（1）新型纳微颗粒疫苗佐剂构建及其免疫增强机制研究。基于前期颗粒性质影响疫苗免疫效应基础上，开展深入颗粒微观结构影响免疫效应相关机制研究，总结微观结构调控免疫效应的规律，指导颗粒疫苗理性设计。针对乙肝表面抗原、HPV疫苗、流感疫苗等，设计构建不同免疫增效需求的颗粒疫苗，完成体外、体内免疫效应评价，开展体内过程及胞内信号途径研究，阐明颗粒增强免疫效应机制，深化颗粒疫苗设计。
（2）mRNA递送系统研究。针对不同部位如肝脏、肺脏、脾脏等，设计构建mRNA的靶向递送系统，实现mRNA的靶器官、靶细胞的定位传输，系统研究颗粒性质影响靶向效率与转染效率的相关规律，实现mRNA递送体系的理性设计。
（3）肿瘤微环境调控纳微体系研究。针对肿瘤乏氧、免疫抑制微环境，设计构建递送微环境改善活性物质的复合体系，通过仿生修饰等实现体内长循环及其对肿瘤部位及其相关细胞的次序靶向递送，经环境响应释放设计，实现活性物质的次序递送及其对不同微环境的调控，阐明相关机制，指导新型递送体系的理性构筑。

   

081703-生物化工

纳微颗粒疫苗递送与佐剂系统
mRNA定位递送体系研究
肿瘤微环境调控纳微体系研究

2002-09--2006-06   中国科学院过程工程研究所   博士学位
1997-09--2000-06   东北林业大学   硕士学位
1993-09--1997-06   东北林业大学   学士学位

   

2016-08~现在, 中国科学院过程工程研究所, 研究员
2009-08~2016-07,中国科学院过程工程研究所, 副研究员
2006-07~2009-07,中国科学院过程工程研究所, 助理研究员
2000-07~2002-08,轻工业环境保护研究所, 中级工程师

2022-01-01-2026-12-31,中国营养学会微量元素营养分会第八届委员会, 常务委员
2019-04-30-今,中国生物医学工程学会纳米医学分会, 高级会员
2017-02-01-今,中国颗粒学会团体标准委员会, 委员
2014-09-05-今,中国颗粒学会生物专业委员会, 委员
2012-09-05-今,中国颗粒学会, 青年理事

   

（1） 华夏医学科学技术奖, 二等奖, 部委级, 2022
（2） 中国食品工业协会科学技术奖, 特等奖, 部委级, 2021
（3） 尺寸均一、可控的乳液微球和微囊, 二等奖, 国家级, 2009
（4） 尺寸均一、可控的微球和微囊的制, 一等奖, 省级, 2006

