doi.org/10.1002/smll.202108090.
[8] Zhuobo Li, Wei Wang, Bo Ma, Jiayue Yin, Chaoqun Hu, Peng Luo, Yanhong Wang. Genomic and biological characteristics of a newly isolated lytic bacteriophage PZJ0206 infecting the Enterobacter cloacae. VIRUS RESEARCH[J]. 2022, 第 3 作者316: 
[9] Meng, Xiaoyan, Jiang, Tonghai, Zhou, Xi, Ma, Bo, Wang, Yi, Zhao, Fan. Improving Distant Supervised Relation Extraction with Noise Detection Strategy. APPLIED SCIENCES-BASEL[J]. 2021, 第 4 作者11(5): 
[10] Ji, Liming, Li, Jianfeng, Zhang, Mingzhen, Lu, Hong, He, Cong, Jin, Peihong, Ma, Bo. Effects of lacustrine hydrothermal activity on the organic matter input of source rocks during the Yanchang period in the Ordos Basin. MARINE AND PETROLEUM GEOLOGY[J]. 2021, 第 7 作者125: http://dx.doi.org/10.1016/j.marpetgeo.2020.104868.
[11] Jing, Xiaoyan, Gong, Yanhai, Xu, Teng, Meng, Yu, Han, Xiao, Su, Xiaolu, Wang, Jianmei, Ji, Yuetong, Li, Yuandong, Jia, Zhongjun, Ma, Bo, Xu, Jian. One-Cell Metabolic Phenotyping and Sequencing of Soil Microbiome by Raman-Activated Gravity-Driven Encapsulation (RAGE). MSYSTEMS[J]. 2021, 第 11 作者  通讯作者  6(3): http://dx.doi.org/10.1128/mSystems.00181-21.
[12] Xu, Teng, Han, Xiao, Zhu, Pengfei, Dai, Jing, Liu, Min, Liu, Yang, Xu, Jian, Ma, Bo. A milliliter to picoliter-level centrifugal microfluidic concentrator for fast pathogen detection and antimicrobial susceptibility testing. SENSORS AND ACTUATORS B-CHEMICAL[J]. 2021, 第 8 作者  通讯作者  343: http://dx.doi.org/10.1016/j.snb.2021.130117.
[13] Li, Mengzhe, Ge, Anle, Liu, Mengmeng, Ma, Bo, Ma, Cuiping, Shi, Chao. A fully integrated hand-powered centrifugal microfluidic platform for ultra- simple and non-instrumental nucleic acid detection. TALANTA[J]. 2020, 第 4 作者219: http://dx.doi.org/10.1016/j.talanta.2020.121221.
[14] Su, Xiaolu, Gong, Yanhai, Gou, Honglei, Jing, Xiaoyan, Xu, Teng, Zheng, Xiaoshan, Chen, Rongze, Li, Yuandong, Ji, Yuetong, Ma, Bo, Xu, Jian. Rational Optimization of Raman-Activated Cell Ejection and Sequencing for Bacteria. ANALYTICAL CHEMISTRY[J]. 2020, 第 10 作者92(12): 8081-8089, http://dx.doi.org/10.1021/acs.analchem.9b05345.
[15] Wu, Xinyu, Bai, Zhongyang, Wang, Lin, Cui, Guangchao, Yang, Mengzheng, Yang, Qing, Ma, Bo, Song, Qinglin, Tian, Dewen, Ceyssens, Frederik, Puers, Robert, Kraft, Michael, Zhao, Weisheng, Wen, Lianggong. Magnetic Cell Centrifuge Platform Performance Study with Different Microsieve Pore Geometries. SENSORS[J]. 2020, 第 7 作者20(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000510493100048.
[16] Xu, Teng, Gong, Yanhai, Su, Xiaolu, Zhu, Pengfei, Dai, Jing, Xu, Jian, Ma, Bo. Phenome-Genome Profiling of Single Bacterial Cell by Raman-Activated Gravity-Driven Encapsulation and Sequencing. SMALL[J]. 2020, 第 7 作者  通讯作者  16(30): https://www.webofscience.com/wos/woscc/full-record/WOS:000538997700001.
[17] Wang, Xixian, Xin, Yi, Ren, Lihui, Sun, Zheng, Zhu, Pengfei, Ji, Yuetong, Li, Chunyu, Xu, Jian, Ma, Bo. Positive dielectrophoresis-based Raman-activated droplet sorting for culture-free and label-free screening of enzyme function in vivo. SCIENCE ADVANCES[J]. 2020, 第 9 作者  通讯作者  6(32): https://www.webofscience.com/wos/woscc/full-record/WOS:000560452300026.
[18] Wang, Baoquan, Jiang, Tonghai, Zhou, Xi, Ma, Bo, Zhao, Fan, Wang, Yi. Time-Series Classification Based on Fusion Features of Sequence and Visualization. APPLIED SCIENCES-BASEL[J]. 2020, 第 4 作者10(12): 
[19] Wang, Baoquan, Jiang, Tonghai, Zhou, Xi, Ma, Bo, Zhao, Fan, Wang, Yi. Time-Series Classification Based on Fusion Features of Sequence and Visualization. APPLIED SCIENCES-BASEL[J]. 2020, 第 4 作者10(12): http://dx.doi.org/10.3390/app10124124.
[20] Liu, Fengyi, Xu, Teng, Liu, Wenjing, Zheng, Xiaoshan, Xu, Jian, Ma, Bo. Spontaneous droplet generation via surface wetting. LAB ON A CHIP[J]. 2020, 第 6 作者  通讯作者  20(19): 3544-3551, https://www.webofscience.com/wos/woscc/full-record/WOS:000573314400002.