（ 1 ） 一种流感病毒疫苗佐剂、疫苗颗粒及其用途, 发明专利, 2023, 第 1 作者, 专利号: 2023108176542

（ 2 ） 臭氧化油及其制备方法和用途, 发明专利, 2022, 第 1 作者, 专利号: 202211186277.9

（ 3 ） 缓、控释载抗原纳米乳的海藻酸盐微胶囊、制备方法, 发明专利, 2022, 第 1 作者, 专利号: CN202211076473.0

（ 4 ） 缓、控释载抗原纳米球的海藻酸盐微胶囊、制备方法, 发明专利, 2022, 第 1 作者, 专利号: 202211076473.0

（ 5 ） 一种载鱼油或藻油微胶囊及其制备方法和用途, 发明专利, 2020, 第 3 作者, 专利号: CN112106991A

（ 6 ） 一种载益生菌的微胶囊的制备方法及由其制得产品和应用, 发明专利, 2020, 第 3 作者, 专利号: CN110946287A

（ 7 ） 阳离子脂质纳米疫苗佐剂及其制备方法, 发明专利, 2020, 第 1 作者, 专利号: CN111467487A

（ 8 ） 一种集化疗与免疫疗法为一体的纳米制剂及制备方法, 发明专利, 2017, 第 2 作者, 专利号: CN106902095A

（ 9 ） 一种集化疗与免疫疗法为一体的载黄芩苷纳米制剂及其制备方法, 发明专利, 2021, 第 2 作者, 专利号: CN106902095B

（ 10 ） 一种海藻酸钠-琼脂糖微球及其制备方法和应用, 专利授权, 2017, 第 2 作者, 专利号: CN106890159A

（ 11 ） 一种纳米级硫酸亚铁营养补充剂微囊化产品及其制备工艺, 发明专利, 2016, 第 2 作者, 专利号: CN105477014A

（ 12 ） 一种新型微纳米级鱼油/藻油微胶囊及其制备工艺, 发明专利, 2016, 第 2 作者, 专利号: CN105533691A

（ 13 ） 一种微纳米级鱼油/藻油微胶囊及其制备工艺, 发明专利, 2019, 第 2 作者, 专利号: CN105533691B

（ 14 ） 一种胞内pH响应聚乳酸类纳微球及其制备方法, 发明专利, 2016, 第 1 作者, 专利号: CN106031794A

（ 15 ） 一种具有治疗或预防HPV病毒的疫苗组合物及其应用, 发明专利, 2015, 第 1 作者, 专利号: CN104338126A

（ 16 ） 一种载活性药物的聚合物脂质球及其制备方法, 发明专利, 2016, 第 2 作者, 专利号: CN105287431A

（ 17 ） 一种W/O型疫苗油佐剂制剂及其制备方法, 发明专利, 2015, 第 2 作者, 专利号: CN105148266A

（ 18 ） 一种装载难溶性药物的壳聚糖-壳聚糖衍生物纳米球、制备方法及其作为口服制剂的应用, 发明专利, 2012, 第 4 作者, 专利号: CN102641245A

（ 19 ） 一种装载难溶性抗肿瘤药物的壳聚糖-羧化壳聚糖纳米球、制备方法及其应用, 发明专利, 2012, 第 3 作者, 专利号: CN102389572A

（ 20 ） 一种10-羟基喜树碱的纳微给药体系及其制备方法, 发明专利, 2012, 第 1 作者, 专利号: CN102349871A

（ 21 ） 一种胃部靶向药物载体及其制备方法, 发明专利, 2012, 第 1 作者, 专利号: CN102652833A

（ 22 ） 壳聚糖纳微球产品及其制备方法, 发明专利, 2010, 第 2 作者, 专利号: CN101675996A

（ 23 ） 荧光壳聚糖微球的制备方法及其在示踪剂领域的应用, 发明专利, 2010, 第 4 作者, 专利号: CN101148511B

（ 24 ） 一种尺寸均一、包埋率高、药物活性保持率高的壳聚糖载药微球及其制备方法, 发明专利, 2005, 第 3 作者, 专利号: CN1698900A

（ 25 ） 一种尺寸均一的琼脂糖凝胶微球及其制备方法, 发明专利, 2005, 第 3 作者, 专利号: CN1640539A

（ 26 ） 一种尺寸均一的壳聚糖微球和微囊及其制备方法, 发明专利, 2005, 第 3 作者, 专利号: CN1607033A

   