[21] Dongjie Zhang, Leqin Peng, Xinglong Shang, Wenxiu Zheng, Hongjun You, Teng Xu, Bo Ma, Bin Ren, Jixiang Fang. Buoyant particulate strategy for few-to-single particle-based plasmonic enhanced nanosensors. NATURECOMMUNICATIONS[J]. 2020, 第 7 作者11(1): http://dx.doi.org/10.1038/s41467-020-16329-y.
[22] He, Yuehui, Wang, Xixian, Ma, Bo, Xu, Jian. Ramanome technology platform for label-free screening and sorting of microbial cell factories at single-cell resolution. BIOTECHNOLOGY ADVANCES. 2019, 第 3 作者  通讯作者  37(6): http://dx.doi.org/10.1016/j.biotechadv.2019.04.010.
[23] Cui, Xiaonan, Ren, Lihui, Shan, Yufei, Wang, Xixian, Yang, Zhenlong, Li, Chunyu, Xu, Jian, Ma, Bo. Smartphone-based rapid quantification of viable bacteria by single-cell microdroplet turbidity imaging. ANALYST[J]. 2018, 第 8 作者  通讯作者  143(14): 3309-3316, https://www.webofscience.com/wos/woscc/full-record/WOS:000438056400006.
[24] 马波, 徐健. 人工细胞的表型测试与分选:构建从光谱学到遗传学的桥梁. 中国科学院院刊[J]. 2018, 第 1 作者33(11): 1193-1204, http://lib.cqvip.com/Qikan/Article/Detail?id=676797246.
[25] JianXu, BoMa, XiaoquanSu, ShiHuang, XinXu, XuedongZhou, WeiHuang, RobKnight. Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data. Engineering[J]. 2017, 第 2 作者3(1): 66-70, https://journal.hep.com.cn/engi/EN/10.1016/J.ENG.2017.01.020.
[26] Wang, Xixian, Ren, Lihui, Su, Yetian, Ji, Yuetong, Liu, Yaoping, Li, Chunyu, Li, Xunrong, Zhang, Yi, Wang, Wei, Hu, Qiang, Han, Danxiang, Xu, Jian, Ma, Bo. Raman-Activated Droplet Sorting (RADS) for Label-Free High-Throughput Screening of Microalgal Single-Cells. ANALYTICAL CHEMISTRY[J]. 2017, 第 13 作者  通讯作者  89(22): 12569-12577, http://dx.doi.org/10.1021/acs.analchem.7b03884.
[27] Jian Xu, Bo Ma, Xiaoquan Su, Shi Huang, Xin Xu, Xuedong Zhou, Wei E. Huang, Rob Knight. Emerging Trends for Microbiome Analysis: From Single-Cell Functional Imaging to Microbiome Big Data. 工程(英文)[J]. 2017, 第 2 作者3(1): 66-70, http://lib.cqvip.com/Qikan/Article/Detail?id=671470460.
[28] 黄适, 滕飞, 杨芳, 朱鹏飞, 苏晓泉, 马波, 徐健. 基于微生物组的口腔“亚健康状态”检测. 生命科学[J]. 2017, 第 6 作者29(7): 660-668, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6044207&detailType=1.
[29] Zhang, Qiang, Wang, Tingting, Zhou, Qian, Zhang, Peng, Gong, Yanhai, Gou, Honglei, Xu, Jian, Ma, Bo. Development of a facile droplet-based single-cell isolation platform for cultivation and genomic analysis in microorganisms. SCIENTIFIC REPORTS[J]. 2017, 第 8 作者  通讯作者  7: http://www.irgrid.ac.cn/handle/1471x/1755909.
[30] Liu, Quanjie, Zhang, Xinwei, Ma, Bo, Lin, Yanni. Densities and viscosities for binary mixtures of polyoxymethylene dimethyl ethers with different CH2O chain length n=2, 3, 4 at different temperatures. JOURNAL OF CHEMICAL THERMODYNAMICS[J]. 2017, 第 3 作者  通讯作者  113: 151-161, http://dx.doi.org/10.1016/j.jct.2017.06.002.
[31] 马波. Reconstituting Microenvironment Simulation System for Bladder cancer Based on Microfluidic Co-culture Model. ONCOTARGET. 2015, 第 1 作者  通讯作者  
[32] Li, Chunyu, Xu, Jian, Ma, Bo. Precise quantitative addition of multiple reagents into droplets in sequence using glass fiber-induced droplet coalescence. ANALYST[J]. 2015, 第 3 作者140(3): 701-705, http://ir.qibebt.ac.cn/handle/337004/6079.
[33] Zhang, Qiang, Zhang, Peiran, Gou, Honglei, Mou, Chunbo, Huang, Wei E, Yang, Menglong, Xu, Jian, Ma, Bo. Towards high-throughput microfluidic Raman-activated cell sorting. ANALYST[J]. 2015, 第 8 作者140(18): 6163-6174, http://www.irgrid.ac.cn/handle/1471x/1000833.
[34] Liu, Pengfei, Cao, Yanwei, Zhang, Shudong, Zhao, Yang, Liu, Xiaoguang, Shi, Haoqing, Hu, Keyao, Zhu, Guanqun, Ma, Bo, Niu, Haitao. A bladder cancer microenvironment simulation system based on a microfluidic co-culture model. ONCOTARGET[J]. 2015, 第 9 作者6(35): 37695-37705, http://dx.doi.org/10.18632/oncotarget.6070.
[35] Zhang, Peiran, Ren, Lihui, Zhang, Xu, Shan, Yufei, Wang, Yun, Ji, Yuetong, Yin, Huabing, Huang, Wei E, Xu, Jian, Ma, Bo. Raman-Activated Cell Sorting Based on Dielectrophoretic Single-Cell Trap and Release. ANALYTICAL CHEMISTRY[J]. 2015, 第 10 作者87(4): 2282-2289, http://ir.qibebt.ac.cn/handle/337004/6084.
[36] Li, Chunyu, Xu, Jian, Ma, Bo. A self-powered microfluidic monodispersed droplet generator with capability of multi-sample introduction. MICROFLUIDICS AND NANOFLUIDICS[J]. 2015, 第 3 作者  通讯作者  18(5-6): 1067-1073, https://www.webofscience.com/wos/woscc/full-record/WOS:000353819900029.
[37] 马波. A Self-Powered Microfluidic Monodispersed Droplet Generator with Capability of Multi-Sample Introduction. Microfluidics and Nanofluidics. Microfluidics and Nanofluidics. 2014, 第 1 作者  通讯作者  
[38] Ma, Bo, Liu, Long, Feng, SongLin, Xu, Qing, Feng, XiangQian. Analysis of the elemental composition of Tang Sancai from the four major kilns in China using EDXRF. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS[J]. 2014, 第 1 作者319: 95-99, http://dx.doi.org/10.1016/j.nimb.2013.11.011.
[39] Zhang, Qiang, Zhang, Peiran, Su, Yetian, Mou, Chunbo, Zhou, Teng, Yang, Menglong, Xu, Jian, Ma, Bo. On-demand control of microfluidic flow via capillary-tuned solenoid microvalve suction. LAB ON A CHIP[J]. 2014, 第 8 作者14(24): 4599-4603, http://ir.qibebt.ac.cn/handle/337004/6280.
[40] Bo Ma, Long Liu, Song-Lin Feng, Qing Xu, Xiang-Qian Feng. Analysis of the elemental composition of Tang Sancai from the four major kilns in China using EDXRF. NUCLEAR INST. AND METHODS IN PHYSICS RESEARCH, B. 2014, 第 1 作者319: 95-99, http://dx.doi.org/10.1016/j.nimb.2013.11.011.
[41] 马波. Portable microfluidics device for quantitative RT-PCR. 2013, 第 1 作者
[42] Ma Bo, Yang Yating, Dong Xinghua, Zhou Junlin. Design and Implementation of Patent Semantics Search Engine Based on Ontology. 2011INTERNATIONALCONFERENCEONFUTURECOMPUTERSCIENCEANDAPPLICATIONFCSA2011VOL2[J]. 2011, 第 1 作者  通讯作者  176-180, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000393845200043.
[43] 唐富江, 刘伟, 徐凤龙, 马波, 霍堂斌, 姜作发. 黑龙江水系(中国)秋大麻哈鱼回归群体变动分析. 上海海洋大学学报[J]. 2010, 第 4 作者74-79, http://lib.cqvip.com/Qikan/Article/Detail?id=32686785.
[44] Ma, Bo, Ghavim, Sima, Sutton, Richard L, Harris, Neil G, Phelps, Michael, Wu, HsiaoMing. Real time blood plasma separation in a microfluidic chip. JOURNAL OF NUCLEAR MEDICINE. 2009, 第 1 作者50: https://www.webofscience.com/wos/woscc/full-record/WOS:000444145700472.
[45] Ma, Bo, Zhang, Guohao, Qin, Jianhua, Lin, Bingcheng. Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device. LAB ON A CHIP[J]. 2009, 第 1 作者9(2): 232-238, http://159.226.238.44/handle/321008/101393.
[46] 张国豪, 马波, 秦建华, 林炳承. 集成药物代谢微流控芯片的研制. 高等学校化学学报[J]. 2008, 第 2 作者29(7): 1356-1358, http://lib.cqvip.com/Qikan/Article/Detail?id=27899048.
[47] Ma, Bo, Zhou, Xiaomian, Wang, Gang, Dai, Zhongpeng, Qin, Jianhua, Lin, Bingcheng. A hybrid microdevice with a thin PDMS membrane on the detection window for UV absorbance detection. ELECTROPHORESIS[J]. 2007, 第 1 作者28(14): 2474-2477, http://159.226.238.44/handle/321008/98697.
[48] Ma Bo, Zhou Xiaomian, Wang Gang, Huang Huaiqing, Dai Zhongpeng, Qin Jianhua, Lin Bingcheng. Integrated isotachophoretic preconcentration with zone electrophoresis separation on a quartz microchip for UV detection of flavonoids. ELECTROPHORESIS[J]. 2006, 第 1 作者27(24): 4904-4909, http://159.226.238.44/handle/321008/98075.
[49] 马波. 玻璃微流控芯片性能评价. 高等学校化学学报. 2005, 第 1 作者  通讯作者  
[50] 马波. 黄酮类化合物抗肿瘤活性量子化学研究. 化学研究与应用. 2002, 第 1 作者
[51] 马波. 四川大学植物标本数据库的构建. 四川大学学报. 2001, 第 1 作者
[52] 马波, 周在德, 李梦龙. 人工神经网络及其在色谱中的应用. 化学研究与应用[J]. 2000, 第 1 作者12(4): 375, http://lib.cqvip.com/Qikan/Article/Detail?id=4511449.