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[100] 马光辉, 王连艳, 魏炜, 吴颉, 张岳玲, 吕坯平, 苏志国. 用于蛋白质多肽药物给药的壳聚糖微球的制备和药物活性保持策略. 2010年全国高分子材料科学与工程研讨会学术论文集（上册）. 2010, 第 2 作者2, http://www.irgrid.ac.cn/handle/1471x/717276.
[101] Yang, Jian, Hao, DongXia, Bi, CaiXia, Su, ZhiGuo, Wang, LianYan, Ma, GuangHui. Rapid Synthesis of Uniform Magnetic Microspheres by Combing Premix Membrane Emulsification and in Situ Formation Techniques. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH[J]. 2010, 第 5 作者  通讯作者  49(13): 6047-6053, http://www.irgrid.ac.cn/handle/1471x/779174.
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[103] Ma GuangHui, Yang Jian, Lv PiPing, Wang LianYan, Wei Wei, Tian Rui, Wu Jie, Su ZhiGuo. Preparation of Uniform Microspheres and Microcapsules by Modified Emulsification Process. MACROMOLECULAR SYMPOSIA. 2010, 第 4 作者288(1): 41-48, 
[104] 曾烨婧, 王连艳, 马光辉, 马润宇. 快速膜乳化法制备载紫杉醇聚乳酸类微球. 过程工程学报[J]. 2010, 第 2 作者10(3): 568-575, https://www.jproeng.com/CN/Y2010/V10/I3/568.
[105] 李娜, 王连艳, 吴有斌, 曾烨婧, 马光辉, 苏志国. 乙肝表面抗原在微球表面的吸附行为、活性和结构变化. 过程工程学报[J]. 2010, 第 2 作者10(3): 559-567, https://www.jproeng.com/CN/Y2010/V10/I3/559.
[106] 岳华, 魏炜, 岳占国, 吕丕平, 王连艳, 马光辉, 苏志国. 纳微球粒径大小对免疫学效应的影响. 生物颗粒与粉体制备、应用技术研讨会论文集. 2010, 第 5 作者2, http://www.irgrid.ac.cn/handle/1471x/717398.
[107] Lv, PiPing, Wei, Wei, Gong, FangLing, Zhang, YueLing, Zhao, HuiYing, Lei, JianDu, Wang, LianYan, Ma, GuangHui. Preparation of Uniformly Sized Chitosan Nanospheres by a Premix Membrane Emulsification Technique. INDUSTRIALENGINEERINGCHEMISTRYRESEARCH[J]. 2009, 第 7 作者  通讯作者  48(19): 8819-8828, http://www.irgrid.ac.cn/handle/1471x/778910.
[108] 王连艳. 利用快速膜乳化法制备粒径均一的PLGA纳微球和纳微囊. 过程工程学报. 2009, 第 1 作者  通讯作者  
[109] 田瑞, 王连艳, 吴颉, 张洁, 曾烨婧, 马光辉, . 快速膜乳化法制备粒径均一的PLGA微球和微囊. 过程工程学报[J]. 2009, 第 2 作者9(4): 754-762, https://www.jproeng.com/CN/Y2009/V9/I4/754.
[110] Zhang, Yueling, Lian, Guoping, Zhu, Shiping, Wang, Lianyan, Wei, Wei, Ma, Guanghui. Investigation on the uniformity and stability of sunflower oil/water emulsions prepared by a shirasu porous glass membrane. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH[J]. 2008, 第 4 作者47(17): 6412-6417, http://www.irgrid.ac.cn/handle/1471x/725410.
[111] Zhou, QingZhu, Wang, LianYan, Ma, GuangHui, Su, ZhiGuo. Multi-stage premix membrane emulsification for preparation of agarose microbeads with uniform size. JOURNAL OF MEMBRANE SCIENCE[J]. 2008, 第 2 作者322(1): 98-104, http://dx.doi.org/10.1016/j.memsci.2008.05.025.
[112] Wei, Qiang, Wei, Wei, Tian, Rui, Wang, Lianyan, Su, ZhiGuo, Ma, GuangHui. Preparation of uniform-sized PELA microspheres with high encapsulation efficiency of antigen by premix membrane emulsification. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2008, 第 4 作者323(2): 267-273, http://dx.doi.org/10.1016/j.jcis.2008.04.058.
[113] Wei, Qiang, Wei, Wei, Lai, Bo, Wang, LianYan, Wang, YuXia, Su, ZhiGuo, Ma, GuangHui. Uniform-sized PLA nanoparticles: Preparation by premix membrane emulsification. INTERNATIONAL JOURNAL OF PHARMACEUTICS[J]. 2008, 第 4 作者359(1-2): 294-297, http://www.irgrid.ac.cn/handle/1471x/725369.
[114] Wei Wei, Wang LianYan, Yuan Lan, Yang XiaoDa, Su ZhiGuo, Ma GuangHui. Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS : OFFICIAL JOURNAL OF ARBEITSGEMEINSCHAFT FUR PHARMAZEUTISCHE VERFAHRENSTECHNIK E.V. 2008, 第 2 作者http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD12102102490040&DbName=SJPD_02&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[115] Wei, Wei, Yuan, Lan, Hu, Gang, Wang, LianYan, Wu, He, Hu, Xue, Su, ZhiGuo, Ma, GuangHui. Monodisperse chitosan microspheres with interesting structures for protein drug delivery. ADVANCED MATERIALS[J]. 2008, 第 4 作者20(12): 2292-+, http://www.irgrid.ac.cn/handle/1471x/725373.
[116] Wei, Wei, Wang, LianYan, Wu, Jie, Ma, GuangHui. Quaternized chitosan microspheres as insulin carrier. JOURNAL OF BIOTECHNOLOGY. 2008, 第 2 作者136: S452-S452, http://dx.doi.org/10.1016/j.jbiotec.2008.07.1050.
[117] Wei, Wei, Wang, LianYan, Yuan, Lan, Yang, XiaoDa, Su, ZhiGuo, Ma, GuangHui. Bioprocess of uniform-sized crosslinked chitosan microspheres in rats following oral administration. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS[J]. 2008, 第 2 作者69(3): 878-886, http://dx.doi.org/10.1016/j.ejpb.2008.02.011.
[118] Wu, Jie, Wei, Wei, Wang, LianYan, Su, ZhiGuo, Ma, GuangHui. Preparation of uniform-sized pH-sensitive quaternized chitosan microsphere by combining membrane emulsification technique and thermal-gelation method. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2008, 第 3 作者63(2): 164-175, http://dx.doi.org/10.1016/j.colsurfb.2007.11.021.
[119] Wu, Jie, Wei, Wei, Wang, LianYan, Su, ZhiGuo, Ma, GuangHui. A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system. BIOMATERIALS[J]. 2007, 第 3 作者28(13): 2220-2232, http://dx.doi.org/10.1016/j.biomaterials.2006.12.024.
[120] Zhou, QingZhu, Wang, LianYan, Ma, GuangHui, Su, ZhiGuo. Preparation of uniform-sized agarose beads by microporous membrane emulsification technique. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2007, 第 2 作者311(1): 118-127, http://dx.doi.org/10.1016/j.jcis.2007.02.040.
[121] Wei, Wei, Wang, LianYan, Yuan, Lan, Wei, Qiang, Yang, XiaoDa, Su, ZhiGuo, Ma, GuangHui. Preparation and application of novel microspheres possessing autofluorescent properties. ADVANCED FUNCTIONAL MATERIALS[J]. 2007, 第 2 作者17(16): 3153-3158, http://www.irgrid.ac.cn/handle/1471x/725801.
[122] Wang, LianYan, Gu, YongHong, Zhou, QingZhu, Ma, GuangHui, Wan, YinHua, Su, ZhiGuo. Preparation and characterization of uniform-sized chitosan microspheres containing insulin by membrane emulsification and a two-step solidification process. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2006, 第 1 作者50(2): 126-135, http://dx.doi.org/10.1016/j.colsurfb.2006.05.006.
[123] 古永红, 王连艳, 谭天伟, 马光辉. 尺寸均一的壳聚糖微球的制备及其作为胰岛素控释载体的研究. 生物工程学报[J]. 2006, 第 2 作者22(1): 150-155, http://lib.cqvip.com/Qikan/Article/Detail?id=21193009.
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（1） 生物材料科学里几丁质和壳聚糖的目前研究和进展：壳聚糖微球的制备和应用, “Current Research and Developments on Chitin and Chitosan in Biomaterial Science”, Preparation and Applications of Chitosan Microsphere, Research Signpost, 2008-07, 第 1 作者
（2） 生物技术中的微球和微囊：设计，制备和应用, Microspheres and Microcapsules for Protein Drug Delivery, published in “Microspheres and Microcapsules in Biotechnology: Design, Preparation and Applications” , Pan Stanford Publishing, 2012-10, 第 1 作者
（3） 海藻酸盐：生产，类型和应用, Alginates: production, types and applications, published in “Alginates: Production, Types and Applications”, , Nova Science Publishers, Inc, 2012-12, 第 1 作者