科研活动

   
科研项目
( 1 ) 单细胞功能基因组及自动培养系统研制, 参与, 部委级, 2012-11--2014-10
( 2 ) 用于农产品致病原及污染物现场即时检测的智能化微流控芯片系统研制, 参与, 部委级, 2013-06--2016-07
( 3 ) 基于阵列介电捕获的微生物单细胞高通量拉曼流式分选方法学研究 , 主持, 国家级, 2015-01--2018-12
( 4 ) 基于液滴微流控技术的快速生长雨声红球藻株高通量筛选方法研究, 主持, 国家级, 2014-06--2016-06
( 5 ) 耦合液滴单细胞培养的快速微生物鉴定质谱接口关键技术 研究, 主持, 国家级, 2018-01--2021-12
( 6 ) 高通量拉曼流式细胞分选仪的研制, 主持, 部委级, 2018-01--2019-12
( 7 ) 高灵敏、高通量、多参数光学检测分析仪器研发, 主持, 国家级, 2019-07--2024-06

指导学生

已指导学生

崔晓楠  硕士研究生  085238-生物工程  

张嘉萍  硕士研究生  085238-生物工程  

刁志钿  硕士研究生  085238-生物工程  

刘沣仪  硕士研究生  085238-生物工程  

徐腾  博士研究生  071005-微生物学  

现指导学生

刘沣仪  博士研究生  071010-生物化学与分子生物学  

周浩  硕士研究生  071005-微生物学