   

（ 1 ） 基于肿瘤微环境重塑和介导T细胞靶向肿瘤的多功能纳米疫苗构建及免疫相关研究, 参与, 地方任务, 2021-01--2023-12
（ 2 ） VZV亚单位/表位颗粒疫苗构建、制备及免疫保护研究, 参与, 地方任务, 2020-12--2023-12
（ 3 ） 基于抗原有序展示的新型纳米佐剂构建及疫苗免疫原性增强机制探索, 负责人, 地方任务, 2020-12--2023-12
（ 4 ） 基于碳酸盐颗粒的VLP疫苗递送体系与免疫治疗应用基础研究, 负责人, 国家任务, 2020-07--2023-06
（ 5 ） 基于肿瘤微环境的时空次序递送VLP纳米疫苗构建及免疫治疗相关研究, 负责人, 国家任务, 2020-01--2023-12
（ 6 ） 模式与特色动物实验平台, 负责人, 中国科学院计划, 2016-01--2020-12
（ 7 ） 聚乳酸类纳米颗粒疫苗佐剂关键技术研究, 负责人, 国家任务, 2016-01--2020-12
（ 8 ） 多功能“薄皮大腔”PLGA 纳微囊佐剂的构建及其作用机制, 负责人, 国家任务, 2015-01--2018-12
（ 9 ） 聚乳酸纳微球佐剂的乙肝疫苗制剂开发, 负责人, 境内委托项目, 2014-06--2016-06
（ 10 ） 聚乳酸纳微球作为宫颈癌疫苗微球制剂的研究, 负责人, 国家任务, 2014-01--2016-12
（ 11 ） 动物疫苗制剂及下游工艺技术研究与示范, 负责人, 国家任务, 2013-01--2017-12
（ 12 ） 免疫原递送微粒载体构建与递呈机制, 参与, 国家任务, 2013-01--2017-12
（ 13 ） 纳微颗粒佐剂剂型化研究, 负责人, 国家任务, 2012-01--2015-12
（ 14 ） 新型纳微球佐剂治疗性乙肝疫苗研制, 负责人, 国家任务, 2011-01--2012-12
（ 15 ） 疫苗新佐剂与新剂型的研发, 负责人, 中国科学院计划, 2011-01--2014-12
（ 16 ） 新型纳微球佐剂治疗性乙肝疫苗研制, 负责人, 国家任务, 2011-01--2012-12
（ 17 ） 纳米技术增加难溶药物功效的生物安全性研究, 参与, 国家任务, 2009-01--2013-12

（1）基于M2靶向纳米疫苗的肿瘤微环境重塑和免疫治疗研究   中国微米纳米技术学会第四届微纳米技术与医疗健康创新大会   2024-05-25
（2）聚合物脂质复合纳米疫苗构建及免疫研究   中国医疗保健国际交流促进会公共卫生与预防医学分会疫苗创新研发与前沿技术应用论坛   王连艳   2024-05-18
（3）基于M2靶向纳米疫苗的肿瘤微环境重塑和免疫治疗研究   第十二届中国颗粒学会年会   王连艳   2023-04-21
（4）肠道定向输送微囊系统研究   营养强化剂和功能配料基础与产业化关键技术研讨会   王连艳   2023-03-15
（5）聚合物纳米颗粒佐剂构建、效果及安全性初步评价   中国颗粒学会第11届学术年会   2020-10-23
（6）基于DC靶向的“薄皮大腔” PLGA纳微囊的肿瘤免疫   2019 生物治疗产业大会   2019-03-23
（7）嗜酸乳杆菌对肠道微生态及口服免疫的影响   食品与功能国际研讨会   王连艳，张宇   2018-05-25
（8）Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation   2015-12-06
（9）PLA Microspheres Induce Robust Immune Responses via Several Commonly Used Parenteral Administration Routes   2015-10-25
（10）以纳微颗粒为佐剂的新型乙肝疫苗研发   中国化工年会   2015-10-17
（11）pH-Responsive Poly(D, L-lactic-co-glycolic acid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response   第五届中国药物制剂大会   2015-09-25
（12）PLA Microspheres Induce Robust Immune Responses via Several Commonly Used Parenteral Administration Routes   2015-09-03
（13）膜乳化技术及其在食品微包埋中的应用   营养食品新技术学术会议   2015-01-25
（14）Preparation of Uniform-sized Polysaccharide Microspheres with Novel Structure and Application as Oral Delivery System for Insulin.    Lianyan Wang, Wei Wei, Yueling Zhang, Guanghui Ma.    2011-05-29
（15）尺寸均一聚合物纳微球制备及应用   中国微米纳米技术学会纳米科学技术分会纳米生物与医药技术专业委员会2010学术年会   王连艳，吕丕平，岳华，刘媛，马光辉   2010-11-26
（16）Preparation of Uniform-sized Mico- and Nano-particles and Their Applications in Drug Delivery Systems.    Lianyan Wang, Wei Wei, Yueling Zhang, Yuan Liu, Guanghui Ma.    2010-10-23
（17）尺寸均一的微球和微囊的制备及作为药物载体的应用   生物颗粒与粉体制备、应用技术研讨会   王连艳，马光辉   2010-09-27
（18）尺寸均一的自发荧光壳聚糖微球制备与应用，   全国第八届海洋生物技术与创新药物学术讨论会   王连艳，魏炜，吕丕平，马光辉   2010-08-08
（19） Preparation and Application of ALG/CHI Microspheres with Narrow Size Distribution for Oral Delivery of Insulin.    L.-Y. Wang, Y.-L. Zhang, W. Wei, G.-H. Ma.   2010-05-22
（20）Effect of particle size in macrophage responses.    Lianyan Wang, Hua Yue, Wei Wei, Guanghui Ma.    2010-05-22
（21）尺寸均一、可控纳微载体制备与应用，   全国生物材料大会   王连艳，马光辉   2010-04-15
（22）Monodisperse Chitosan Microspheres with Interesting Structures for Proein Drug Delivery   Lianyan Wang, Wei Wei, Guanghui Ma, Zhiguo Su   2009-10-22
（23）Preparation of Uniform-sized Chitosan Microspheres with Autofluorescence and Its Application in Vivo   Lianyan Wang, Wei Wei, Jie Wu, Yueling Zhang, Guanghui Ma, Zhiguo Su   2009-09-24
（24）Preparation of Uniform-sized Chitosan Microspheres with Autofluorescence and Its Application in Vivo   Lian-Yan Wang, Wei Wei, Jie Wu, Yue-Ling Zhang, Guang-Hui Ma, Zhi-guo Su   2009-04-26
（25）Preparation of Uniform Chitosan Micro- and Nano-spheres by Membrane Emulsification Technique   Lian-Yan Wang, Pi-Ping Lv, Wei Wei, Yue-Ling Zhang, Jie Wu, Guang-Hui Ma   2008-12-09
（26）Autofluorescence of Chitosan Microspheres and Its Application in Vivo   Lianyan Wang, Wei Wei, Guanggui Ma.   2006-11-25
（27）尺寸均一、高活性保持的壳聚糖载药微球的制备   第三届全国化学工程与生物化工年会   王连艳，魏炜，马光辉，苏志国   2006-11-10
（28）Preparation and Characterization of Uniform-sized Chitosan Microspheres Containing Bioactive Drug   Lian-Yan Wang, Guang-Hui Ma   2005-10-24
（29）尺寸均一的壳聚糖载药微球的制备和应用   第三届海洋生物高技术论坛论文集   王连艳，马光辉，苏志国   2005-08-22
（30）尺寸均一的壳聚糖微球的制备   第一届全国化学工程与生物化工年会   王连艳，孟凡涛，马光辉   2004-11-05

已指导学生

杨铸  硕士研究生  085600-材料与化工  

现指导学生

迟永杰  博士研究生  081704-应用化学  

刘雨梦  硕士研究生  086000-生物与医药